Clinical trials
Osteoarthritis (OA) of the Knee clinical trials
Below are recruiting osteoarthritis (oa) of the knee clinical trials, each written for real people, not researchers. We’re tracking 159 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06245109RecruitingPhase 4
Pain medicine study for knee osteoarthritis
This study tests how well different pain medicines work for knee osteoarthritis and looks at brain patterns to understand why some people get more relief. It may help you find a treatment that works best for you.
Chicago, IllinoisAges 41 years+ - NCT06251167Recruiting
Shoe insoles for knee osteoarthritis
This study tests whether shoe insoles can help people with knee osteoarthritis. You might be eligible if you have had knee pain for at least 6 months, your pain is at least moderate, and you also have pain in the same foot.
Vancouver, British ColumbiaAges 50 years+ - NCT07481461Recruiting
Knee alignment and biology in osteoarthritis
This study looks at how changes in knee alignment affect symptoms and joint biology in people with early knee osteoarthritis. It may help doctors understand how to better treat knee OA.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06451510Recruiting
Knee osteoarthritis study in Northern Sweden
This trial studies knee osteoarthritis in people from Norrbotten, Sweden, who broke their tibial plateau between 2001 and 2015. It aims to understand how the injury affects the knee over time.
Luleå, Norrbotten CountyAges 18 years+ - NCT06462560Recruiting
Live fitness program for knee osteoarthritis
This trial tests a live, interactive strength training program for people recently diagnosed with knee osteoarthritis. It aims to see if this home-based program can help reduce pain and improve daily function.
Murray, UtahAges 55–85 - NCT06485843RecruitingPhase 2
Testing a new injection for moderate to severe knee osteoarthritis
This study tests the safety of an experimental injection called OA-SYS for people with moderate to severe knee osteoarthritis. It may help if you have not had recent injections or certain other health problems.
Las Vegas, NevadaAges 35–75 - NCT06511557Recruiting
Virtual reality vs. leg exercises for knee arthritis
This study compares virtual reality exercises with standard leg-strengthening moves to see which better reduces pain and improves function in people with knee osteoarthritis (OA).
Rawalpindi, Punjab ProvinceAges 50 years+ - NCT06514716Recruiting
Steroid shot vs. standard procedure for knee arthritis
This study tests whether a corticosteroid shot (a strong anti-inflammatory medicine) into the knee joint works better than the standard GAE procedure for people with knee osteoarthritis. It aims to see which approach provides better pain relief and function.
ZagazigAges 18–80 - NCT06563258Recruiting
Balance training vs vibration therapy for knee arthritis
This study compares two types of exercise therapy—balance training and whole-body vibration—to see which helps knee pain and function better. It is for people with moderate knee osteoarthritis who have not found relief from other treatments.
CairoAges 40–60 - NCT06574191Recruiting
Knee osteoarthritis study: pain and health outcomes
This study looks at how knee pain from osteoarthritis affects your daily life and health. You'll use a topical anti-inflammatory gel and answer questions by text or email for two months.
Sacramento, CaliforniaAges 50 years+ - NCT06576557Recruiting
Exercise and education for knee pain from meniscal tear
This study tests whether a special exercise and education program, designed by experts, can help people with knee pain from meniscal tears or early arthritis feel better and move better. It is run by a university and involves working with your GP and a physiotherapist.
Tralee, KerryAges 35–69 - NCT06596824Recruiting
Digital training to reduce inflammation after ACL knee surgery
This trial tests a personalized digital training program for people who recently had ACL knee surgery. The goal is to see if correcting movement patterns can lower inflammation and prevent early knee arthritis.
BerlinAges 18–50 - NCT06600958Recruiting
Study of knee arthritis severity and progression
This study looks at how knee osteoarthritis or other types of knee arthritis progress over time, using blood tests and X-rays. It aims to find markers that could predict whether the disease will get worse, which may help guide treatment decisions.
CréteilAges 18 years+ - NCT06603662RecruitingPhase 4
Steroids for sudden osteoarthritis pain in the emergency room
This trial tests if a short course of oral steroids (glucocorticoids) can relieve sudden osteoarthritis pain in the knee, hip, or shoulder for people who come to the emergency department and are well enough to go home.
York, PennsylvaniaAges 18 years+ - NCT06608134RecruitingEarly Phase 1
Umbilical cord injection for knee osteoarthritis pain
This trial tests whether a special injection made from umbilical cord tissue can safely help with knee osteoarthritis pain. If you have moderate knee arthritis and haven't had recent injections or surgery, you may be able to join.
Scottsdale, ArizonaAges 30 years+ - NCT06611618Recruiting
Predicting fall risk in knee osteoarthritis using muscle tests
This study looks at how loss of muscle strength and control in people with knee osteoarthritis can predict falls. It uses tests and MRI to understand your risk, with the goal of helping prevent future falls.
BolognaAges 65–80 - NCT06617975Recruiting
Spa therapy for knee arthritis
This trial tests whether spa therapy (balneotherapy) can help people with knee osteoarthritis. You would receive treatment at the Santenay spa as part of your regular care.
Santenay, BurgundyAges 50–80 - NCT06658249Recruiting
Core exercises vs foot-ankle strength for knee arthritis
This study compares core strengthening exercises with foot-ankle exercises to see which helps more with knee osteoarthritis symptoms like pain and walking difficulty. It might help you move better and climb stairs more easily.
Lahore, Punjab ProvinceAges 40–65 - NCT06681142Recruiting
Pharmacist-physiotherapist team care for early knee osteoarthritis
This study tests a new way to manage early knee osteoarthritis by having a pharmacist and physiotherapist work together. You might get help with pain, stiffness, and movement without needing surgery or strong medications.
Sherwood Park, AlbertaAges 50 years+ - NCT06690710RecruitingPhase 1
Gene therapy injection for knee osteoarthritis
This trial tests a new gene therapy injection for knee osteoarthritis. It aims to see if the treatment is safe and if it can help with knee pain and joint function in people with moderate knee osteoarthritis.
OxfordAges 40 years+ - NCT06702046Recruiting
Pulsed radiofrequency acupuncture for knee osteoarthritis
This trial tests whether a special type of acupuncture using mild radiofrequency energy can reduce knee pain and improve function in people with knee osteoarthritis. It involves 4 weeks of treatment and a 3-month follow-up to see if the benefits last.
Taipei, StateAges 45–85 - NCT06744036Recruiting
Exercise and electrical stimulation for knee arthritis
This study tests whether adding a gentle electrical current (interferential therapy) to a personalized exercise program can reduce pain and improve function in people with knee osteoarthritis. If you have knee pain from arthritis and have not had physical therapy or certain injections in the past six months, you may be able to join.
São PauloAges 40–75 - NCT06753019Recruiting
Knee Osteoarthritis: Thoughts, Feelings, and Function
This study looks at how your thoughts and feelings about knee pain (and your daily function) relate to osteoarthritis. It aims to help understand your overall health better.
IspartaAges 40–84 - NCT06781463Recruiting
Knee arthritis treatment registry
This study tracks patients with knee arthritis who undergo a procedure called genicular artery embolization (GAE), a minimally invasive option for those not ready for or not eligible for knee replacement. The goal is to see how well GAE works for pain relief.
Chicago, IllinoisAges 18 years+
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Common questions
- Are there clinical trials for osteoarthritis (oa) of the knee?
- Yes. Clin2 currently lists 159 recruiting osteoarthritis (oa) of the knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis (oa) of the knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis (oa) of the knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.