Clinical trials
Parkinson Disease Dementia clinical trials
Below are recruiting parkinson disease dementia clinical trials, each written for real people, not researchers. We’re tracking 320 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06451419Enrolling by invitation
Non-motor symptoms in GBA-related Parkinson's disease
This study looks at non-motor symptoms (like mood, thinking, or sleep problems) in people with a specific genetic change linked to Parkinson's disease. It compares those with the GBA gene change to those without it to see how symptoms differ.
Pozuelo de Alarcón, MadridAges 18 years+ - NCT06104397Enrolling by invitation
Exercise strategies for Parkinson's disease
This study compares different exercise plans to see which works best for people with Parkinson's. You will use an activity tracker and a phone app to track your progress.
Chicago, IllinoisAges 18–89 - NCT05826457Enrolling by invitation
Study for early RBD as a possible Parkinson’s risk
This study looks at people with REM sleep behavior disorder (RBD), confirmed by a sleep test, who may be in the early “prodromal” stage before Parkinson’s or related diseases. It also enrolls healthy controls to compare results from brain and body testing to better understand who is at risk.
Los Angeles, CaliforniaAges 18 years+ - NCT05779475Enrolling by invitation
Study of people with moderate Parkinson’s disease
This is an observational study, meaning it doesn’t test a new drug—researchers mainly follow people to better understand moderate Parkinson’s disease and who may be good candidates for future cell therapy. If you have moderate symptoms that aren’t well controlled with tablets, this study may help inform better future treatments.
Irvine, CaliforniaAges 50–68 - NCT04994015RecruitingTeam says not enrolling
Genetic registry for people with Parkinson’s
This study builds a genetics “registry” of people diagnosed with Parkinson’s disease who agree to genetic testing. Your information may help researchers understand why Parkinson’s happens and improve future treatments.
Birmingham, AlabamaAges 18 years+ - NCT06742450Recruiting
Comparing two ways to stimulate the brain for Parkinson's
This trial compares two methods of deep brain stimulation (constant current vs constant voltage) for people with Parkinson's who already have the device placed but haven't turned it on yet. The goal is to see which method works better.
BeijingAges 18–75 - NCT06701955Recruiting
Reliability of a Fluctuation Scale in Parkinson's
This study tests how consistently a new scale measures 'on-off' fluctuations in Parkinson's disease. If you experience motor fluctuations (times when your symptoms change) and are on stable medication, you may help validate this tool.
GrenobleAges 30–75 - NCT07100171RecruitingEarly Phase 1
GM101 injection for advanced Parkinson's disease
This trial tests an investigational gene therapy injection called GM101 for people with advanced Parkinson's disease whose symptoms are not well controlled by standard medications. The study will see if this treatment can help improve movement and quality of life.
ChangshaAges 40–70 - NCT07734181Recruiting
Music Therapy for Parkinson's Disease
This trial tests whether music therapy can help people with Parkinson's disease. It might improve movement, mood, or quality of life.
Arlesheim, Basel-LandschaftAges 50–79 - NCT07730073Recruiting
LSVT-LOUD therapy for voice and speech in Parkinson's disease
This study tests whether LSVT-LOUD, a speech therapy program, can improve voice, speech, and quality of life in people with Parkinson's disease who have voice or speech problems. Participants must be native Turkish speakers, aged 40-80, with mild to moderate Parkinson's.
Kâğıthane, IstanbulAges 40–80 - NCT04799470Recruiting
Testing new brain-stimulation patterns for Parkinson’s with DBS
This study tests whether different deep brain stimulation settings can improve symptoms in people with Parkinson’s who already have an implanted DBS system in the subthalamic nucleus (STN). To join, you must already have the specific Medtronic device and show good brain signal and symptom response after surgery.
Omaha, NebraskaAges 19–80 - NCT03025334Recruiting
Brain stimulation study for thinking changes in Parkinson’s
This study tests whether a non-invasive brain stimulation approach (tDCS) can improve thinking and memory in people with Parkinson’s disease. You may be invited because your Parkinson’s is typical and your memory testing shows you do not have dementia.
