Clinical trials · California
Obesity clinical trials in California
We’re tracking 118 recruiting obesity studies with a site in California — including Phase 1, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07684235RecruitingPhase 3
Long-term study of a weight-loss drug for trial graduates
This study tests a drug called Maridebart Cafraglutide for long-term weight management in people who completed a previous related trial. It looks at how well the drug works and its safety over time.
Fountain Valley, CaliforniaAges 18–99 - NCT07675590RecruitingPhase 1
Safety study of TIX100 in healthy volunteers
This study tests a new oral medication called TIX100 in healthy people to see if it is safe and how the body handles it. It is the first step in human testing, so it focuses on safety and side effects.
Chula Vista, CaliforniaAges 18–70 - NCT07668414RecruitingPhase 3
Study comparing Zenagamtide and Semaglutide for weight loss
This trial tests a new medicine Zenagamtide to see if it helps people with excess weight lose more weight than Semaglutide, an existing weight loss drug. You may join if you are an adult with overweight or obesity but do not have diabetes.
Lancaster, CaliforniaAges 18 years+ - NCT07667803RecruitingPhase 3
Study of elecoglipron for weight loss in obesity or overweight
This trial tests an investigational drug called elecoglipron to see if it helps people with obesity or overweight lose weight. It may be an option if you have a high body mass index or weight-related health issues like high blood pressure or prediabetes.
Lynwood, CaliforniaAges 18 years+ - NCT07607587RecruitingPhase 1
Testing a new weight-loss drug for people who couldn't tolerate GLP-1 shots
This study tests a new injectable medication called cagrilintide for people with obesity who had to stop GLP-1 drugs (like Ozempic or Wegovy) because of stomach problems. The goal is to see if cagrilintide causes fewer stomach side effects while still helping with weight.
Walnut Creek, CaliforniaAges 18 years+ - NCT05833217Recruiting
Study for persistent COVID symptoms with insulin resistance
This trial studies people who have ongoing effects after COVID (often called PASC) and may be related to weight and insulin resistance. It may help researchers find better ways to understand the condition and improve treatment.
Palo Alto, CaliforniaAges 18–80 - NCT07571005RecruitingPhase 3
Testing a New Weight-Loss Medicine for Sleep Apnea
This study tests whether a new injectable medicine called NNC0487-0111 helps people with excess weight and moderate-to-severe obstructive sleep apnea (a condition where breathing stops repeatedly during sleep) lose weight and improve their sleep apnea—without needing a CPAP machine. The goal is to see if better weight loss can reduce sleep apnea symptoms.
San Diego, CaliforniaAges 18 years+ - NCT07533175RecruitingPhase 3
Testing a new weight-loss medicine for type 2 diabetes
This study tests whether a new medicine called NNC0487-0111 helps people with type 2 diabetes and excess weight lose weight. You'll take the medicine along with your current diabetes care to see if it works better than standard treatment.
Walnut Creek, CaliforniaAges 18 years+ - NCT07509307RecruitingPhase 3
Study of a new medicine for weight loss and knee pain in osteoarthritis
This trial tests if a new medicine, NNC0487-0111, can help people with excess weight and knee osteoarthritis lose weight and reduce knee pain. It is for people who have had knee pain for at least three months and who can stop taking pain relievers for short periods before study visits.
Lancaster, CaliforniaAges 18 years+ - NCT07481630RecruitingPhase 3
Testing a new medicine for weight loss and knee pain
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
Walnut Creek, CaliforniaAges 18 years+ - NCT07478263Recruiting
Healthy eating trial for Latinas to prevent type 2 diabetes
This study tests a behavioral program designed to help Latinas with prediabetes improve their nutrition and eating patterns to prevent type 2 diabetes. It focuses on reducing cravings and building healthy habits.
La Jolla, CaliforniaAges 18–55 - NCT07446439RecruitingPhase 3
Tradipitant for nausea from weight loss injections
This study tests whether the drug tradipitant can help reduce nausea and vomiting caused by weight loss injections like Ozempic or Wegovy. If you have these side effects and are not diabetic, you may be eligible.
