Clinical trials
Migraine clinical trials
A neurological condition causing recurring, often disabling headaches. We’re tracking 200 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05598723RecruitingPhase 3
Botox versus Xeomin for chronic migraine in adults
This Phase 3 study compares two headache injections—Botox and Xeomin—for people with chronic migraine. It may help find out which option works better to reduce frequent, long-lasting migraine days.
Jacksonville, North CarolinaAges 18–89 - NCT07617441Recruiting
Brain and Psychology Study of Hard-to-Treat Migraines
This research study compares brain structure and psychological traits in people with chronic migraines that don't respond well to standard treatments versus healthy volunteers without migraines. Understanding these differences may help doctors develop better treatment options for difficult-to-treat migraines.
Catanzaro, CatanzaroAges 18–75 - NCT07609914RecruitingPhase 4
Safety study of an extra dose of rimegepant for migraine
This study tests whether taking an additional dose of rimegepant (a migraine medicine you may already use) is safe and helpful for adults with migraine. Rimegepant is a calcitonin gene-related peptide (CGRP) receptor antagonist—a type of medicine that blocks a protein involved in migraine pain.
Canoga Park, CaliforniaAges 18 years+ - NCT07347067Recruiting
Trigger point injections for chronic migraine
This study tests if injecting medication into specific painful spots in your muscles (called trigger points) can help reduce chronic migraine pain. It may be an option if you've tried other treatments but still have significant pain.
Beijing, Beijing MunicipalityAges 18–65 - NCT07743255Enrolling by invitation
Preventing migraines in children with melatonin and propranolol
This study tests whether two common medicines, melatonin and propranolol, can help prevent migraines in children. If your child has frequent, disabling migraines, this treatment might reduce how often they occur and improve daily life.
Multan, Punjab ProvinceAges 5–15 - NCT04743141RecruitingPhase 3
Long-term migraine medicine study for kids with migraine attacks
This Phase 3 study checks the long-term safety of rimegepant, a migraine treatment, in children and teens. You might join if your child has had migraine for at least 6 months and still gets a certain number of moderate-to-severe migraine attacks.
Scottsdale, ArizonaAges 6–17 - NCT06972056RecruitingPhase 4
Comparing migraine prevention drugs: atogepant, propranolol, topiramate
This study compares three common migraine prevention medications to see which works best. You might be able to join if you have migraines at least 4 days a month and haven't taken these specific drugs before.
Flagstaff, ArizonaAges 18–70 - NCT07646613RecruitingPhase 2
Testing an inhaled migraine medicine for quick relief
This study tests a new inhaled powder form of a migraine medication called dihydroergotamine (DHE) to see if it safely and effectively stops migraine attacks. If you have frequent migraines, this trial might offer you a new treatment option to try.
Walnut Creek, CaliforniaAges 18–65 - NCT07698249Enrolling by invitation
Headache diary for migraine patients
This trial tests whether a headache diary can help people with migraine track their symptoms and improve their care.
Edison, New JerseyAges 18 years+ - NCT03404336Recruiting
Well-being therapy for chronic migraine in outpatients
This study tests whether a “well-being therapy” program can reduce symptoms of chronic migraine compared with a control therapy. You may qualify if you have long-lasting chronic migraine and can follow the study schedule.
Florence, FlorenceAges 18–65 - NCT04151472RecruitingPhase 3
Idebenone to prevent episodic migraine attacks
This trial tests idebenone, a preventive medicine, to see if it can reduce how often migraine attacks happen. It mainly focuses on people with episodic migraine who have regular attacks and are not already using other migraine prevention treatments.
Hangzhou, ZhejiangAges 18–65 - NCT04748601RecruitingPhase 4
Qudexy XR to help prevent migraine in kids ages 6 to 11
This study tests whether Qudexy XR can reduce migraine headaches in children ages 6 to 11. It looks for kids who are having frequent, disruptive migraine attacks and checks safety with careful medication rules.
