Clinical trials
Chronic Obstructive Pulmonary Disease Severe clinical trials
Below are recruiting chronic obstructive pulmonary disease severe clinical trials, each written for real people, not researchers. We’re tracking 197 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07285122RecruitingPhase 1
Inhaled study drug for healthy smokers and people with COPD
This study tests an inhaled medication called RB042 in healthy adults, healthy smokers, and people with COPD. It aims to see how the drug works in the body and whether it is safe, which could help in developing a new treatment for COPD.
Nedlands, Western AustraliaAges 18–80 - NCT06986070RecruitingPhase 1
Stem cell therapy for mild to moderate COPD
This study tests whether a new type of stem cell (SMS cells) can help people with mild or moderate COPD caused by smoking or pollution. You will receive the treatment by inhalation and be followed to see if your breathing improves.
Melbourne, VictoriaAges 39–69 - NCT07751705Recruiting
Sputum collection with a chest vibration device for COPD
This study tests whether a chest vibration device helps people with COPD produce sputum (phlegm) more easily during a breathing test. It may help researchers collect better samples to understand and treat COPD.
Hanover, Lower SaxonyAges 40–70 - NCT07684820RecruitingPhase 2
A study of ExPD-101 for COPD with chronic bronchitis and frequent flare-ups
This study tests an experimental drug (ExPD-101) given daily as a pill for 52 weeks for people with COPD who have chronic bronchitis and frequent flare-ups. It compares the drug to a placebo (inactive pill) to see if it reduces flare-ups and improves symptoms.
Phoenix, ArizonaAges 40–85 - NCT06419062Enrolling by invitation
Using wearables to monitor COPD at home
This study tests if a wearable device can help track your COPD symptoms between doctor visits. You'll use a smartphone or computer to share data, which may help your care team stay on top of your health.
GlasgowAges 18 years+ - NCT07402551RecruitingPhase 2
Testing RC1416 injection for COPD flare-ups
This trial tests an injection called RC1416 for people with moderate-to-severe COPD who still have flare-ups despite using triple inhaler therapy. It may help reduce those flare-ups and improve breathing.
Hefei, AnhuiAges 40–85 - NCT04018729RecruitingPhase 2/Phase 3
Cell treatment through a breathing tube for severe emphysema
This trial tests a cell-based treatment placed into the lung using an airway valve, to help people with severe emphysema breathe easier. You may be eligible if your emphysema is uneven in the lungs and testing suggests your “collateral ventilation” is low, meaning the treatment area may benefit more from blocking airflow.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT06419036Enrolling by invitation
Using medical devices to monitor COPD at home
This study tests whether wearable medical devices can help monitor your COPD symptoms at home. You will use a smartphone app and a small chest patch to track your breathing, which may help you and your doctor better manage your condition.
GlasgowAges 18 years+ - NCT05976919Recruiting
Testing different treatable traits in lung disease and controls
This study looks at “treatable traits” (specific features of lung disease) across people with chronic airflow problems, including cystic fibrosis, and compares them with healthy volunteers. You may be asked to do several breathing and exercise tests to see how well different traits can be measured and how they relate to symptoms.
Leeds, LeedsAges 18–65 - NCT06198309Recruiting
Predicting worsening COPD in severe patients
This study builds a tool to predict which COPD patients are likely to have worsening symptoms. It may help your doctor better manage your care if you have severe COPD.
Beijing, Beijing MunicipalityAges 40–85 - NCT06531798RecruitingPhase 4
Safety study of Breztri aerosphere in Indian COPD patients
This study tests a medication called Breztri aerosphere (a triple-combination inhaler) to see how safe and well-tolerated it is in Indian patients with COPD who have had recent flare-ups. It may help people who need better control of their breathing symptoms.
Dalgate, DrugjanAges 18 years+ - NCT07743021Recruiting
Blood sample study for better health screening
This study collects blood samples and health information over time to improve early detection of diseases. It may help researchers find ways to prevent serious conditions.
