Clinical trials
Opioid Use Disorder clinical trials
Below are recruiting opioid use disorder clinical trials, each written for real people, not researchers. We’re tracking 296 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07004686Recruiting
Guided anesthesia to reduce opioid use in gallbladder surgery
This study tests a new way of guiding anesthesia during gallbladder removal surgery, with the goal of using less opioid pain medicine. It may help you have a smoother recovery with fewer side effects.
Shenzhen, GuangdongAges 18–64 - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT05995535RecruitingPhase 2
Pregabalin and Lofexidine for Opioid Withdrawal
This study tests whether combining two medications, pregabalin and lofexidine, can help people stop using opioids by easing withdrawal symptoms. It's for adults who use opioids heavily and want to switch to a non-addictive blocker medication.
Baltimore, MarylandAges 18 years+ - NCT06636227RecruitingPhase 1
Diclofenac dose study for alcohol use disorder
This study tests whether different doses of diclofenac, an anti-inflammatory drug, can help people reduce heavy drinking. It looks at how the drug affects drinking patterns and overall health.
Catonsville, MarylandAges 21–65 - NCT07119567Recruiting
Cocaine use and withdrawal effects on sleep
This study looks at how cocaine use and stopping cocaine affect sleep. It may help people with cocaine use disorder who are planning to detox in a hospital.
Bron, AURAAges 18 years+ - NCT06580457Recruiting
Personalized smartphone program for Veterans with substance use
This study tests a personalized smartphone program to help Veterans reduce harmful substance use. It uses daily surveys and feedback to support healthier habits.
Minneapolis, MinnesotaAges 18 years+ - NCT07315308Recruiting
Nerve block before heart surgery and painkiller use
This study tests whether a numbing injection in the chest before heart surgery can reduce the amount of pain medicine needed during the operation. It may help you manage pain better and recover more comfortably.
Gaziantep, SahinbeyAges 18–65 - NCT06532708Recruiting
Pain Medicine Use After Laparoscopic Hysterectomy
This study looks at how doctors prescribe pain medicine after laparoscopic hysterectomy (a type of keyhole surgery to remove the uterus). It aims to find better ways to manage pain after surgery.
Memphis, TennesseeAges 18–80 - NCT05607381Recruiting
Meditation program study for opioid-treated chronic low back pain
This trial studies how meditation may change brain activity and help people with long-lasting low back pain who are already taking prescription opioids. The goal is to understand the “neural” (brain) effects of meditation to improve pain treatment.
La Jolla, CaliforniaAges 18–65 - NCT06747871Recruiting
Opioids, low nicotine cigarettes, and chronic pain study
This study tests if using cigarettes with very low nicotine can help people with chronic pain who are on buprenorphine for opioid use disorder. It aims to see if this approach reduces smoking and helps you think about quitting.
Durham, North CarolinaAges 21 years+ - NCT07063394Recruiting
Virtual reality to reduce opioid use after heart or lung surgery
This trial tests if using virtual reality after heart or chest surgery can help reduce the amount of strong painkillers (opioids) patients need. It may offer a non-drug way to manage pain and speed up recovery.
São Paulo, São PauloAges 16–40 - NCT05958017Recruiting
ReSET program to help stimulant use in HIV clinics
This study tests a care-support program called ReSET to improve adherence to treatment and reduce stimulant use for people living with HIV who are not currently in drug treatment. You may be offered support through HIV clinic care to help you stay on track, especially if you have access to a smartphone and stable housing.
Miami, FloridaAges 18–90 - NCT07178158Recruiting
Extra education via app for addiction treatment
This trial tests a smartphone app called NIPA that provides extra education and support for people already taking medication for opioid or stimulant use disorder. It aims to improve addiction treatment by helping you learn more and stay on track.
Richmond, VirginiaAges 18–65 - NCT06015711Recruiting
Does a pre-surgery painkiller reduce strong IV pain meds needed?
This trial tests if taking Maxigesic® (a combination of two pain relievers) before surgery can lower the amount of a strong IV pain medicine called remifentanil needed during anesthesia. It may help patients have a smoother recovery with fewer side effects.
Suwon, Gyeonggi-doAges 19–60 - NCT06039566RecruitingPhase 3
NAC vs placebo for pain after hysterectomy
This trial tests if a medicine called N-acetylcysteine (NAC) can reduce the need for strong pain pills after hysterectomy surgery. If you are having a laparoscopic or robotic hysterectomy, this study may help you recover with less opioid pain medicine.
Charleston, South CarolinaAges 18 years+ - NCT05380531Recruiting
Personalized pain plan for planned C-section using opioid options
This trial tests a personalized approach to pain control during and after a scheduled C-section. It may help by matching pain medicine choices to each person’s needs, including the use of in-hospital opioids for relief.
Indianapolis, IndianaAges 18 years+ - NCT04793685RecruitingPhase 2
Prazosin for alcohol withdrawal symptoms in alcohol use disorder
This study tests whether prazosin can reduce symptoms that happen when someone stops or cuts back on heavy drinking. It may help people with moderate-to-severe alcohol use disorder who also have alcohol withdrawal symptoms.
New Haven, ConnecticutAges 18–70 - NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT06989853RecruitingEarly Phase 1
Testing troriluzole for methamphetamine use disorder
This study tests whether a medication called troriluzole can help people who use methamphetamine. If you have methamphetamine use disorder and are not seeking treatment right now, this study may be an option for you.
Lexington, KentuckyAges 18–55 - NCT06851533Recruiting
Pain relief methods for lumbar microsurgery recovery
This trial compares two different types of nerve blocks to see which one reduces the need for strong pain medicine after lumbar microsurgery. It may help patients have better pain control and fewer side effects from opioids.
IstanbulAges 18–80 - NCT03823534RecruitingPhase 3
Study pain control after preventive femur bone surgery
This Phase 3 study tests a pain medicine plan used after preventive surgery to place a metal rod inside the thigh bone (femur) before a fracture happens. The goal is to find an approach that controls post-surgery pain while being safe for the right patients.
St Louis, MissouriAges 18 years+ - NCT04084860RecruitingPhase 2
Brief medicine trial to help reduce heavy alcohol drinking
This Phase 2 study tests a brief medication approach meant to reduce “problem drinking.” It may help people cut back or stop alcohol use by adjusting brain signaling related to drinking cravings and urges.
New York, New YorkAges 21–70 - NCT05630781Recruiting
Orexin's role in the neurobiology of addiction
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Baltimore, MarylandAges 18–60 - NCT05028062RecruitingPhase 4
Naltrexone injections for people who want to cut alcohol drinking
This Phase 4 study tests whether naltrexone injections can help people with alcohol use disorder (AUD) reduce or stop heavy drinking. You may get two injections over 8 weeks, and you can join if you meet specific drinking pattern and eligibility rules.
Philadelphia, PennsylvaniaAges 18–65
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Common questions
- Are there clinical trials for opioid use disorder?
- Yes. Clin2 currently lists 296 recruiting opioid use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.