Clinical trials
Opioid Use clinical trials
Below are recruiting opioid use clinical trials, each written for real people, not researchers. We’re tracking 287 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06903819RecruitingPhase 4
Ketamine for pain and mental health after orthopedic injury
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
Lubbock, TexasAges 18–65 - NCT06379984RecruitingPhase 2
Quick-start buprenorphine for opioid addiction with fentanyl use
This trial tests a way to quickly start buprenorphine (a medication for opioid addiction) in an outpatient clinic for people who use fentanyl. It aims to make starting treatment easier and faster, without needing to go through full withdrawal first.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06962033Recruiting
Pride III: Prison and HIV prevention study
This study looks at ways to improve HIV prevention and treatment for people on probation who have injected opioids. Researchers want to learn from your experiences to help create better services.
New Haven, ConnecticutAges 18 years+ - NCT06565416Recruiting
Pain & opioid treatment in Native communities
This study is testing better ways to treat pain and opioid use in Native American communities. It may help if you have chronic pain or struggle with opioids.
Arcata, CaliforniaAges 18 years+ - NCT06133933Enrolling by invitation
Shoulder replacement and pain medication study
This study looks at how your pain tolerance before a total shoulder replacement might relate to how much pain medication you need after surgery. The goal is to help doctors better manage pain medication after surgery.
Camden, New JerseyAges 18 years+ - NCT07439783Enrolling by invitation
Testing a training program to improve staff retention in child welfare
This trial tests a new training model designed to help keep child welfare supervisors and their teams (including case workers and peer supporters) happy and on the job, so they can better help families. It focuses on agencies that are part of Ohio START.
Columbus, OhioAges 18 years+ - NCT05829655RecruitingEarly Phase 1
Measuring drug cravings in people with opioid use disorder
This study tests whether the medication suvorexant can reduce drug cravings in people with opioid use disorder. You will take either suvorexant or a placebo and have your cravings measured in a safe setting.
Baltimore, MarylandAges 18–65 - NCT06593093RecruitingPhase 1/Phase 2
Continuing buprenorphine after an overdose emergency
This study tests a bundled approach to help adults who have had an opioid overdose and are starting buprenorphine in the emergency department continue their recovery after being discharged. It is for people who want to stay on buprenorphine and need support after leaving the hospital.
Birmingham, AlabamaAges 19 years+ - NCT07672015RecruitingPhase 4
Testing a new pain drug in surgery patients at risk for opioid dependence
This trial tests a new painkiller called suzetrigine for post-surgery pain. It's designed for people whose medical records suggest they may have a higher chance of needing strong painkillers (opioids) long after surgery. We want to see if suzetrigine works better at preventing that.
La Jolla, CaliforniaAges 18 years+ - NCT06870110Recruiting
Brain training for opioid use disorder
This trial tests a brain-training program for people with opioid use disorder. It uses an EEG headset to measure brain activity while you do computer exercises, and aims to see if this training can help recovery.
Minneapolis, MinnesotaAges 18–65 - NCT04356274Enrolling by invitation
Improving access to addiction and mental health care at VA clinics
This study tests an approach to help VA clinics reach more Veterans with proven treatments for addiction and mental health conditions. It focuses on clinic-level processes (not individual medications) to increase how widely evidence-based care is delivered.
Palo Alto, CaliforniaAges 18 years+ - NCT04094701Recruiting
Study of opioid needs after hip arthroscopy surgery
This study looks at how much pain medicine (opioids) people actually need after hip arthroscopy and what factors may affect it. It may help improve safer, more personalized pain control after surgery.
Chicago, IllinoisAges 18–80 - NCT04173416Recruiting
Support program for young adults in opioid recovery
This study tests a structured recovery support program for adults age 18–28 who have opioid use disorder. It may help by adding extra involvement and support while you receive common long-acting opioid treatment from a medical clinic.
Baltimore, MarylandAges 18–28 - NCT06774248Recruiting
Teen opioid recovery support program with medication
This study tests a program called YORS that helps teens with opioid use disorder stick with their medication. It involves you and a support person (like a parent) working together with the study team to stay on track.
Baltimore, MarylandAges 13–21 - NCT06731348Enrolling by invitationPhase 4
Pain pill options after pelvic surgery
This trial compares two different amounts of opioid pain pills after surgery for women with pelvic floor problems. The goal is to see if a lower dose still provides good pain relief and keeps patients satisfied.
Bethesda, MarylandAges 18 years+ - NCT06358040Recruiting
Opioid dispenser after back surgery trial
This trial tests a special device that gives you pain medication (opioids) after back surgery, instead of a prescription. It may help you use just the right amount of pain medicine, and you'll use your smartphone for follow-up visits.
New York, New YorkAges 18 years+ - NCT06033599RecruitingPhase 3
Mindfulness and motivation to quit smoking while on methadone
This study combines counseling (motivational interviewing) with mindfulness training (like guided exercises) to help people on methadone quit smoking. It tests if adding mindfulness can make it easier to stop smoking and stay quit.
New Brunswick, New JerseyAges 18 years+ - NCT06689072Enrolling by invitation
High-frequency brain stimulation for opioid use disorder
This study tests whether a treatment called repetitive transcranial magnetic stimulation (rTMS) can help people with opioid use disorder. It involves a non-invasive procedure that uses magnetic pulses to stimulate certain parts of the brain.
Asyut, Asyut GovernorateAges 18–45 - NCT03745339Recruiting
Smell-based memory task in people with opioid-use disorder
This study tests how people learn and infer what something means using a smell-and-memory task. It compares people with opioid-use disorder who are abstinent, those in maintenance treatment, and healthy controls to see what affects learning and decision-making after opioid use.
Baltimore, MarylandAges 21–60 - NCT06350409Recruiting
Opioid use after surgery in teens
This study looks at how teens aged 12–17 use opioids after a scheduled surgery. It aims to understand outcomes and help improve pain management.
Aurora, ColoradoAges 12–17 - NCT06639464RecruitingPhase 2
Semaglutide to help with opioid recovery
This trial tests if semaglutide, a medicine sometimes used for weight management, can help people recovering from opioid use disorder stay on track. It is for adults who have already started buprenorphine treatment and are ready to take part in a research study.
Boston, MassachusettsAges 18 years+ - NCT06718491Recruiting
A smartphone program to reduce heavy drinking for people on opioid treatment
This study tests a brief smartphone-based program to help people reduce heavy drinking while they are receiving medication for opioid use disorder (MOUD). It aims to improve both alcohol and mental health outcomes.
Columbus, OhioAges 18 years+ - NCT06940674RecruitingPhase 3
CBD plus opioid treatment for recovery
This study tests whether adding cannabidiol (CBD) to your usual methadone or buprenorphine treatment helps you recover from opioid use disorder. If you're already in stable treatment with those medications, the trial aims to see if CBD can improve your outcomes.
New York, New YorkAges 18–65 - NCT05336188Enrolling by invitation
Smartphone help to prevent relapse in opioid use disorder
This study looks at whether a smartphone-based program can help people avoid relapse from opioid use disorder. Some participants may also do brain scans to better understand the brain changes behind relapse prevention.
Little Rock, ArkansasAges 18 years+
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Common questions
- Are there clinical trials for opioid use?
- Yes. Clin2 currently lists 287 recruiting opioid use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.