Clinical trials
Opioid Use clinical trials
Below are recruiting opioid use clinical trials, each written for real people, not researchers. We’re tracking 287 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06608979Recruiting
Trauma screening and violence prevention for women in addiction treatment
This study offers trauma screening and a program to help prevent interpersonal violence for women who are currently receiving treatment for substance use. It aims to understand how these services can improve safety and well-being.
Greenville, South CarolinaAges 18 years+ - NCT05985850RecruitingPhase 2
Can cannabis help with opioid addiction treatment?
This trial tests if adding a specific cannabis product to standard methadone treatment helps people with opioid use disorder. It's for adults over 25 who recently started methadone and have used cannabis before.
Vancouver, British ColumbiaAges 25 years+ - NCT06454903Recruiting
Smartphone app support for veterans treating opioid use disorder
This study tests a smartphone app to support Veterans in their recovery from opioid use disorder. The app aims to improve daily functioning alongside medication treatment.
West Haven, ConnecticutAges 18 years+ - NCT04798469RecruitingPhase 2
Testosterone to reduce long-term spine pain in men on opioids
This Phase 2 study tests whether taking testosterone can lessen chronic non-cancer spinal pain in men who have low testosterone while using opioid pain medicines. It may help by improving hormone levels that could be affecting pain and overall wellbeing.
Boston, MassachusettsAges 18 years+ - NCT04912531Recruiting
Virtual reality and smell tools to ease surgery pain
This trial tests whether a combination of virtual reality and guided smells can reduce pain and anxiety around major heart and chest surgeries. If you’re scheduled for one of the listed operations, the study may help make recovery feel more comfortable by using sensory-based distraction.
Boston, MassachusettsAges 18 years+ - NCT05877157Recruiting
Study how pain and opioids change after surgery
This study follows adults in the hospital after surgery to understand how pain and opioid (strong pain medicine) use affect them. Your answers on questionnaires help researchers see what happens after different types of anesthesia.
Zagreb, Vinogradska 29Ages 18 years+ - NCT07179614Recruiting
Kentucky women's overdose recovery program
This trial tests a support program for women in Kentucky jails who have opioid or stimulant use disorder. It aims to reduce overdose risk after release by connecting them with community support.
Harlan, KentuckyAges 18 years+ - NCT06432465Recruiting
Brain stimulation to help prevent opioid relapse
This study uses a type of brain stimulation called tDCS (transcranial direct current stimulation) to see if it can help people who have recently started medication for opioid dependence (buprenorphine or methadone) stay on track and avoid relapse. The treatment is non-invasive and involves a mild electrical current applied to the scalp.
Providence, Rhode IslandAges 21–60 - NCT07558187Recruiting
Health Inequalities Study in Rural and Urban Communities
This research study examines how health differences vary between rural and urban areas and among different groups of people. Researchers want to understand what factors affect health outcomes and why some communities experience worse health than others.
LarissaAges 18 years+ - NCT06965010Enrolling by invitation
Tracking Care in Opioid Treatment Programs
This study tests whether tracking your progress with regular check-ins (measurement-based care) helps improve treatment for people starting medication for opioid use disorder at a treatment program.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT03396276Enrolling by invitationPhase 4
Emergency system to help people stop opioid misuse
This Phase 4 study tests an “emergency opioid engagement system” that aims to help people who are opioid-dependent start stopping opioid use. If you’re willing to stop and can safely participate, the program may offer structured support when you’re in the emergency setting.
Houston, TexasAges 18 years+ - NCT05142267Recruiting
Study stress and opioid-risk factors in chronic low back pain
This study looks at how stress and the body’s natural opioid/cannabinoid systems may relate to risk of opioid misuse. It tests people with long-lasting low back pain to see what biological or psychological factors might increase or lower that risk.