Winnipeg, ManitobaAges 40 years+ - NCT04496973Recruiting
Parkinson’s disease research registry for adults
This registry asks people with Parkinson’s disease to join a research program at the University of Delaware. Being in the registry may help you get invited to investigator-led studies that could improve understanding or treatment of Parkinson’s.
Newark, DelawareAges 21–100 - NCT05400499Recruiting
Deep brain stimulation study in Parkinson’s visuomotor function
This trial studies how deep brain stimulation affects hand-eye (visuomotor) coordination in people with Parkinson’s. It may help researchers understand whether the stimulation settings change movement control for daily tasks.
Cleveland, OhioAges Any age - NCT05518617Recruiting
Imaging study for inherited Parkinson’s using PET, SPECT, and spinal fluid
This trial tests how well special brain scans (PET/SPECT) and spinal fluid tests can show changes in people with inherited (genetic) Parkinson’s. It may help researchers understand what’s happening in the brain and improve how these conditions are measured.
Exeter, DevonAges 25–80 - NCT05557864Recruiting
Brain scan study for Parkinson’s patients with deep brain stimulators
This study looks at how the location of a deep brain stimulator in Parkinson’s disease affects movement problems. It mainly uses advanced 7T brain imaging to compare brain activity and motor symptoms.
Minneapolis, MinnesotaAges 21–89 - NCT05968703Recruiting
Deep brain stimulation study for mild memory trouble in Parkinson’s
This trial looks at a specific type of deep brain stimulation (DBS) to see if it can help people with Parkinson’s who have mild cognitive problems (mild memory/thinking changes). You may also be asked to temporarily stop Parkinson’s medications around research visits to measure effects more clearly.
Stanford, CaliforniaAges 21–80 - NCT06028529Recruiting
Exoskeleton trial for mobility in Parkinson's
This study tests a wearable robotic exoskeleton called Keeogo to see if it can help people with Parkinson's walk better and move more easily. You would come to the Richmond VA Medical Center for visits and try walking with the device.
Richmond, VirginiaAges 18–90 - NCT06231563RecruitingPhase 2
Ketamine for depression in veterans with Parkinson's
This study tests if ketamine can help treat depression in veterans with Parkinson's disease. It involves several in-person and remote visits, and you will need to avoid certain medications and cannabis for a short time before and during some visits.
San Francisco, CaliforniaAges 40–80 - NCT06402955RecruitingPhase 2
Imaging depression in Parkinson's disease
This study uses brain imaging (PET scans) to understand depression in people with Parkinson's disease. It may also test a depression treatment called ketamine, but the main goal is to see how the brain changes with depression.
New Haven, ConnecticutAges 40–80 - NCT06405334Recruiting
Study on balance problems in Parkinson's disease
This study looks at how Parkinson's disease affects balance and the brain signals involved. It aims to understand why some people with Parkinson's have trouble with balance, and in part of the study, it will look at how deep brain stimulation (a device that sends electrical impulses to the brain) affects balance.
Minneapolis, MinnesotaAges 18 years+ - NCT06442033Recruiting
Exercise and genetics to slow Parkinson's
This trial studies whether a regular aerobic cycling program can slow the progression of Parkinson's disease. Researchers will also look at how genetics may affect the benefits of exercise.
Cleveland, OhioAges 18 years+ - NCT06087926Recruiting
TMS for apathy in Parkinson's disease
This study tests whether a non-invasive brain stimulation treatment called TMS (transcranial magnetic stimulation) can help improve apathy, or loss of motivation, in people with Parkinson's disease. You must have had symptoms for at least 4 years and be on stable Parkinson's medications.
Chapel Hill, North CarolinaAges 55–80 - NCT01682668Recruiting
Deep brain stimulation study for Parkinson movement problems
This study looks at how deep brain stimulation (an implanted brain device) affects Parkinson’s symptoms, especially movement problems like freezing, slowness, or involuntary movements. It may help people whose symptoms are not fully controlled by standard Parkinson medicines.
Paris, PARISAges 18–70
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Common questions
- Are there clinical trials for parkinson disease dementia?
- Yes. Clin2 currently lists 320 recruiting parkinson disease dementia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a parkinson disease dementia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a parkinson disease dementia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.