Clinical trials
Opioid Use Disorder clinical trials
Below are recruiting opioid use disorder clinical trials, each written for real people, not researchers. We’re tracking 298 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03923374Recruiting
Study of buprenorphine for opioid use during pregnancy
This study looks at pregnancy and baby outcomes for people who are pregnant and taking buprenorphine for opioid use disorder. It may help doctors understand what to expect long-term for both parent and child when opioid treatment continues during pregnancy.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06415994Enrolling by invitation
Placental imaging and outcomes in opioid use disorder in pregnancy
This study looks at how the placenta and baby's development may be affected when a mother takes buprenorphine or methadone for opioid use disorder during pregnancy. It aims to find better ways to monitor health and improve outcomes for both mothers and babies.
Indianapolis, IndianaAges 18–100 - NCT04173416Recruiting
Support program for young adults in opioid recovery
This study tests a structured recovery support program for adults age 18–28 who have opioid use disorder. It may help by adding extra involvement and support while you receive common long-acting opioid treatment from a medical clinic.
Baltimore, MarylandAges 18–28 - NCT04197921Recruiting
Brain-focused ultrasound for opioid addiction-related substance use
This trial studies Exablate, a non-surgical brain treatment that aims to change activity in a specific brain area involved in cravings and substance use. It is meant for people in structured opioid or substance use treatment who are currently abstaining from opioids and other illicit drugs.
Tampa, FloridaAges 18–60 - NCT04234191RecruitingPhase 2
Test faster buprenorphine/naloxone start versus usual start for opioid use disorder
This Phase 2 study compares a rapid way to start buprenorphine/naloxone versus the standard way, for people with opioid use disorder. It aims to see whether the faster start is safe and works well enough to help people begin treatment sooner.
Vancouver, British ColumbiaAges 19 years+ - NCT04354077Recruiting
Deep brain stimulation for opioid use disorder cravings
This trial studies whether deep brain stimulation (a device that delivers small electrical signals to the brain) can reduce cravings and improve symptoms in adults with opioid use disorder. You may be eligible if you have a long history of opioid dependence and have tried multiple treatment options without lasting success.
Pittsburgh, PennsylvaniaAges 22–65 - NCT04375033RecruitingPhase 4
Oral versus injection buprenorphine for opioid use disorder
This trial compares taking buprenorphine by mouth versus as an injection for opioid use disorder. It aims to see which option helps people stay on treatment and reduces opioid use over about a year.
Tuscaloosa, AlabamaAges 18 years+ - NCT04458545RecruitingPhase 1/Phase 2
Opioid vaccine study for adults with heroin or fentanyl use
This trial tests a vaccine made from parts designed to help the body respond to opioids (heroin or fentanyl). It is mainly for adults with moderate-to-severe opioid use disorder who are using opioids that match the study dosing needs and who are willing to do frequent visits over about a year.
Eatontown, New JerseyAges 18–59 - NCT04587791RecruitingEarly Phase 1
Cannabidiol (CBD) for opioid use disorder and chronic pain
This early study tests whether CBD can reduce symptoms of chronic pain in people receiving opioid maintenance treatment for opioid use disorder. It also looks at safety and whether CBD can be added without causing major problems.
West Haven, ConnecticutAges 18–70 - NCT04811014RecruitingPhase 4
Helping young adults stop opioids after an emergency visit
This study offers an engagement program for young people who tested positive for opioids and meet criteria for opioid dependence. The goal is to help participants stop opioid use safely and learn whether this approach works well in the real-world emergency setting.
Houston, TexasAges 13–17 - NCT04892251RecruitingPhase 1/Phase 2
Ketamine-assisted therapy for opioid use disorder
This trial tests whether ketamine-assisted therapy can help people with opioid use disorder, alongside standard treatment with buprenorphine. It also looks at whether you can safely take part in group mindfulness-style sessions during the study.
Salt Lake City, UtahAges 18 years+ - NCT04925427Recruiting
Reducing overdose deaths by targeting opioid use
This study aims to reduce opioid-related overdose deaths in Illinois by identifying people who are likely using opioids in a non-medical way. You may be invited to participate if you live in a specific area and meet criteria for opioid use.
