Clinical trials · Raleigh–Durham, NC
Pediatrics clinical trials in Raleigh–Durham
We’re tracking 64 recruiting pediatrics studies with a site in or near Raleigh–Durham — including Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Raleigh–Durham
- NCT05839379Recruiting
Targeted therapy study for children and young adults with brain tumors
This trial studies a targeted medicine approach for high-grade glioma (a fast-growing brain tumor) and some diffuse midline tumors, including DIPG. It may help by matching treatment to tumor biology using tumor testing done before or around starting standard therapy.
Durham, North CarolinaAges 1–39 - NCT06116422Recruiting
Food Insecurity Program for Healthy Baby Weight
This study tests a program to help families with food insecurity and early signs of obesity in infants. It aims to learn the best ways to support healthy weight in babies at risk for overweight.
Durham, North CarolinaAges 1–2 - NCT06139523Recruiting
Improving eye imaging in adults and children
This study aims to improve how we take pictures of the back of the eye (called OCT imaging) in both healthy adults and children. It will help doctors get better images to diagnose and manage eye conditions.
Durham, North CarolinaAges Any age - NCT06672549RecruitingPhase 3
Weight loss medication study for children with obesity
This trial tests a medication for children and teens with obesity or overweight who have not been able to lose enough weight with diet and exercise alone. It aims to see if a new treatment can help them safely lose weight and improve related health problems.
Durham, North CarolinaAges 6–17 - NCT07166926Recruiting
Portable CT scanner for children at bedside
This study tests a portable CT scanner that can be brought to your child's bedside. It may help children who are too small or too sick to travel to the radiology department get the imaging they need.
Durham, North CarolinaAges Up to 5 years - NCT05090345Recruiting
Registry for young people getting bone marrow transplants
This trial is a registry that follows children and young adults up to age 26 who are having a bone marrow transplant, to better understand complications related to blood vessel and organ injury. It may help future patients by improving how doctors predict and prevent these problems.
Durham, North CarolinaAges birth–26 years - NCT06847282Recruiting
Motor skills study for children with FSHD
This study looks at how children with FSHD move and function over time. It uses walking tests and optional MRI scans to understand muscle changes. Your child's participation could help researchers learn more about FSHD progression in kids.
Durham, North CarolinaAges 5–17 - NCT05835310RecruitingPhase 3
IV anifrolumab for active lupus in children
This study tests whether an intravenous medicine called anifrolumab can safely improve active systemic lupus (SLE) in children. If you qualify, you may receive the study treatment and be closely monitored for safety and lupus symptoms.
Durham, North CarolinaAges 5–17 - NCT06994442RecruitingPhase 3
Best pain relief for children on a breathing tube
This study tests adding extra pain medicines (acetaminophen or an NSAID) to usual opioid pain treatment for children on a breathing machine. The goal is to find the safest and most effective way to manage pain.
Durham, North CarolinaAges 2 months–17 years - NCT02418442Recruiting
Kid rheumatic disease registry study for follow-up care
This is an observational study that follows children and teens with rheumatic (joint/inflammatory) diseases to better understand how they develop and are cared for over time. You may help by letting the study contact your family in the future and by completing study tasks as needed.
Durham, North CarolinaAges Up to 21 years - NCT06428175Recruiting
Hospital-to-home support for children with complex needs
This study tests a program to help children with complex medical needs and their families transition smoothly from the hospital to home. It focuses on improving communication and support during that critical time.
Durham, North CarolinaAges Up to 18 years - NCT06841575Recruiting
Better eye imaging for children and adults at Duke
This study tests a new camera that automatically adjusts to take clear pictures of the back of the eye. It aims to improve retinal imaging for healthy adults, adult eye clinic patients, and children seen at Duke Eye Center.
Durham, North CarolinaAges 1 month+ - NCT07198113Recruiting
Comparing newer treatments for pediatric inflammatory bowel disease
This study is for children and teens with inflammatory bowel disease (Crohn's, colitis, or indeterminate) whose previous anti-TNF medicine stopped working. It compares several newer treatments to see which works best.
Durham, North CarolinaAges 1–18 - NCT04629014Recruiting
Quality of life study for kids with intestinal failure
This study looks at how children with intestinal failure feel and function day to day, using questionnaires. It aims to better understand quality of life to improve care for families managing specialized nutrition needs.
