Clinical trials
Osteoarthritis clinical trials
Below are recruiting osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 592 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06965452Recruiting
Embolization for back pain from worn-out facet joints
This study tests if a minimally invasive procedure, called trans-arterial embolization, can reduce low back pain caused by aging facet joints (facet arthropathy). It may help people who haven't found relief from other treatments like injections or nerve blocks.
Manhasset, New YorkAges 18–85 - NCT06966206RecruitingPhase 3
Study of Multiprofen-CC for hand arthritis pain
This trial tests a topical medication called Multiprofen-CC to reduce pain and improve hand function in people with hand arthritis. If you have hand osteoarthritis and it affects your daily life, you may be able to join.
Hamilton, OntarioAges 18 years+ - NCT06968143Recruiting
Patient Satisfaction With Smart Knee Implants Trial
This trial looks at how satisfied patients are with a new 'smart' knee implant that tracks motion and function. If you are getting a total knee replacement, you might be able to join and help compare the smart implant with standard implants.
Chicago, IllinoisAges 18 years+ - NCT06955481Recruiting
Navigated knee replacement study for better outcomes
This study tests a computer-guided system for total knee replacement. It aims to see if using the OrthoPilot® navigation system helps improve surgical precision and long-term results.
ŠumperkAges 18–80 - NCT06951477Recruiting
Gut health and knee replacement revision study
This study looks at how the bacteria in your gut might affect recovery after a second knee replacement surgery. Researchers want to learn more about the connection between gut health and surgical outcomes.
London, OntarioAges Any age - NCT06343714RecruitingPhase 1
Testing a new drug for knee osteoarthritis pain
This study tests a new antibody drug (FB1003) for people with knee osteoarthritis pain. It will check if the drug is safe and helps reduce pain. You may be eligible if you have moderate to severe knee pain and are willing to temporarily stop your usual pain medications.
Brisbane, QueenslandAges 18–75 - NCT06932887RecruitingPhase 3
Walking to reduce arthritis pain
This study tests a walking program to help reduce pain from osteoarthritis. It is designed for people with arthritis in their hips, knees, feet, or spine.
Salt Lake City, UtahAges 45 years+ - NCT06932614Recruiting
Growth factor vs PRP for knee arthritis
This trial compares two injections—a special growth factor treatment and a platelet-rich plasma (PRP) injection—to see which works better for knee osteoarthritis. It aims to help people with mild to moderate knee arthritis who have had pain for at least 3 months.
TaipeiAges 20–80 - NCT06929871Recruiting
Cementless vs. cementless knee replacement for osteoarthritis
This trial compares two types of knee replacements: one where the implant is glued in (cemented) and one where it locks into the bone without glue (cementless). It is for people with knee osteoarthritis who need a first-time total knee replacement.
LondonAges 18 years+ - NCT06915363Recruiting
BioPoly implant for knee cartilage repair
This trial tests a BioPoly implant to repair a small damaged cartilage spot in your knee. If you have a specific type of cartilage injury that didn't get better with other treatments, this implant may help relieve pain and improve function.
Fort Wayne, IndianaAges 30–65 - NCT06920459Recruiting
Zimmer Biomet Shoulder Replacement Study
This study is testing a shoulder replacement system made by Zimmer Biomet to see how well it works for people with severe shoulder problems, like arthritis or fractures. If you qualify, you would receive the implant and be asked to come back for regular checkups to track your recovery.
PforzheimAges 20 years+ - NCT06911437Enrolling by invitation
Knee pain relief with Chinese formula and massage
This study tests if combining a Chinese herbal formula called Xiaoyu Zhitong with a gentle drainage massage can reduce knee pain and swelling. It may help people whose knee symptoms are worse in cold, damp weather.
BeijingAges 25–70 - NCT06906094Enrolling by invitation
Preventing arthritis after meniscus tear surgery
This trial tests a new approach to prevent arthritis after surgery to remove part of a torn meniscus. It looks at whether a treatment can stop the knee from wearing down after the operation.
Milan, MilanoAges 19 years+ - NCT06902285RecruitingPhase 4
Magnesium supplement for better sleep after joint replacement
This study tests whether taking magnesium L-threonate can improve sleep quality after total knee or hip replacement surgery. It may help you sleep better during recovery.
Miami, FloridaAges 18 years+ - NCT06906939RecruitingEarly Phase 1
Brain stimulation and tai chi for knee arthritis and depression
This pilot study tests if combining brain stimulation (rTMS) with Tai Chi can help knee arthritis pain and improve depression. It compares these two treatments to see which works better for people with both pain and low mood.
Los Angeles, CaliforniaAges 50–95 - NCT06893302Recruiting
Bone marrow injection during knee scope for cartilage or meniscus
This trial tests if adding a bone marrow injection to standard knee arthroscopy helps your knee heal better. It is for people with a torn meniscus or damaged cartilage who have healthy knee joints without arthritis.
New York, New YorkAges 18–64 - NCT06885372Enrolling by invitation
Long-term follow-up of ACL tear patients without surgery
This trial is for people with a torn ACL who are young (up to 25) and have certain risk factors for knee instability. It will follow them long-term to see how their knee does without surgery, focusing on those who are active in pivoting sports, have a loose knee joint, or have naturally loose joints.
Banff, AlbertaAges 14–25 - NCT06880653Recruiting
Exercise dose study for arthritis pain
This study looks at how different amounts of exercise affect arthritis symptoms. If you have arthritis or a related condition, you may be asked to try a specific weekly exercise goal to see if it helps your pain and mobility.
Columbia, South CarolinaAges 18 years+ - NCT06872567Recruiting
Knee artery block vs. steroid injection for arthritis pain
This study compares two treatments for knee arthritis pain: a procedure that blocks blood flow to the painful area (genicular artery embolization) versus a steroid injection into the knee joint. The goal is to see which one provides better pain relief.
Charlottesville, VirginiaAges 40 years+ - NCT06850818Recruiting
Hip and knee implant registry study
This study is creating a registry of patients who have hip or knee replacement surgery or revision surgery at a specific hospital. The goal is to track outcomes and improve care for future patients.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT06857123Recruiting
Rest breaks during exercise for knee osteoarthritis
This study is testing whether adding short rest breaks during exercise can help people with knee osteoarthritis feel better and stick with a program. It may be a good option if you have mild to moderate knee pain and are not very active right now.
Pittsburgh, PennsylvaniaAges 45–79 - NCT06843980Recruiting
Knee implant trial for inner knee pain
This trial tests a knee implant for people with pain on the inner side of the knee that gets worse with activity. It may be an option if other non-surgical treatments haven't helped.
Davis, CaliforniaAges Any age - NCT06836934Enrolling by invitation
Knee brace vs. wedge for osteoarthritis
This study compares two non-surgical options—a soft knee brace vs. a lateral wedge shoe insert—to see which better relieves pain and improves function in people with knee osteoarthritis. If you're between 40 and 60 and have pain on one side of your knee, this study may help you find better relief.
Giza, Giza GovernorateAges 40–60 - NCT06506201Recruiting
Hip replacement methods and leg length difference
This study compares two ways to perform hip replacement to see which one helps reduce leg length differences after surgery. The findings could help people with severe arthritis get better alignment and feel more comfortable.
BolognaAges 50–80
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Common questions
- Are there clinical trials for osteoarthritis?
- Yes. Clin2 currently lists 592 recruiting osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.