Clinical trials
Optimal Medical Therapy clinical trials
Below are recruiting optimal medical therapy clinical trials, each written for real people, not researchers. We’re tracking 117 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05950802RecruitingPhase 1
Improving how CAR T cells are timed for lymphoma outcomes
This Phase 1 trial tests a method to better time “cell therapy” (CAR T) called Yescarta in people with relapsed or refractory large B-cell lymphoma. The goal is to improve outcomes by optimizing how the body is prepared before CAR T treatment.
Toronto, OntarioAges 18 years+ - NCT06501768RecruitingPhase 1/Phase 2
Genistein for heart failure inflammation
This trial tests a natural substance called genistein (found in soy) to reduce inflammation in people with heart failure. It may help your heart work better and feel better.
LjubljanaAges 40–80 - NCT06499870RecruitingPhase 2
Study of two drugs with radiation for high-risk prostate cancer
This trial tests whether combining two hormone therapy drugs, relugolix and enzalutamide, with radiation therapy can help treat very high-risk prostate cancer. The goal is to see if this combination is safe and effective for men whose cancer has a high chance of coming back.
Chicago, IllinoisAges 18 years+ - NCT06761287Recruiting
Choosing surgery after chemo for advanced rectal cancer
This study looks at patients with advanced rectal cancer who had treatment (chemotherapy or radiation) before surgery. They want to see if it's safe to avoid surgery in those who had a good response to initial treatment.
BrusselsAges 18 years+ - NCT06541509RecruitingPhase 1/Phase 2
Semaglutide for heart failure in overweight patients
This trial studies whether the drug semaglutide can help people with heart failure who are overweight. It aims to see if the drug improves heart function and symptoms.
Palo Alto, CaliforniaAges 20–80 - NCT07505199RecruitingPhase 1
Immune cell therapy for advanced heart failure from blocked arteries
This early-phase study tests a new type of immune cell therapy (CAR-DC) for people with advanced heart failure due to blocked arteries. It aims to see if the treatment is safe and may help improve heart function.
Hangzhou, Zhejiang / 浙江Ages 18–75 - NCT06607471Recruiting
Study on non-ischemic heart muscle diseases
This study looks at different types of heart muscle diseases that are not caused by blocked arteries (non-ischemic cardiomyopathies). It aims to better understand how to diagnose, predict outcomes, and treat these conditions by gathering information from many patients over time.
Milan, MilanoAges 18 years+ - NCT06162767Recruiting
Surgery comparison for junction cancer
This trial compares two surgical techniques for treating a specific type of cancer at the junction of the stomach and esophagus. It aims to find which surgery offers better outcomes for patients.
Nanjing, JiangsuAges 18–80 - NCT06215651RecruitingPhase 2
Testing cadonilimab and lenvatinib before liver cancer surgery
This study tests whether a combination of two drugs (cadonilimab and lenvatinib) can shrink liver cancer enough to make it removable by surgery for people whose cancer was previously too advanced for surgery. You may qualify if your cancer hasn't spread far, you haven't had treatment before, and your liver is still working fairly well.
Beijing, Beijing MunicipalityAges 18–75 - NCT05019495Recruiting
Study to improve quit-smoking support for people with HIV
This trial tests ways to deliver tobacco-quit treatment more effectively for people living with HIV. You may help researchers compare different quit-support approaches to see what works best.
Charleston, South CarolinaAges 21 years+ - NCT07177300RecruitingPhase 4
Hydroxyurea for sickle cell disease in children
This trial tests different ways to start hydroxyurea for children with sickle cell anemia. The goal is to find the safest and most effective approach to help manage symptoms and prevent complications.
Cincinnati, OhioAges 6 months+ - NCT06916676Recruiting
Laser therapy for knee osteoarthritis pain
This study tests a type of laser treatment called HILT to see if it can help reduce knee pain from osteoarthritis. You would attend 3 sessions each week for 4 weeks.
CairoAges 18–65 - NCT04430790RecruitingPhase 3
Doxapram for apnea in very preterm babies on breathing support
This trial studies whether the medicine doxapram can better treat breathing pauses (apnea) in very preterm babies who are already on breathing support in the NICU. It aims to reduce the need for extra interventions and improve outcomes in this high-risk group.
