Clinical trials
MRD clinical trials
Below are recruiting mrd clinical trials, each written for real people, not researchers. We’re tracking 110 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05950087Recruiting
Blood tests after chemoradiotherapy for cervical cancer prognosis
This study looks at blood markers—tiny DNA from the blood (cfDNA) and minimal residual disease (MRD)—to better predict outcomes after standard chemoradiotherapy for locally advanced cervical cancer. It may help doctors identify who is more likely to do well and who may need closer follow-up or additional treatment planning.
Guiyang, GuizhouAges 18–75 - NCT05433753Recruiting
Study for leftover cancer DNA in HER2-positive early breast cancer
This study looks for tiny traces of cancer after treatment by testing blood for “ctDNA,” which is leftover cancer DNA. It includes people with HER2-positive early breast cancer who are getting chemotherapy before surgery to see if this blood test can detect signs of remaining disease.
Chuo-ku, TokyoAges 20 years+ - NCT06924710Recruiting
Adaptive therapy for early stage lung cancer with no MRD detected
This study tests a new approach for people with early-stage non-small cell lung cancer (NSCLC) who have had their tumor completely removed. It uses regular blood tests (MRD monitoring) to watch for any cancer cells left behind, so treatment can be given only if needed.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07080021Recruiting
Tracking ctDNA for Pancreatic Cancer Before Surgery
This study looks at using a special blood test (ctDNA MRD) to track how well the tumor responds to chemotherapy before surgery for pancreatic cancer. It may help doctors decide if the treatment is working and guide next steps.
ShanghaiAges 18–75 - NCT06157060Recruiting
Predicting liver cancer return after surgery with a blood test
This trial is for people with early-stage liver cancer who are scheduled for surgery. It uses a simple blood test to look for tiny bits of tumor DNA after treatment, which may help predict if the cancer will come back.
Foshan, GuangdongAges 18–75 - NCT07034742RecruitingEarly Phase 1
MRD testing after stomach cancer surgery
This study looks at whether a blood test for leftover cancer cells (called MRD) after stomach cancer surgery can help guide treatment. It is for people with a certain type of stomach cancer that has spread to nearby tissues but not to distant organs, and who are having surgery as their first treatment.
BeijingAges 18–75 - NCT07566364RecruitingPhase 2
Mosunetuzumab for Chronic Lymphocytic Leukemia with Minimal Residual Disease
This study tests a new antibody drug called mosunetuzumab in patients with chronic lymphocytic leukemia (CLL) who have already tried other treatments and still have detectable leukemia cells in their bone marrow. The drug is designed to work in a way that might help your immune system fight the remaining cancer cells.
Houston, TexasAges 18 years+ - NCT07392970RecruitingPhase 2
Motixafortide to improve AML treatment response after chemo
This trial tests if adding motixafortide can help find and eliminate leftover leukemia cells in people with AML who are in remission after initial chemotherapy. The goal is to make remission deeper and more durable.
St Louis, MissouriAges 18 years+ - NCT03793517RecruitingPhase 2/Phase 3
Decitabine plus chemotherapy before stem cell transplant for high-risk leukemia
This trial studies whether adding decitabine plus chemotherapy before a stem cell transplant can better control “minimal residual disease” (very small amounts of leukemia left behind) in certain high-risk acute leukemia types. It may help reduce the chance of the leukemia coming back after transplant.
Beijing, Beijing MunicipalityAges 18–55 - NCT04168502RecruitingPhase 3
Gemtuzumab added to chemotherapy for certain adult AML
This Phase 3 trial tests whether adding gemtuzumab to standard chemotherapy helps people with newly diagnosed, favorable-intermediate AML reduce “MRD” (very small remaining leukemia cells). If MRD levels drop more, it may lower the chance of relapse.
AlessandriaAges 18–60 - NCT04513639RecruitingPhase 2/Phase 3
Checking treatment for multiple myeloma after MRD becomes negative
This study looks at whether people with newly diagnosed multiple myeloma can safely continue or adjust treatment after they reach “MRD-negative,” meaning very low signs of disease in the bone marrow. It may help reduce the chance of relapse while avoiding unnecessary treatment for some patients.
ÅlesundAges 18–75 - NCT04842006Recruiting
Personalized treatment plan for rectal cancer before and after surgery
This trial looks at a personalized treatment approach for rectal cancer. It aims to guide the best chemotherapy and (if needed) radiotherapy before and after surgery, based on scans and specific test results.
