Clinical trials
Moderately to Severely Active Ulcerative Colitis clinical trials
Below are recruiting moderately to severely active ulcerative colitis clinical trials, each written for real people, not researchers. We’re tracking 105 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03804931RecruitingPhase 2/Phase 3
Stool transplant for moderate to severe ulcerative colitis
This trial tests whether transplanting stool bacteria into the colon (fecal microbiota transplantation) can improve ulcerative colitis symptoms in people with active, moderate to severe disease. If you qualify, the study team will also check that it’s safe for you and that you can safely undergo a scope exam.
Guangzhou, GuangdongAges 18–65 - NCT04314375RecruitingPhase 4
Budesonide tablets for children with mild to moderate ulcerative colitis
This trial studies whether budesonide extended-release tablets are safe and effective for improving symptoms in children ages 5–17 with active, mild to moderate ulcerative colitis. It also measures how the medicine moves through the body.
Garden Grove, CaliforniaAges 5–17 - NCT04999228RecruitingPhase 4
Top-down versus step-up treatment for pediatric ulcerative colitis
This trial compares two treatment approaches for children newly diagnosed with ulcerative colitis: starting with stronger medicines right away versus beginning simpler and stepping up if needed. It may help your child learn which strategy controls symptoms better with fewer flare-ups.
Shanghai, Shanghai MunicipalityAges 6–18 - NCT05076175RecruitingPhase 2/Phase 3
Oral ozanimod for children with moderate to severe ulcerative colitis
This trial tests whether an oral medicine called ozanimod can improve ulcerative colitis (UC) in children whose disease is moderate to severe. It’s meant for kids who didn’t fully respond—or couldn’t tolerate—standard UC treatments.
Phoenix, ArizonaAges 2–17 - NCT05428345Recruiting
Shot of vedolizumab skin injection for active bowel inflammation
This study tests whether a weekly/regular skin injection version of vedolizumab can help adults with moderate to severe ulcerative colitis or Crohn’s disease who did not fully respond to other treatments or TNF blockers. It may help by moving you from an intravenous (IV) infusion to a self/clinic injection option.
Goyang-si, Gyeonggi-doAges 18 years+ - NCT05456893Recruiting
Testing blood and stool markers in active ulcerative colitis treatments
This study checks biomarkers (signals in blood and/or stool) in adults with moderate-to-severe ulcerative colitis. It compares patients starting targeted medicines and looks for marker patterns that may reflect how the disease is behaving.
Nancy, LorraineAges 18 years+ - NCT05666960RecruitingPhase 1
Study drug R-3750 for mild to moderate ulcerative colitis
This Phase 1 study tests whether R-3750 is safe in people with mild to moderate ulcerative colitis and looks for early signs it could help. You may be able to join if you have stable treatment, confirmed diagnosis, and meet several health and medication timing rules.
Valencia, CaliforniaAges 18–65 - NCT05739864RecruitingPhase 1/Phase 2
Test of donor gut bacteria for ulcerative colitis
This early-stage study tests whether a one-time transfer of “donor gut bacteria” can improve ulcerative colitis. It’s designed for people with mild to moderate ulcerative colitis who are stable on maintenance treatment.
Rome, LazioAges 18–75 - NCT05791487Recruiting
Diet plus oral budesonide for mild to moderate ulcerative colitis
This trial studies whether combining a specific diet with an oral steroid called budesonide can calm symptoms in people with mild to moderate ulcerative colitis. It may help reduce inflammation in the colon while building on stable current treatments.
AfulaAges 17–65 - NCT06029972RecruitingPhase 2
Experimental drug for moderate to severe ulcerative colitis
This trial tests an experimental medication (tilpisertib fosmecarbil) for people with moderate to severe ulcerative colitis who have already tried at least one advanced therapy but it didn't work well enough. The study aims to see if this new drug can help reduce inflammation and improve symptoms.
Sun City, ArizonaAges 18–75 - NCT06067698Recruiting
Alpha lipoic acid for mild to moderate ulcerative colitis
This trial tests whether adding alpha lipoic acid (an antioxidant) to your usual mesalamine treatment helps control mild to moderate ulcerative colitis. It is for people newly diagnosed and not on other UC treatments.
TantaAges 18 years+ - NCT06073873Recruiting
Safety study of ozanimod for ulcerative colitis in Korea
This study is checking the safety of ozanimod, a daily pill, for people with moderate to severe active ulcerative colitis. It looks at how well patients tolerate the medicine in real-world use in Korea.