Brussels, Avenaue Hippocrate 10Ages 5 months–7 months - NCT06505109Recruiting
Better sleep and less stress for heart rehab patients
This study is testing a new program to help people in cardiac rehab improve their sleep and manage stress. It uses simple techniques and trackers to see if better rest and less stress can help your heart recovery.
Eindhoven, North BrabantAges 18 years+ - NCT06367257Recruiting
App to improve nutrition during head and neck cancer radiation
This study tests whether a smartphone app (Emento) can help people with head and neck cancer track and improve their nutrition during and after radiation therapy. The goal is to see if using the app makes it easier to eat well and stay healthy during treatment.
Erlangen, BavariaAges 18 years+ - NCT04510051RecruitingPhase 1
CAR T cell therapy for IL13Rα2 positive pediatric brain tumors
This Phase 1 study tests a type of immune therapy (CAR T cells) for children with brain tumors that come back or do not respond to standard treatment. The cells are given after chemotherapy that temporarily lowers the body’s immune system, which may help the CAR T cells work better.
Duarte, CaliforniaAges 4–25 - NCT07036705Recruiting
Sauna blanket and app for better sleep in insomnia
This study tests whether using a heated sauna blanket before bed, along with a mind-body app, can help adults with insomnia fall asleep faster and sleep better. You would use the blanket at home for a few weeks and answer questions about your sleep.
San Francisco, CaliforniaAges 18 years+ - NCT03836196Recruiting
Improve treatment for advanced prostate cancer with careful planning
This study looks at how to best plan and deliver treatment for men with advanced local prostate cancer. It may help find the most effective approach while keeping side effects manageable.
Vancouver, British ColumbiaAges 18 years+ - NCT04787354RecruitingPhase 3
Choosing the best length of oxaliplatin after stomach surgery
This trial tests whether giving oxaliplatin for a shorter or longer time works best after curative surgery for stage II–III stomach (or stomach–esophagus junction) cancer. It aims to improve outcomes while balancing side effects from chemotherapy.
Gyeonggi-doAges 19 years+ - NCT07200466Recruiting
Personalized risk assessment for endometrial cancer
This trial uses a prediction model to better estimate the risk of endometrial cancer coming back. It aims to help doctors and patients make more personalized treatment decisions after surgery.
Arnhem, GelderlandAges 45 years+ - NCT07448077RecruitingPhase 2
Short radiation with immunotherapy for rectal cancer
This trial tests a combination of short-course radiation, chemotherapy, and an immunotherapy drug (Enlonstobart) for patients with a specific type of rectal cancer called pMMR. It aims to see if this approach can shrink tumors before surgery and improve outcomes.
Shijiazhuang, HebeiAges 18 years+ - NCT07033819RecruitingPhase 2
Fuzuloparib and apatinib before surgery for ovarian cancer
This trial tests a combination of two oral drugs—fuzuloparib (a PARP inhibitor) and apatinib (which blocks blood vessel growth to tumors)—given before surgery for advanced ovarian cancer that cannot be removed right away. It is for people whose tumors have a specific genetic marker (HRD positive) and who have not had prior cancer treatment.
Beijing, Beijing MunicipalityAges 18–70 - NCT07619560Recruiting
Probiotic Cocktail to Slow Early Parkinson's Disease
This study tests whether a special blend of probiotics (good bacteria), an amino acid called tryptophan, and branched-chain amino acids can help slow the progression of early-stage Parkinson's disease. The idea is that these supplements may work through your gut bacteria to help protect your brain.
TaipeiAges 30–85 - NCT05377463Recruiting
Behavior coaching to help keep HIV virus levels controlled
This study tests a counseling program (bio-behavioral intervention) designed to help people with HIV keep their virus levels under control over time. It may be especially relevant if your current HIV treatment has been hard to stick with or you haven’t had recent viral load checks.
Ciudad Juárez, ChihuahuaAges 18 years+
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Common questions
- Are there clinical trials for optimal medical therapy?
- Yes. Clin2 currently lists 117 recruiting optimal medical therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a optimal medical therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a optimal medical therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.