Clinical trials
Opioid Use Disorder, Severe clinical trials
Below are recruiting opioid use disorder, severe clinical trials, each written for real people, not researchers. We’re tracking 150 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06494904RecruitingPhase 3
Standard vs. High Dose Buprenorphine in the ER
This study compares a higher dose of buprenorphine (a medicine that helps stop opioid cravings and withdrawal) to the usual dose, given in the emergency department. It aims to see if the higher dose works better to start treatment for opioid use disorder.
Oakland, CaliforniaAges 18–65 - NCT04161066RecruitingPhase 1
Psilocybin plus buprenorphine to help opioid use disorder symptoms
This Phase 1 study tests how adding psilocybin to a standard opioid treatment (buprenorphine-naloxone) affects recovery and symptoms in people with moderate-to-severe opioid use disorder. It may help researchers understand whether this combination is safe and beneficial alongside medication for opioid withdrawal and cravings.
Madison, WisconsinAges 21–65 - NCT06786325RecruitingPhase 2
Psilocybin treatment study for opioid use disorder
This trial tests whether psilocybin can help people recovering from opioid use disorder while living at a residential treatment center. If you are already taking buprenorphine/naloxone (Suboxone), methadone, or have received Sublocade, this study may be an option for you.
Philadelphia, PennsylvaniaAges 18–60 - NCT06799117Recruiting
Decision Support for Opioid Addiction Treatment
This study tests a new way to help people in the emergency department who have moderate to severe opioid use disorder. It looks at using a decision-support tool to guide treatment choices.
Guilford, ConnecticutAges 18 years+ - NCT06810310RecruitingPhase 2
Psilocybin for motivation in opioid use disorder
This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder stay motivated in recovery. It uses brain scans to see how psilocybin affects brain areas linked to motivation.
Philadelphia, PennsylvaniaAges 18–60 - NCT06877858RecruitingPhase 1
MethaLoad dose-finding study for opioid use disorder
This study tests a new way to start methadone treatment (called 'MethaLoad') for people with opioid use disorder who have used fentanyl. If you qualify, you will receive methadone to help manage withdrawal and reduce cravings, and the doctors will closely monitor your safety and response.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07262190Recruiting
NavSTAR program for opioid use disorder
This trial tests a program to help people with opioid use disorder start or continue treatment while in the hospital. It aims to connect patients to care after they leave.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07439549RecruitingPhase 4
Quick-start buprenorphine with naloxone for opioid use disorder
This study tests a faster way to start buprenorphine (a medication for opioid use disorder) by using naloxone to briefly trigger mild withdrawal. This could help people get started on treatment more comfortably and quickly.
Vancouver, British ColumbiaAges 19 years+ - NCT07541417Recruiting
Peer Support for Starting Medication Treatment for Opioid Use
This study tests whether peer coaches—people with lived experience of opioid addiction—can help newly enrolled patients stay engaged with medication-based treatment through a mobile app. The goal is to improve treatment success by combining peer support with digital health tools.
Greenville, South CarolinaAges 18 years+ - NCT06835582Enrolling by invitation
Checking Methadone and Its Breakdown Levels
This study is checking the levels of methadone and its breakdown products in your blood. It helps make sure the medication is working safely for conditions like opioid use disorder or chronic pain.
Lemon Grove, CaliforniaAges 18–70 - NCT06903819RecruitingPhase 4
Ketamine for pain and mental health after orthopedic injury
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
Lubbock, TexasAges 18–65 - NCT06405607RecruitingPhase 2
Psilocybin vs Ketamine for Alcohol Use Disorder Trial
This trial tests two psychedelic-assisted therapies, psilocybin and ketamine, to see which works better for reducing heavy drinking in people with alcohol use disorder (AUD). You'll receive either drug along with counseling, and the study monitors safety closely.
