Clinical trials · Boston, MA
Pain clinical trials in Boston
We’re tracking 99 recruiting pain studies with a site in or near Boston — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Boston
- NCT04288427Recruiting
Testing a prostate marker to predict response to finasteride
This study looks at a prostate test marker to understand who is more likely to benefit from 5-ARI medicines such as finasteride or dutasteride. If you have enlarged prostate symptoms and are getting a biopsy, the results may help doctors better choose or interpret 5-ARI treatment.
Boston, MassachusettsAges 50 years+ - NCT06069154Enrolling by invitation
Freezing nerves for rib fracture pain
This study tests a procedure called cryoneurolysis, which uses cold to temporarily freeze nerves near broken ribs to relieve pain. It is for adults who have 1 to 6 recently broken ribs with at least moderate pain and are already getting a nerve block injection.
Boston, MassachusettsAges 18 years+ - NCT01788410Recruiting
MRI-guided freezing treatment for neck, head, and spine pain
This trial studies an MRI-guided procedure that “freezes” targeted nerves or joints to reduce pain in the head, neck, or spine. It may help if your pain comes from a joint problem or a compressed/damaged nerve and you can safely have MRI scans before and after the treatment.
Boston, MassachusettsAges 18 years+ - NCT07118722Recruiting
Quiet focus: mindfulness for pain and depression
This study compares two programs—mindfulness-based therapy and a general health program—to see which better helps older Black adults manage long-term pain and mild depression. It aims to find new ways to improve well-being.
Boston, MassachusettsAges 50–120 - NCT01719055Recruiting
Long-term follow-up for Boston Scientific pain nerve stimulation
This study looks at how well a Boston Scientific nerve stimulation device works over the long term for pain in everyday care. You may be able to join if you’re already being set up to use one of these approved systems and can reliably report your pain outcomes.
Boston, MassachusettsAges 18 years+ - NCT06721819RecruitingPhase 3
Sleep and brain training before heart surgery to prevent delirium
This study tests whether a combination of sleep therapy, brain games, and light exercise before heart surgery can help prevent confusion or disorientation (delirium) after the operation. Participants will be asked to use a tablet and fitness tracker daily for about an hour before their surgery.
Boston, MassachusettsAges 60 years+ - NCT03858205Recruiting
Low-dose radiation to relieve pain from bone tumors
This trial studies whether low-dose radiation can reduce pain from a specific bone lesion caused by multiple myeloma. It may help people whose main problem is painful bone metastasis, with targeted treatment to the painful spot.
Boston, MassachusettsAges 18 years+ - NCT07209436Recruiting
Comparing two nerve blocks for implant-based breast reconstruction pain
This trial compares two types of nerve blocks (pectoral and paravertebral) to see which one provides better pain relief and physical recovery after immediate implant-based breast reconstruction. It is for adults having this surgery for the first time, either for treatment or prevention.
Boston, MassachusettsAges 18 years+ - NCT07268118RecruitingPhase 2
Pain relief for cervical ripening balloon in labor
This study tests if using lidocaine gel on the cervix before placing a ripening balloon can reduce pain for pregnant women at full term. It may help women who want this balloon to start labor feel more comfortable.
Boston, MassachusettsAges 18 years+ - NCT03705598Recruiting
Tai chi for older adults with chronic pain
This study tests whether practicing Tai Chi can reduce pain and improve balance in older adults who have chronic pain in multiple areas. Tai Chi is a gentle form of exercise that involves slow movements and breathing, and it may help you feel better and reduce your risk of falling.
Boston, MassachusettsAges 65 years+ - NCT06639438Recruiting
Sensory outcomes in people who use opioids
This study looks at how opioids affect the senses in people having planned surgery. Researchers want to compare patients who use opioids (for pain or addiction) with those who don't, to see if there are differences in sensation.
Boston, MassachusettsAges 18 years+ - NCT05661903RecruitingPhase 2
Spinal cord stimulator study for nerve pain and brain effects
This Phase 2 study looks at how spinal cord (or nerve-root) stimulation affects pain signals in the brain and body. You may qualify if you already have a stimulator set to a comfort mode that avoids “tingling” sensations.
Boston, MassachusettsAges 18–80 - NCT07231419RecruitingPhase 3
Study of suzetrigine for diabetic nerve pain
This trial tests an experimental pain drug called suzetrigine for people with diabetic peripheral neuropathy (nerve damage from diabetes that causes pain in the feet and legs). It aims to see if the drug can safely reduce pain over time.
