Clinical trials
Parkinson Disease Dementia clinical trials
Below are recruiting parkinson disease dementia clinical trials, each written for real people, not researchers. We’re tracking 320 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07786116Recruiting
Gut bacteria in Parkinson's disease and related conditions
This study looks at how certain gut bacteria (methanogens) are involved in the progression of Parkinson's disease and related conditions. It aims to understand the connection between gut health and brain health, which may lead to better treatments.
Cambridge, CB2Ages 55 years+ - NCT07761936RecruitingPhase 3
Safinamide for Parkinson's disease pain
This study tests whether safinamide, an add-on medication for Parkinson's disease, can reduce chronic pain in people who also experience motor fluctuations (times when symptoms return between doses). It aims to see if this treatment can improve pain and quality of life.
Verona, VenetoAges 18 years+ - NCT07567794Recruiting
Gut-Brain Connection Study in Parkinson's Disease
This research examines how the gut and brain are connected in Parkinson's disease and aims to better understand the disease. You'd participate in visits and tests over three years, including some involving your digestive system.
Stanford, CaliforniaAges 21–80 - NCT07630545RecruitingPhase 1
Testing a new drug for Parkinson's disease
This study tests an experimental drug, MTX325, in people with Parkinson's disease. The goal is to see if it is safe and how the body processes it, which may lead to new treatment options.
AdelaideAges 18–75 - NCT05357612RecruitingPhase 4
PET scan study for brain serotonin in neurodegenerative diseases
This study uses a special PET brain scan tracer to better understand serotonin receptor activity in people with certain neurodegenerative conditions, especially when they develop hallucinations or delusions. The results may help researchers improve how these brain changes are measured and tracked over time.
Nashville, TennesseeAges 50–85 - NCT03019757Recruiting
Testing ways to tell dementia causes apart
This study looks at how to distinguish Alzheimer’s disease, Lewy body dementia, and Parkinson’s disease when someone has memory and thinking problems. It may help doctors choose the most accurate diagnosis and treatment path for the right condition.
Columbus, OhioAges 18 years+ - NCT03174938Recruiting
BioFINDER 2 study for healthy aging and memory problems
This study uses brain scans and a spinal fluid test to better understand memory and thinking changes in different groups, from people with healthy thinking to early or established dementia. If you qualify, it may help researchers learn what’s driving these conditions and how they progress.
ÄngelholmAges 20–100 - NCT03233646Recruiting
Retina scans in memory and nerve disorders
This study uses pictures of the back of your eye (retinal imaging) to look for differences in people with neurodegenerative diseases and compares them with people without these conditions. It may help researchers understand eye changes that could connect to brain or nerve health.
Durham, North CarolinaAges 18 years+ - NCT03402919Recruiting
Brain and memory study for people with thinking changes
This study looks at memory and thinking changes using questionnaires, memory testing, and brain scans. It may help researchers better understand neurodegeneration and dementia and how these problems show up over time.
Calgary, AlbertaAges 50–90 - NCT04114994Recruiting
Memory testing study for adults 50 and older
This study checks how people’s thinking and memory change over time using a specific cognitive test. It may help researchers understand patterns of memory change and supports future research on brain health.
Miami, FloridaAges 50 years+ - NCT04335994Recruiting
Home sleep testing for people with memory trouble
This study looks at how well home sleep apnea testing works for people with cognitive impairment (memory/thinking problems) to help improve outcomes. You may be asked to do a home sleep test (and possibly an in-lab test) and will involve a caregiver if needed.
Toronto, OntarioAges Any age - NCT04389437Recruiting
Eye imaging study for people with memory problems
This study uses detailed eye scans to look for changes that might relate to memory problems. You may be able to join if you are being seen for memory concerns and meet the health and eye-scan requirements.
ParisAges 18 years+ - NCT04396873RecruitingPhase 1
PET brain scan study of inflammation markers in neurodegeneration
This Phase 1 study tests a PET scan to measure inflammation-related changes in the brain using a medication called ketoprofen. It may help researchers understand which people with certain brain diseases could benefit from treatments aimed at inflammation.
