Clinical trials
Mild Cognitive Impairment clinical trials
Below are recruiting mild cognitive impairment clinical trials, each written for real people, not researchers. We’re tracking 410 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06379594Enrolling by invitation
Remote brain health clinic for mild memory problems
This study tests a remote 'brain health clinic' for people with mild memory or thinking problems (mild cognitive impairment). It aims to help diagnose the cause of memory issues from home, so you don't need to travel to a clinic.
London, Denmark HillAges 18 years+ - NCT06347315Recruiting
Studying a nutritional drink for mild memory loss in older adults
This study tests whether a special drink containing medium-chain triglycerides (MCTs, a type of fat) and B vitamins can help support memory and thinking in older adults with mild cognitive impairment (MCI). You would take the drink daily for 18 months and have regular check-ins including memory tests.
BronAges 60 years+ - NCT06245031Enrolling by invitation
Long-term follow-up of sensory stimulation for Alzheimer's
This is a follow-up study for people who already completed the 12-month Hope Study (CA-0011). It tests long-term safety and effects of a gentle sensory stimulation device (light and sound) for Alzheimer's disease. You will continue using the device at home with a study partner.
Phoenix, ArizonaAges 50–92 - NCT06201533Recruiting
Light exercise and thinking activities for memory
This study tests if a program that combines light physical activity with simple mental tasks can help improve memory and thinking in people with mild cognitive impairment (MCI). It is for people who are not already exercising regularly and do not take memory medications.
Chiang MaiAges 60 years+ - NCT06121544Recruiting
Pre-Alzheimer's Study: Find Early Brain Changes
This study is looking for healthy volunteers to help detect the very earliest signs of Alzheimer's disease—before memory loss starts. You will have tests like memory checks, blood draws, brain scans, and a spinal tap to look for Alzheimer's-related changes.
MalmöAges 50–80 - NCT06120361Recruiting
Primary care study for early cognitive decline
This research study looks at people who have noticed problems with memory or thinking (like trouble focusing or finding words) and visit their primary care doctor for help. It aims to better understand and diagnose conditions that cause these symptoms, such as Alzheimer's disease.
MalmöAges 40 years+ - NCT06122415Recruiting
Memory clinic study with fluid and cognitive tests
This study looks at people who are being checked for memory or thinking problems. It uses standard tests done at the memory clinic, like a spinal tap and blood draw, plus memory and thinking tests, to learn more about these symptoms. You can join if these tests are already planned as part of your regular care, even if you don't take part in the study.
MalmöAges Any age - NCT03665831Recruiting
Deep TMS for depression and memory problems in older adults
This study tests a type of brain stimulation called Deep TMS to help reduce depression and improve or stabilize memory-related symptoms in older adults with Alzheimer’s disease. It’s mainly for people whose depression did not improve or could not be tolerated with antidepressant medicine.
Toronto, OntarioAges 60 years+ - NCT05245903Recruiting
Test a supplement and track brain changes with wearable sensors
This study tests whether taking nicotinamide riboside (a form of niacin) affects early memory changes in people with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD). It also uses passive wearable or sensor data (“digital biomarkers”) to measure changes over time.
Belmont, MassachusettsAges 18–89 - NCT06029114Enrolling by invitation
Brain scan study for memory problems
This study uses a special MRI to look at brain stiffness in people with normal memory, mild memory problems, or Alzheimer's disease. The goal is to see if this scan can help tell the difference between these groups.
Rochester, MinnesotaAges 18–100 - NCT06017505Enrolling by invitation
Using eSAGE for early detection of cognitive decline
This study uses a simple computer-based self-assessment (eSAGE) to detect early signs of memory or thinking problems. It may help identify cognitive impairment sooner and track changes over time.
Columbus, OhioAges 50 years+ - NCT05948930Recruiting
Exercise and brain training for mild memory problems
This study tests whether a mix of physical exercise and computer brain training can improve working memory in people with mild cognitive impairment (MCI). It may help by strengthening memory skills and supporting brain health through supervised activity and computer-based practice.
Baltimore, MarylandAges 50–80 - NCT05924425RecruitingPhase 4
Daridorexant for insomnia in early memory decline
This trial tests whether daridorexant can improve sleep in people who have mild cognitive impairment or early Alzheimer’s disease and struggle with insomnia. It may help by improving how long and how well you sleep, with monitoring of sleep patterns and memory-related measures.