Boston, MassachusettsAges 18–80 - NCT07270276Recruiting
Dry needling for shoulder muscle pain
This study tests if dry needling (a therapy that uses thin needles to release muscle knots) can help with shoulder muscle pain. It uses special tests to measure how the treatment affects your muscles and pain.
Boston, MassachusettsAges 18–80 - NCT05895383RecruitingPhase 4
Nitrous oxide breathing during vasectomy: a feasibility study
This study looks at whether self-adjusting nitrous oxide (a calming gas) with oxygen can be safely and comfortably used during a vasectomy, and how people experience it. You may be offered the gas to see how it fits into care during the procedure.
Boston, MassachusettsAges 21–85 - NCT05684692RecruitingPhase 2
Pain-relief study for adults with schwannomatosis
This Phase 2 study tests whether an antibody medicine (either siltuximab or erenumab) can reduce moderate-to-severe pain in adults with schwannomatosis. It compares the medicine to a placebo and looks for improved pain control and tolerability.
Boston, MassachusettsAges 18 years+ - NCT06812247Recruiting
Therapy dog visits for hospitalized trauma patients
This study looks at whether visits from therapy dogs can help people who are in the hospital after a traumatic injury feel better. You must be able to talk to the research team and not be afraid of dogs.
Boston, MassachusettsAges 18 years+ - NCT07197710Recruiting
Imagined acupuncture for pain after spine surgery
This trial tests if imagining acupuncture, guided by a video, can help reduce pain after spinal surgery. It is for adults having their first spine surgery on one or two bones.
Boston, MassachusettsAges 18 years+ - NCT06027099RecruitingPhase 3
Testing tizanidine to help reduce opioids after surgery
This study tests whether adding a low-dose muscle relaxant (tizanidine) to your pain plan after surgery can help you safely lower your opioid use. It's for people who have been on long-term opioids and are having surgery at specific hospitals.
Boston, MassachusettsAges 18–75 - NCT06991205Recruiting
Web mind-body program for pain and substance use
This trial tests a web-based mind-body program to help people who have ongoing arm or hand pain and also use substances like alcohol or cannabis. It aims to improve resilience and reduce pain without requiring in-person visits.
Boston, MassachusettsAges 18 years+ - NCT06723158Recruiting
Virtual reality glasses for oral surgery with sedation
This trial tests if wearing virtual reality (VR) glasses during oral surgery helps patients relax while under IV sedation. It may be a good option if you need sedation for a tooth extraction or other mouth procedure.
Boston, MassachusettsAges 16–65 - NCT06799052Recruiting
Cervical preparation for same-day abortion procedure
This study compares two methods of preparing the cervix (the opening to the uterus) on the same day as a dilation and evacuation (D&E) procedure for abortion at 16 to 18 weeks of pregnancy. The goal is to see which preparation approach works best and is safest.
Boston, MassachusettsAges 16 years+ - NCT06117709Recruiting
Smartphone app for cancer pain relief
This study tests a smartphone app designed to help people with advanced cancer manage their pain. It's for adults who have had cancer pain and want to try a digital tool to improve their comfort and quality of life.
Boston, MassachusettsAges 21 years+ - NCT07265557Recruiting
Comparing two pain plans after orthopedic surgery
This trial compares two different pain medication plans after major orthopedic surgery. It aims to find which plan helps you recover with less pain and fewer side effects.
Boston, MassachusettsAges 18 years+
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Pain trials in other cities
Where these studies are running near Boston
Institutions with a site for the recruiting pain studies listed above.
- Massachusetts General Hospital · 8 studies
- Beth Israel Deaconess Medical Center · 6 studies
- Brigham and Women's Hospital · 4 studies
- Dana-Farber Cancer Institute · 2 studies
- Boston Clinical Trials
- Boston Medical Center
- Boston Medical Center, Trauma Inpatient Service
- Boston Medical Center/Boston University Medical Campus
What taking part in a pain study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting pain studies in Massachusetts.
Common questions
- Are there pain clinical trials near Boston?
- Yes. We're currently tracking 99 recruiting pain studies with a site near Boston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pain study near Boston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Boston to take part?
- Not necessarily. These studies have a site near Boston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pain studies open near Boston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.