Helsinki, UusimaaAges 18–100 - NCT04920032RecruitingPhase 1
Blood test–guided extra treatment for colon cancer recurrence risk
This Phase 1 study uses a blood test called ctDNA to decide whether and how to adjust treatment in people with colon cancer who still have a small amount of disease left after surgery. If your blood test remains positive, the trial aims to reduce recurrence risk by guiding treatment changes.
Orange, CaliforniaAges 18 years+ - NCT05192122RecruitingPhase 1
Stop maintenance medicine in multiple myeloma with low remaining disease
This early-phase study looks at whether it’s safe to stop the usual “maintenance” medicine after a strong response in multiple myeloma. It aims to see if stopping treatment for people with very low remaining disease reduces drug exposure without allowing relapse too soon.
Chicago, IllinoisAges 18 years+ - NCT05231629RecruitingPhase 2
MRD-guided step-by-step treatment for multiple myeloma
This Phase 2 study tests a treatment plan for newly diagnosed multiple myeloma that changes based on MRD results. MRD is a very sensitive lab test that looks for tiny amounts of remaining cancer, which may help tailor therapy to work better and potentially avoid overtreatment.
Birmingham, AlabamaAges 18 years+ - NCT05255354Recruiting
Testing blood cancer DNA monitoring during CAR-T treatment
This trial checks whether a blood test that looks for small amounts of cancer DNA can accurately track minimal residual disease (MRD) in lymphoma patients during CAR-T therapy. It may help doctors detect relapse earlier and better judge how well CAR-T is working.
Palo Alto, CaliforniaAges 18 years+ - NCT05262673RecruitingPhase 1
Combination immunotherapy for B-cell acute lymphoblastic leukemia
This trial tests a combination of immune cells (CTL and DC vaccines) to target B-ALL. It may help patients with high levels of leukemia cells who have not responded to other treatments.
Shenzhen, GuangdongAges 6 months–65 years - NCT05277753RecruitingPhase 1
Personalized immune therapy for T-ALL
This trial tests a combination of personalized immune therapies (using your own cells to fight cancer) for T-cell acute lymphoblastic leukemia. It targets specific markers on your leukemia cells and uses a bone marrow sample to create a custom treatment.
Shenzhen, GuangdongAges 6 months–65 years - NCT05408897Recruiting
Blood test to predict risk after surgery for high-risk GIST
This study uses a “liquid biopsy” blood test to look for leftover cancer signals after surgery. It aims to predict how well treatment will work and how likely the cancer is to come back in people with high-risk GIST.
Beijing, Beijing MunicipalityAges Any age - NCT05530096Recruiting
Genetic test to find minimal residual myeloma in remission
This study tests a genetic technology (ClonoSeq-based) to detect very small amounts of multiple myeloma that may remain after treatment. It may help doctors better track how well treatment is working and predict how the disease responds over time.
Montreal, QuebecAges 18 years+ - NCT05535855RecruitingPhase 1
UCD19 CAR T for adult ALL with MRD in remission
This early-phase study tests a personalized immune-cell treatment (CAR T) for adults with B-cell acute lymphoblastic leukemia (ALL) who still have tiny amounts of cancer detectable by a special test called MRD. It aims to improve outcomes for people who are in first remission but not completely “cancer-free” by MRD testing.
Aurora, ColoradoAges 18 years+ - NCT05788679RecruitingPhase 2
Use a patient’s genetic test to guide treatment after transplant
This study looks at a personalized lab test to detect small amounts of disease after a stem cell transplant and then decide what treatment comes next. It may help some people with certain bone-marrow diseases stay in remission while avoiding unnecessary treatment.
StockholmAges 18 years+ - NCT05867901Recruiting
Test stopping imatinib early using blood DNA tests
This trial studies whether some people with high-risk GIST can safely take a “drug holiday” (pause imatinib) after surgery. They use a blood test looking for leftover cancer DNA to help decide who may benefit from stopping treatment.
Beijing, Beijing MunicipalityAges 18–75 - NCT05872724RecruitingPhase 2
Personalized add-on treatment after cervical cancer surgery
This study tests whether a tailored “extra” treatment after surgery—guided by a lab test called minimal residual disease (MRD)—can reduce the risk of cervical cancer coming back. It focuses on people with certain stages of cervical cancer who can follow the treatment plan and study follow-up.
Suzhou, JiangsuAges 18 years+
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Common questions
- Are there clinical trials for mrd?
- Yes. Clin2 currently lists 110 recruiting mrd studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mrd trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mrd trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.