Clinical trials
Orofacial Pain clinical trials
Below are recruiting orofacial pain clinical trials, each written for real people, not researchers. We’re tracking 14 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07123233Recruiting
Cognitive behavioral treatment for chronic face and mouth pain
This trial tests a new cognitive-behavioral therapy (a type of talk therapy) for people with chronic orofacial pain – pain in the face, mouth, or jaw that has lasted for months. The goal is to learn skills to help manage pain and improve quality of life.
MilanAges 18–70 - NCT07352384Enrolling by invitation
Brain stimulation for chronic face and mouth pain
This trial tests if a non-invasive brain stimulation technique (called TMS or tDCS) can help reduce long-lasting pain in the face, jaw, or mouth. It's for people who have tried other treatments without enough relief.
Almada, Setúbal DistrictAges 18–75 - NCT06405646Enrolling by invitation
Cannabidiol and Cannabinol for Chronic Jaw Muscle Pain
This study tests whether certain compounds from the cannabis plant (CBD and CBN) can help relieve long-term pain in the jaw muscles. It is for adults with chronic orofacial pain who have not recently taken medications that affect the nerves or muscles.
WroclawAges 18–80 - NCT06932406Recruiting
Personality and self-help for jaw pain
This study tests whether a self-management program for jaw and face pain works differently in people with different personalities. You will learn techniques to manage your pain at home.
Valencia, ValenciaAges 18–65 - NCT05961501Enrolling by invitationPhase 2/Phase 3
CBD and CBN for long-lasting facial pain and muscle headaches
This trial tests whether CBD and CBN can reduce facial pain and headaches caused by muscle-related problems that have lasted more than 3 months. It may help people who have ongoing symptoms find a new treatment option.
WroclawAges 18 years+ - NCT07109882RecruitingPhase 4
Comparing two muscle relaxants for bruxism pain
This study compares two muscle relaxant medications—chlorzoxazone and orphenadrine citrate—to see which works better for relieving pain caused by teeth grinding or jaw clenching (bruxism). If you have jaw or face pain and no other major health issues, you may be able to join.
BaghdadAges 15 years+ - NCT07321483Recruiting
Reflex therapy for jaw pain
This trial tests if a special reflex therapy can help people with jaw muscle pain that isn't caused by joint damage. It might be a new way to reduce discomfort and improve function.
OlomoucAges 18 years+ - NCT04059172RecruitingEarly Phase 1
Ibuprofen plus acetaminophen for braces pain
This early study compares braces pain relief using: ibuprofen alone, ibuprofen plus acetaminophen together, or placebo (no active pain medicine). It may help find which approach works best and is safest for people starting orthodontic treatment.
Aurora, ColoradoAges 12–80 - NCT07280338Recruiting
Emotional intelligence and chronic face pain study
This study looks at how emotional intelligence (understanding and managing emotions) relates to chronic pain in the face or jaw. If you have temporomandibular dysfunction (TMD) or have no chronic pain, you may be able to join and help researchers learn more.
BrestAges 18 years+ - NCT03906422Recruiting
Study of pain after placing braces archwire
This study compares how much pain people feel after their braces archwire is first put in. It may help orthodontists choose approaches that make the early pain experience easier.
Aurora, ColoradoAges 12 years+ - NCT07474662Recruiting
Online vs. in-person physiotherapy for jaw muscle pain
This trial compares online physiotherapy sessions with face-to-face visits to see which works better for treating jaw muscle pain (myalgia). It aims to find a more convenient way to get care for this common condition.
Budapest, Pest CountyAges 18 years+ - NCT07443930Recruiting
Musicians' Health Education Study
This study looks at how well health education programs work for musicians. You can take part simply by filling out a questionnaire.
GöttingenAges Any age - NCT07486609Enrolling by invitation
Comparing tests for jaw joint pain diagnosis
This study compares two different ways to diagnose jaw joint (TMJ) problems: a jaw-motion analyzer and an MRI. It aims to see which method is more accurate for people with ongoing face or jaw pain.
CairoAges 18–50 - NCT07557576Recruiting
Pain management approaches for children having cleft surgery
This study compares two types of anesthesia (with and without opioid painkillers) for children undergoing cleft lip or palate surgery. The goal is to see which approach better controls pain after surgery and reduces agitation as the child wakes up.
ZagrebAges 3 months–7 years
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Common questions
- Are there clinical trials for orofacial pain?
- Yes. Clin2 currently lists 14 recruiting orofacial pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a orofacial pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a orofacial pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.