Clinical trials
Opioid Use After Surgery clinical trials
Below are recruiting opioid use after surgery clinical trials, each written for real people, not researchers. We’re tracking 117 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04912531Recruiting
Virtual reality and smell tools to ease surgery pain
This trial tests whether a combination of virtual reality and guided smells can reduce pain and anxiety around major heart and chest surgeries. If you’re scheduled for one of the listed operations, the study may help make recovery feel more comfortable by using sensory-based distraction.
Boston, MassachusettsAges 18 years+ - NCT03858231RecruitingPhase 4
Opioid vs non-opioid pain relief after knee arthroscopy
This study compares opioid pain medicine with non-opioid pain medicine after arthroscopic (keyhole) knee surgery. It aims to see which approach controls pain well while keeping side effects and risks lower.
Fargo, North DakotaAges 18–80 - NCT06507293Recruiting
Pain relief methods comparison for lung surgery
This trial tests two numbing injections to see which reduces pain medicine use during lung surgery. A special pain monitor guides the treatment. It may help you need fewer opioids during your procedure.
KocaeliAges 18–65 - NCT07115030Recruiting
Support program for women with opioid use disorder and past abuse
This trial tests a stepped care program for women who have experienced intimate partner violence and are in treatment for opioid use disorder. It aims to improve recovery by addressing post-traumatic stress symptoms and overall well-being.
Bridgeport, ConnecticutAges 18 years+ - NCT06706375Recruiting
Comparing two types of penile nerve blocks for child circumcision
This study tests two ways of numbing the penis before circumcision in children. The goal is to see which method works better and causes less discomfort.
Lausanne, Canton of VaudAges Up to 17 years - NCT06437886Enrolling by invitation
Comparing high-dose vs. lower-dose opioid anesthesia for heart surgery
This trial compares two types of anesthesia during heart surgery: one that uses high doses of strong painkillers (opioids) and one that uses less opioids. The goal is to see which approach is safer and helps patients recover better.
BeijingAges 45–70 - NCT07674836Recruiting
Comparing two nerve blocks for chronic pain after breast surgery
This study tests two types of nerve blocks (SPSIP and ESP blocks) to see which one works better for long-term pain after a single-sided breast surgery like mastectomy. It aims to find a safer, more effective way to manage chronic pain after surgery.
İzmit, KocaeliAges 18–65 - NCT03596424Recruiting
Testing ketamine and dexmedetomidine during lung surgery
This trial studies whether the anesthesia medicines ketamine and dexmedetomidine can improve care during elective lung (video-assisted) surgery. It may help with comfort during and after the operation, depending on how these medicines affect pain and recovery.
Montreal, QuebecAges 18–80 - NCT05271331Recruiting
Numbing injection options for back surgery pain
This trial compares two ways of numbing tissue during a planned back surgery called a laminectomy: an “ESPB block” versus numbing the wound directly. It aims to see which method works better for pain control and comfort after surgery.
Padova, VenetoAges 18 years+ - NCT06100172Recruiting
Ear Stimulation After Back Surgery
This study tests whether a gentle electrical stimulation placed on the ear (tAuricular Neurostimulation) can help reduce pain and improve recovery after lumbar spine surgery. It is for people who are already scheduled for a lumbar fusion or laminectomy and want to see if this non-invasive approach can ease their post-surgery discomfort.
Dallas, TexasAges 18–85 - NCT06909851Recruiting
Comparing nerve blocks for pain after knee arthroscopy
This study compares two different types of nerve blocks to see which provides better pain relief after arthroscopic knee surgery. You will receive one of the blocks after your surgery, and your pain levels will be tracked.
IstanbulAges 18–72 - NCT06507345Recruiting
Non-opioid pain relief after breast surgery
This trial tests whether non-opioid pain medicines can effectively control pain after mastectomy or lumpectomy, allowing you to go home the same day without needing strong opioids.
Montreal, QuebecAges 18 years+ - NCT06358040Recruiting
Opioid dispenser after back surgery trial
This trial tests a special device that gives you pain medication (opioids) after back surgery, instead of a prescription. It may help you use just the right amount of pain medicine, and you'll use your smartphone for follow-up visits.
New York, New YorkAges 18 years+ - NCT07222072RecruitingPhase 4
Methadone to reduce opioid use after spine surgery
This study tests whether giving methadone during and after major spine surgery can help reduce the need for other opioid pain medicines later. It is for adults having multilevel fusion in the lower or mid-back.
Cleveland, OhioAges 18–72 - NCT07639281Enrolling by invitation
Opioid Education for Ventral Hernia Repair Surgery
This study teaches patients about opioid pain medication before hernia repair surgery. It aims to help patients make informed decisions about pain management and understand safer opioid use.
Lexington, KentuckyAges 18–85 - NCT07541040Recruiting
Nerve Blocks for Breast Surgery Pain Relief
This trial tests two different nerve-block techniques to reduce pain after breast surgery. The study compares a serratus block with an ESP block—both are injections of numbing medication near nerves—to see which works better for managing pain without heavy opioid use.
İzmit, KocaeliAges 18–65 - NCT06345872Recruiting
Better sleep to help reduce opioid use for chronic pain
This study tests a sleep improvement program to help people with chronic widespread pain reduce or stop their opioid pain medication. If you want to cut back on opioids and have trouble sleeping, this treatment might be a good fit.
Tampa, FloridaAges 18 years+ - NCT07672015RecruitingPhase 4
Testing a new pain drug in surgery patients at risk for opioid dependence
This trial tests a new painkiller called suzetrigine for post-surgery pain. It's designed for people whose medical records suggest they may have a higher chance of needing strong painkillers (opioids) long after surgery. We want to see if suzetrigine works better at preventing that.
La Jolla, CaliforniaAges 18 years+ - NCT04094701Recruiting
Study of opioid needs after hip arthroscopy surgery
This study looks at how much pain medicine (opioids) people actually need after hip arthroscopy and what factors may affect it. It may help improve safer, more personalized pain control after surgery.
Chicago, IllinoisAges 18–80 - NCT06639464RecruitingPhase 2
Semaglutide to help with opioid recovery
This trial tests if semaglutide, a medicine sometimes used for weight management, can help people recovering from opioid use disorder stay on track. It is for adults who have already started buprenorphine treatment and are ready to take part in a research study.
Boston, MassachusettsAges 18 years+ - NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT06139666Enrolling by invitationPhase 4
Liposomal bupivacaine nerve block for rotator cuff surgery
This study tests whether a long-lasting numbing medicine called liposomal bupivacaine (Exparel) works better than standard pain relief for people having rotator cuff surgery. It aims to lessen pain after surgery so you may need fewer pain pills.
Camden, New JerseyAges 18 years+ - NCT04798469RecruitingPhase 2
Testosterone to reduce long-term spine pain in men on opioids
This Phase 2 study tests whether taking testosterone can lessen chronic non-cancer spinal pain in men who have low testosterone while using opioid pain medicines. It may help by improving hormone levels that could be affecting pain and overall wellbeing.
Boston, MassachusettsAges 18 years+ - NCT07104825Recruiting
Nerve block for pain after weight loss surgery
This trial tests if a nerve block can help control pain after gastric bypass or sleeve gastrectomy. The goal is to reduce the need for strong pain medicines and improve recovery.
Evanston, IllinoisAges 18–90
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Common questions
- Are there clinical trials for opioid use after surgery?
- Yes. Clin2 currently lists 117 recruiting opioid use after surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use after surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use after surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.