Clinical trials
Opioid Use Disorder, Severe clinical trials
Below are recruiting opioid use disorder, severe clinical trials, each written for real people, not researchers. We’re tracking 149 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06877858RecruitingPhase 1
MethaLoad dose-finding study for opioid use disorder
This study tests a new way to start methadone treatment (called 'MethaLoad') for people with opioid use disorder who have used fentanyl. If you qualify, you will receive methadone to help manage withdrawal and reduce cravings, and the doctors will closely monitor your safety and response.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06835582Enrolling by invitation
Checking Methadone and Its Breakdown Levels
This study is checking the levels of methadone and its breakdown products in your blood. It helps make sure the medication is working safely for conditions like opioid use disorder or chronic pain.
Lemon Grove, CaliforniaAges 18–70 - NCT06810310RecruitingPhase 2
Psilocybin for motivation in opioid use disorder
This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder stay motivated in recovery. It uses brain scans to see how psilocybin affects brain areas linked to motivation.
Philadelphia, PennsylvaniaAges 18–60 - NCT06799117Recruiting
Decision Support for Opioid Addiction Treatment
This study tests a new way to help people in the emergency department who have moderate to severe opioid use disorder. It looks at using a decision-support tool to guide treatment choices.
Guilford, ConnecticutAges 18 years+ - NCT06786325RecruitingPhase 2
Psilocybin treatment study for opioid use disorder
This trial tests whether psilocybin can help people recovering from opioid use disorder while living at a residential treatment center. If you are already taking buprenorphine/naloxone (Suboxone), methadone, or have received Sublocade, this study may be an option for you.
Philadelphia, PennsylvaniaAges 18–60 - NCT06494904RecruitingPhase 3
Standard vs. High Dose Buprenorphine in the ER
This study compares a higher dose of buprenorphine (a medicine that helps stop opioid cravings and withdrawal) to the usual dose, given in the emergency department. It aims to see if the higher dose works better to start treatment for opioid use disorder.
Oakland, CaliforniaAges 18–65 - NCT06306443RecruitingPhase 3
Buprenorphine treatment for people leaving jail
This trial offers buprenorphine (a medication for opioid use disorder) to people in jail who are soon to be released. It helps you start treatment while incarcerated and continue it after you return to the community, aiming to reduce overdose and improve recovery.
Baltimore, MarylandAges 18 years+ - NCT06136247Recruiting
Brain & thinking tests in opioid use disorder
This study tests whether brain scans and thinking tests can help understand opioid use disorder. It is for people on stable buprenorphine or methadone treatment.
Philadelphia, PennsylvaniaAges 18–60 - NCT05589181RecruitingPhase 3
High-dose buprenorphine start in the emergency department for fentanyl use
This Phase 3 study tests whether starting a high dose of buprenorphine in the emergency department helps people with opioid use disorder come through withdrawal more safely and effectively. It focuses on people whose urine test shows fentanyl and who are already in withdrawal when they arrive.
Newark, New JerseyAges 18 years+ - NCT05459402RecruitingPhase 2/Phase 3
Methadone dose testing for opioid use disorder pain relief
This study compares taking methadone as one dose versus split into two doses to see which approach works better for people who have pain. It’s meant for adults already on a steady methadone program and who can follow study visits and procedures.
Baltimore, MarylandAges 18–100 - NCT05033028RecruitingPhase 3
Using a smartphone to support opioid addiction recovery
This Phase 3 study tests whether using smartphones can help people with opioid-use disorder stick with treatment and recover more successfully. It focuses on people starting or already in treatment using methadone or buprenorphine, with support delivered through the study app or messages.
Piscataway, New JerseyAges 18–85 - NCT04893525RecruitingPhase 2/Phase 3
Buprenorphine-naloxone microdosing versus standard dosing after ED discharge
This study compares a smaller “microdose” starting method versus the usual starting dose of buprenorphine/naloxone for people with opioid use disorder when they are discharged from the emergency department. It may help find a safer, easier way to start treatment right after an ED visit and avoid problems caused by starting too early.
