Clinical trials
Migraine clinical trials
A neurological condition causing recurring, often disabling headaches. We’re tracking 190 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07698249Enrolling by invitation
Headache diary for migraine patients
This trial tests whether a headache diary can help people with migraine track their symptoms and improve their care.
Edison, New JerseyAges 18 years+ - NCT07694063Recruiting
Online yoga for frequent migraines
This trial tests if online Hatha yoga classes can help adults who have frequent migraines (but not daily). If you have migraines 8–14 days a month and are already on stable medication, this study may offer a gentle addition to your treatment.
Seville, SevillaAges 18–65 - NCT06659120Recruiting
Fremanezumab to prevent period-related migraines
This study tests whether the migraine prevention drug fremanezumab can reduce the number of migraines you get around your period. It is for women who have regular cycles and migraines that are clearly linked to their menstrual period.
BernAges 18 years+ - NCT06662461Recruiting
Nerve block for stubborn migraines: Stellate vs occipital
This trial tests which nerve block works better for stubborn migraines: one on the stellate ganglion (a cluster of nerves in the neck) or the greater occipital nerve (at the back of the head). They will also check how these blocks affect a chemical linked to migraine pain. If you have chronic migraines that haven't improved with multiple treatments, you may be eligible.
CairoAges 18 years+ - NCT07674654RecruitingPhase 3
Long-term safety study of an investigational migraine medication
This study is testing the long-term safety of an investigational migraine medication called elismetrep. It is for people who have already completed a previous study of this drug and are willing to continue using a smartphone app to track their symptoms daily.
Birmingham, AlabamaAges 18 years+ - NCT07671703Recruiting
Physiotherapy for migraine relief
This trial tests whether a combination of physical therapy techniques can reduce migraine symptoms. It may help people whose migraines are not caused by other conditions.
Osnabrück, Low SaxonyAges 18–70 - NCT07656922Recruiting
Shoulder muscle function and migraine
This study looks at how the muscles around your shoulder blade work during migraine attacks. It may help find better ways to treat migraine-related shoulder problems.
Ankara, ÇubukAges 18–55 - NCT07657377Recruiting
Physical therapy for migraine relief
This trial tests whether physiotherapy (physical therapy) can help reduce migraine symptoms. It focuses on people diagnosed with migraine by a neurologist, excluding those with other headache types or certain health conditions.
AnkaraAges 18–55 - NCT07646613RecruitingPhase 2
Testing an inhaled migraine medicine for quick relief
This study tests a new inhaled powder form of a migraine medication called dihydroergotamine (DHE) to see if it safely and effectively stops migraine attacks. If you have frequent migraines, this trial might offer you a new treatment option to try.
Phoenix, ArizonaAges 18–65 - NCT07645924RecruitingPhase 3
Elismetrep for fast relief of migraine attacks
This trial tests a new oral medication called elismetrep (K-304) for quickly stopping migraine pain and other symptoms. If you have regular migraines, this could offer a new option that works fast when a migraine starts.
Birmingham, AlabamaAges 18–75 - NCT04925414RecruitingPhase 4
Testing high-flow oxygen for migraine in the emergency room
This trial looks at whether breathing high-flow oxygen in the emergency department can help relieve migraine-like headaches. You may qualify if you are 18+ and are admitted to the ER for a migraine that fits standard diagnostic rules.
NiceAges 18 years+ - NCT07629635RecruitingPhase 3
Closing a heart hole to treat migraines
This trial tests whether closing a small hole in the heart (called a PFO) can help eliminate migraines. If you have frequent migraines and no other major health issues, this procedure might reduce or stop your headaches.
New York, New YorkAges 18–55 - NCT07626307Recruiting
Migraine Screening Tool to Guide Physical Therapy Referral
This study tests whether a simple assessment tool can help neurologists decide which migraine patients would benefit from physical therapy. You'll be evaluated by both a neurologist and a physical therapist to see if the tool correctly identifies patients who could improve with hands-on treatment.
MilanAges 18–70 - NCT07617441Recruiting
Brain and Psychology Study of Hard-to-Treat Migraines
This research study compares brain structure and psychological traits in people with chronic migraines that don't respond well to standard treatments versus healthy volunteers without migraines. Understanding these differences may help doctors develop better treatment options for difficult-to-treat migraines.
Catanzaro, CatanzaroAges 18–75 - NCT07616128RecruitingPhase 2
Testing EVO756 to prevent migraines in adults
This study tests a new medication called EVO756 to help prevent migraines in adults who haven't had success with other preventive treatments. Researchers want to see if this new drug can reduce how often migraines happen.
Chandler, ArizonaAges 18–64 - NCT07609914RecruitingPhase 4
Safety study of an extra dose of rimegepant for migraine
This study tests whether taking an additional dose of rimegepant (a migraine medicine you may already use) is safe and helpful for adults with migraine. Rimegepant is a calcitonin gene-related peptide (CGRP) receptor antagonist—a type of medicine that blocks a protein involved in migraine pain.
Canoga Park, CaliforniaAges 18 years+ - NCT07579481Recruiting
Vortioxetine for Depression with Migraine
This study tests whether vortioxetine, a depression medication, can help people who have both depression and episodic migraine (recurring headaches). You'd take vortioxetine for depression while researchers track how it affects both your mood and migraine symptoms.
Rome, LazioAges 18 years+ - NCT07571889Recruiting
Numbing spray to reduce Botox injection pain for chronic migraine
This study tests whether a numbing spray applied inside the nose before Botox injections can reduce injection pain in people with chronic migraine. The goal is to make the treatment more comfortable without affecting how well it works.
East Providence, Rhode IslandAges 18 years+ - NCT07568496Recruiting
Nerve block for migraine with medication overuse headache
This study tests a nerve block injection at the back of the head to see if it can reduce migraines in people who also have headaches from overusing pain medication. It aims to provide a new treatment option for this difficult-to-treat condition.
Bangkok, BangkokAges 18–80 - NCT06735768Recruiting
Daily magnetic brain stimulation to prevent migraines
This study tests a type of magnetic brain stimulation (repetitive TMS) given daily at home to prevent migraines. It may be an option if your migraine medications aren't enough or you want a non-drug treatment.
Vienna, State of ViennaAges 18–65 - NCT07500558Recruiting
Ultrasound-guided nerve block for chronic migraine pain relief
This study tests two power levels of a pulsed radiofrequency treatment aimed at a nerve cluster behind your cheekbone to reduce chronic migraine pain. If you have frequent migraines that haven't responded well to two or more preventive medications, this could be an option for you.
MinyaAges 20–70 - NCT07496034RecruitingPhase 3
Gou-Teng-San for frequent migraines
This study tests a Chinese herbal formula called Gou-Teng-San (GTS) for preventing episodic migraines. It is for adults who have frequent migraines but have not tried many prevention medicines.
Taichung, SouthAges 18–70 - NCT07493434Enrolling by invitation
Can essential oils help with migraine pain?
This trial tests if inhaling essential oils can reduce pain in people with migraine. You may join if you have migraines and are not allergic to essential oils.
São Paulo, São PauloAges 18–60 - NCT06322407Recruiting
Ultrasound-guided neck injection for treating chronic migraine
This study tests whether a nerve block injection near the neck (called stellate ganglion block), guided by ultrasound, can reduce chronic migraine pain. It may be a good option if you have chronic migraine and haven't found relief from standard preventive medications.
Beijing, Beijing MunicipalityAges 18–65
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Common questions
- Are there clinical trials for migraine?
- Yes. Clin2 currently lists 190 recruiting migraine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.