Clinical trials
Placebo - Control clinical trials
Below are recruiting placebo - control clinical trials, each written for real people, not researchers. We’re tracking 3,962 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04442191RecruitingPhase 2
Convalescent plasma for hospitalized COVID-19 patients over 40
This trial tests whether donated “recovered patient” plasma (antibodies from people who had COVID-19) can improve outcomes for people hospitalized with COVID-19. It focuses on patients early in their illness who need a small amount of oxygen.
Chicago, IllinoisAges 40 years+ - NCT04447911RecruitingPhase 4
Empagliflozin for chronic low blood sodium in certain fluid states
This trial studies whether empagliflozin, a blood-sugar–related medicine, can safely improve chronic low blood sodium when you are not too “dry” or have an imbalanced fluid state. It may help stabilize sodium levels and related health symptoms, but you must meet specific blood and organ-function criteria.
WürzburgAges 18 years+ - NCT04449198RecruitingEarly Phase 1
Study for mitochondrial and blood-vessel issues in type 1 diabetes
This early study looks at how a new approach may affect energy-making (mitochondria) and blood-vessel signaling in people with insulin-dependent type 1 diabetes. It may help researchers understand whether these pathways can be improved in type 1 diabetes.
Augusta, GeorgiaAges 18 years+ - NCT04479072RecruitingPhase 4
Aspirin for preeclampsia during delivery
This trial tests whether taking aspirin during pregnancy around the time of delivery helps people with preeclampsia. You may be asked to take aspirin as part of a study plan, with monitoring to see how you do.
Chicago, IllinoisAges 18–45 - NCT04490720Recruiting
Buckwheat husk extract for heart risk factors
This trial studies whether buckwheat husk extract can improve certain heart-related measurements in people with mildly high blood pressure. It may help lower cardiovascular risk factors by affecting things like blood pressure.
TaipeiAges 20–65 - NCT04496895Recruiting
Orange peel drink study for reducing body fat
This trial looks at whether a fermented orange peel product can lower body fat in adults. It may help if you have higher body fat and/or fatty liver, and you meet safety and health limits.
Taipei, TaiwanAges 20–65 - NCT04500665RecruitingPhase 2
Colchicine for kidney-related heart inflammation
This Phase 2 trial tests whether colchicine can reduce inflammation and improve heart function in people with kidney disease and a certain type of heart problem. If you qualify, you’ll be closely monitored for side effects and lab changes.
Boston, MassachusettsAges 21–80 - NCT04500847RecruitingPhase 1
Testing repurposed HIV-like drugs for early Alzheimer’s symptoms
This Phase 1 study tests whether an existing type of anti-viral medicine (nucleoside reverse transcriptase inhibitors) can help people with early Alzheimer’s disease. It also focuses on safety and proper dosing while measuring brain-related changes and memory-related symptoms.
Los Angeles, CaliforniaAges 50–85 - NCT04513288Recruiting
Immunonutrition with L-citrulline for ICU sepsis patients
This trial tests whether adding L-citrulline to tube feeding (enteral nutrition) can improve outcomes for people in the ICU with sepsis or septic shock. It may help support the body’s immune response while you’re critically ill.
Rennes, Brittany RegionAges 18 years+ - NCT04516057RecruitingPhase 3
Tested medicine nabilone for agitation in Alzheimer’s dementia
This Phase 3 trial studies whether nabilone can reduce agitation (restlessness, anger, or difficult behavior) in people with Alzheimer’s dementia. It’s designed for older adults who already have agitation despite standard dementia care.
Calgary, AlbertaAges 55 years+ - NCT04520178RecruitingPhase 2/Phase 3
5HTP trial for long-term spinal cord injury
This trial tests whether 5HTP can help people with spinal cord injury caused by trauma at least 6 months ago. It is mainly designed to see if the treatment is safe and helpful over the study period.
Louisville, KentuckyAges 18–65 - NCT04528082RecruitingPhase 3
Apremilast for children with frequent mouth ulcers from Behçet’s disease
This study tests apremilast to help reduce active, recurring mouth (oral) ulcers in children with Behçet’s disease. It may help if your child has had repeated mouth ulcers despite at least one non-biologic treatment.
