Clinical trials
Opioid Use Disorder clinical trials
Below are recruiting opioid use disorder clinical trials, each written for real people, not researchers. We’re tracking 303 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04793685RecruitingPhase 2
Prazosin for alcohol withdrawal symptoms in alcohol use disorder
This study tests whether prazosin can reduce symptoms that happen when someone stops or cuts back on heavy drinking. It may help people with moderate-to-severe alcohol use disorder who also have alcohol withdrawal symptoms.
New Haven, ConnecticutAges 18–70 - NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT06989853RecruitingEarly Phase 1
Testing troriluzole for methamphetamine use disorder
This study tests whether a medication called troriluzole can help people who use methamphetamine. If you have methamphetamine use disorder and are not seeking treatment right now, this study may be an option for you.
Lexington, KentuckyAges 18–55 - NCT06851533Recruiting
Pain relief methods for lumbar microsurgery recovery
This trial compares two different types of nerve blocks to see which one reduces the need for strong pain medicine after lumbar microsurgery. It may help patients have better pain control and fewer side effects from opioids.
IstanbulAges 18–80 - NCT03823534RecruitingPhase 3
Study pain control after preventive femur bone surgery
This Phase 3 study tests a pain medicine plan used after preventive surgery to place a metal rod inside the thigh bone (femur) before a fracture happens. The goal is to find an approach that controls post-surgery pain while being safe for the right patients.
St Louis, MissouriAges 18 years+ - NCT04084860RecruitingPhase 2
Brief medicine trial to help reduce heavy alcohol drinking
This Phase 2 study tests a brief medication approach meant to reduce “problem drinking.” It may help people cut back or stop alcohol use by adjusting brain signaling related to drinking cravings and urges.
New York, New YorkAges 21–70 - NCT05630781Recruiting
Orexin's role in the neurobiology of addiction
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Baltimore, MarylandAges 18–60 - NCT05028062RecruitingPhase 4
Naltrexone injections for people who want to cut alcohol drinking
This Phase 4 study tests whether naltrexone injections can help people with alcohol use disorder (AUD) reduce or stop heavy drinking. You may get two injections over 8 weeks, and you can join if you meet specific drinking pattern and eligibility rules.
Philadelphia, PennsylvaniaAges 18–65 - NCT05271331Recruiting
Numbing injection options for back surgery pain
This trial compares two ways of numbing tissue during a planned back surgery called a laminectomy: an “ESPB block” versus numbing the wound directly. It aims to see which method works better for pain control and comfort after surgery.
Padova, VenetoAges 18 years+ - NCT05726045Recruiting
Sleep-based brain training to help you quit smoking
This study tests a way to improve smoking cessation using special sleep-based brain stimulation and memory support. If it works, it may help you stay committed to quitting by strengthening helpful brain learning during sleep.
Mannheim, Baden-WurttembergAges 18–65 - NCT05985811Recruiting
Ketamine for chronic pain and mood in adults
This trial tests if ketamine injections can improve both pain and mood in adults with chronic pain who also have a mood disorder and trouble sleeping. It may help if you already get regular ketamine treatments.
Surrey, British ColumbiaAges 20–99 - NCT06100172Recruiting
Ear Stimulation After Back Surgery
This study tests whether a gentle electrical stimulation placed on the ear (tAuricular Neurostimulation) can help reduce pain and improve recovery after lumbar spine surgery. It is for people who are already scheduled for a lumbar fusion or laminectomy and want to see if this non-invasive approach can ease their post-surgery discomfort.
Dallas, TexasAges 18–85 - NCT06125054RecruitingPhase 2
Ketamine and brain training for cocaine addiction
This trial tests whether a combination of ketamine (a medicine that may help the brain change) and neurofeedback training (a brain-exercise technique) can help people with cocaine addiction. The goal is to see if these treatments can improve brain flexibility and reduce cravings.
Zurich, Canton of ZurichAges 18–55 - NCT06206252Recruiting
Can Medical Cannabis Help Reduce Opioid Use?
This study tests whether medical cannabis can help people who take opioids for long-term pain reduce their opioid use. Participants will either use medical cannabis or continue without it for 3 months.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06291363RecruitingPhase 4
Esmolol for pain control during laparoscopic surgery
This trial tests a drug called esmolol to see if it helps control pain during and after laparoscopic surgeries that involve a small cut below the belly button. It may help people having a hysterectomy or left colon removal feel less pain during anesthesia.
Montreal East, QuebecAges 18–65 - NCT06302413Recruiting
Thinking about the future during early recovery
This study looks at how thinking about the future might help people in early recovery from substance use. It recruits people who have been abstinent for 2 weeks to 1 year and are in outpatient treatment.
Indianapolis, IndianaAges 18–60 - NCT06420336Recruiting
Pain relief after cleft palate surgery
This study compares two ways to manage pain after cleft palate repair surgery that uses a bone graft from the hip. The goal is to see which method provides better pain control for children and teens.
Charleston, South CarolinaAges 6–18 - NCT06494891RecruitingPhase 2
Understanding motivation for IV alcohol drinking
This study looks at why people with alcohol use disorder choose to drink alcohol given through an IV. The goal is to better understand the motivation behind drinking, which could help improve treatments.
Los Angeles, CaliforniaAges 21–65 - NCT06639438Recruiting
Sensory outcomes in people who use opioids
This study looks at how opioids affect the senses in people having planned surgery. Researchers want to compare patients who use opioids (for pain or addiction) with those who don't, to see if there are differences in sensation.
Boston, MassachusettsAges 18 years+ - NCT06784908Recruiting
Stress and pain study for people living with HIV
This study looks at how stress affects pain in people with HIV. It may help find better ways to manage pain in this group.
New Haven, ConnecticutAges 18–68 - NCT06787235Recruiting
Can a special diet help reduce alcohol intake?
This study tests whether a nutritional program (a modified ketogenic diet) can help people with alcohol use disorder reduce their drinking. It aims to find out if changing what you eat can support your goals around alcohol.
BernAges 18–80 - NCT07027839RecruitingPhase 1
Alcohol effects on brain imaging for phosphodiesterase
This study uses PET scans to see how alcohol affects a protein in the brain called PDE4B. It may help explain how alcohol works in the body.
Bethesda, MarylandAges 21–70 - NCT07052318Recruiting
Music app for stress relief in early alcohol recovery
This study tests whether listening to music through a smartphone app can help reduce stress for people who are in the first year of recovery from alcohol use disorder. If you're 18-35 and have a smartphone, you may be able to join.
Spokane, WashingtonAges 18–35 - NCT07223398Recruiting
Making HIV care decisions with people who've been in the justice system
This trial helps people recently involved with the justice system and who use stimulants or opioids decide on HIV prevention or treatment. It tests a shared decision-making approach for taking HIV medication (ART) or PrEP.
New Haven, ConnecticutAges 18 years+
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Common questions
- Are there clinical trials for opioid use disorder?
- Yes. Clin2 currently lists 303 recruiting opioid use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.