Bethesda, MarylandAges 18–99 - NCT04643327RecruitingPhase 2
Levetiracetam study to lower dementia risk in Parkinson’s
This Phase 2 study tests whether an added medication strategy can change brain targets linked to memory decline in people with Parkinson’s disease, including those with no memory problems or mild memory changes. It may help lower risk of developing dementia, but you must be able to safely do MRI scans and meet other health and medication rules.
Brisbane, QueenslandAges Any age - NCT04735627Recruiting
Real-time monitoring of levodopa levels in Parkinson’s
This study checks whether measuring levodopa (a Parkinson medicine) in real time can help better understand Parkinson medication effects. You may be asked to wear/perform study monitoring while taking your usual carbidopa/levodopa tablets.
San Diego, CaliforniaAges 40–85 - NCT04844060Recruiting
Study collecting spinal fluid from patients needing a lumbar puncture
This study collects cerebrospinal fluid (the fluid around the brain and spinal cord) during a lumbar puncture. It aims to improve how doctors use this information for accurate diagnosis in patients who need the procedure.
StrasbourgAges Any age - NCT04997642Recruiting
Parkinson’s patient database for memory and movement tracking
This study builds a research database of people who receive care for Parkinson’s disease, including those with mild memory problems or dementia. It aims to collect consistent information that researchers can use to better understand Parkinson’s and related thinking changes.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05348837Recruiting
Two-week sleep tracking for people with Parkinson’s
This study uses a wristband and a headband to track your sleep for two weeks. It’s meant to better understand sleep patterns in Parkinson’s, and may require temporarily changing your evening medication timing.
Aurora, ColoradoAges 18–80 - NCT05516719Recruiting
Study tracking I2BS in Parkinson’s over time
This study follows people with Parkinson’s to see how “I2BS” changes over time using special brain scans and other tests. It may help researchers better understand Parkinson’s and improve how it’s measured in future trials.
Exeter, DevonAges 25 years+ - NCT05568498RecruitingPhase 2
Probiotic trial for depression in Parkinson’s disease
This Phase 2 study tests whether taking probiotics can improve depression and mood symptoms in people with Parkinson’s disease. It’s meant for those with mild to moderate depression and stable Parkinson’s and mood treatments.
Vancouver, British ColumbiaAges 40–80 - NCT05603715RecruitingPhase 2
Pyridostigmine to help constipation in Parkinson’s
This trial tests whether pyridostigmine can improve constipation symptoms in people with Parkinson’s disease. If you have Parkinson’s and functional constipation (with infrequent bowel movements), this study may offer a new medication option and closely track your bowel function.
Burlington, VermontAges 18 years+ - NCT05962489Recruiting
Sleep-focused DBS therapy study for Parkinson’s disease
This study looks at a sleep-focused approach to brain stimulation (DBS) in people with Parkinson’s disease. You may be able to join if you’re planning or scheduled for specific DBS surgery at the University of Minnesota and have the needed brain imaging.
Minneapolis, MinnesotaAges 21 years+ - NCT05997043RecruitingEarly Phase 1
Botulinum toxin for overactive bladder in Parkinson's disease
This trial tests if botulinum toxin A injections can help control overactive bladder symptoms in people with Parkinson's disease who haven't gotten enough relief from standard bladder medications. It aims to see if the treatment is safe and effective.
Guangzhou, GuangdongAges 25–80 - NCT06088121Recruiting
TMS with cognitive training for mild Alzheimer's dementia
This study tests a combination of brain stimulation (TMS) and cognitive training to improve memory and thinking in people with mild Alzheimer's. It may help if you are already on a stable dose of a donepezil-type medication and have a confirmed Alzheimer's diagnosis.
Incheon, Bupyeong 6(yuk)-dong, Bupyeong-guAges 60–85
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Common questions
- Are there clinical trials for parkinson disease dementia?
- Yes. Clin2 currently lists 320 recruiting parkinson disease dementia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a parkinson disease dementia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a parkinson disease dementia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.