MontpellierAges 60–85 - NCT05881239Recruiting
Remote smell tests to track early Alzheimer’s health changes
This trial uses remote, at-home (or remote) smell-based testing to help researchers assess health in people with preclinical Alzheimer’s disease and in control participants. It may help by showing how well smell-related changes can signal disease status over time.
Boston, MassachusettsAges 18–100 - NCT05907343Recruiting
Brain stimulation study for memory and thinking concerns
This study tests a new brain stimulation method that may help improve memory and thinking in older adults who have memory concerns. It uses a safe, non-invasive technique called transcranial magnetic stimulation (TMS) that sends magnetic pulses to the brain.
Austin, TexasAges 18–90 - NCT05858008Recruiting
Time-restricted eating program for women with mild memory loss
This trial tests whether a structured “time-restricted eating” schedule is practical and safe for women with mild cognitive impairment (mild memory/thinking changes). You may be able to join if your routine and health conditions fit the study rules, and they will focus on eating timing and daily patterns.
Lexington, KentuckyAges 45–95 - NCT05877196Recruiting
Adaptive walking and fitness program for mild memory decline
This study tests an “adaptive” exercise plan that adjusts over time to help improve aerobic fitness and your body’s fitness response in people with mild memory problems or early Alzheimer’s. It may help you safely build the kind of fitness that supports brain health, while researchers monitor changes with fitness testing and blood work.
Phoenix, ArizonaAges 65 years+ - NCT05791994Recruiting
Study tests visual stimulation to improve attention in mild memory issues
This study looks at whether repeated visual stimulation exercises can improve attention in people age 60+ with a specific type of mild cognitive impairment. A study team will also want you to have an informal caregiver to support participation.
AngersAges 60 years+ - NCT05790707Recruiting
Ablation for persistent atrial fibrillation to help memory
This study checks whether a procedure called atrial fibrillation ablation can slow memory problems in people who already have mild cognitive impairment. Participants will be tested on thinking and memory before and after treatment to see if the procedure helps.
AngersAges 60–80 - NCT05770479Enrolling by invitation
Testing long-lasting cognitive training for older veterans
This study looks at whether a cognitive training program you’ve already completed can keep helping over time, and whether it can be improved with “booster” sessions. It may help older veterans maintain thinking and daily functioning skills after earlier training.
San Diego, CaliforniaAges 55 years+ - NCT05725668Recruiting
Dual-task exercise to help prevent falls in memory trouble
This study tests a type of exercise training (doing a physical task while also doing a thinking task) to help older adults with mild memory problems prevent falls. If you have fallen before or have trouble with balance, this program may help you improve safety and coordination.
Springfield, OregonAges 65–95 - NCT05561205Recruiting
Brain stimulation to treat persistent apathy
This trial tests a noninvasive brain stimulation treatment (called rTMS) to help people who have had ongoing apathy (lack of motivation/interest) for at least a month. You might benefit if your apathy is persistent, your other symptoms are stable, and you meet the safety and medication rules.
Toronto, OntarioAges Any age - NCT04171323Recruiting
Active mind training to improve thinking and delay dementia
This study tests an “active mind” computer-based program to help improve thinking skills and possibly slow the process toward dementia. You may be randomly assigned to different program options to see which approach works best for your goals.
San Francisco, CaliforniaAges 55–89 - NCT05495087Recruiting
Breathing low-oxygen air to test brain benefits in mild memory loss
This study tests whether breathing controlled low-oxygen air (through a disposable face mask) can improve brain function in people with mild cognitive impairment (MCI). You’d be randomly assigned to the real treatment or a sham (placebo-like) control, and you’d need multiple lab visits.
Fort Worth, TexasAges 55–79
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Common questions
- Are there clinical trials for mild cognitive impairment?
- Yes. Clin2 currently lists 410 recruiting mild cognitive impairment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mild cognitive impairment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mild cognitive impairment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Amnestic Mild Cognitive Impairment
- Mild Cognitive Impairment (MCI) Amnestic
- Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
- Mild Cognitive Impairment Due to Alzheimer's Disease
- Cognitive Impairment
- Subjective Cognitive Impairment
- Post-Stroke Cognitive Impairment (PSCI)
- Vascular Cognitive Impairment
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.