Obstructive Pulmonary Disease clinical trials

Tadalafil for severe lung blood-pressure problems from COPD

This study tests whether tadalafil can improve outcomes for people with severe pulmonary hypertension caused by COPD (chronic lung disease). It compares how you do with tadalafil versus standard care, focusing on breathing symptoms and how well your heart and lungs cope.

Exercise Performance on Ambient Air vs. Low-Flow Liquid Oxygen Therapy in Pulmonary Vascular Disease (PVD)

Study of Galvokimig for moderate-to-severe COPD with chronic bronchitis

This study tests an experimental drug called Galvokimig (taken as a pill) to see if it can reduce COPD flare-ups and improve lung function in people with moderate to severe COPD and chronic bronchitis. It is for those who have had recent flare-ups and are already using maintenance inhalers.

Home-based exercise program for lung recovery after COPD flare-ups

This study tests whether a supervised home-based exercise program, delivered via video calls, can help people recovering from a COPD flare-up feel stronger and breathe easier, compared with usual care. If you join, you'll have regular online sessions with a rehab team from home.

Two ventilator settings for asthma and COPD patients

This study compares two different ways of delivering breaths from a ventilator for people with severe asthma or COPD. The goal is to see which method might be better for your lungs.

Inhaled study drug for healthy smokers and people with COPD

This study tests an inhaled medication called RB042 in healthy adults, healthy smokers, and people with COPD. It aims to see how the drug works in the body and whether it is safe, which could help in developing a new treatment for COPD.

Stem cell therapy for mild to moderate COPD

This study tests whether a new type of stem cell (SMS cells) can help people with mild or moderate COPD caused by smoking or pollution. You will receive the treatment by inhalation and be followed to see if your breathing improves.

Heart care support for older African American patients

This study aims to improve care for older African American patients with heart conditions and other health problems. It tests ways to provide more patient-centered support.

Balance training for people with COPD

This study looks at whether adding balance training after standard pulmonary rehabilitation helps people with COPD improve their balance and reduce the risk of falls. It may help you feel more steady and confident in daily activities.

Testing different treatable traits in lung disease and controls

This study looks at “treatable traits” (specific features of lung disease) across people with chronic airflow problems, including cystic fibrosis, and compares them with healthy volunteers. You may be asked to do several breathing and exercise tests to see how well different traits can be measured and how they relate to symptoms.

Predicting worsening COPD in severe patients

This study builds a tool to predict which COPD patients are likely to have worsening symptoms. It may help your doctor better manage your care if you have severe COPD.

NLR blood test for COPD flare-ups

This study looks at whether the neutrophil-to-lymphocyte ratio (NLR) in your blood can help doctors understand how serious a COPD flare-up is. You may join if you are 18 or older and admitted to the hospital with a COPD exacerbation.

Blood sample study for better health screening

This study collects blood samples and health information over time to improve early detection of diseases. It may help researchers find ways to prevent serious conditions.

Sleep apnea screening in diverse groups

This study is screening people from different backgrounds for obstructive sleep apnea (a condition where breathing stops and starts during sleep). It uses a sleep test and questionnaires to see if you might have it.

Testing depemokimab for COPD with type 2 inflammation

This study tests an early treatment called depemokimab for people with moderate to severe COPD who have a type of inflammation linked to high eosinophils. It aims to reduce flare-ups and improve breathing.

Study of PF-07275315 for moderate to severe COPD

This trial tests a new medicine called PF-07275315 for people with moderate to severe COPD. It aims to see if it can help reduce flare-ups (sudden worsening of symptoms) when added to your usual treatment.

Study of BBT002 for healthy people and COPD patients

This trial tests an experimental drug called BBT002 in healthy volunteers and people with chronic obstructive pulmonary disease (COPD), a lung condition that makes breathing hard. It aims to see if the drug is safe and how the body processes it.

Portable Oxygen During Daily Activity for Lung Disease

This study tests whether using portable oxygen during everyday activities helps people with certain lung diseases (like pulmonary fibrosis or COPD) who only experience low oxygen levels when moving around. Researchers want to see if a portable oxygen device improves how well participants can function and feel during daily life.

Using MoblO2 to maintain oxygen levels during activity

This study tests a device called MoblO2 to help people with COPD or interstitial lung disease keep their oxygen levels up during activity. If you normally use oxygen when you walk or exert yourself, this might help you stay active more safely.

Using dynamic chest x-ray to diagnose COPD

This study tests if a new type of chest x-ray (dynamic chest x-ray) can help diagnose COPD. You would breathe normally and deeply while the x-ray takes images for 20 seconds. This could be a more comfortable way to check for COPD compared to standard breathing tests.

Stem cell transplant for COPD: a safety and early efficacy study

This trial tests whether transplanting a patient's own lung stem cells can improve lung function in people with chronic obstructive pulmonary disease (COPD). It aims to see if this treatment is safe and helps repair damaged lung tissue.

Finding biomarkers in lung disease and lung cancer

This trial studies blood and tissue samples from people with COPD, IPF, or lung cancer to find markers that can help diagnose and predict these conditions. It aims to discover why some lung diseases progress to cancer.

Testing blood vessel function in people of different health conditions

This early study measures how well your blood vessels work using tests that may include MRI. It compares healthy people with people who have conditions like COPD, pulmonary arterial hypertension, heart failure, or high blood pressure, to better understand “vascular function” in health and disease.

Check how respiratory health changes in people without lung problems

This trial enrolls adults who recently had a chest X-ray as part of routine health screening and did not show major abnormal findings, and who do not have significant breathing symptoms. It may help researchers understand changes in respiratory health over time and improve how respiratory disease risk is monitored.