Clinical trials
Migraine clinical trials
A neurological condition causing recurring, often disabling headaches. We’re tracking 190 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06641466RecruitingPhase 3
Study of Rimegepant for preventing menstrual migraine in women
This study tests whether the medicine rimegepant can help prevent migraines that happen around your period. It is for women with regular menstrual cycles who have a history of menstrual migraines.
Phoenix, ArizonaAges 18–45 - NCT06628921Recruiting
Eptinezumab for treating a migraine attack right now
This trial tests if eptinezumab can stop a migraine attack that is already happening. It may help people who get migraines often and are already part of the TACHIS study.
RomaAges 18 years+ - NCT06602479RecruitingPhase 2
Study of MEDI0618 for episodic migraine
This trial tests a new medicine, MEDI0618, against a placebo for people with episodic migraine. The goal is to see if MEDI0618 is safe and effective at reducing migraine days.
Birmingham, AlabamaAges 18–70 - NCT06584409Recruiting
Laser Acupuncture vs Standard for Migraine – Blood Test Study
This trial tests whether laser acupuncture can help migraines by checking two substances in your blood (MMP2 and CGRP). You may be able to join if you have migraines and are not pregnant.
Taichung, TaichangAges 18 years+ - NCT06485336RecruitingPhase 2
Atorvastatin for prevention of chronic migraine
This trial tests whether the cholesterol drug atorvastatin can reduce the number of migraine days in people with chronic migraine (15 or more headache days per month, including at least 8 migraine days). If you have frequent migraines and haven't tried statins before, this study may offer a new preventive option.
BergenAges 18–65 - NCT06473597RecruitingPhase 4
Comparing Nurtec and Maxalt for migraine in the ER
This trial tests two fast-dissolving migraine medicines, Nurtec ODT and Maxalt MLT-ODT, in adults coming to the emergency room with a migraine. The goal is to see which one works better and faster for pain relief.
Brooklyn, New YorkAges 18–65 - NCT06450444Recruiting
Neuromodulation implant for chronic or frequent migraine
This trial tests a new implantable device that uses mild electrical pulses to prevent migraines. It is for people who have tried at least three migraine prevention medicines without success and still have frequent migraines.
Broadmeadow, New South WalesAges 18–84 - NCT06426316Recruiting
Immune cells and migraines study
This study looks at how certain immune cells and inflammatory chemicals relate to migraines. If you have migraines or an autoimmune condition (like lupus, rheumatoid arthritis, or Crohn's disease), you may be able to participate. The goal is to understand what causes migraines.
Clermont-Ferrand, AURAAges 18–50 - NCT06401642RecruitingPhase 4
Zavegepant for acute migraine with CGRP preventives
This study tests how well a new acute migraine medicine, zavegepant, works and is tolerated in people who are already taking a CGRP-targeting preventive medication. It may help you find an effective treatment when you get a migraine attack.
Phoenix, ArizonaAges 18 years+ - NCT06229834Recruiting
Chiropractic care for episodic migraine
This study tests whether chiropractic adjustments (spinal manipulation) can help reduce the number of migraine days you have each month. You will be randomly assigned to one of two groups: one group gets chiropractic care plus usual care, the other gets a sham (fake) treatment plus usual care, so researchers can see if the real adjustments work better.
Boston, MassachusettsAges 18–65 - NCT06248671RecruitingPhase 2
Atorvastatin for preventing migraine attacks
This trial tests whether a daily dose of atorvastatin (a common cholesterol medicine) can prevent migraine attacks in people with episodic migraine. You would keep a headache diary and be randomly assigned to take atorvastatin or a placebo for about 3 months.
BergenAges 18–65 - NCT06219694Recruiting
Laser acupuncture for chronic migraine
This trial tests whether laser acupuncture can help people whose chronic migraine medications aren't working well. It's a non-invasive treatment that uses low-level laser light on specific points on the body.
