Clinical trials
Nicotine Dependence clinical trials
Below are recruiting nicotine dependence clinical trials, each written for real people, not researchers. We’re tracking 42 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05513872RecruitingPhase 1/Phase 2
Help to quit smoking using nicotine replacement while not quitting yet
This early-stage study tests ways to help adults who currently smoke daily start making progress toward quitting (or changing smoking habits) over the next 6 months. You may use nicotine replacement, and the study checks safety for people who can use it.
Chicago, IllinoisAges 18 years+ - NCT05962229RecruitingPhase 1
Testing how synthetic nicotine is processed in regular e-cig users
This Phase 1 study tests how a synthetic nicotine product is absorbed and how the body responds (so researchers can better understand nicotine effects and handling). You may be able to join if you’re generally healthy and regularly use e-cigarettes, but you’ll need to avoid certain medicines and nicotine products during the study.
San Francisco, CaliforniaAges 21–65 - NCT06347055Recruiting
Brain stimulation study for quitting nicotine
This trial tests if a type of brain stimulation (TMS) can help people with nicotine dependence reduce cravings. It may be an option if you smoke or use e-cigarettes heavily and want to understand how your brain responds to treatment.
Columbia, MissouriAges 18–60 - NCT05487807RecruitingPhase 1
Quit-smoking program for people with HIV in Uganda and Zambia
This study tests a tailored quit-smoking (tobacco cessation) program for people living with HIV in Uganda and Zambia. It aims to help you reduce or stop tobacco use in a way that fits your needs and local setting.
KampalaAges 18 years+ - NCT04163081Recruiting
Help to quit smoking started from the emergency department
This study tests a program to help people who smoke quit, beginning when they are seen in the emergency department. It aims to see if starting nicotine-cessation support right away improves quitting over the next year.
Ottawa, OntarioAges 18 years+ - NCT06678789Recruiting
Testing low vs high nicotine pouches for smokers
This study compares how low and high nicotine pouches affect adult smokers who want to try a tobacco-free option. You'll attend two visits in Charleston to check health markers.
Charleston, South CarolinaAges 21 years+ - NCT06506162Recruiting
Oral nicotine pouch study for young adult vapers
This study looks at how young adults who vape react to oral nicotine pouches (like Zyn). It tests whether these products might be appealing or lead to misuse. You must be 21–25, an exclusive vaper, and never have used nicotine pouches before.
Los Angeles, CaliforniaAges 21–25 - NCT07698470Recruiting
Brain response to smoking cues after using nicotine pouches
This study looks at how your brain reacts to smoking cues after using an oral nicotine pouch. You would need to try the pouch and avoid nicotine for 12 hours before each session.
Los Angeles, CaliforniaAges 21–55 - NCT07466875Recruiting
Ear stimulation for nicotine withdrawal in psychiatric patients
This trial tests whether gentle electrical stimulation on the ear can help relieve nicotine withdrawal symptoms for smokers who are in a psychiatric hospital and must stop smoking. It is added on top of standard nicotine replacement therapy.
Nantou CityAges 18–65 - NCT06534047RecruitingPhase 4
Brain stimulation or nicotine patch to help you quit smoking
This study tests whether a brain stimulation treatment called rTMS can help people with psychiatric conditions quit smoking. You will be randomly assigned to get either rTMS or a nicotine patch, and your progress will be tracked to see which treatment works better.
Toronto, OntarioAges 18–70 - NCT07167225Recruiting
Chemical exposure in young adults who use e-cigarettes and cannabis
This study looks at how young adults who use e-cigarettes, cannabis, or both are exposed to harmful chemicals. It aims to understand the health effects of using these products together.
Buffalo, New YorkAges 18–25 - NCT05665465RecruitingEarly Phase 1
Study how childhood stress may affect future smoking risk
This early study looks at how experiences from childhood may affect brain and behavior patterns related to nicotine and smoking risk. It may help researchers design better prevention strategies for people who have never smoked.
Durham, North CarolinaAges 18–21 - NCT07059377RecruitingPhase 3
Semaglutide to help smokers with diabetes quit
This study tests if the diabetes drug semaglutide can help people with type 2 diabetes stop smoking more easily. Participants will get either semaglutide or a placebo to see if it improves quit rates.
Ottawa, OntarioAges 18 years+ - NCT07250230Recruiting
Nicotine patch for pain after lung surgery in male smokers
This study tests if a high-dose nicotine patch worn before and after lung surgery can reduce pain in men who smoke but are quitting for the procedure. It aims to help manage pain during recovery.
Zhengzhou, HenanAges 18–75 - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT06053567RecruitingPhase 3
Community smoking cessation for adults with high anxiety sensitivity
This study tests a smoking cessation program designed for adults who are very sensitive to anxiety (like feeling panicky about physical symptoms). It takes place at local YMCA centers and aims to help you quit smoking through a community-based approach.
Austin, TexasAges 18 years+ - NCT06043362Recruiting
Nicotine pouches for daily smokers
This study tests if nicotine pouches can help daily smokers reduce how many cigarettes they smoke. You'll try nicotine pouches, and researchers will track your progress.
Hershey, PennsylvaniaAges 21–70 - NCT05515354RecruitingPhase 4
Smoking quit plan matched to your menstrual cycle phase
This Phase 4 study tests a smoking-quit treatment plan timed to your menstrual cycle. It may help you quit smoking and learn how quitting support works for people who menstruate regularly.
Toronto, OntarioAges 18–40 - NCT07145866RecruitingPhase 4
Varenicline and TMS for quitting nicotine use
This study tests whether combining the medication varenicline (Chantix) with a special brain stimulation treatment (TMS) can help people quit vaping or smoking nicotine. If you're motivated to quit and use nicotine daily, you may be able to join.
Boston, MassachusettsAges 18–65 - NCT07001930RecruitingPhase 1
Cannabidiol effects on stress and nicotine withdrawal
This trial tests whether a cannabis-derived compound called cannabidiol (CBD) can help people who smoke cigarettes cope with stress and withdrawal symptoms when they stop smoking. CBD is not the part of cannabis that makes you high.
Baltimore, MarylandAges 21–70 - NCT06798324RecruitingPhase 4
Brain stimulation plus smoking cessation medication for quitting smoking
This trial tests whether combining brain stimulation (tDCS) with a smoking cessation medication (varenicline) helps people quit smoking. You would attend daily visits for two weeks.
Toronto, OntarioAges 18–85 - NCT06862050Recruiting
Testing a smoking cessation program for tobacco users
This trial tests a program to help people quit tobacco. It focuses on offering support to daily tobacco users living in the Augusta or Central Savannah River Area.
Augusta, GeorgiaAges 18 years+ - NCT06077240Recruiting
E-cigarettes vs pouches for quitting smoking
This study compares the effects of e-cigarettes and nicotine pouches on smoking habits and addiction. The goal is to see which method helps people smoke less and reduces their dependence on cigarettes.
New Haven, ConnecticutAges 21 years+ - NCT05852860Enrolling by invitation
Mentoring program for HIV clinicians on tobacco cessation
This study tests a mentoring program to help clinicians who care for HIV patients learn more about helping patients quit smoking. It aims to improve how doctors and nurses support tobacco cessation in HIV care.
Philadelphia, PennsylvaniaAges Any age
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Nicotine Dependence trials by city
Studies with a site in or near these metro areas.
Nicotine Dependence trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for nicotine dependence?
- Yes. Clin2 currently lists 42 recruiting nicotine dependence studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a nicotine dependence trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a nicotine dependence trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.