Clinical trials
Periodontal Diseases clinical trials
Below are recruiting periodontal diseases clinical trials, each written for real people, not researchers. We’re tracking 108 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07262606Recruiting
Saliva protein levels in gum disease severity and smoking
This study looks at a protein called Mitofusin-1 in your saliva to see if its levels are linked to how serious gum disease is, whether you smoke, and how you respond to treatment. Samples will be taken once before any treatment begins.
Erzincan, ErzincanAges 18–65 - NCT07311512Recruiting
Gum treatment and mouthwash study for gum disease
This trial tests if a professional gum cleaning combined with a special mouthwash can improve gum health and blood vessel function. It may help people with early gum disease who haven't had recent gum treatment.
Portsmouth, HampshireAges 30–75 - NCT07312552Recruiting
Gum health, smoking, and saliva markers study
This study looks at how gum health and smoking affect certain proteins in your saliva. It may help researchers understand more about gum disease and inflammation.
IstanbulAges 18–65 - NCT01568697Recruiting
Studying gum disease in people with immune and genetic differences
This study looks at how mouth bacteria and the immune system may work together to cause gum disease (periodontitis), especially in people with certain genetic immune problems. It may help researchers understand what drives severe gum disease and how to better monitor or treat it in the future.
Bethesda, MarylandAges 7–100 - NCT07446127Recruiting
Adding Laser to Gum Disease Treatment
This trial tests adding a special laser (diode laser) to standard deep cleaning for gum disease. The goal is to see if the laser helps reduce infection and improve healing better than cleaning alone.
Afula, NorthAges 18 years+ - NCT04567030Recruiting
AI tool to help improve gum treatment outcomes
This trial tests whether an artificial intelligence (AI) system can help plan and improve results of gum (periodontal) treatment. You may be a good match if you have diagnosed periodontal disease and enough healthy teeth.
Kaohsiung CityAges 35–65 - NCT07367737Enrolling by invitation
Comparing histatin-1 levels in smokers and non-smokers with gum disease
This study looks at a protein called histatin-1 in your saliva to see how it changes with gum disease treatment. Researchers want to compare levels between smokers and non-smokers before and after deep cleaning (a non-surgical treatment for periodontitis). It may help understand how smoking affects gum healing.
Baghdad, Medical CityAges Any age - NCT07233512Enrolling by invitation
Periodontal treatment for Alzheimer's disease
This trial tests whether treating gum disease can improve outcomes for people with Alzheimer's disease. If you have mild to moderate Alzheimer's and gum disease, you may be able to join.
LiègeAges Any age - NCT05858411Recruiting
Biologic gum treatments added to non-surgical cleaning
This trial studies whether adding a biologic medicine to standard non-surgical gum (periodontal) treatment can improve deep gum pockets in certain bone defects. It may help people whose gum disease has specific “intrabony” defects, but you must meet several health and medication rules.
TiranaAges 18 years+ - NCT06929676Enrolling by invitation
Tooth mobility after gum disease treatment and splinting
This trial tests how much tooth movement improves after deep cleaning and splinting (connecting loose teeth) in people with advanced gum disease. It may help if you have loose front teeth from gum disease.
Piracicaba, São PauloAges 18 years+ - NCT07054177Recruiting
Saliva test for gum disease in pregnancy
This study looks at how pregnancy and gum disease might change the chemicals in your saliva. By comparing pregnant women and non-pregnant women, researchers hope to find a simple way to screen for gum problems during pregnancy.
Istanbul, FatihAges 18–40 - NCT07671274RecruitingEarly Phase 1
Comparing two ways to treat gum disease without surgery
This study compares a standard deep cleaning method with a newer, less invasive approach for treating advanced gum disease (periodontitis). It aims to see if one works better for patients with good oral hygiene and no other health issues.
Al Mansurah, DakhliaAges 20–40 - NCT07421960Recruiting
Periodontitis and sleep quality study
This study looks at how gum disease (periodontitis) might be related to sleep quality. It compares people with healthy gums to those with gum disease.
Istanbul, IstanbulAges 18–65 - NCT07384221Recruiting
Gum health and disease severity in Pemphigus Vulgaris
This study looks at how Pemphigus Vulgaris (a rare blistering skin condition) affects gum health. Researchers will check your teeth and gums to see if the disease is linked to gum problems.
AnkaraAges 18 years+ - NCT05232331Recruiting
Eat nitrate-rich vegetables to study gum inflammation and mouth bacteria
This study looks at whether eating more nitrate-rich vegetables changes inflammatory markers and the balance of bacteria in the mouth for people with periodontitis (serious gum disease). It may help us understand better diet-based support alongside standard non-surgical gum treatment.
Guadalajara, JaliscoAges 30–65 - NCT07673185Recruiting
Omega-3 and low-dose aspirin for gum disease in smokers
This trial tests whether taking omega-3 supplements with low-dose aspirin can improve gum health in smokers with advanced gum disease (stage III periodontitis). It aims to see if this combination safely reduces gum pocket depth and tissue damage.
CairoAges 30–50 - NCT07711431Recruiting
Connection between gum disease and ongoing neck pain
This study looks at whether there is a link between gum (periodontal) disease and long-term neck pain without a clear cause. If you are between 30 and 55, have most of your own teeth, and don't take regular pain medicine, you may be able to help doctors understand this connection.
Niğde, Niğde ProvinceAges 30–55 - NCT07551115Recruiting
Oral Parasites and Gum Health Study
This study examines whether certain microscopic parasites in the mouth are linked to gum disease. Researchers will compare people with healthy gums to those with gum inflammation or disease to understand this connection better.
Bolu, GölköyAges 18 years+ - NCT06435208Recruiting
Gum cleaning for mental health in teeth grinders with gum disease
This study tests whether a deep gum cleaning procedure (subgingival instrumentation) can reduce stress and improve mental health in people who grind their teeth and have gum disease. It aims to see if treating the gums can also help with psychological distress.
Rohtak, HaryanaAges 30–50 - NCT07410351Recruiting
Periodontal risk self-assessment for Saudi adults
This trial is creating a simple online tool to help you assess your risk for gum disease. If you join, you will answer a questionnaire and have a quick gum check at the same visit.
Abhā, 'Asir RegionAges 18 years+ - NCT06753682Recruiting
Healthy plant-based diet and gum disease treatment for Chinese adults
This study tests whether eating more fresh vegetables and fruits can improve treatment outcomes for gum disease. You may qualify if you have gum disease, are Chinese, and currently eat fewer than the recommended daily servings of vegetables and fruits.
Hong KongAges 18–64 - NCT06890676Recruiting
Dental care in nursing homes to prevent infections and improve health
This study tests whether bringing dental care to nursing home residents can reduce mouth infections, pneumonia, and help control blood sugar in people with diabetes. If you live in a nursing home and are 60 or older, you may be able to join.
Jefferson City, MissouriAges 60–100 - NCT07579338Enrolling by invitation
Bacteria and Gum Health: A Detection Study
This study examines specific bacteria in your mouth to understand their role in healthy gums versus gum disease. Researchers will collect samples to measure bacterial levels and help improve how gum disease is diagnosed and treated.
Hillah, BabelAges 30 years+ - NCT06514664Enrolling by invitation
Do probiotic toothpastes help gums and teeth?
This trial tests whether using a probiotic toothpaste can improve gum health in people with gum disease (periodontitis). It may help reduce inflammation and slow bone loss.
KütahyaAges 18–99
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Common questions
- Are there clinical trials for periodontal diseases?
- Yes. Clin2 currently lists 108 recruiting periodontal diseases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontal diseases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontal diseases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.