Taichung, Xitun DistrictAges 20 years+ - NCT05524493Recruiting
Brain scans for migraine, visual snow, or epilepsy symptoms
This study uses a very strong MRI brain scanner to better understand conditions like migraine, visual snow, or epilepsy that don’t fully respond to treatment. You may be able to join if you meet specific diagnosis and safety requirements for the scanner.
ZurichAges 18–65 - NCT06085144Recruiting
Emgality for migraine in breastfeeding women
This trial studies how the migraine medication Emgality (galcanezumab) passes into breastmilk and whether it is safe for nursing babies. It may help new mothers who need migraine treatment while breastfeeding.
San Francisco, CaliforniaAges 18–45 - NCT05943457Recruiting
Vitamin K2 for adults with episodic migraine
This trial tests whether taking vitamin K2 can reduce the number of migraine days per month. It may help people who have had episodic migraines for at least a year and meet specific migraine frequency and medication requirements.
Beirut, BeirutAges 18 years+ - NCT05897320RecruitingPhase 3
Eptinezumab trial for kids with episodic migraine
This Phase 3 study tests eptinezumab to reduce migraine attacks in children who have episodic migraine (not daily chronic migraine). It may help by lowering the number of headache days and migraine days over time. You must complete a headache diary during screening to be considered.
Stamford, ConnecticutAges 6–17 - NCT05769348Recruiting
PET brain study to test opioid signaling in migraine
This study uses brain scans (PET) to look at how the body’s “opioid” pain system works in people with migraine. It may help researchers understand migraine biology and test approaches that could improve migraine treatment.
Ann Arbor, MichiganAges 18–65 - NCT05711394RecruitingPhase 3
Atogepant for preventing episodic migraine in children
This study tests whether an oral medicine called atogepant can reduce migraine activity in children ages 6–17 and checks its side effects. It’s meant for kids with episodic migraine (not the more constant types) who may benefit from preventive treatment.
Huntsville, AlabamaAges 6–17 - NCT05734625RecruitingPhase 2
Nerve block injections for episodic migraine pain relief
This Phase 2 trial tests whether nerve block injections can reduce pain from episodic migraines. It may help some people who get frequent migraine attacks but are not also using certain migraine preventions or strong pain medicines.
Rochester, MinnesotaAges 18 years+ - NCT05707949Enrolling by invitationPhase 3
Long-term safety study of atogepant for kids with migraine
This trial studies the long-term safety (side effects over time) of atogepant tablets in children and teens with migraine. It may help families understand whether the medicine is safe for longer use in ages 6 to 17.
Huntsville, AlabamaAges 6–17 - NCT05598723RecruitingPhase 3
Botox versus Xeomin for chronic migraine in adults
This Phase 3 study compares two headache injections—Botox and Xeomin—for people with chronic migraine. It may help find out which option works better to reduce frequent, long-lasting migraine days.
Jacksonville, North CarolinaAges 18–89 - NCT05156398RecruitingPhase 3
Rimegepant to prevent migraine attacks in children
This trial studies whether rimegepant can reduce how often migraine attacks happen in children and teens. It also looks at safety and how well the treatment fits day-to-day life and school activities.
Fort Smith, ArkansasAges 6–17 - NCT05164172RecruitingPhase 3
Eptinezumab for kids with ongoing or recurring migraine
This trial studies eptinezumab, a migraine treatment, in children and teens ages 6 to 17 who already completed an earlier migraine study. It mainly helps doctors learn whether the treatment can be continued safely and effectively over time.
New Haven, ConnecticutAges 6–17 - NCT05125302RecruitingPhase 3
Ubrogepant for acute migraine relief in kids and teens
This study tests how safe ubrogepant is and whether it helps treat an individual migraine attack in children and teens. It focuses on measuring side effects and whether headaches improve 2 hours after taking the study medicine.
Huntsville, AlabamaAges 6–17
Hear when a new Migraine trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for migraine?
- Yes. Clin2 currently lists 190 recruiting migraine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.