Clinical trials
Migraine clinical trials
A neurological condition causing recurring, often disabling headaches. We’re tracking 200 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04930887RecruitingPhase 2
Numbing injection in the face to ease craniofacial pain
This trial tests whether an injection of a numbing medicine (bupivacaine) guided by an endoscope can reduce craniofacial pain. It may help people with certain headache or facial pain conditions by targeting the pain area more precisely.
Stanford, CaliforniaAges 18–80 - NCT06464367RecruitingEarly Phase 1
Psilocybin study for migraine and healthy volunteers
This study looks at how psilocybin affects the brain in people with migraines and in healthy volunteers. The goal is to understand why it may help with headache disorders.
West Haven, ConnecticutAges 21–70 - NCT05046613Recruiting
Pregnancy outcomes after rimegepant use for migraine
This observational study looks at health outcomes for moms, babies, and infants after rimegepant is used during pregnancy for migraine. It may help doctors understand potential risks or reassuring safety information for future pregnancies.
Wilmington, North CarolinaAges birth+ - NCT05158894Recruiting
Pregnancy safety registry for migraine medicines Ubrelvy and Qulipta
This is an observational study (no treatment is assigned) that tracks side effects and pregnancy outcomes in people taking Ubrelvy or Qulipta for migraine during pregnancy. It may help doctors better understand how these medicines affect mothers and babies.
Durham, North CarolinaAges 18 years+ - NCT05337033RecruitingPhase 2
Testing cannabis for chronic headaches in teens
This trial studies whether cannabis can reduce chronic migraine headaches in adolescents who have not improved with other treatments. It also asks participants to work with psychology and physiotherapy during the study.
Vancouver, British ColumbiaAges 14–17 - NCT05342493Recruiting
Survey study of long-term Ajovy injections
This is a study that collects information about how people use Ajovy (a medication for migraine) over time by injection. It mainly looks at safety and real-world use, and it may help researchers understand long-term treatment needs.
OsakaAges 18 years+ - NCT05582837RecruitingPhase 4
Using migraine medicines to treat Meniere’s disease symptoms
This Phase 4 study tests whether migraine-type medications can help people with active or frequent Meniere’s disease. If you have symptoms like inner-ear episodes, the trial may help find a better way to control them.
Orange, CaliforniaAges 25–85 - NCT05752396Recruiting
Study of Pain Patterns Over Time in Kids
This study follows kids who have a specific type of chronic pain (headaches, stomach pain, or muscle/joint pain) to better understand how pain changes over time. It also checks whether certain factors are linked to those pain patterns.
Cincinnati, OhioAges 10–19 - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT05814497Recruiting
Brain scan study of how kids process chronic pain
This study looks at how the brain processes pain sensations in children with certain long-lasting pain conditions. It may help researchers understand what’s happening in the nervous system and guide better treatments.
Cincinnati, OhioAges 10–17 - NCT06016465RecruitingEarly Phase 1
Nerve block plus steroid to prevent migraine return in 72 hours
This trial tests whether adding a steroid pill (dexamethasone) to a nerve block can stop a migraine from coming back within three days. It's for people whose headache got much better after a nerve block.
El Paso, TexasAges 18–85 - NCT06077838Recruiting
RELAXaHEAD app test for migraine relief
This study tests a smartphone app called RELAXaHEAD that teaches relaxation techniques to help people with migraine. If you have 4–29 headache days per month and haven't tried relaxation therapy for headaches recently, this app might help reduce your symptoms.
New York, New YorkAges 16–80 - NCT06150781Recruiting
Aimovig pregnancy safety study for migraine
This study tracks the health of pregnant women with migraine who take Aimovig. It helps doctors understand if the medicine is safe to use during pregnancy.
Durham, North CarolinaAges 18–99 - NCT06309251Recruiting
Ketogenic diet for children with epilepsy or other conditions
This trial studies how well a ketogenic diet works for children with hard-to-treat epilepsy or certain other diseases. It aims to see if the diet improves quality of life.
Milan, MIAges Up to 18 years - NCT06398353Recruiting
Acupuncture for frequent primary headaches
This study tests whether acupuncture can improve quality of life for people with frequent primary headaches (like migraines or tension headaches). If you have headaches more than twice a week, this trial may help you find relief.
Taoyuan, Select A StateAges 18 years+ - NCT06652724Recruiting
Psychological help for chronic pain in fibromyalgia and migraine
This study looks at how psychological factors and treatments might help with chronic pain in people with fibromyalgia and/or chronic migraine. It compares different groups to understand what works best.
Rome, RMAges 18–50 - NCT06665867Recruiting
Video Follow-Up for Kids With Stomach Pain
This trial tests whether video consultations (video calls) are a good option for follow-up appointments in children with functional abdominal pain disorders. It aims to make check-ups easier for families.
AmsterdamAges 4–17 - NCT06745648Recruiting
Head massage in a head-down position for headache relief
This trial tests a simple, non-drug technique (carotid sinus massage while lying with your head lower than your body) to see if it can relieve headaches. If you have a migraine, tension headache, or mixed headache that started in the last day, you may be able to join.
Trenque Lauquen, Buenos AiresAges 16 years+ - NCT06961864Recruiting
Brain function in visual snow syndrome
This study uses visual tests and brain scans to understand how the brain processes vision in people with visual snow syndrome compared to those without. It may help researchers learn more about what causes this condition.
Minneapolis, MinnesotaAges 18–60 - NCT07177885Recruiting
Tryptophan and triptan effectiveness in migraine
This study looks at how tryptophan (a natural amino acid) affects how well triptans work for migraines. You may be able to join if you've taken triptans before, whether they helped or not.
Clermont-FerrandAges 18–50 - NCT07681466Recruiting
Study of early warning signs before migraines
This study looks at the early signs that happen before a migraine starts, such as fatigue or mood changes. It aims to help people understand their migraine patterns better.
Latina, ItalyAges 18–65 - NCT07347028Recruiting
Trigger point injections for knee osteoarthritis pain
This trial tests whether injecting medication into muscle knots (trigger points) can reduce knee pain in people with knee osteoarthritis. It may be an option if other treatments haven't helped enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT02670161Enrolling by invitationPhase 4
Using electronic records to improve care for brain and nerve conditions
This study looks at how doctors use electronic medical records to improve treatment and care for people with certain brain and nervous system conditions. It may help because it tests practice-based approaches across neurology visits.
Evanston, IllinoisAges 18–100 - NCT07402954Recruiting
Test of lidocaine infusion for severe migraine or face pain
This trial tests whether giving a numbing medicine (lidocaine) into a small artery in the face (the external carotid artery) can help people with hard-to-treat chronic migraines or persistent face/skull pain. It is for those who haven't found relief from standard treatments.
Galveston, TexasAges 18–100
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Common questions
- Are there clinical trials for migraine?
- Yes. Clin2 currently lists 200 recruiting migraine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.