Clinical trials
Opioid Use clinical trials
Below are recruiting opioid use clinical trials, each written for real people, not researchers. We’re tracking 287 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT07064564RecruitingPhase 1
Study comparing naltrexone implants with monthly injection in healthy volunteers
This trial compares two forms of naltrexone (a medication used for alcohol and opioid dependence) in healthy volunteers. It tests how well the body processes and tolerates a low or high-dose implant versus the standard monthly injection.
Millcreek, UtahAges 18–65 - NCT07421102RecruitingEarly Phase 1
Mailing buprenorphine after hospital stay
This study tests whether mailing buprenorphine (a medication for opioid use disorder) to patients after they leave the hospital helps them stay on treatment. If you started buprenorphine in the hospital and are heading home to South Carolina, this option might make it easier to continue your recovery.
Charleston, South CarolinaAges 18 years+ - NCT07104825Recruiting
Nerve block for pain after weight loss surgery
This trial tests if a nerve block can help control pain after gastric bypass or sleeve gastrectomy. The goal is to reduce the need for strong pain medicines and improve recovery.
Evanston, IllinoisAges 18–90 - NCT06851533Recruiting
Pain relief methods for lumbar microsurgery recovery
This trial compares two different types of nerve blocks to see which one reduces the need for strong pain medicine after lumbar microsurgery. It may help patients have better pain control and fewer side effects from opioids.
IstanbulAges 18–80 - NCT07711795Recruiting
Mindfulness texts for pain and medication
This study tests if text messages with meditation tips and medication reminders can help people with chronic pain stick to their treatment for opioid use. If you recently started or restarted methadone or buprenorphine, this might be for you.
Albuquerque, New MexicoAges 18 years+ - NCT06556602Recruiting
Study to improve access to methadone treatment
This trial tests a new way to help people get methadone treatment by working with staff at opioid treatment programs. It might lead to better access for patients.
Tucson, ArizonaAges 18 years+ - NCT03596424Recruiting
Testing ketamine and dexmedetomidine during lung surgery
This trial studies whether the anesthesia medicines ketamine and dexmedetomidine can improve care during elective lung (video-assisted) surgery. It may help with comfort during and after the operation, depending on how these medicines affect pain and recovery.
Montreal, QuebecAges 18–80 - NCT03823534RecruitingPhase 3
Study pain control after preventive femur bone surgery
This Phase 3 study tests a pain medicine plan used after preventive surgery to place a metal rod inside the thigh bone (femur) before a fracture happens. The goal is to find an approach that controls post-surgery pain while being safe for the right patients.
St Louis, MissouriAges 18 years+ - NCT04379115Recruiting
Brain stimulation study for people with opioid addiction
This study tests a non-invasive brain stimulation approach to reduce opioid cravings in people who are actively using non-prescribed opioids while on stable methadone. It may help people feel less craving and improve recovery support.
Hinsdale, IllinoisAges 18–85 - NCT04512144Recruiting
Mindfulness coaching for endometrial or cervical cancer patients
This study tests a mindfulness program (using an app) for people newly diagnosed with endometrial cancer surgery or cervical cancer treated with chemo-sensitizing radiation. It may help improve how you cope during treatment.
St Louis, MissouriAges 18–90 - NCT04724252RecruitingPhase 2/Phase 3
Gabapentin to help children use less opioid after surgery
This study tests whether gabapentin can reduce how much opioid pain medicine children need after certain major chest or heart surgeries. If it works, it may lower opioid-related side effects while still helping with postoperative pain.
Sacramento, CaliforniaAges Up to 17 years - NCT04893525RecruitingPhase 2/Phase 3
Buprenorphine-naloxone microdosing versus standard dosing after ED discharge
This study compares a smaller “microdose” starting method versus the usual starting dose of buprenorphine/naloxone for people with opioid use disorder when they are discharged from the emergency department. It may help find a safer, easier way to start treatment right after an ED visit and avoid problems caused by starting too early.
Calgary, AlbertaAges 18 years+ - NCT05033028RecruitingPhase 3
Using a smartphone to support opioid addiction recovery
This Phase 3 study tests whether using smartphones can help people with opioid-use disorder stick with treatment and recover more successfully. It focuses on people starting or already in treatment using methadone or buprenorphine, with support delivered through the study app or messages.
Piscataway, New JerseyAges 18–85 - NCT05120076RecruitingPhase 3
Dexamethasone during surgery to reduce hip surgery pain and nausea
This trial tests whether a single steroid medicine called dexamethasone given around the time of surgery can reduce pain and nausea after a periacetabular osteotomy. It may help you feel more comfortable in the first days after surgery, depending on your medical history.
ZurichAges 18–99 - NCT05219175RecruitingPhase 2
MDMA therapy for PTSD and opioid addiction after childbirth
This Phase 2 study tests whether MDMA-assisted therapy can reduce symptoms of PTSD and help with opioid use disorder in people after childbirth. You must be on a stable, low enough dose of methadone or buprenorphine and be able to follow study rules, including therapy sessions and safety monitoring.
Albuquerque, New MexicoAges 18 years+ - NCT05271331Recruiting
Numbing injection options for back surgery pain
This trial compares two ways of numbing tissue during a planned back surgery called a laminectomy: an “ESPB block” versus numbing the wound directly. It aims to see which method works better for pain control and comfort after surgery.
Padova, VenetoAges 18 years+ - NCT05459402RecruitingPhase 2/Phase 3
Methadone dose testing for opioid use disorder pain relief
This study compares taking methadone as one dose versus split into two doses to see which approach works better for people who have pain. It’s meant for adults already on a steady methadone program and who can follow study visits and procedures.
Baltimore, MarylandAges 18–100 - NCT05534815Recruiting
Long-term support for opioid use disorder treatment
This study looks at long-term treatment support for people receiving medicine-assisted treatment for opioid use disorder. It may help by testing an approach to improve long-term outcomes while you receive buprenorphine or methadone.
Marquette, MichiganAges 18 years+ - NCT05579470Recruiting
Study opioid treatment access with staff, patients, and local leaders
This study looks at how to expand opioid addiction treatment in Central Asia by gathering survey and discussion input from people with opioid dependence, people delivering treatment, and local health leadership. It may help improve how treatment programs are set up and delivered in the future.
New Haven, ConnecticutAges 18 years+ - NCT05589181RecruitingPhase 3
High-dose buprenorphine start in the emergency department for fentanyl use
This Phase 3 study tests whether starting a high dose of buprenorphine in the emergency department helps people with opioid use disorder come through withdrawal more safely and effectively. It focuses on people whose urine test shows fentanyl and who are already in withdrawal when they arrive.
Newark, New JerseyAges 18 years+ - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT05662371Recruiting
Testing pain-monitor guided pain medicine during robot bowel surgery
This study checks whether using a pain-activity monitor during robot-assisted colorectal surgery can help the surgical team choose the right pain medicine. It may improve comfort and reduce the chance of giving too much or too little pain medicine.
AabenraaAges 18–80 - NCT05669534RecruitingPhase 4
HIV prevention support for people starting PrEP
This study tests how to better support HIV prevention for people who inject drugs and are newly starting PrEP (medicine to prevent HIV). It focuses on people taking medication for opioid use disorder and who have mild thinking and memory problems, to help them stay safe and adhere to prevention.
New Haven, ConnecticutAges 18 years+
Hear when a new Opioid Use trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for opioid use?
- Yes. Clin2 currently lists 287 recruiting opioid use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.