Chicago, IllinoisAges 18 years+ - NCT04927143Recruiting
Using phone incentives to support substance abstinence
This study tests a smartphone app that gives changing rewards to help people avoid drug use. It targets adults in substance treatment and tries to see if incentives can improve abstinence during treatment.
Oconomowoc, WisconsinAges 18 years+ - NCT07439783Enrolling by invitation
Testing a training program to improve staff retention in child welfare
This trial tests a new training model designed to help keep child welfare supervisors and their teams (including case workers and peer supporters) happy and on the job, so they can better help families. It focuses on agencies that are part of Ohio START.
Columbus, OhioAges 18 years+ - NCT05011266RecruitingPhase 2/Phase 3
Buprenorphine plus naltrexone shot to prevent opioid relapse
This trial tests whether a combination of buprenorphine (through your care plan) and a monthly extended-release naltrexone (XR-NTX) shot can help prevent opioid relapse. It may help people who are ready to move toward a naltrexone-based relapse-prevention treatment after detox.
Rockville, MarylandAges 18–65 - NCT05027919RecruitingPhase 2
Testing ways to predict opioid withdrawal during a taper
This Phase 2 study looks at what opioid withdrawal looks like in the body and whether they can measure it in a meaningful way. You may join if you have an opioid use disorder, can show physical dependence, and are interested in tapering (gradually reducing) opioids under study care.
Baltimore, MarylandAges 18–65 - NCT05138614Recruiting
Help for people with opioid use disorder and mental health needs
This trial studies a program meant to improve treatment access and support recovery for people with opioid use disorder who also have mental health symptoms. It may help if you are new to the program or recently relapsed, or if mental health symptoms have worsened—even without a relapse.
Holyoke, MassachusettsAges 18 years+ - NCT05142267Recruiting
Study stress and opioid-risk factors in chronic low back pain
This study looks at how stress and the body’s natural opioid/cannabinoid systems may relate to risk of opioid misuse. It tests people with long-lasting low back pain to see what biological or psychological factors might increase or lower that risk.
Nashville, TennesseeAges 18 years+ - NCT05219175RecruitingPhase 2
MDMA therapy for PTSD and opioid addiction after childbirth
This Phase 2 study tests whether MDMA-assisted therapy can reduce symptoms of PTSD and help with opioid use disorder in people after childbirth. You must be on a stable, low enough dose of methadone or buprenorphine and be able to follow study rules, including therapy sessions and safety monitoring.
Albuquerque, New MexicoAges 18 years+ - NCT05450718RecruitingPhase 4
Low-dose buprenorphine start for opioid use disorder
This trial tests whether starting buprenorphine using a low-dose plan is a safe and workable way to treat opioid use disorder. You may be able to join if you are 18+, have opioid use disorder, and can follow the study medication and visits.
The Bronx, New YorkAges 18 years+ - NCT05495984Recruiting
Brain change study for mothers in opioid treatment
This study looks at whether supportive interventions can affect brain “plasticity,” or how the brain adapts, in mothers who are in treatment for opioid use disorder. If you qualify, you may be asked to take part in assessments and follow-up so researchers can better understand recovery during early motherhood.
New Haven, ConnecticutAges 21–45 - NCT05511909RecruitingPhase 2
Buspirone study for opioid withdrawal symptoms
This Phase 2 study tests whether buspirone can help reduce symptoms during opioid detox (withdrawal). You may be able to take part if you have opioid withdrawal and are planning medically supervised detox.
Baltimore, MarylandAges 18–75 - NCT05534568Recruiting
Parent support program for families affected by pregnancy substance use
This program aims to help mothers and young children get safer, better support services when substance use occurred during pregnancy. It may help connect you (or your child) to the right community resources and reduce risk of ongoing alcohol or drug exposure.
Oklahoma City, OklahomaAges 18 years+ - NCT05547048RecruitingPhase 4
Phone-based support to help prevent HIV in justice-involved women
This study tests an integrated phone-based health program (e-health) designed for women involved with the justice system who have opioid use disorder. It aims to help people who qualify for HIV prevention (PrEP) stay protected, especially by using simple, ongoing support through phone access.
Birmingham, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for opioid use disorder?
- Yes. Clin2 currently lists 298 recruiting opioid use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.