Clinical trials
Musculoskeletal Diseases or Conditions clinical trials
Below are recruiting musculoskeletal diseases or conditions clinical trials, each written for real people, not researchers. We’re tracking 4,023 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02592291Recruiting
Using a phone app to help manage long-term health needs
This study tests a mobile phone system that helps people with long-term, complex health conditions manage daily life and get support. If you can use a smartphone and pass the study checks, you may be able to try the self-management tools.
Pittsburgh, PennsylvaniaAges 12 years+ - NCT02240862Recruiting
Carotid artery disease registry for symptom and risk groups
This is a registry that enrolls adults with narrowed carotid arteries (with symptoms or no symptoms). It collects health and treatment information to better understand which patients benefit from procedures and when.
Baltimore, MarylandAges 18–80 - NCT02306200Recruiting
A study to improve heart and aorta health
This trial looks at ways to improve cardiovascular (heart and blood vessel) health, especially conditions that affect the aorta, such as aneurysms, or vascular problems that may run in families. If you have an aortic-related or other cardiovascular diagnosis (or you’re a healthy comparison participant), you may be invited to take part in this health-improvement program.
Ann Arbor, MichiganAges Any age - NCT02639299Recruiting
Screening healthy adults for malaria vaccines and drug studies
This study screens healthy adults to see who can join future malaria vaccine or investigational malaria drug studies, including a controlled malaria exposure. It may help researchers test safer vaccines/drugs, but participation requires good health and strict medical eligibility.
Bethesda, MarylandAges 18–50 - NCT02734277Recruiting
Extending a past Type 1 diabetes immune study
This study is for people who already took part in an earlier immune-tolerance program for Type 1 diabetes. It tests whether continuing follow-up and assessments can be done safely and may help learn more about long-term immune effects of treatment.
San Francisco, CaliforniaAges 8–35 - NCT02422641RecruitingPhase 2
High-dose methotrexate for breast cancer in the brain lining
This Phase 2 trial tests whether giving high-dose methotrexate into the bloodstream can help treat breast cancer that has spread to the thin lining covering the brain and spinal cord. It may help reduce cancer in the leptomeningeal (brain-lining) area and control symptoms.
Baltimore, MarylandAges 18 years+ - NCT02450006Recruiting
Intermountain INSPIRE health registry for patients and families
This study is a health registry that collects information from people seen at Intermountain Health facilities (and sometimes unaffected family members). It aims to better understand health conditions and how people do over time, and it may help improve future care.
Murray, UtahAges Any age - NCT02986516Recruiting
Surgery or definitive radiation for primary sacral chordoma
This trial compares two standard treatment approaches—surgery versus definitive radiation—for people with a primary sacral chordoma (a bone tumor at the lower spine/pelvis area). It aims to find which approach works best for controlling the tumor while considering treatment side effects.
GrazAges 18–80 - NCT03049462RecruitingPhase 1
Study how a beta-3 drug changes body fat in healthy adults
This Phase 1 study tests how chronic treatment with a beta-3–type medicine affects brown fat (a special kind of body fat) in the body. It mainly looks at safety and how the body responds over time, which could help future treatments for weight and metabolic health.
Bethesda, MarylandAges 18–40 - NCT03307304Recruiting
Studying different forms of childhood brain-wasting disease
This study looks at people with CLN3 and other related forms of NCL (a childhood brain-wasting illness) to better describe symptoms and disease changes over time. You may be followed with regular check-ins, medical records, and sometimes NIH visits or sample collection.
Bethesda, MarylandAges 1 week–100 years - NCT03109288RecruitingPhase 1/Phase 2
Biomarker-guided combination treatment for residual multiple sclerosis activity
This early-phase study tests combination treatments for multiple sclerosis (MS) based on lab “biomarkers” found in the spinal fluid. It aims to reduce ongoing MS activity and help determine which treatment combinations may work best for different people.
Bethesda, MarylandAges 18–120 - NCT03222375Recruiting
Home treatment for autism using special sound and imaging devices
This trial studies a home-based treatment for autism (or related conditions) using specially designed sound, image, and electromagnetic devices. It aims to see whether this personalized “treatment code” and device approach can improve autism-related skills and behaviors.
