Clinical trials
Chronic Obstructive Pulmonary Disease Severe clinical trials
Below are recruiting chronic obstructive pulmonary disease severe clinical trials, each written for real people, not researchers. We’re tracking 212 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07587658RecruitingPhase 4
Dupilumab after a severe COPD flare-up
This study tests whether adding the drug dupilumab to usual hospital care for a severe COPD flare-up helps patients recover better than usual care alone. It is for adults with a specific type of inflammation in their blood, and may reduce the chance of future flare-ups.
Mullica Hill, New JerseyAges 40 years+ - NCT07875036Recruiting
Breathing exercises for COPD-related shortness of breath
This study compares two types of breathing exercises to see which one works better for reducing shortness of breath and improving lung function in people with mild to moderate COPD.
RawalpindiAges 40–75 - NCT07875049Recruiting
Breathing exercises for COPD patients after heart bypass surgery
This trial tests whether adding a device called a Flutter to standard chest physical therapy can improve your breathing and lung function after heart bypass surgery. It may help you recover better if you have mild to moderate COPD.
RawalpindiAges 40–70 - NCT07701096Enrolling by invitation
Home breathing support monitoring for advanced COPD
This study tests a home monitoring system that watches how well noninvasive breathing support (a mask that helps you breathe) works for people with severe COPD. The system sends early warnings to your care team if your breathing patterns change, which may help prevent flare-ups.
BeijingAges 18 years+ - NCT04018729RecruitingPhase 2/Phase 3
Cell treatment through a breathing tube for severe emphysema
This trial tests a cell-based treatment placed into the lung using an airway valve, to help people with severe emphysema breathe easier. You may be eligible if your emphysema is uneven in the lungs and testing suggests your “collateral ventilation” is low, meaning the treatment area may benefit more from blocking airflow.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT07428785Recruiting
Measuring lung and blood volume in COPD
This study looks at how COPD affects the amount of air your lungs can hold and the total blood in your body. The goal is to better understand the disease, which may help improve future treatments.
CopenhagenAges 45–80 - NCT07854210Recruiting
High-flow nasal oxygen versus non-invasive ventilation for COPD
This trial compares two breathing support methods for people hospitalized with COPD and mild-to-moderate carbon dioxide retention. It aims to see if high-flow nasal oxygen is as effective as the standard mask-based ventilation.
Al Mansurah, Dakahlia GovernorateAges 40 years+ - NCT06198309Recruiting
Predicting worsening COPD in severe patients
This study builds a tool to predict which COPD patients are likely to have worsening symptoms. It may help your doctor better manage your care if you have severe COPD.
Beijing, Beijing MunicipalityAges 40–85 - NCT07860008Recruiting
Breathing and step exercises for COPD wellness
This study tests a program combining breathing training with step exercises to see if it improves breathing, exercise ability, and quality of life in people with COPD. You may join if you have COPD and are able to do light exercise and fill out questionnaires.
New Taipei City, New Taipei CityAges 40 years+ - NCT07870655Enrolling by invitation
Long-term effects of exercise habits in COPD
This study looks at how exercise habits from an earlier COPD exercise trial affect patients over the long term. It helps understand if the benefits last and how to keep patients active.
CopenhagenAges 40–80 - NCT06068322Recruiting
Very intense interval training for people with COPD
This study tests whether a very intense, short burst of exercise (supramaximal high-intensity interval training) is safe and effective for people aged 60 and older with or without COPD. It aims to see if this type of exercise can improve fitness and daily life.
Hasselt, DiepenbeekAges 60 years+ - NCT07842510Recruiting
Controlled oxygen for copd flare-ups in the icu
This trial tests whether giving oxygen in a carefully controlled way (using a target range) works better than standard oxygen treatment for people in the ICU with a COPD flare-up. It aims to see if the controlled approach leads to better outcomes, like helping you recover faster.