Iowa City, IowaAges 21–65 - NCT06484075RecruitingPhase 1/Phase 2
Suvorexant for alcohol use disorder: brain effects
This study tests whether the sleep medication suvorexant can help people with alcohol use disorder by looking at its effects on brain activity. Participants will stay in the hospital for about a month, take suvorexant or a placebo, and have brain scans.
Bethesda, MarylandAges 18–75 - NCT05538910Recruiting
Study brain links between depression and substance use
This study uses brain imaging and questionnaires to understand how substance use and depression are connected in the brain. It may help researchers identify biological patterns that could guide better treatments in the future.
Baltimore, MarylandAges 18–60 - NCT07571226Recruiting
Urban Stress and Mental Health Monitoring Study
This study explores how city living and daily stress affect depression, anxiety, and alcohol use disorders by having you wear a monitoring wristband and use a smartphone app to track your physical responses. Researchers hope to better understand the link between environmental stress and mental health symptoms.
BeijingAges 18–60 - NCT06201676RecruitingPhase 4
Low-dose short-term ketorolac to cut opioid use after bone surgery
This study tests whether giving a low dose of a non-steroidal anti-inflammatory drug (NSAID) called ketorolac for a short time after orthopedic surgery can reduce the need for strong painkillers like opioids. It is for people who have broken bones that need surgery with metal plates, screws, or rods.
Boston, MassachusettsAges 18–70 - NCT06345872Recruiting
Better sleep to help reduce opioid use for chronic pain
This study tests a sleep improvement program to help people with chronic widespread pain reduce or stop their opioid pain medication. If you want to cut back on opioids and have trouble sleeping, this treatment might be a good fit.
Tampa, FloridaAges 18 years+ - NCT06788587RecruitingPhase 2
Long-term stimulant for methamphetamine recovery
This study tests whether a high dose of a stimulant medication (lisdexamfetamine, an ADHD medicine) taken over many weeks can help people who have already completed a methamphetamine treatment program to stay off meth, reduce use, or avoid relapse.
Montreal, QuebecAges 18–55 - NCT07040592RecruitingPhase 2
Semaglutide for HIV and alcohol use
This study is testing whether semaglutide, a medication already used for diabetes and weight loss, can help people with HIV who also have an alcohol use disorder cut back on drinking. It is for patients treated at the Atlanta VA Healthcare System.
Decatur, GeorgiaAges 18–99 - NCT06470698Recruiting
Using emotional awareness to predict treatment success in addiction
This trial tests whether tracking emotional awareness can help predict how well people recover from cocaine or alcohol addiction. It uses a mobile app to monitor feelings and progress.
HuelvaAges 18 years+ - NCT06030154Recruiting
Boosting positive feelings for people with alcohol use disorder
This study tests a program designed to help people with alcohol use disorder who also struggle with low mood or anxiety. It aims to increase positive emotions, which may make it easier to reduce drinking.
Tulsa, OklahomaAges 18–65 - NCT05146778Recruiting
Opioid-free anesthesia to reduce long-term post-mastectomy pain
This study tests whether a pain-control approach without opioids (strong pain medicines) can lower persistent pain after mastectomy. It may help people avoid long-term pain and opioid side effects.
SeoulAges 19–80 - NCT05886582RecruitingPhase 2
Rotigotine patch added to therapy for cocaine use
This Phase 2 study tests whether a rotigotine skin patch, used alongside behavioral therapy, can help people reduce cocaine use. It also looks at changes in brain activity while you do study tasks.
Richmond, VirginiaAges 25–70 - NCT07004686Recruiting
Guided anesthesia to reduce opioid use in gallbladder surgery
This study tests a new way of guiding anesthesia during gallbladder removal surgery, with the goal of using less opioid pain medicine. It may help you have a smoother recovery with fewer side effects.
Shenzhen, GuangdongAges 18–64
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Common questions
- Are there clinical trials for opioid use disorder, severe?
- Yes. Clin2 currently lists 150 recruiting opioid use disorder, severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder, severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder, severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.