Clinical trials
Nicotine Dependence, Cigarettes clinical trials
Below are recruiting nicotine dependence, cigarettes clinical trials, each written for real people, not researchers. We’re tracking 35 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04163081Recruiting
Help to quit smoking started from the emergency department
This study tests a program to help people who smoke quit, beginning when they are seen in the emergency department. It aims to see if starting nicotine-cessation support right away improves quitting over the next year.
Ottawa, OntarioAges 18 years+ - NCT05513872RecruitingPhase 1/Phase 2
Help to quit smoking using nicotine replacement while not quitting yet
This early-stage study tests ways to help adults who currently smoke daily start making progress toward quitting (or changing smoking habits) over the next 6 months. You may use nicotine replacement, and the study checks safety for people who can use it.
Chicago, IllinoisAges 18 years+ - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT05665465RecruitingEarly Phase 1
Study how childhood stress may affect future smoking risk
This early study looks at how experiences from childhood may affect brain and behavior patterns related to nicotine and smoking risk. It may help researchers design better prevention strategies for people who have never smoked.
Durham, North CarolinaAges 18–21 - NCT05962229RecruitingPhase 1
Testing how synthetic nicotine is processed in regular e-cig users
This Phase 1 study tests how a synthetic nicotine product is absorbed and how the body responds (so researchers can better understand nicotine effects and handling). You may be able to join if you’re generally healthy and regularly use e-cigarettes, but you’ll need to avoid certain medicines and nicotine products during the study.
San Francisco, CaliforniaAges 21–65 - NCT06077240Recruiting
E-cigarettes vs pouches for quitting smoking
This study compares the effects of e-cigarettes and nicotine pouches on smoking habits and addiction. The goal is to see which method helps people smoke less and reduces their dependence on cigarettes.
New Haven, ConnecticutAges 21 years+ - NCT06678789Recruiting
Testing low vs high nicotine pouches for smokers
This study compares how low and high nicotine pouches affect adult smokers who want to try a tobacco-free option. You'll attend two visits in Charleston to check health markers.
Charleston, South CarolinaAges 21 years+ - NCT07040566RecruitingPhase 2
Varenicline to help stop vaping
This trial tests whether varenicline, a medicine that reduces cravings, can help people quit using e-cigarettes that contain nicotine. You must be a daily nicotine vaper and live in Connecticut or South Carolina.
New Haven, ConnecticutAges 18 years+ - NCT05224154Recruiting
Help to quit smoking using a smartphone program
This study tests a smartphone-based program to help people quit smoking. It may help if you want to stop and are comfortable using a phone and speaking/read English.
Glassboro, New JerseyAges 18 years+ - NCT06924697Enrolling by invitation
Testing a diabetes drug to help men quit smoking
This study tests if a medication used for type 2 diabetes (GLP-1 receptor agonists) can also reduce smoking in men with diabetes who smoke. If you qualify, you may receive this drug or a standard diabetes pill to see if it helps you smoke less.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06909500Recruiting
Vaping cessation app for young adults
This trial tests a smartphone app called ACT on Vaping to help young adults quit vaping. It may help you if you are ready to stop using e-cigarettes and want support through a digital tool.
Seattle, WashingtonAges 18–30 - NCT07698470Recruiting
Brain response to smoking cues after using nicotine pouches
This study looks at how your brain reacts to smoking cues after using an oral nicotine pouch. You would need to try the pouch and avoid nicotine for 12 hours before each session.
Los Angeles, CaliforniaAges 21–55 - NCT06534047RecruitingPhase 4
Brain stimulation or nicotine patch to help you quit smoking
This study tests whether a brain stimulation treatment called rTMS can help people with psychiatric conditions quit smoking. You will be randomly assigned to get either rTMS or a nicotine patch, and your progress will be tracked to see which treatment works better.
Toronto, OntarioAges 18–70 - NCT07059377RecruitingPhase 3
Semaglutide to help smokers with diabetes quit
This study tests if the diabetes drug semaglutide can help people with type 2 diabetes stop smoking more easily. Participants will get either semaglutide or a placebo to see if it improves quit rates.
Ottawa, OntarioAges 18 years+ - NCT07250230Recruiting
Nicotine patch for pain after lung surgery in male smokers
This study tests if a high-dose nicotine patch worn before and after lung surgery can reduce pain in men who smoke but are quitting for the procedure. It aims to help manage pain during recovery.
Zhengzhou, HenanAges 18–75 - NCT06053567RecruitingPhase 3
Community smoking cessation for adults with high anxiety sensitivity
This study tests a smoking cessation program designed for adults who are very sensitive to anxiety (like feeling panicky about physical symptoms). It takes place at local YMCA centers and aims to help you quit smoking through a community-based approach.
Austin, TexasAges 18 years+ - NCT06043362Recruiting
Nicotine pouches for daily smokers
This study tests if nicotine pouches can help daily smokers reduce how many cigarettes they smoke. You'll try nicotine pouches, and researchers will track your progress.
Hershey, PennsylvaniaAges 21–70 - NCT05515354RecruitingPhase 4
Smoking quit plan matched to your menstrual cycle phase
This Phase 4 study tests a smoking-quit treatment plan timed to your menstrual cycle. It may help you quit smoking and learn how quitting support works for people who menstruate regularly.
Toronto, OntarioAges 18–40 - NCT07145866RecruitingPhase 4
Varenicline and TMS for quitting nicotine use
This study tests whether combining the medication varenicline (Chantix) with a special brain stimulation treatment (TMS) can help people quit vaping or smoking nicotine. If you're motivated to quit and use nicotine daily, you may be able to join.
Boston, MassachusettsAges 18–65 - NCT07001930RecruitingPhase 1
Cannabidiol effects on stress and nicotine withdrawal
This trial tests whether a cannabis-derived compound called cannabidiol (CBD) can help people who smoke cigarettes cope with stress and withdrawal symptoms when they stop smoking. CBD is not the part of cannabis that makes you high.
Baltimore, MarylandAges 21–70 - NCT06798324RecruitingPhase 4
Brain stimulation plus smoking cessation medication for quitting smoking
This trial tests whether combining brain stimulation (tDCS) with a smoking cessation medication (varenicline) helps people quit smoking. You would attend daily visits for two weeks.
Toronto, OntarioAges 18–85 - NCT07322432RecruitingPhase 2
The CONQUER trial: quitting vaping with e-cigarette reduction
This study tests whether gradually reducing nicotine in e-cigarettes helps people who vape quit completely. It is for adults who are ready to stop and want a structured program.
New York, New YorkAges 21 years+ - NCT06688539RecruitingPhase 4
Quitting e-cigarettes in adults who also use cannabis
This trial tests if varenicline, a stop-smoking medication, can help people ages 18 to 40 quit e-cigarettes while also using cannabis. It's designed for regular e-cigarette users who want to quit and who use cannabis at least 10 days per month.
Charleston, South CarolinaAges 18–40 - NCT06372899Recruiting
Switching to E-cigarettes or Nicotine Pouches for Smokers
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
Philadelphia, PennsylvaniaAges 21 years+
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Common questions
- Are there clinical trials for nicotine dependence, cigarettes?
- Yes. Clin2 currently lists 35 recruiting nicotine dependence, cigarettes studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a nicotine dependence, cigarettes trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a nicotine dependence, cigarettes trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.