Birmingham, AlabamaAges 6–11 - NCT04925414RecruitingPhase 4
Testing high-flow oxygen for migraine in the emergency room
This trial looks at whether breathing high-flow oxygen in the emergency department can help relieve migraine-like headaches. You may qualify if you are 18+ and are admitted to the ER for a migraine that fits standard diagnostic rules.
NiceAges 18 years+ - NCT04939922Recruiting
Headache and dizziness registry for people with headache disorders
This study is a registry, meaning it collects information over time about people with headaches (including migraine, tension-type, and some dizziness-related headaches). It may help researchers better understand these conditions and plan future studies.
Hangzhou, ZhejiangAges 4–99 - NCT05164172RecruitingPhase 3
Eptinezumab for kids with ongoing or recurring migraine
This trial studies eptinezumab, a migraine treatment, in children and teens ages 6 to 17 who already completed an earlier migraine study. It mainly helps doctors learn whether the treatment can be continued safely and effectively over time.
New Haven, ConnecticutAges 6–17 - NCT05418218Recruiting
International headache registry for people with headache diagnoses
This study collects information from people who have headaches to better understand different headache types. You may help researchers by keeping headache records and allowing follow-up over time.
Hangzhou, ZhejiangAges 4–99 - NCT05524493Recruiting
Brain scans for migraine, visual snow, or epilepsy symptoms
This study uses a very strong MRI brain scanner to better understand conditions like migraine, visual snow, or epilepsy that don’t fully respond to treatment. You may be able to join if you meet specific diagnosis and safety requirements for the scanner.
ZurichAges 18–65 - NCT05570149Recruiting
Study of eptinezumab in people with frequent migraine
This real-world study looks at how well eptinezumab (an antibody medicine for migraine prevention) works for people with frequent episodic or chronic migraine as they get usual care. You may be asked to share health information and treatment details to see what helps most in everyday life.
Roma, RMAges 18–75 - NCT05690737Recruiting
Tai chi program to prevent episodic migraine
This trial tests whether a tai chi routine can help prevent episodic migraine attacks and reduce bothersome symptoms like nausea or light/sound sensitivity. It also looks at how tai chi may change the brain or body processes involved in migraine.
Hong Kong, HONG KONGAges 18–65 - NCT05700318Recruiting
Test of a device therapy for frequent migraine
This trial studies a migraine device (the ShiraTronics Migraine Therapy System) to help people with frequent migraine headaches. It may be a good option if you’ve tried common migraine preventions but they didn’t work for you, weren’t safe, or you couldn’t take them.
Broadmeadow, New South WalesAges 22 years+ - NCT05741775RecruitingPhase 3
Physiotherapy program for migraine symptoms
This trial tests whether a physiotherapy treatment can reduce migraine symptoms. You may be eligible if you have likely migraine headaches and meet the trial’s symptom screening rules.
Kajang, SelangorAges 18–40 - NCT05943457Recruiting
Vitamin K2 for adults with episodic migraine
This trial tests whether taking vitamin K2 can reduce the number of migraine days per month. It may help people who have had episodic migraines for at least a year and meet specific migraine frequency and medication requirements.
Beirut, BeirutAges 18 years+ - NCT06219694Recruiting
Laser acupuncture for chronic migraine
This trial tests whether laser acupuncture can help people whose chronic migraine medications aren't working well. It's a non-invasive treatment that uses low-level laser light on specific points on the body.
Taichung, Xitun DistrictAges 20 years+ - NCT06224959Recruiting
Migraine and nerve pain in osteoarthritis study
This study looks at whether people with osteoarthritis also have migraine headaches or nerve pain. Researchers want to better understand these connections to improve treatment.
Clermont-Ferrand, FranceAges 18 years+
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Common questions
- Are there clinical trials for migraine?
- Yes. Clin2 currently lists 200 recruiting migraine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.