Clinical trials
Migraine clinical trials
A neurological condition causing recurring, often disabling headaches. We’re tracking 200 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06788977Recruiting
Migraine treatment in pregnancy with a nerve stimulation device
This trial tests if a device that gently stimulates a nerve on your forehead can safely treat migraines during pregnancy. You'll use the device at home and track your headaches via text or email.
Darien, ConnecticutAges 18–44 - NCT06795867Recruiting
ACT therapy for chronic migraine disability
This study tests whether Acceptance and Commitment Therapy (ACT), a type of talk therapy that helps you accept difficult thoughts and feelings, can reduce disability caused by chronic migraine. You will be placed in one of two groups to compare ACT with your usual care.
Boston, MassachusettsAges 18–65 - NCT06796725Recruiting
Study of TMS for migraine guided by brain imaging
This study tests whether repetitive transcranial magnetic stimulation (rTMS), guided by magnetoencephalography (MEG), can help people with frequent migraines or tension-type headaches. If you have headaches 15 or more days per month, this treatment might reduce your pain.
ShanghaiAges 15–50 - NCT06808230Recruiting
Cocoa extract for migraine prevention study
This trial tests whether taking cocoa extract daily can help prevent migraine attacks in people with 4-14 migraines per month. You'll use a phone app to track your headaches and take either cocoa extract or a placebo.
Boston, MassachusettsAges 18 years+ - NCT06810505RecruitingPhase 3
Oral atogepant for preventing migraines in teens
This trial tests an oral medication called atogepant to see if it can prevent migraines in teens aged 12–17. It aims to reduce how often migraines happen and track any side effects.
Huntsville, AlabamaAges 12–17 - NCT06904287RecruitingPhase 3
Magnesium for migraine treatment in adults
This trial tests if adding magnesium to a standard migraine medication (prochlorperazine) helps treat migraines more effectively. It could be a good option for adults with migraines who haven't taken these drugs recently.
Oak Lawn, IllinoisAges 18 years+ - NCT06921109Recruiting
Virtual reality for headache relief in kids
This study tests if using virtual reality to learn relaxation techniques can help reduce headaches in children and teens who have migraines or frequent tension headaches.
Sart Tilman, LiegeAges 8–15 - NCT06943625Recruiting
Green light and brain stimulation for migraine
This trial tests whether combining green light therapy with a gentle brain stimulation technique (transcranial direct current stimulation, or tDCS) can help reduce migraine pain. It may be an option for people with frequent migraines who have not found relief from other treatments.
Rawalpindi, Punjab ProvinceAges 18 years+ - NCT06953622Recruiting
Migraine and PFO: A Follow-up Study
This study is for people who have migraines and a small hole in their heart called a patent foramen ovale (PFO). It will track your health over time to learn more about how these conditions are related.
BeijingAges Any age - NCT06959004Recruiting
Does substance P trigger migraine attacks without aura?
This study tests whether a substance called substance P can cause migraine attacks in people who have migraine without aura. Results may help understand new ways to prevent or treat migraine.
Glostrup MunicipalityAges 18–65 - NCT06995729RecruitingPhase 1
Testing zavegepant nasal spray in children with migraines
This trial tests whether the medicine zavegepant (given as a nasal spray) is safe and works well for children aged 6 to 11 who have a history of migraines. If your child gets migraines, this study may help find a new treatment option.
Little Rock, ArkansasAges 6–11 - NCT07029126Recruiting
Fremanezumab for migraine with depression: caregiver impact study
This trial tests if fremanezumab, a migraine prevention drug, can also reduce the stress and improve the relationship between migraine patients with mild depression and their caregivers. If you or someone you care for has migraines and low mood, this study may help understand how the caregiver is affected.
Rome, ItalyAges 18 years+ - NCT07061847RecruitingPhase 2
Lidocaine infusion for severe chronic migraines
This trial tests if a lidocaine infusion into an artery in the head can reduce severe chronic daily headaches. It is for people who have tried multiple treatments without enough relief.
Great Neck, New YorkAges 18–75 - NCT07072910RecruitingPhase 2
Cabergoline for migraine prevention
This trial tests if a once-weekly medication called cabergoline can reduce how often you get migraine headaches. It is for adults who have between 4 and 14 migraine days per month.
Aarhus NAges 18 years+ - NCT07093138RecruitingPhase 4
CBD cream for migraine attacks
This trial tests whether a cream made with cannabidiol (CBD) can help stop migraine attacks. It is for people aged 18 to 55 who have had migraines for at least a year and get 2 to 8 attacks per month.
TehranAges 18–55 - NCT07163416Recruiting
Italian migraine registry study for adults
This study tracks people with migraine to learn more about their condition and improve care. You may join if you have episodic or chronic migraine, with or without aura or medication overuse headaches.
Roma, RomaAges 18 years+ - NCT07170176Recruiting
PFO closure and migraine: can it help?
This trial tests if closing a common heart defect (PFO) can improve migraine symptoms and brain function. It compares people with migraine who get the closure procedure to those without migraine.
Luoyang, HenanAges 18–60 - NCT06459648Recruiting
Can anti-CGRP antibodies prevent chronic migraine?
This study tests a new treatment (anti-CGRP antibodies) to prevent migraine attacks from becoming chronic. It looks at whether we can predict who will respond best, aiming to find better long-term control for people with frequent or chronic migraine.
Zaragoza, AragonAges 18–65 - NCT07267819Recruiting
Xeomin for migraines after a brain injury or health incident
This trial looks at whether Xeomin (a shot that relaxes muscles) helps prevent migraines in people who have had a traumatic brain injury or an unexplained health event, such as a blast or sudden illness. It is for U.S. government employees and their families who have already tried Xeomin at a U.S. military or medical facility.
Bethesda, MarylandAges 18 years+ - NCT07279623Recruiting
Nasal stimulation device for migraine prevention
This trial tests if a gentle nasal stimulation device can help prevent migraines. It is for adults with frequent migraines (at least 8 days per month).
StockholmAges 18–65 - NCT07304518RecruitingPhase 2
PRT-064040 nasal spray for migraine in adults
This trial tests a new nasal spray, PRT-064040, to see if it can help treat migraine attacks. It is for adults who have had migraines for at least a year and get 2 to 8 moderate to severe migraines per month.
Beijing, Beijing MunicipalityAges 18–75 - NCT07310290Recruiting
Study of Ubrogepant for Migraine During the Prodrome Phase
This study looks at how well the migraine medication ubrogepant works when taken during the early signs of a migraine (prodrome). It may help people who already use ubrogepant for their migraines.
Aliso Viejo, CaliforniaAges 18 years+ - NCT07328685Recruiting
Body awareness therapy for migraine relief
This trial tests a gentle therapy called Basic Body Awareness Therapy to see if it helps reduce migraine attacks. It focuses on improving how you sense and move your body, which may ease migraine symptoms.
Antakya, HatayAges 18–55 - NCT07349004Recruiting
Migraine with aura and PFO study
This study looks at the link between migraine with aura and a small hole in the heart called PFO. It may help researchers understand what causes migraines in some people.
Bologna, BOAges 18 years+
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Common questions
- Are there clinical trials for migraine?
- Yes. Clin2 currently lists 200 recruiting migraine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.