Clinical trials
Opioid Use Disorder clinical trials
Below are recruiting opioid use disorder clinical trials, each written for real people, not researchers. We’re tracking 295 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07420283RecruitingPhase 2
Study of Brenipatide for opioid use disorder
This trial tests a new medicine called Brenipatide for people with opioid use disorder who are already taking buprenorphine but still occasionally use non-prescribed opioids. It aims to see if the study drug can help reduce opioid use.
Phoenix, ArizonaAges 18–75 - NCT07405398Recruiting
Smartwatch study to detect opioid use and withdrawal
This study uses a smartwatch to track wrist data and help detect when someone is using opioids or experiencing withdrawal. It's designed for people with opioid use disorder who are starting or already on treatment with methadone or buprenorphine.
Wilmington, North CarolinaAges 22 years+ - NCT05985850RecruitingPhase 2
Can cannabis help with opioid addiction treatment?
This trial tests if adding a specific cannabis product to standard methadone treatment helps people with opioid use disorder. It's for adults over 25 who recently started methadone and have used cannabis before.
Vancouver, British ColumbiaAges 25 years+ - NCT07386769Recruiting
Brain activity during social interaction in opioid use
This study looks at how the brain works during social interactions in people who use opioids regularly. It may help researchers understand how opioid use affects the way you connect with others.
La Jolla, CaliforniaAges 18 years+ - NCT07362082Recruiting
Telehealth treatment for opioid use disorder
This study tests whether treatment for opioid use disorder can be done effectively through telehealth (video calls and texts). It is designed for people who are not currently on medication for opioid addiction and want to start treatment from home.
New Haven, ConnecticutAges 18 years+ - NCT07342504Recruiting
Brief alcohol support for people on buprenorphine
This trial tests a brief alcohol-focused support program designed for people who are already taking buprenorphine for opioid addiction. The goal is to help you reduce your drinking in a way that fits with your current treatment.
Notre Dame, IndianaAges 18 years+ - NCT06870110Recruiting
Brain training for opioid use disorder
This trial tests a brain-training program for people with opioid use disorder. It uses an EEG headset to measure brain activity while you do computer exercises, and aims to see if this training can help recovery.
Minneapolis, MinnesotaAges 18–65 - NCT07318480Recruiting
Brain stimulation for drug addiction
This study tests a type of brain stimulation (called tDCS) to help people reduce their use of stimulants (like crack/cocaine) or opioids. It might help lessen cravings and improve treatment outcomes.
New York, New YorkAges 18–60 - NCT07278518Recruiting
Emergency department decision aid for buprenorphine
This trial is testing a tool to help people in the emergency department decide whether to start buprenorphine (a medication for opioid use disorder). It's for patients who are not already on medication for their condition.
Charleston, South CarolinaAges 18 years+ - NCT07232641Recruiting
How pandemic rules affected opioid addiction treatment in the VA
This study looks at how changes in federal and state rules about medications for opioid use disorder during the pandemic affected veterans. It uses information already in your VA records, so there are no extra visits or tests needed.
Boston, MassachusettsAges 18 years+ - NCT07226570Recruiting
Ibogaine brain mapping study for opioid use disorder
This study uses MRI and EEG scans to map how ibogaine affects the brain in people with opioid use disorder. You must already be scheduled to receive ibogaine treatment in Tijuana, Mexico, on your own, as the study does not cover treatment costs.
Irvine, CaliforniaAges 21–70 - NCT07218549RecruitingPhase 1
Study of psychoactive substances in people with past opioid use
This trial tests how safe certain psychoactive substances are and what effects they have in people who have used opioids in the past but are not currently dependent on them. It aims to gather information that could help future treatment options.
Houston, TexasAges 18–55 - NCT07214467Recruiting
Adaptive brain stimulation for opioid use disorder
This study tests a new type of brain stimulation that adapts to your brain activity, aiming to reduce cravings and help you control opioid use. It is for people with long-standing opioid use disorder who have not gotten lasting relief from at least 3 treatment attempts, including medication.
San Francisco, CaliforniaAges 22–75 - NCT07197801Recruiting
Peer support program for opioid use disorder treatment
This study tests if a peer recovery support program helps people stay in treatment for opioid use disorder. Participants who recently started medication for opioid use disorder may get extra support from a peer who has been through recovery themselves.
Danville, PennsylvaniaAges 18–89 - NCT07179614Recruiting
Kentucky women's overdose recovery program
This trial tests a support program for women in Kentucky jails who have opioid or stimulant use disorder. It aims to reduce overdose risk after release by connecting them with community support.
Barbourville, KentuckyAges 18 years+ - NCT07169409RecruitingPhase 1
Telehealth for opioid use disorder in vulnerable settings
This trial tests whether a telehealth program can help people with opioid use disorder get and stay on buprenorphine treatment. It aims to make care more accessible for those in vulnerable situations.
Portland, OregonAges 18 years+ - NCT07171359Recruiting
TMS therapy for opioid and alcohol use recovery
This trial tests whether TMS (a non-invasive brain stimulation) can improve recovery for people with both opioid and alcohol use disorders. You must be in a specific outpatient program in Portland, Oregon.
Portland, OregonAges 18 years+ - NCT07158853RecruitingPhase 1
Brain stimulation and training for opioid use disorder
This trial combines a gentle brain stimulation technique called tDCS with thinking exercises to see if it helps people with opioid use disorder who are already on medication. It aims to improve treatment outcomes
Minneapolis, MinnesotaAges 18 years+ - NCT07135323Recruiting
AvertD Test for First-Time Opioid Users
This study is testing a new tool called AvertD that helps doctors see if a patient might be at higher risk of developing opioid use disorder before they get their first opioid painkiller prescription. If you are getting your first opioid prescription for 4 to 30 days, you may be able to join.
Indianapolis, IndianaAges 18 years+ - NCT07129902Recruiting
Reward program to support opioid medication after ER
This study tests if a reward-based program (called contingency management) helps people stick with their medication for opioid use disorder (like buprenorphine or methadone) after an emergency department visit.
Burlington, VermontAges 18 years+ - NCT07128524RecruitingPhase 2
Ketones for opioid craving study
This trial tests if a ketone supplement can help reduce cravings during opioid withdrawal treatment. Participants take the supplement daily and are monitored for changes in craving and withdrawal symptoms.
Wernersville, PennsylvaniaAges 18–75 - NCT07115030Recruiting
Support program for women with opioid use disorder and past abuse
This trial tests a stepped care program for women who have experienced intimate partner violence and are in treatment for opioid use disorder. It aims to improve recovery by addressing post-traumatic stress symptoms and overall well-being.
Bridgeport, ConnecticutAges 18 years+ - NCT07079215Recruiting
Device trial for opioid withdrawal symptoms
This trial tests a physical device (ADTPM 1) to help manage withdrawal symptoms in people who are dependent on opioids. The goal is to see if the device can safely reduce withdrawal discomfort.
Daegu, DaeguAges 19–80 - NCT07079826Recruiting
Sparrow Link device for opioid withdrawal in hospital
This trial tests a device placed on the ear to help manage opioid withdrawal symptoms in hospitalized adults. It's for people still having withdrawal despite standard medications or those who've chosen not to take methadone or buprenorphine.
Pittsburgh, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for opioid use disorder?
- Yes. Clin2 currently lists 295 recruiting opioid use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.