Louisville, KentuckyAges 1 month–21 years - NCT07677033Recruiting
Bone and muscle health study for adults
This study looks at how well your bones and muscles work together. By measuring your bone density and handgrip strength, doctors can better understand your bone health and find ways to keep you strong as you age.
Küçükçekmece, IstanbulAges 18 years+ - NCT07280091Recruiting
Skin and gut bacteria in Netherton syndrome
This study looks at the bacteria on the skin and in the gut of people with Netherton syndrome, a condition that affects the skin barrier and often causes allergies. It also compares these findings to healthy volunteers to understand how the microbiome might be different.
Paris, Île-de-France RegionAges 10 years+ - NCT06488638Recruiting
Beetroot juice supplement for lung fibrosis
This trial tests whether a beetroot juice drink (rich in nitrates) can help people with idiopathic pulmonary fibrosis breathe better and exercise more. It's a small pilot study to see if it's safe and worth studying further.
SouthamptonAges 18–85 - NCT07672938Recruiting
Olive supplement and Mediterranean diet for mild memory loss
This trial tests whether a dietary supplement made from olive polyphenols, combined with following a Mediterranean diet, can help protect thinking and memory in people with mild cognitive impairment (MCI). It may be a good fit if you have early memory changes and want to try a nutrition-based approach.
Thessaloniki, Central MacedoniaAges 50–85 - NCT07604116RecruitingPhase 1
Safety study of SST001 in Parkinson's and MSA patients
This is an early-stage study testing a new experimental medicine called SST001 in people with Parkinson's disease (PD) and multiple system atrophy (MSA), as well as healthy volunteers. The study checks whether SST001 is safe, how the body processes it, and where it goes in the body using imaging scans.
Wuxi, JiangsuAges 40 years+ - NCT07473154RecruitingPhase 1/Phase 2
Calming an overactive immune system with special cells
This trial tests a new type of cell therapy made from a patient's own white blood cells (called lymphocytes) that are designed to help control the immune system. The goal is to reduce inflammation and symptoms in people with hard-to-treat rheumatoid arthritis or a severe form of scleroderma (dcSSc).
BirminghamAges 18 years+ - NCT03225625Enrolling by invitation
Stem cell, virtual reality, and training after spinal cord injury
This study tests whether stem cell treatment along with virtual reality–based training can improve function after spinal cord injury that is not expected to recover with standard care. It’s designed for adults who are medically stable and can safely complete follow-up assessments.
Coral Springs, FloridaAges 18 years+ - NCT02414178Enrolling by invitation
Tau PET brain scan for inherited Alzheimer’s disease
This study uses a special brain scan to measure “tau” buildup in people with an inherited form of Alzheimer’s. It may help researchers better understand disease changes and evaluate whether the scan can track them over time.
St Louis, MissouriAges 18 years+ - NCT02511002Enrolling by invitation
Long-term follow-up after an influenza challenge study
This study keeps track of how your body’s immune responses change over time after an influenza exposure. Researchers may use stored blood samples to study specific antibody levels, which could help improve future flu vaccines or treatments.
Bethesda, MarylandAges 18–120 - NCT01186913Enrolling by invitation
Natural history study for severe combined immune deficiency (SCID)
This study follows children and adults with SCID and related immune disorders to understand how the illness behaves over time. It also helps researchers learn which testing results and genetic types of SCID match different treatment plans.
Birmingham, AlabamaAges Any age - NCT00585572Enrolling by invitation
Wisconsin Brain Donor Program for research after death
This program collects donated brain tissue and related samples after death to help researchers study brain diseases. You may be eligible if you’re an approved family member of a specific study participant, or you meet certain health and consent requirements.
Madison, WisconsinAges 18 years+ - NCT00895271Enrolling by invitation
Making lab cell lines from skin biopsies in immune disorders
This study creates special lab cell lines from skin (or nasal) samples from people with immune system disorders and certain family members. It’s meant to help researchers build tools to better study these conditions using patient cells.
Bethesda, MarylandAges 2–85
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Common questions
- Are there clinical trials for musculoskeletal diseases or conditions?
- Yes. Clin2 currently lists 4,023 recruiting musculoskeletal diseases or conditions studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a musculoskeletal diseases or conditions trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a musculoskeletal diseases or conditions trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.