Clinical trials
Osteoarthritis clinical trials
Below are recruiting osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 610 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07473232Recruiting
Comparing platelet-rich plasma and cytokine-rich serum injections for knee osteoarthritis
This trial compares two types of injections (PRP and ACS) to see which one works better for knee osteoarthritis. It may help people with knee pain who have not had these injections recently.
Pamukkale, DenizliAges 40–80 - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Birmingham, AlabamaAges 40 years+ - NCT06887829Recruiting
Radiation Therapy for Knee Osteoarthritis
This study tests a low-dose radiation treatment for knee osteoarthritis pain. If you have moderate arthritis pain and are a Mayo Clinic patient in Rochester, you may be able to join.
Rochester, MinnesotaAges 50–100 - NCT06401317RecruitingPhase 2
Steroid vs saline injections for thumb arthritis pain
This study compares two types of injections for thumb arthritis pain: a steroid (cortisone) and salt water (saline). We want to see if the steroid provides better pain relief than the salt water.
Montreal, QuebecAges 18 years+ - NCT07065591RecruitingEarly Phase 1
Metformin, Exercise, and Diet for Knee Osteoarthritis
This trial tests whether a common diabetes drug (metformin) combined with exercise and a healthy diet can help people with knee osteoarthritis who are overweight.
Hong Kong, Sandy BayAges 40–80 - NCT07767812Recruiting
Motivational interviewing for knee osteoarthritis pain
This study tests whether talking with a counselor (motivational interviewing) helps people with knee osteoarthritis feel more confident in managing their pain and become more physically active. It may help you feel better and move more easily.
Afyonkarahisar, TürkiyeAges 40 years+ - NCT07308834RecruitingPhase 1/Phase 2
Injection for knee osteoarthritis pain
This study tests an injection called CX-011 for people with knee osteoarthritis who still have moderate to severe pain despite trying other treatments. The goal is to see if the injection can reduce pain and improve knee function.
Los Angeles, CaliforniaAges 40–75 - NCT07522489Recruiting
New knee replacement surgery guidance methods compared
This study compares two ways doctors use computer guidance during robotic knee replacement surgery for severe knee arthritis. The trial tests whether both methods work equally well or if one is better for patient recovery and results.
Warsaw, MazovianAges 18 years+ - NCT07664371Recruiting
Cold therapy versus heat therapy for knee arthritis pain
This study compares two minimally invasive treatments for knee pain caused by arthritis when other treatments haven't worked. One uses cold (cryoneurolysis) and the other uses heat (radiofrequency) to calm nerves and reduce pain.
TantaAges 18 years+ - NCT07754175Recruiting
Stem cell knee treatment for osteoarthritis patients
This study tests a stem cell injection for knee osteoarthritis in patients who previously received a placebo. It aims to see if the treatment is safe and effective over a longer period.
SeoulAges 19 years+ - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Birmingham, AlabamaAges 45–80 - NCT07744789Recruiting
Knee ligament stiffness and osteoarthritis treatment
This study looks at how knee ligament stiffness changes in people with knee osteoarthritis and compares it to healthy volunteers. It may help find better ways to treat knee pain and stiffness.
Taipei, Taipei CityAges 20 years+ - NCT07353931RecruitingPhase 3
Study of eloralintide for knee osteoarthritis pain in people with overweight or obesity
This trial tests an investigational drug called eloralintide to see if it can reduce knee pain in people with osteoarthritis who also have overweight or obesity. You may be able to join if you have knee osteoarthritis, a BMI of 27 or higher, and have tried to lose weight with diet before.
Mobile, AlabamaAges 18 years+ - NCT07153471RecruitingPhase 3
A study of an experimental pill for weight loss and knee arthritis
This trial tests an investigational medication (orforglipron) to see if it helps people with knee arthritis lose weight. You may qualify if you have overweight or obesity and have tried dieting before without lasting success.
Phoenix, ArizonaAges 18 years+ - NCT05378841Recruiting
Surgery to reduce pain in finger osteoarthritis
This trial tests whether surgical “nerve disconnection” (joint denervation) can reduce pain from osteoarthritis in a finger joint. It focuses on people who have ongoing finger pain despite usual treatments for at least 3 months.
ParisAges 18 years+ - NCT05412615Recruiting
Meniscal graft surgery for wrist arthritis
This trial studies whether using a donor meniscus (meniscal allograft) during wrist replacement surgery can help people with painful wrist osteoarthritis. It’s mainly for certain types of arthritis changes in the wrist (SLAC or SNAC) and specific age ranges.
Englewood, ColoradoAges 30–80 - NCT04228419Recruiting
Shoulder replacement approach comparison for advanced shoulder arthritis
This trial compares two ways of doing shoulder arthroplasty (shoulder replacement) for people with advanced shoulder arthritis who have not improved with non-surgical treatments. It may help determine which approach works better for pain and function.
Edmonton, AlbertaAges 65 years+ - NCT03513731Recruiting
Regenerative fat cell injection for facet joint arthritis pain
This trial tests whether injecting regenerative cells made from your body’s fat can reduce pain from facet joint osteoarthritis in the low back. It focuses on people whose pain has lasted months and did not improve with standard care, after a positive diagnostic injection test.
Deerfield Beach, FloridaAges 18–75 - NCT05127005Recruiting
Compare thumb arthritis surgery versus placebo surgery
This study compares a real thumb basal joint surgery (trapeziectomy) with a sham/placebo operation to see which option helps pain and daily function better. It is for people with thumb arthritis who have tried non-surgical treatments but still have significant thumb pain.
HelsinkiAges 45 years+ - NCT04260165Recruiting
Wrist surgery options for certain wrist arthritis
This trial compares two types of wrist surgery for osteoarthritis in the wrist bones (SLAC/SNAC stage II–III). It may help you and your surgeon choose the procedure that best improves pain and wrist function for your specific wrist arthritis pattern.
HelsinkiAges 18–75 - NCT05267093Recruiting
Acupuncture for hand osteoarthritis pain
This study compares real acupuncture to sham (placebo) acupuncture to see which one better reduces pain and improves function in people with hand osteoarthritis. It may help you understand whether acupuncture provides meaningful relief beyond placebo.
BeijingAges 18–80 - NCT03650673Recruiting
Study of early finger osteoarthritis symptoms over time
This study follows people with early finger (hand) osteoarthritis symptoms to better understand how the condition starts and changes. You may be asked for blood tests, symptom checks, and imaging to see what’s happening in the joints.
MontpellierAges 18–60 - NCT06098586Recruiting
Nerve surgery vs exercise for wrist arthritis
This study compares two treatments for wrist arthritis: a surgery that cuts certain wrist nerves to stop pain signals, versus structured hand exercises. It may help if you have chronic wrist pain from a specific type of arthritis and haven't had previous wrist nerve surgery.
MalmöAges 18 years+ - NCT06281184Enrolling by invitation
Long-term follow-up of methotrexate for hand osteoarthritis
This study follows up on people who took part in the MERINO trial to see if methotrexate has lasting benefits for hand osteoarthritis. It aims to understand how the drug affects pain and joint health over 30 months.
OsloAges 18 years+
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Common questions
- Are there clinical trials for osteoarthritis?
- Yes. Clin2 currently lists 610 recruiting osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.