Los Angeles, CaliforniaAges 18–65 - NCT07316816Recruiting
Weight loss study for teens with severe obesity
This study evaluates how continuous glucose monitors and other wearable devices can help teens in a bariatric program lose weight. You may join if you are in the program and ready for sleeve gastrectomy or GLP-1 medication.
Palo Alto, CaliforniaAges 10–18 - NCT07253285RecruitingPhase 3
Study on cagrilintide and CagriSema for kids with excess weight
This trial tests two new medicines (cagrilintide and CagriSema) to see if they help children and teens lose weight. It's for young people who have tried lifestyle changes without enough success.
Escondido, CaliforniaAges 8–18 - NCT07225816RecruitingPhase 1
How fasting affects stomach food with GLP-1 drugs
This study looks at how long fasting and temporarily stopping certain diabetes or weight-loss medications (like semaglutide or liraglutide) affects how much food stays in your stomach. It may help understand how these medications work in people who are overweight.
Cypress, CaliforniaAges 18 years+ - NCT07209202Recruiting
Study on Fructose Handling in Obesity
This study looks at how the body handles fructose (a natural sugar) in people with different weights. It may help explain why some people process sugars differently.
Vallejo, CaliforniaAges 20–55 - NCT07202884RecruitingPhase 3
Orforglipron for Women with Stress Incontinence and Overweight
This study tests an oral medication called orforglipron to see if it helps women with stress urinary incontinence who are also overweight or have obesity. The medicine may reduce leaking episodes and also help with weight loss.
Los Angeles, CaliforniaAges 18 years+ - NCT05309395RecruitingPhase 3
Food prescriptions to help Latino families eat affordably
This trial tests whether giving free/covered “food prescriptions” helps multigenerational Latino households lose weight by improving diet within a budget. It may help families who want to eat healthier without worrying as much about grocery costs.
Pasadena, CaliforniaAges 2 years+ - NCT06207110Recruiting
Family support program for children with high food responsiveness
This study tests a program for families with children ages 7–12 who have overweight or obesity and often feel strong urges to eat. The program helps parents support their child in eating healthier and being more active.
La Jolla, CaliforniaAges 7–12 - NCT07044570Recruiting
Examining attitudes in physical activity engagement
This trial tests if a program can help people who are not very active start and stick with a physical activity routine. Participants will wear a study-provided smartwatch to track their activity and answer brief surveys.
Los Angeles, CaliforniaAges 18 years+ - NCT06994338RecruitingPhase 2
Tirzepatide for alcohol use disorder
This study tests whether a medication called tirzepatide (a once-weekly injection) can help people reduce their alcohol consumption. It is for people who drink heavily, have a high BMI, and are actively seeking help to drink less.
Los Angeles, CaliforniaAges 21–65 - NCT06934655RecruitingPhase 3
Starting semaglutide again after weight-loss surgery in teens
This trial tests if restarting semaglutide (a weekly injection for weight loss) soon after sleeve gastrectomy helps teens with severe obesity keep losing weight. It is for patients who were already taking semaglutide before their surgery.
Los Angeles, CaliforniaAges 12–18 - NCT06570642Recruiting
Study on emotions and physical activity
This study looks at how emotions affect your desire to be active. You'll wear a Fitbit smartwatch and answer short surveys to help researchers understand what helps people start and stick with physical activity.
Los Angeles, CaliforniaAges 18 years+ - NCT06897982Recruiting
Nutrition program for prediabetes at health center
This study tests a nutrition program for people with prediabetes at a health center. It aims to see if the program is practical and can help prevent type 2 diabetes.
Los Angeles, CaliforniaAges 18–99
Obesity trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting obesity studies listed above.
- Diablo Clinical Research · 4 studies
- Artemis Insitute for Clin Res · 2 studies
- Desert Oasis Healthcare Medical Group · 2 studies
- First Valley Medical Group · 2 studies
- Neighborhood Healthcare · 2 studies
- Alarcon Urology Center
- Altasciences Clinical LA, Inc.
- Apex Clinical Research
What taking part in a obesity study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Obesity trials in other states
Common questions
- Are there obesity clinical trials in California?
- Yes. We're currently tracking 118 recruiting obesity studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a obesity study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a obesity trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New obesity studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.