Clinical trials
Opioid clinical trials
Below are recruiting opioid clinical trials, each written for real people, not researchers. We’re tracking 430 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07153614Recruiting
Pain management after cancer surgery to start chemo sooner
This trial compares different methods of managing pain after cancer surgery to see which helps patients start chemotherapy sooner. It focuses on people having open abdominal surgery for certain cancers who are scheduled for chemotherapy afterward.
Knoxville, TennesseeAges 18–80 - NCT07135323Recruiting
AvertD Test for First-Time Opioid Users
This study is testing a new tool called AvertD that helps doctors see if a patient might be at higher risk of developing opioid use disorder before they get their first opioid painkiller prescription. If you are getting your first opioid prescription for 4 to 30 days, you may be able to join.
Indianapolis, IndianaAges 18 years+ - NCT07129902Recruiting
Reward program to support opioid medication after ER
This study tests if a reward-based program (called contingency management) helps people stick with their medication for opioid use disorder (like buprenorphine or methadone) after an emergency department visit.
Burlington, VermontAges 18 years+ - NCT07128524RecruitingPhase 2
Ketones for opioid craving study
This trial tests if a ketone supplement can help reduce cravings during opioid withdrawal treatment. Participants take the supplement daily and are monitored for changes in craving and withdrawal symptoms.
Wernersville, PennsylvaniaAges 18–75 - NCT04978168Recruiting
Peer support and opioid treatment help for people on probation
This study tests whether adding peer recovery support and coordinated opioid treatment support can improve care for people with opioid use disorder (OUD) who are on probation. It also trains and involves probation and treatment staff to better support clients over 12 months.
Durham, North CarolinaAges 18 years+ - NCT07115030Recruiting
Support program for women with opioid use disorder and past abuse
This trial tests a stepped care program for women who have experienced intimate partner violence and are in treatment for opioid use disorder. It aims to improve recovery by addressing post-traumatic stress symptoms and overall well-being.
Bridgeport, ConnecticutAges 18 years+ - NCT07063394Recruiting
Virtual reality to reduce opioid use after heart or lung surgery
This trial tests if using virtual reality after heart or chest surgery can help reduce the amount of strong painkillers (opioids) patients need. It may offer a non-drug way to manage pain and speed up recovery.
São Paulo, São PauloAges 16–40 - NCT07044466Recruiting
Social functioning study for people in treatment for opioid use
This study looks at how people recovering from opioid use disorder get along with a close friend or family member (called a CSO). It may help improve social support during early treatment.
Charleston, South CarolinaAges 18 years+ - NCT07044583Recruiting
Safe Opioid Use Video Education for Breast Reconstruction
This trial tests a video education program to help women safely use opioids after breast reconstruction surgery. It is for patients who have had a mastectomy and are getting a breast rebuilt using their own tissue.
Salt Lake City, UtahAges 18 years+ - NCT07004686Recruiting
Guided anesthesia to reduce opioid use in gallbladder surgery
This study tests a new way of guiding anesthesia during gallbladder removal surgery, with the goal of using less opioid pain medicine. It may help you have a smoother recovery with fewer side effects.
Shenzhen, GuangdongAges 18–64 - NCT06999811Recruiting
Technology vs. medication monitoring for buprenorphine in pregnancy
This study compares two approaches to help pregnant people stay on buprenorphine (a medication for opioid use disorder): one uses technology to support therapy, and the other uses standard medication monitoring. It aims to see which method works better for keeping you in treatment during pregnancy.
Charleston, South CarolinaAges 18–45 - NCT06905340Recruiting
Pain-guided opioid use during surgery with regional anesthesia
This trial uses a special monitor (NOL index) to help doctors give just the right amount of pain medicine during surgery. It is for people having trauma or orthopedic surgery who are also getting regional anesthesia.
HamburgAges 18 years+ - NCT06965010Enrolling by invitation
Tracking Care in Opioid Treatment Programs
This study tests whether tracking your progress with regular check-ins (measurement-based care) helps improve treatment for people starting medication for opioid use disorder at a treatment program.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06969261Recruiting
Chatbot to support pregnant women with opioid use disorder
This study tests a chatbot to help pregnant and new mothers being treated for opioid use disorder. The goal is to provide extra support and information during and after pregnancy.
Philadelphia, PennsylvaniaAges Any age - NCT06962033Recruiting
Pride III: Prison and HIV prevention study
This study looks at ways to improve HIV prevention and treatment for people on probation who have injected opioids. Researchers want to learn from your experiences to help create better services.
New Haven, ConnecticutAges 18 years+ - NCT06956352Enrolling by invitation
Study on better care for pregnant women with opioid use disorder
This study tests a team-based approach to help pregnant women with opioid use disorder get better support during pregnancy. It may improve care for mothers and babies.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06954402Recruiting
Resilience study for people with opioid use disorder
This study looks at resilience in people with opioid use disorder. Researchers want to understand what helps people stay strong and recover. You may be able to join if you are currently using opioids or receiving treatment.
Baltimore, MarylandAges 18 years+ - NCT06943859RecruitingPhase 2
Ketamine for opioid use disorder
This study tests whether ketamine, when added to methadone treatment, helps reduce opioid use and cravings. It is for adults with opioid use disorder who are already in a methadone program and have had recent cravings or illicit use. The trial involves multiple visits and follow-up assessments.
Baltimore, MarylandAges 18–65 - NCT06933498Recruiting
Nerve block for less pain meds in back surgery
This trial tests whether a nerve block (called an erector spinae plane block) given before surgery can reduce the amount of pain medicine and anesthesia needed during lumbar disc surgery. It may help people have less pain and fewer side effects.
AnkaraAges 18–75 - NCT06940674RecruitingPhase 3
CBD plus opioid treatment for recovery
This study tests whether adding cannabidiol (CBD) to your usual methadone or buprenorphine treatment helps you recover from opioid use disorder. If you're already in stable treatment with those medications, the trial aims to see if CBD can improve your outcomes.
New York, New YorkAges 18–65 - NCT06903819RecruitingPhase 4
Ketamine for pain and mental health after orthopedic injury
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
Lubbock, TexasAges 18–65 - NCT06880718RecruitingPhase 4
Injectable buprenorphine for opioid use disorder in prison
This study tests whether a once-monthly injection of buprenorphine (called extended-release buprenorphine, or XR-B) works well for people in prison who are already in a medication program for opioid use disorder. It looks at preferences and outcomes in the last months before release.
Cranston, Rhode IslandAges 18 years+ - NCT06857968Enrolling by invitation
Mobile mindfulness training for opioid use disorder treatment
This study tests if a mobile mindfulness training app can help people who are receiving medication treatment for opioid use disorder. It is for people with a history of childhood trauma who are stable on their medication.
Lexington, KentuckyAges 18–65 - NCT06837662Recruiting
Counseling and peer support for opioid use disorder in primary care
This study tests whether adding counseling and peer support helps people with opioid use disorder and other medical problems stay in treatment. It is for patients seen at Central City Concern in Portland who are starting or restarting medication for opioid use disorder, or who are not yet on medication but want help.
Portland, OregonAges 18 years+
Hear when a new Opioid trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for opioid?
- Yes. Clin2 currently lists 430 recruiting opioid studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.