Nashville, TennesseeAges 18 years+ - NCT07004686Recruiting
Guided anesthesia to reduce opioid use in gallbladder surgery
This study tests a new way of guiding anesthesia during gallbladder removal surgery, with the goal of using less opioid pain medicine. It may help you have a smoother recovery with fewer side effects.
Shenzhen, GuangdongAges 18–64 - NCT04458545RecruitingPhase 1/Phase 2
Opioid vaccine study for adults with heroin or fentanyl use
This trial tests a vaccine made from parts designed to help the body respond to opioids (heroin or fentanyl). It is mainly for adults with moderate-to-severe opioid use disorder who are using opioids that match the study dosing needs and who are willing to do frequent visits over about a year.
Eatontown, New JerseyAges 18–59 - NCT06617949RecruitingEarly Phase 1
Pain Control Study for New Mothers on Opioid Medication
This study looks at better ways to manage pain after childbirth for mothers who are taking medication for opioid use disorder. It aims to find which pain control method works best and is safest for you and your baby.
Milwaukee, WisconsinAges 18–40 - NCT07568938Recruiting
Anesthesia types and stress response in weight-loss surgery
This study compares two anesthesia methods—inhaled gas (desflurane) versus IV medication (TIVA)—during weight-loss surgery to see how each affects your body's stress response and recovery. The goal is to understand which approach may be safer and more comfortable for patients having bariatric surgery.
AthensAges 18–65 - NCT05995535RecruitingPhase 2
Pregabalin and Lofexidine for Opioid Withdrawal
This study tests whether combining two medications, pregabalin and lofexidine, can help people stop using opioids by easing withdrawal symptoms. It's for adults who use opioids heavily and want to switch to a non-addictive blocker medication.
Baltimore, MarylandAges 18 years+ - NCT06837662Recruiting
Counseling and peer support for opioid use disorder in primary care
This study tests whether adding counseling and peer support helps people with opioid use disorder and other medical problems stay in treatment. It is for patients seen at Central City Concern in Portland who are starting or restarting medication for opioid use disorder, or who are not yet on medication but want help.
Portland, OregonAges 18 years+ - NCT05058287RecruitingPhase 3
Steroid shot during low-back surgery
This trial tests whether using a steroid medicine (a steroid shot) around the time of low-back decompression surgery improves pain and recovery. It is for adults having a limited-area laminectomy, and it compares steroid use versus not using it.
New York, New YorkAges 18–85 - NCT05547048RecruitingPhase 4
Phone-based support to help prevent HIV in justice-involved women
This study tests an integrated phone-based health program (e-health) designed for women involved with the justice system who have opioid use disorder. It aims to help people who qualify for HIV prevention (PrEP) stay protected, especially by using simple, ongoing support through phone access.
Birmingham, AlabamaAges 18 years+ - NCT06157840Recruiting
Sleep program for people on buprenorphine treatment
This trial tests a mobile health sleep program for people who are on buprenorphine for opioid use disorder and have trouble sleeping. It aims to help improve sleep and support your recovery journey.
Charleston, South CarolinaAges 18 years+ - NCT06732596Recruiting
Recovery support app for people on buprenorphine
This study tests a smartphone app that uses a conversational helper to support people in recovery from opioid use disorder who are taking buprenorphine. It aims to help you stay on track with treatment.
Boston, MassachusettsAges 18 years+ - NCT07044583Recruiting
Safe Opioid Use Video Education for Breast Reconstruction
This trial tests a video education program to help women safely use opioids after breast reconstruction surgery. It is for patients who have had a mastectomy and are getting a breast rebuilt using their own tissue.
Salt Lake City, UtahAges 18 years+ - NCT07315308Recruiting
Nerve block before heart surgery and painkiller use
This study tests whether a numbing injection in the chest before heart surgery can reduce the amount of pain medicine needed during the operation. It may help you manage pain better and recover more comfortably.
Gaziantep, SahinbeyAges 18–65
Hear when a new Opioid Use trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for opioid use?
- Yes. Clin2 currently lists 287 recruiting opioid use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.