Pelvic Cancer clinical trials

Life and Intimacy After Gynecologic Cancer Surgery

This study explores how women's quality of life and sexual health are affected after having extensive pelvic cancer surgery. Researchers want to understand your experiences to help improve care for future patients.

Ozone therapy for pelvic pain after gynecological cancer treatment

This study is looking at whether ozone therapy can help relieve chronic pelvic pain caused by gynecological cancer treatments like radiation and chemotherapy. It aims to understand how the treatment works at a molecular level.

New prostate cancer trial adding darolutamide to standard treatment

This Phase 3 trial tests whether adding darolutamide to standard hormone therapy and radiation works better than standard treatment alone for newly diagnosed prostate cancer that has spread to pelvic lymph nodes. If you qualify, you may receive darolutamide or a placebo alongside long-term hormone therapy and radiation.

Pelvic cancer registry for online adapted radiotherapy

This study collects data from patients receiving a type of radiation therapy that is adjusted in real-time. It aims to learn more about how well this approach works for pelvic and chest tumors.

early pelvic floor therapy for women having pelvic radiation

This study tests whether starting pelvic floor physical therapy early can help women with cervical cancer who are receiving radiation and chemotherapy. It aims to improve quality of life by addressing muscle-related side effects of treatment.

Comparing lymph node removal approaches in aggressive prostate cancer

This trial compares two surgical approaches for removing lymph nodes during prostate cancer surgery in men with high-risk disease on one side of the prostate. The goal is to determine whether removing lymph nodes from both sides or just one side provides better outcomes.

Pelvic floor exercises after rectal surgery

This trial tests whether doing pelvic floor exercises after a type of rectal surgery called 'low anterior resection' can help prevent bowel problems known as Low Anterior Resection Syndrome (LARS). It may help you maintain better bowel control after surgery.

A COhort Study on Factors Leading to Vulnerability in Adult Patients With Serious Medical cOnditionS: the COSMOS-I Trial

Chemo before rectal surgery, without pelvic radiation

This Phase 3 study tests whether giving chemotherapy before rectal surgery can work as well as standard treatment that usually includes pelvic radiation. It aims to reduce the need for pelvic radiation while still keeping the cancer under control.

Personalized after-surgery treatment for endometrial cancer by tumor type

This trial studies which after-surgery (adjuvant) treatment works best when endometrial cancer is classified by specific tumor DNA/molecular features. You may be offered treatment based on the tumor results, aiming to improve outcomes and lower the risk of the cancer coming back.

Surgery for early prostate cancer spread seen on PSMA PET

This trial studies whether operating on a small, one-sided (unilateral) area of prostate cancer spread in the pelvic lymph nodes—found on a PSMA PET scan—can help control recurrence. It’s meant for people whose PSA is still low and whose spread appears limited on the scan.

Studying leg swelling and nighttime urination after pelvic node surgery

This trial looks at why some people develop leg swelling (lymphedema) and frequent nighttime urination (nocturia) after pelvic lymph node surgery for prostate or bladder cancer. It may help doctors better predict and manage these side effects after the operation.

Men's health after prostate cancer surgery study

This study looks at how men recover control of urine and sexual function after prostate removal surgery. It also tests if a 12-week exercise program can help improve these functions.

Extra radiation boost for high-risk prostate cancer

This Phase 2 study tests a treatment plan that uses standard focused radiation to the prostate, plus an extra “boost” delivered inside the prostate. It may help improve control of high-risk prostate cancer, especially by aiming radiation more precisely.

AI Symptom Tracking for Pelvic Radiation Therapy

This trial uses an AI tool to help track your weekly symptoms during pelvic radiation therapy. It aims to make it easier for you and your care team to monitor and manage side effects.

Palliative radiation for pelvic tumor symptoms

This trial tests a type of radiation to help relieve symptoms like pain, bleeding, or other discomfort from tumors in the pelvic area. It is for people whose cancer has spread or cannot be cured, and who are not able to have stronger treatments.

Biobank study for pelvic cancers and endometriosis samples

This study collects and stores biological samples (like tissue or other lab samples) from people with pelvic gynecologic cancers or endometriosis, and links them with imaging/radiology information. It may help researchers learn more about these conditions and how they behave over time.

Test a stronger prostate radiation boost for high-risk prostate cancer

This trial studies whether giving a moderate “boost” dose of radiation to the prostate—along with radiation to the pelvic area—can better control high-risk localized prostate cancer. You may benefit if you have high-risk disease and can safely receive radiation.

Using PSMA PET scan before prostate cancer surgery

This trial is testing whether a special scan (PSMA PET/CT) before surgery can help doctors decide if you need to remove lymph nodes. It is for men with high-risk prostate cancer who are already planning to have robot-assisted prostate removal.

Immunotherapy plus radiation after surgery for advanced UTUC

This trial is testing whether adding immunotherapy and radiation after surgery can improve outcomes for people with advanced upper tract urothelial cancer (UTUC) who cannot have chemotherapy. It compares the combination to surgery alone.

Radiation plus drugs vs drugs alone for limited spread bladder cancer

This trial tests whether adding targeted radiation to standard drug therapy can help people with a limited number of bladder or urinary tract cancer metastases. It's for those whose cancer has spread to a few spots that can be treated with full coverage radiation.

MRI study for repeat pelvic colorectal cancer

This study uses a special MRI to help understand and stage colorectal cancer that has come back in the pelvis. The goal is to improve how doctors make treatment decisions after previous surgery.

Short-course prostate and pelvic SBRT using 5 treatment sessions

This study compares two schedules of highly focused radiation (SBRT): 5 sessions to the prostate only, versus 5 sessions to the prostate and nearby pelvic lymph nodes. It aims to see which approach controls high-risk localized prostate cancer better while you also take hormone therapy.

Radiofrequency and exercise for pelvic floor issues after breast cancer

This trial tests whether radiofrequency therapy combined with exercise can help with pelvic floor problems like pain, urgency, or incontinence that some women have after breast cancer treatment.