Durham, North CarolinaAges 6 months–25 years - NCT03827694Recruiting
Testing a noninvasive scan for serious lung mold infections in kids
This study uses noninvasive breathing/relates imaging (MRI or CT) to help diagnose mold infections in the lungs in children and young adults. It may help doctors find these infections sooner, especially in people with weakened immune systems.
Durham, North CarolinaAges 4 months–21 years - NCT05879835Recruiting
EDTA lock solution to prevent line blockages in children
This trial tests whether a solution called KiteLock (4% EDTA) put into a special feeding line can help prevent blockages in children who need long-term nutrition through the vein. It may reduce line occlusions (blockages) and the complications they can cause.
Durham, North CarolinaAges 4 weeks–18 years - NCT04457154Recruiting
Registry for teens and young adults with OSA who can’t use CPAP
This study collects information in a registry to help doctors understand outcomes for young people with moderate-to-severe obstructive sleep apnea who cannot use CPAP and may use an implantable breathing stimulation device. You might qualify if you’ve tried and couldn’t tolerate CPAP and you’re able/willing to get and use the device and return for follow-ups and sleep tests.
Durham, North CarolinaAges 18–21 - NCT06941389Recruiting
Comparing stem cell transplant vs standard therapy for sickle cell disease
This study compares two treatment approaches for children with sickle cell anemia: a stem cell transplant from a matched family donor versus continuing regular disease-modifying medicines. It aims to see which treatment works better over time.
Chapel Hill, North CarolinaAges 3–20 - NCT06186752Recruiting
Action planning test for teens with IBD
This study tests if a planning tool helps teenagers with Crohn's disease or ulcerative colitis manage their condition. It's for patients aged 13 to 19 who have had their diagnosis for at least 3 months and are seen at UNC.
Chapel Hill, North CarolinaAges 13–19 - NCT05948943RecruitingPhase 2/Phase 3
Alpelisib for lymphatic malformations with a PIK3CA change
This trial tests alpelisib (a targeted medicine) for people who have lymphatic malformations (LyM) that cause symptoms and have a PIK3CA mutation. It may help shrink or control these lesions when other procedures are delayed until after the first 24 weeks.
Chapel Hill, North CarolinaAges birth–100 years - NCT06814795Recruiting
Medically tailored meals for kids with cancer
This study tests whether providing specially designed meals to children undergoing chemotherapy can help with taste changes and improve their eating. It is for kids ages 12 to 17 who are being treated at UNC Chapel Hill and plan to have at least two more chemo cycles.
Chapel Hill, North CarolinaAges 12–99 - NCT06997588RecruitingPhase 2
Alpelisib for pediatric and adult PROS
This trial tests a drug called alpelisib for children and adults with a rare overgrowth condition called PROS that is caused by a PIK3CA gene change. It aims to see if the drug can safely shrink overgrowth and improve symptoms.
Chapel Hill, North CarolinaAges 2–100 - NCT06789666Recruiting
Digital art therapy for young cancer survivors
This trial is testing a digital art therapy program designed to help young adults who survived childhood cancer feel better emotionally. You'll use an app to create art and connect with others, all from home.
Chapel Hill, North CarolinaAges 18–25 - NCT07581938Recruiting
Early Dental Screening for Sleep Problems in Kids
This study uses a smartphone app and a wearable device to check for early signs of sleep-disordered breathing—a condition where breathing stops briefly during sleep—in children ages 8–13. The goal is to catch dental and jaw problems that might lead to sleep issues before they become serious.
Chapel Hill, North CarolinaAges 8–13
Hear when a new Pediatrics trial opens near Raleigh–Durham, NC
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Pediatrics trials in other cities
Where these studies are running near Raleigh–Durham
Institutions with a site for the recruiting pediatrics studies listed above.
- Duke University Medical Center · 5 studies
- University of North Carolina at Chapel Hill · 5 studies
- Duke Children's Hospital & Health Center · 3 studies
- Duke University · 3 studies
- Duke University Health System · 3 studies
- UNC Children's Hospital · 2 studies
- Adams School of Dentistry
- Duke Children's Primary Care North Durham
What taking part in a pediatrics study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting pediatrics studies in North Carolina.
Common questions
- Are there pediatrics clinical trials near Raleigh–Durham?
- Yes. We're currently tracking 64 recruiting pediatrics studies with a site near Raleigh–Durham, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pediatrics study near Raleigh–Durham?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Raleigh–Durham to take part?
- Not necessarily. These studies have a site near Raleigh–Durham, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pediatrics trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pediatrics studies open near Raleigh–Durham regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.