BalatonfüredAges 40 years+ - NCT07725939RecruitingPhase 2
Study of Galvokimig for moderate-to-severe COPD with chronic bronchitis
This study tests an experimental drug called Galvokimig (taken as a pill) to see if it can reduce COPD flare-ups and improve lung function in people with moderate to severe COPD and chronic bronchitis. It is for those who have had recent flare-ups and are already using maintenance inhalers.
Boerne, TexasAges 40–80 - NCT07192016RecruitingPhase 4
MRI study of triple inhaler for COPD with breathlessness
This study uses a special MRI scan to see how well a single triple inhaler works for people with COPD who have moderate to severe shortness of breath or feel their health is not good. It compares two groups: those with a low risk of flare-ups and those with a high risk, to find out if the treatment helps both groups.
London, OntarioAges 50–85 - NCT07736872Recruiting
Sleep apnea screening in diverse groups
This study is screening people from different backgrounds for obstructive sleep apnea (a condition where breathing stops and starts during sleep). It uses a sleep test and questionnaires to see if you might have it.
Guangzhou, GuangdongAges 18–80 - NCT07177339RecruitingPhase 3
Testing depemokimab for COPD with type 2 inflammation
This study tests an early treatment called depemokimab for people with moderate to severe COPD who have a type of inflammation linked to high eosinophils. It aims to reduce flare-ups and improve breathing.
Newport Beach, CaliforniaAges 40–75 - NCT07363694RecruitingPhase 2/Phase 3
Study of PF-07275315 for moderate to severe COPD
This trial tests a new medicine called PF-07275315 for people with moderate to severe COPD. It aims to see if it can help reduce flare-ups (sudden worsening of symptoms) when added to your usual treatment.
Birmingham, AlabamaAges 35–80 - NCT06958666Recruiting
Comparing two breathing exercises for COPD symptoms
This study compares two breathing exercise methods (DITM vs IMT) for people with COPD to see which helps improve symptoms and quality of life better. It's for people who are already using a specific type of inhaler.
Hangzhou, ZhejiangAges 40 years+ - NCT07288554RecruitingPhase 1
Study of BBT002 for healthy people and COPD patients
This trial tests an experimental drug called BBT002 in healthy volunteers and people with chronic obstructive pulmonary disease (COPD), a lung condition that makes breathing hard. It aims to see if the drug is safe and how the body processes it.
Hefei, AnhuiAges 18–75 - NCT06862206Recruiting
Benralizumab study for severe asthma in China
This study looks at people in China with severe eosinophilic asthma who are starting a new medicine called benralizumab. It will collect information about their symptoms and quality of life to understand who benefits most.
AnhuiAges Any age - NCT06653413Recruiting
Using dynamic chest x-ray to diagnose COPD
This study tests if a new type of chest x-ray (dynamic chest x-ray) can help diagnose COPD. You would breathe normally and deeply while the x-ray takes images for 20 seconds. This could be a more comfortable way to check for COPD compared to standard breathing tests.
Guangzhou, GuangdongAges 40–80 - NCT07353034Recruiting
Social Support for COPD Self-Management
This trial studies whether social support from friends, family, or community can help you better manage your COPD at home. You'll be asked to use online tools and report how you're doing.
Charleston, South CarolinaAges 40 years+ - NCT07707245Recruiting
Finding biomarkers in lung disease and lung cancer
This trial studies blood and tissue samples from people with COPD, IPF, or lung cancer to find markers that can help diagnose and predict these conditions. It aims to discover why some lung diseases progress to cancer.
Milan, MilanAges 18 years+ - NCT07707271Recruiting
Continuous vs. interval exercise for COPD
This trial compares two types of exercise training—steady moderate exercise versus short bursts of higher intensity—to see which is more helpful for people with COPD. It aims to find a better way to improve your breathing and fitness.
Thessaloniki, ExohiAges Any age
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Common questions
- Are there clinical trials for chronic obstructive pulmonary disease severe?
- Yes. Clin2 currently lists 197 recruiting chronic obstructive pulmonary disease severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic obstructive pulmonary disease severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic obstructive pulmonary disease severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.