Mahdia, Mahdia GovernorateAges 40 years+ - NCT07823842Recruiting
Biologics for asthma and COPD
This study looks at how well medicines called biologics work for people with asthma or COPD. Biologics are special shots that target certain parts of the immune system to reduce inflammation. Researchers want to see if these treatments can help control symptoms and prevent flare-ups.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06491043RecruitingPhase 2
Stem cells for COPD: safety and early effectiveness study
This trial tests whether an infusion of donor stem cells can help people with moderate to severe COPD breathe easier. If you are a current or former smoker aged 40 to 80, your symptoms are stable, and your lung function meets specific targets, you may be able to join.
New Taipei CityAges 40–80 - NCT07816835RecruitingPhase 4
Comparing nebulizer vs inhaler for COPD treatment
This study compares two ways of taking COPD maintenance medicines: using a nebulizer vs. using a handheld inhaler. The goal is to see which method works better for people with severe COPD, so researchers can help guide treatment choices.
Saint Charles, MissouriAges 60 years+ - NCT07805330Recruiting
Blood flow restriction rehab for COPD balance and mobility
This study tests a special exercise method that uses a cuff to limit blood flow in the arms or legs while you exercise. It may help improve your balance and ability to move around if you have COPD.
LahoreAges 20–65 - NCT07793409RecruitingPhase 3
Long-term safety study of lunsekimig for COPD
This study is a long-term follow-up for people with COPD who have already completed an earlier lunsekimig study. It aims to check the safety and effectiveness of the treatment over a longer period.
Newport Beach, CaliforniaAges 40–80 - NCT07789899RecruitingPhase 1
Safety study of a new investigational drug in healthy volunteers
This trial tests a new medicine to see how the body handles it and whether it is safe. It is for healthy people, not for treating a disease, and helps researchers decide if the drug can move to the next stage of testing.
CambridgeAges 18–55 - NCT07780656RecruitingPhase 3
Felcorekibart for chronic obstructive pulmonary disease (COPD)
This study tests a new medicine, felcorekibart, to see if it can reduce COPD flare-ups better than a placebo after 52 weeks. It's designed for people with high eosinophils, a type of white blood cell linked to inflammation.
Miami, FloridaAges 40–80 - NCT07780669RecruitingPhase 3
Study of a new drug for moderate to severe COPD in smokers
This study tests a new medication (GSK5784283) for people with moderate to severe COPD who have a certain type of inflammation (eosinophilic). Participants must be on standard inhaler therapy and have a history of smoking. The trial will compare the new drug to a placebo.
Doral, FloridaAges 40–80 - NCT07777445Recruiting
Oxygen treatment during exercise for lung and pulmonary vascular disease
This study compares breathing normal air versus low-flow liquid oxygen during exercise to see if oxygen helps improve performance in people with conditions affecting the lungs or the blood vessels in the lungs. You would exercise while using a portable oxygen device and then without it to compare the effects.
Zurich, Canton of ZurichAges 18 years+ - NCT07777367Recruiting
Exercise with liquid oxygen in chronic lung disease
This study compares how well people with chronic lung diseases perform during exercise when breathing regular air versus when using low-flow liquid oxygen. It aims to see if using liquid oxygen during exercise can improve exercise ability and quality of life.
Zurich, Canton of ZurichAges 18 years+ - NCT07759245RecruitingPhase 2
Brenipatide for moderate-to-severe COPD
This trial tests a new medicine called Brenipatide to see if it can help people with moderate-to-severe COPD who still have symptoms despite using standard inhalers. The study will compare the effects of Brenipatide against a placebo to understand if it is safe and effective.
Birmingham, AlabamaAges 40–75 - NCT07751705Recruiting
Using sound waves to collect lung mucus samples in COPD patients
This trial is testing whether a device that uses sound waves can help collect lung mucus samples more easily in people with COPD. It compares two groups: current smokers and ex-smokers, to see if the device works differently for them.
Hanover, Lower SaxonyAges 40 years+
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Common questions
- Are there clinical trials for chronic obstructive pulmonary disease severe?
- Yes. Clin2 currently lists 212 recruiting chronic obstructive pulmonary disease severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic obstructive pulmonary disease severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic obstructive pulmonary disease severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.