Clinical trials
Opioid Use Disorder clinical trials
Below are recruiting opioid use disorder clinical trials, each written for real people, not researchers. We’re tracking 295 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07027839RecruitingPhase 1
Alcohol effects on brain imaging for phosphodiesterase
This study uses PET scans to see how alcohol affects a protein in the brain called PDE4B. It may help explain how alcohol works in the body.
Bethesda, MarylandAges 21–70 - NCT06989853RecruitingEarly Phase 1
Testing troriluzole for methamphetamine use disorder
This study tests whether a medication called troriluzole can help people who use methamphetamine. If you have methamphetamine use disorder and are not seeking treatment right now, this study may be an option for you.
Lexington, KentuckyAges 18–55 - NCT05271331Recruiting
Numbing injection options for back surgery pain
This trial compares two ways of numbing tissue during a planned back surgery called a laminectomy: an “ESPB block” versus numbing the wound directly. It aims to see which method works better for pain control and comfort after surgery.
Padova, VenetoAges 18 years+ - NCT06851533Recruiting
Pain relief methods for lumbar microsurgery recovery
This trial compares two different types of nerve blocks to see which one reduces the need for strong pain medicine after lumbar microsurgery. It may help patients have better pain control and fewer side effects from opioids.
IstanbulAges 18–80 - NCT06784908Recruiting
Stress and pain study for people living with HIV
This study looks at how stress affects pain in people with HIV. It may help find better ways to manage pain in this group.
New Haven, ConnecticutAges 18–68 - NCT06787235Recruiting
Can a special diet help reduce alcohol intake?
This study tests whether a nutritional program (a modified ketogenic diet) can help people with alcohol use disorder reduce their drinking. It aims to find out if changing what you eat can support your goals around alcohol.
BernAges 18–80 - NCT06639438Recruiting
Sensory outcomes in people who use opioids
This study looks at how opioids affect the senses in people having planned surgery. Researchers want to compare patients who use opioids (for pain or addiction) with those who don't, to see if there are differences in sensation.
Boston, MassachusettsAges 18 years+ - NCT06494891RecruitingPhase 2
Understanding motivation for IV alcohol drinking
This study looks at why people with alcohol use disorder choose to drink alcohol given through an IV. The goal is to better understand the motivation behind drinking, which could help improve treatments.
Los Angeles, CaliforniaAges 21–65 - NCT06420336Recruiting
Pain relief after cleft palate surgery
This study compares two ways to manage pain after cleft palate repair surgery that uses a bone graft from the hip. The goal is to see which method provides better pain control for children and teens.
Charleston, South CarolinaAges 6–18 - NCT06302413Recruiting
Thinking about the future during early recovery
This study looks at how thinking about the future might help people in early recovery from substance use. It recruits people who have been abstinent for 2 weeks to 1 year and are in outpatient treatment.
Indianapolis, IndianaAges 18–60 - NCT06015711Recruiting
Does a pre-surgery painkiller reduce strong IV pain meds needed?
This trial tests if taking Maxigesic® (a combination of two pain relievers) before surgery can lower the amount of a strong IV pain medicine called remifentanil needed during anesthesia. It may help patients have a smoother recovery with fewer side effects.
Suwon, Gyeonggi-doAges 19–60 - NCT06173973Enrolling by invitationPhase 2/Phase 3
Ketone supplement for alcohol withdrawal symptoms
This study tests whether a special supplement (ketones) can help people feel better during alcohol withdrawal. It is for adults who are already in a treatment program for alcohol withdrawal.
Philadelphia, PennsylvaniaAges 18–75 - NCT06100172Recruiting
Ear Stimulation After Back Surgery
This study tests whether a gentle electrical stimulation placed on the ear (tAuricular Neurostimulation) can help reduce pain and improve recovery after lumbar spine surgery. It is for people who are already scheduled for a lumbar fusion or laminectomy and want to see if this non-invasive approach can ease their post-surgery discomfort.
Dallas, TexasAges 18–85 - NCT05630781Recruiting
Orexin's role in the neurobiology of addiction
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Baltimore, MarylandAges 18–60 - NCT05380531Recruiting
Personalized pain plan for planned C-section using opioid options
This trial tests a personalized approach to pain control during and after a scheduled C-section. It may help by matching pain medicine choices to each person’s needs, including the use of in-hospital opioids for relief.
Indianapolis, IndianaAges 18 years+ - NCT05028062RecruitingPhase 4
Naltrexone injections for people who want to cut alcohol drinking
This Phase 4 study tests whether naltrexone injections can help people with alcohol use disorder (AUD) reduce or stop heavy drinking. You may get two injections over 8 weeks, and you can join if you meet specific drinking pattern and eligibility rules.
Philadelphia, PennsylvaniaAges 18–65 - NCT03823534RecruitingPhase 3
Study pain control after preventive femur bone surgery
This Phase 3 study tests a pain medicine plan used after preventive surgery to place a metal rod inside the thigh bone (femur) before a fracture happens. The goal is to find an approach that controls post-surgery pain while being safe for the right patients.
St Louis, MissouriAges 18 years+ - NCT05146778Recruiting
Opioid-free anesthesia to reduce long-term post-mastectomy pain
This study tests whether a pain-control approach without opioids (strong pain medicines) can lower persistent pain after mastectomy. It may help people avoid long-term pain and opioid side effects.
SeoulAges 19–80 - NCT07793383Recruiting
Testing ways to support opioid treatment decisions in the ER
This study is testing different ways to help people with opioid use disorder decide if they want to start medication treatment while they're in the emergency department. It's looking at how to improve the support and guidance given in that setting.
Guilford, ConnecticutAges 18 years+ - NCT07587359Recruiting
Family-Based Therapy for Women in Treatment Court
This study tests a new therapy that involves you and a family member working together to support your recovery from opioid use disorder. The program is designed specifically for women in specialty treatment courts who have experience with sex trade work.
Columbus, OhioAges 18 years+ - NCT07569783Recruiting
Can brain stimulation reduce itching after C-section?
This study tests whether a gentle brain stimulation technique (tDCS) can reduce itching after a C-section. It is for women who are having a C-section with epidural anesthesia and morphine.
Nantong, JiangsuAges 18–40 - NCT06001749RecruitingPhase 2
Psilocybin for cancer pain study
This trial tests whether psilocybin (a psychedelic drug) can help with severe cancer pain. You may qualify if your pain is high despite strong medications and you are willing to be monitored closely.
Boston, MassachusettsAges 18 years+ - NCT05973838Recruiting
Telemedicine support plus recovery coaching for multiple drug use
This study tests whether adding peer recovery support to a phone/video treatment program helps people stay in treatment longer and reduce polysubstance use. It focuses on adults in opioid use disorder care who have used other non-prescribed substances in the last three months.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06991205Recruiting
Web mind-body program for pain and substance use
This trial tests a web-based mind-body program to help people who have ongoing arm or hand pain and also use substances like alcohol or cannabis. It aims to improve resilience and reduce pain without requiring in-person visits.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for opioid use disorder?
- Yes. Clin2 currently lists 295 recruiting opioid use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.