Calgary, AlbertaAges 18 years+ - NCT04379115Recruiting
Brain stimulation study for people with opioid addiction
This study tests a non-invasive brain stimulation approach to reduce opioid cravings in people who are actively using non-prescribed opioids while on stable methadone. It may help people feel less craving and improve recovery support.
Hinsdale, IllinoisAges 18–85 - NCT04161066RecruitingPhase 1
Psilocybin plus buprenorphine to help opioid use disorder symptoms
This Phase 1 study tests how adding psilocybin to a standard opioid treatment (buprenorphine-naloxone) affects recovery and symptoms in people with moderate-to-severe opioid use disorder. It may help researchers understand whether this combination is safe and beneficial alongside medication for opioid withdrawal and cravings.
Madison, WisconsinAges 21–65 - NCT06903819RecruitingPhase 4
Ketamine for pain and mental health after orthopedic injury
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
Lubbock, TexasAges 18–65 - NCT06405607RecruitingPhase 2
Psilocybin vs Ketamine for Alcohol Use Disorder Trial
This trial tests two psychedelic-assisted therapies, psilocybin and ketamine, to see which works better for reducing heavy drinking in people with alcohol use disorder (AUD). You'll receive either drug along with counseling, and the study monitors safety closely.
Iowa City, IowaAges 21–65 - NCT06484075RecruitingPhase 1/Phase 2
Sleep medication for alcohol use disorder
This study tests whether suvorexant, a sleep aid, can help people with alcohol use disorder by looking at brain changes. It may improve sleep and reduce drinking.
Bethesda, MarylandAges 18–75 - NCT05538910Recruiting
Brain imaging study on substance use and depression
This study uses brain scans to understand how substance use and mental illness, like depression, are linked. It may help develop better treatments by looking at brain activity in people with and without depression.
Baltimore, MarylandAges 18–60 - NCT07571226Recruiting
Urban Stress and Mental Health Monitoring Study
This study explores how city living and daily stress affect depression, anxiety, and alcohol use disorders by having you wear a monitoring wristband and use a smartphone app to track your physical responses. Researchers hope to better understand the link between environmental stress and mental health symptoms.
BeijingAges 18–60 - NCT06201676RecruitingPhase 4
Low-dose short-term ketorolac to cut opioid use after bone surgery
This study tests whether giving a low dose of a non-steroidal anti-inflammatory drug (NSAID) called ketorolac for a short time after orthopedic surgery can reduce the need for strong painkillers like opioids. It is for people who have broken bones that need surgery with metal plates, screws, or rods.
Boston, MassachusettsAges 18–70 - NCT07773649RecruitingEarly Phase 1
PET scan to study energy use in brain of people with cocaine use disorder
This study uses a special PET scan to look at how brain cells make energy, which may be changed by cocaine. It might help researchers find better ways to treat cocaine use disorder.
Pittsburgh, PennsylvaniaAges 18–45 - NCT07040592RecruitingPhase 2
Semaglutide for HIV and alcohol use
This study is testing whether semaglutide, a medication already used for diabetes and weight loss, can help people with HIV who also have an alcohol use disorder cut back on drinking. It is for patients treated at the Atlanta VA Healthcare System.
Decatur, GeorgiaAges 18–99 - NCT06788587RecruitingPhase 2
Long-term stimulant for methamphetamine recovery
This study tests whether a high dose of a stimulant medication (lisdexamfetamine, an ADHD medicine) taken over many weeks can help people who have already completed a methamphetamine treatment program to stay off meth, reduce use, or avoid relapse.
Montreal, QuebecAges 18–55 - NCT06345872Recruiting
Better sleep to help reduce opioid use for chronic pain
This study tests a sleep improvement program to help people with chronic widespread pain reduce or stop their opioid pain medication. If you want to cut back on opioids and have trouble sleeping, this treatment might be a good fit.
Tampa, FloridaAges 18 years+
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Common questions
- Are there clinical trials for opioid use disorder, severe?
- Yes. Clin2 currently lists 149 recruiting opioid use disorder, severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder, severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder, severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.