Clinical trials
Opioid Use clinical trials
Below are recruiting opioid use clinical trials, each written for real people, not researchers. We’re tracking 287 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05769218Recruiting
Rapid HIV prevention and opioid treatment access for people who inject
This study helps people who inject drugs start HIV prevention (PrEP) and medication for opioid use disorder (MOUD) faster. It may reduce HIV risk and improve access to treatment, while the study checks whether the “rapid access” approach works.
Boston, MassachusettsAges 18 years+ - NCT05790252RecruitingPhase 3
Buprenorphine patch for starting opioid treatment during pregnancy
This Phase 3 study tests whether a skin patch can help pregnant people start buprenorphine treatment for opioid use disorder safely and effectively. It may help with easier “induction” (starting the medication) while you’re pregnant.
St Louis, MissouriAges 18–110 - NCT05804591RecruitingPhase 4
Pregabalin during weight-loss surgery to reduce pain
This trial tests whether pregabalin can help with pain control for people having laparoscopic sleeve gastrectomy (a weight-loss surgery). It may help reduce the discomfort around surgery and improve the overall recovery experience.
Warsaw, WarsawAges 18 years+ - NCT05817825Recruiting
Remote program to support recovery after opioid use
This study tests a new intensive outpatient program delivered by video or phone to help people with opioid use disorder (and other substance use disorders) stay on track after leaving the hospital. It may help by offering structured support while you are at home.
Boston, MassachusettsAges 18 years+ - NCT05888038Recruiting
Virtual reality to reduce pain after scoliosis surgery
This trial looks at whether virtual reality can lower pain for children and teens after scoliosis repair surgery, which may also reduce how much opioid pain medicine they need. If you join, you would use a virtual reality experience during the post-operative period.
Staten Island, New YorkAges 7–21 - NCT05981105Recruiting
Recovery and Chronic Pain After Knee Replacement
This study tests a special recovery program after knee replacement surgery to see if it helps reduce long-term pain. You may be eligible if you are having a first-time knee replacement for osteoarthritis, are between 18 and 65, and live near the hospital.
New York, New YorkAges 18–75 - NCT06032559RecruitingPhase 3
Mindfulness and methadone for chronic pain
This study tests if adding a mindfulness program (MORE) to regular methadone treatment helps people with long-term pain. It may improve pain and support recovery.
New Brunswick, New JerseyAges 18 years+ - NCT06051890RecruitingPhase 4
Assessing switching to long-acting buprenorphine injection in jail
This study tests whether switching from daily buprenorphine/naloxone (Suboxone) to a long-acting injectable buprenorphine (XRB) is safe and effective for men who are unsentenced and in jail for at least 4 days. It aims to see if the injection can help continue treatment without needing daily medication.
Boston, MassachusettsAges Any age - NCT06100172Recruiting
Ear Stimulation After Back Surgery
This study tests whether a gentle electrical stimulation placed on the ear (tAuricular Neurostimulation) can help reduce pain and improve recovery after lumbar spine surgery. It is for people who are already scheduled for a lumbar fusion or laminectomy and want to see if this non-invasive approach can ease their post-surgery discomfort.
Dallas, TexasAges 18–85 - NCT06113211RecruitingPhase 4
Non-opioid pain control after fracture surgery
This trial tests a combination of non-opioid medications to manage pain after surgery for a broken bone, aiming to reduce or avoid the use of opioids. It may help you control pain without the risks of strong painkillers.
Detroit, MichiganAges 18–80 - NCT06136247Recruiting
Brain & thinking tests in opioid use disorder
This study tests whether brain scans and thinking tests can help understand opioid use disorder. It is for people on stable buprenorphine or methadone treatment.
Philadelphia, PennsylvaniaAges 18–60 - NCT06206252Recruiting
Can Medical Cannabis Help Reduce Opioid Use?
This study tests whether medical cannabis can help people who take opioids for long-term pain reduce their opioid use. Participants will either use medical cannabis or continue without it for 3 months.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06223503Recruiting
Pain support service study for veterans after surgery
This study tests a telehealth pain support program for veterans having orthopedic surgery. It aims to help manage pain after surgery and reduce the need for long-term opioid use.
Salt Lake City, UtahAges 18 years+ - NCT06270147RecruitingPhase 2
Timing of nerve blocks for weight loss surgery pain
This trial tests whether giving a nerve block before or after bariatric surgery works better for pain control. It could help you have less pain and use fewer painkillers after your procedure.
Hamilton, OntarioAges 18 years+ - NCT06288711Recruiting
Video therapy for PTSD in people taking opioid medication
This trial tests a therapy called prolonged exposure (a type of talk therapy) delivered via video calls to help people with both opioid use disorder and PTSD. It aims to see if this approach can reduce PTSD symptoms.
Burlington, VermontAges 18 years+ - NCT06291363RecruitingPhase 4
Esmolol for pain control during laparoscopic surgery
This trial tests a drug called esmolol to see if it helps control pain during and after laparoscopic surgeries that involve a small cut below the belly button. It may help people having a hysterectomy or left colon removal feel less pain during anesthesia.
Montreal East, QuebecAges 18–65 - NCT06297200Recruiting
Ultrasound treatment for complex back pain patients
This study tests a new, non-invasive ultrasound treatment for people with long-term back pain who also have opioid use disorder and anxiety. It aims to see if this gentle brain stimulation can reduce pain and improve quality of life.
Roanoke, VirginiaAges 18–65 - NCT06306443RecruitingPhase 3
Buprenorphine treatment for people leaving jail
This trial offers buprenorphine (a medication for opioid use disorder) to people in jail who are soon to be released. It helps you start treatment while incarcerated and continue it after you return to the community, aiming to reduce overdose and improve recovery.
Baltimore, MarylandAges 18 years+ - NCT06338280RecruitingPhase 2
Observing methadone treatment remotely
This study tests if using a smartphone app to watch you take your methadone works as well as going to a clinic every day. It might make treatment easier for you.
Chicago, IllinoisAges 18–64 - NCT06453109Recruiting
Focused ultrasound for chronic back pain with opioid use
This study tests whether focused ultrasound (a non-invasive treatment using sound waves) can help people with chronic back pain who also have opioid use disorder and anxiety. It aims to find a better way to manage pain without relying on opioids.
Washington D.C., District of ColumbiaAges 18–75 - NCT06466941Recruiting
Understanding acute pain after surgery
This study surveys surgical patients about their pain and emotional experience to better understand acute pain. You may help by answering questions or sharing your story.
Boston, MassachusettsAges 18 years+ - NCT06420336Recruiting
Pain relief after cleft palate surgery
This study compares two ways to manage pain after cleft palate repair surgery that uses a bone graft from the hip. The goal is to see which method provides better pain control for children and teens.
Charleston, South CarolinaAges 6–18 - NCT06494904RecruitingPhase 3
Standard vs. High Dose Buprenorphine in the ER
This study compares a higher dose of buprenorphine (a medicine that helps stop opioid cravings and withdrawal) to the usual dose, given in the emergency department. It aims to see if the higher dose works better to start treatment for opioid use disorder.
Oakland, CaliforniaAges 18–65 - NCT06526143Recruiting
Pain care pathway for recent veterans
This study tests a new approach to help veterans manage pain in their back, neck, knee, or shoulder after leaving the military. It includes phone or online check-ins and support tailored to your needs.
West Haven, ConnecticutAges 18 years+
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Common questions
- Are there clinical trials for opioid use?
- Yes. Clin2 currently lists 287 recruiting opioid use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.