SeoulAges 19 years+ - NCT06095596Recruiting
Combining vedolizumab and upadacitinib for ulcerative colitis
This trial tests whether two medications, vedolizumab (a biologic given by IV) and upadacitinib (a pill), work together to help people with moderate to severe ulcerative colitis. The goal is to see if this combination is safe and effective for controlling symptoms and healing the colon.
Guangzhou, GuangdongAges 18 years+ - NCT06294925Recruiting
Effectiveness of etrasimod in ulcerative colitis
This study looks at how well the daily pill etrasimod works for people with moderate to severe ulcerative colitis. It's for patients whose doctor has already decided to prescribe etrasimod as part of their routine care.
Kelowna, British ColumbiaAges 18–64 - NCT06311123Recruiting
Study of Ozanimod's Effects on Immune Cells in Ulcerative Colitis
This study looks at how the medicine ozanimod works in people with active ulcerative colitis. Researchers will use a special blood test to understand how the drug affects your immune system.
San Diego, CaliforniaAges 18 years+ - NCT06453317RecruitingPhase 2
Comparing UC treatments: infliximab vs ustekinumab vs both
This study compares an existing UC medication (infliximab) with a newer one (ustekinumab) and a combination of both. The goal is to see which works best for moderate to severe UC when other treatments have failed.
LodzAges 18–64 - NCT06456593RecruitingPhase 2
Obefazimod for moderate to severe Crohn's disease
This trial tests an experimental oral medication called obefazimod for people with moderate to severe Crohn's disease. It aims to see if the drug can reduce inflammation and improve symptoms when other treatments have not worked well.
Fairhope, AlabamaAges 18–75 - NCT06469424Recruiting
Safety of Tofacitinib in Ulcerative Colitis
This study follows people with moderately to severely active ulcerative colitis who are taking the medication tofacitinib (Xeljanz). It aims to track any safety concerns in a real-world setting, using information already collected in a European registry (UR-CARE).
BonheidenAges 18 years+ - NCT07692165RecruitingPhase 1/Phase 2
Testing INT-210 capsules for active ulcerative colitis
This trial tests an experimental capsule called INT-210 for people with active ulcerative colitis (UC) who haven't improved enough with standard treatments. It aims to see if the drug can help control symptoms and improve the condition.
Guangzhou, GuangdongAges 18–75 - NCT06398626Recruiting
Observational study of etrasimod for ulcerative colitis
This study watches how well etrasimod works for adults with moderate to severe ulcerative colitis (UC). You must already be prescribed etrasimod by your doctor, and the study collects information through a web-based tool.
Mesa, ArizonaAges 18–64 - NCT07296315RecruitingPhase 2
Testing a new treatment for mild-to-moderate ulcerative colitis
This study tests an investigational drug for people with active mild-to-moderate ulcerative colitis. It aims to see if the drug can improve symptoms without needing advanced treatments like biologics.
Miami, FloridaAges 16 years+ - NCT06488625RecruitingPhase 2/Phase 3
Nicotinamide for mild to moderate ulcerative colitis
This trial tests whether a special oral form of nicotinamide (a type of vitamin B3) can help control mild to moderate ulcerative colitis. The pill is designed to release the medication in the lower part of your gut, where UC often affects. Participation involves taking the study drug and having regular checkups to see how your symptoms and inflammation respond.
Kiel, Schleswig-HolsteinAges 18–80 - NCT06595719Recruiting
Probiotics plus standard care for mild to moderate UC
This trial tests whether adding a multi-strain probiotic supplement to your usual care can help manage mild to moderate ulcerative colitis (UC). It lasts 12 weeks and requires you to stay on your current medications without changes.
Cheras, Kuala LumpurAges 18–90 - NCT06598943RecruitingPhase 2
Study of two new drugs for ulcerative colitis
This study tests two experimental drugs, Eltrekibart and Mirikizumab, for adults with moderate to severe ulcerative colitis who have not responded well to other treatments. The goal is to see if these drugs can help control the disease.
Chandler, ArizonaAges 18–75
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Common questions
- Are there clinical trials for moderately to severely active ulcerative colitis?
- Yes. Clin2 currently lists 105 recruiting moderately to severely active ulcerative colitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a moderately to severely active ulcerative colitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a moderately to severely active ulcerative colitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.