Clinical trials
Migraine clinical trials
A neurological condition causing recurring, often disabling headaches. We’re tracking 200 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07354126Recruiting
Flunarizine vs. propranolol for migraine in children
This trial tests two medicines—flunarizine and propranolol—to see which one works better for preventing migraines in children ages 8 to 15. If your child has frequent migraines that affect their daily life, this study may help find a treatment that works for them.
Lahore, Punjab ProvinceAges 8–15 - NCT07454798Recruiting
Virtual reality neurofeedback for teens with migraine
This study tests whether using virtual reality neurofeedback can help teens with migraine. You would wear a VR headset and learn to control your brain's activity to reduce headache frequency.
Kansas City, MissouriAges 10–16 - NCT07476053Recruiting
How light exposure affects migraine and sleep
This study looks at how office lighting and sleep quality affect migraine. You'll track your headaches and light exposure. The goal is to find ways to improve sleep and reduce migraine attacks.
Tempe, ArizonaAges 18 years+ - NCT07500558Recruiting
Ultrasound-guided nerve block for chronic migraine pain relief
This study tests two power levels of a pulsed radiofrequency treatment aimed at a nerve cluster behind your cheekbone to reduce chronic migraine pain. If you have frequent migraines that haven't responded well to two or more preventive medications, this could be an option for you.
MinyaAges 20–70 - NCT07554664Recruiting
Desk Work, Stress, and Muscle Pain With or Without Migraine
This study looks at how office work, job stress, and muscle tension relate to migraines and neck/shoulder pain in desk workers. Researchers want to understand if certain body changes (called central sensitization) connect these issues, which could lead to better ways to help office workers feel better.
Gaziantep, MerkezAges 18–65 - NCT07579481Recruiting
Vortioxetine for Depression with Migraine
This study tests whether vortioxetine, a depression medication, can help people who have both depression and episodic migraine (recurring headaches). You'd take vortioxetine for depression while researchers track how it affects both your mood and migraine symptoms.
Rome, LazioAges 18 years+ - NCT07626307Recruiting
Migraine Screening Tool to Guide Physical Therapy Referral
This study tests whether a simple assessment tool can help neurologists decide which migraine patients would benefit from physical therapy. You'll be evaluated by both a neurologist and a physical therapist to see if the tool correctly identifies patients who could improve with hands-on treatment.
MilanAges 18–70 - NCT07656922Recruiting
Shoulder muscle function and migraine
This study looks at how the muscles around your shoulder blade work during migraine attacks. It may help find better ways to treat migraine-related shoulder problems.
Ankara, ÇubukAges 18–55 - NCT07671703Recruiting
Physiotherapy for migraine relief
This trial tests whether a combination of physical therapy techniques can reduce migraine symptoms. It may help people whose migraines are not caused by other conditions.
Osnabrück, Low SaxonyAges 18–70 - NCT07493434Enrolling by invitation
Can essential oils help with migraine pain?
This trial tests if inhaling essential oils can reduce pain in people with migraine. You may join if you have migraines and are not allergic to essential oils.
São Paulo, São PauloAges 18–60 - NCT07295587Enrolling by invitation
Headache impact study for Libbs employees
This trial looks at how headaches affect employees at Libbs Pharmaceutical. It uses health data from the Dr. Cefaleia app to understand the burden of headaches at work.
São Paulo, São PauloAges Any age - NCT07163559Enrolling by invitation
Coping skills program for migraine relief
This study tests a 6-month program that teaches coping skills to help manage migraine headaches. It may help you feel more in control of your symptoms.
Ankara, AltındağAges 18–65 - NCT06871852Enrolling by invitation
Video exercises for migraine relief
This study tests if watching and following a video exercise program can help reduce migraine symptoms. If you have migraines and are between 18 and 65, this might be a way to manage your symptoms without extra medication.
Bandırma, BalıkesirAges 18–65 - NCT06834022Enrolling by invitation
Comparing acupuncture and brain stimulation for migraine
This study compares two non-drug treatments—acupuncture and a gentle form of brain stimulation (tDCS)—to see which one helps reduce migraine headaches better. It's for people who have at least 4 migraine days per month and have never tried acupuncture before.
Ljubljana, LjubljanaAges 18–65 - NCT06716944Enrolling by invitationPhase 1/Phase 2
Self-acupuncture for migraines: a feasibility study
This study tests whether teaching people with migraines to do acupuncture on themselves (self-acupuncture) is practical and helpful. It is for people who have already had a course of acupuncture that worked for them at a specific London hospital.
LondonAges 18 years+ - NCT05127954Enrolling by invitationPhase 3
Long-term migraine tablet study for kids and teens ages 6–17
This study follows kids and teens who already took part in an earlier migraine medication study to check long-term safety and comfort with oral ubrogepant tablets. It may help families understand whether this migraine tablet is safe to keep using over time.
Huntsville, AlabamaAges 6–17 - NCT07779486Recruiting
Intravenous magnesium for acute headache pain relief
This study compares two doses of intravenous (IV) magnesium to see which is more effective at relieving acute headache pain in the emergency department. It aims to provide a fast and effective treatment option for migraine, tension-type, or cluster headaches.
MonastirAges 18 years+ - NCT07685769RecruitingPhase 4
Rimegepant safety study for adults with migraine in India
This study tests if the medicine rimegepant is safe for people with migraine. You may be able to join if you have had migraine for at least a year, have 4–14 migraine days per month, and have not had good results with other migraine medicines called triptans.
Bangalore, KarnatakaAges 18 years+ - NCT07221292RecruitingPhase 3
Study of N-acetyl-L-leucine for CACNA1A disorders
This trial tests a potential treatment for people with CACNA1A disorders, which can cause movement problems, migraine, or seizures. The medication may help improve balance and coordination.
Baltimore, MarylandAges 4 years+ - NCT05669703Recruiting
Tracking mood and activity patterns in bipolar disorder families
This study watches how a person’s mood and movement change over time, and how those patterns relate to bipolar disorder. It may help researchers better understand the condition in families and potentially improve future care.
Bethesda, MarylandAges 8–70 - NCT07720765Recruiting
Using eye scans to study brain diseases
This trial uses a type of eye scan (OCT) to look at the retina in people with brain conditions like multiple sclerosis, Alzheimer's, Parkinson's, or migraines. It aims to see if these scans can help doctors learn more about the disease and monitor it over time.
Milan, MilanoAges 18 years+ - NCT03231241Recruiting
Study of worsening headaches using scans and blood testing
This study looks at why headaches can become long-lasting (“chronified”) by combining answers from online questionnaires, brain imaging, and blood protein tests. Your participation may help researchers find biological clues that could improve how headache problems are understood and treated.
Stanford, CaliforniaAges 18 years+ - NCT03694626Recruiting
Test a light-response study to measure and track light sensitivity
This study aims to objectively measure how your pupils respond to light and how your eye muscles react using recording tests. It may help confirm the cause of light sensitivity (especially after a brain injury) and better track how it responds to care.
Iowa City, IowaAges 18–80 - NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+
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Common questions
- Are there clinical trials for migraine?
- Yes. Clin2 currently lists 200 recruiting migraine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.