BronAges 2–17 - NCT04547439RecruitingPhase 2
Melatonin for diabetic eye disease and better sleep
This Phase 2 study tests whether melatonin can improve sleep and possibly outcomes related to diabetic retinopathy (damage to the retina from diabetes). It also checks whether it affects related symptoms while keeping people safe.
Chicago, IllinoisAges 40–65 - NCT04550377RecruitingPhase 2
Cannabidiol for PTSD, including PTSD after mild head injury
This Phase 2 study tests whether cannabidiol (CBD) can reduce PTSD symptoms, including in people who also had a mild traumatic brain injury (TBI). It’s meant to see if CBD is helpful and safe for PTSD symptoms over the study period.
New York, New YorkAges 18–70 - NCT04551482RecruitingPhase 2
Oxytocin to help teens lose weight
This study tests whether the hormone oxytocin can help adolescents with obesity lose weight. You may be asked to stay on your usual diet and routines during the 18-week study to see how well the treatment works.
Boston, MassachusettsAges 10–18 - NCT04565925RecruitingPhase 2
Sildenafil to reduce urine leaks after spinal cord injury
This trial studies whether sildenafil (a prescription pill) can lessen urinary incontinence in adults with spinal cord injuries. If it works, it may reduce the number of urine leakage episodes each week.
College Station, TexasAges 18–70 - NCT04566991RecruitingPhase 2
Deferoxamine after aneurysm brain bleed to improve recovery
This trial studies deferoxamine, a medicine that targets iron-related injury, in people with an aneurysmal subarachnoid hemorrhage (a brain bleed caused by a burst aneurysm). It aims to improve neurologic recovery after the aneurysm is treated.
Ann Arbor, MichiganAges 18–80 - NCT04570085RecruitingPhase 3
Caffeine treatment to improve thinking in Alzheimer’s disease
This trial tests whether changing caffeine intake can improve thinking and brain function in people with Alzheimer’s disease. You may qualify if you can follow a low-caffeine diet and have stable Alzheimer’s treatment and sleep/heart conditions.
AmiensAges 50 years+ - NCT04572256RecruitingEarly Phase 1
Montelukast after ACL surgery to protect knee cartilage
This early trial tests whether montelukast, a tablet used for allergies, can help protect knee cartilage after ACL surgery. It is specifically for people who have a meniscus injury along with their ACL tear.
Lexington, KentuckyAges 25–50 - NCT04576078RecruitingPhase 2
Nefopam for less pain after knee replacement surgery
This Phase 2 study tests whether oral nefopam can reduce pain after total knee replacement done with spinal anesthesia. It looks at whether this medicine works better than the usual post-surgery pain plan and how safely it can be used.
Lyon, LyonAges 18–75 - NCT04573673Recruiting
Tapping the shin nerve to help bladder control in MS
This study tests a noninvasive nerve stimulation applied to the lower leg to improve bladder emptying problems in people with multiple sclerosis. It may help reduce bladder dysfunction while you keep using clean intermittent self-catheterization.
LilleAges 18–65 - NCT04591990RecruitingPhase 3
Hydrocortisone and vasopressin for shock after cardiac arrest
This Phase 3 trial tests whether hydrocortisone plus vasopressin (or related hormone treatments) can improve shock in adults after a resuscitated cardiac arrest. It targets people who remain very low in blood pressure despite fluids and need strong IV medicines to maintain blood pressure.
AmiensAges 18 years+ - NCT04594018RecruitingPhase 3
Test a hair lotion for male pattern hair loss
This Phase 3 study tests whether a specific hair lotion works and is safe for men with male pattern hair loss. It also checks that results are consistent while you keep similar hair care and avoid certain other hair-loss treatments.
Osasco, São PauloAges 18–60 - NCT04601116RecruitingPhase 3
Atorvastatin for hormone-positive breast cancer to prevent recurrence
This Phase 3 study tests whether taking atorvastatin (a cholesterol-lowering medicine) can improve outcomes for women with estrogen-receptor–positive breast cancer. It may help by affecting cancer-related pathways and reducing risk of recurrence or progression.
AarhusAges 18 years+
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Common questions
- Are there clinical trials for placebo - control?
- Yes. Clin2 currently lists 3,962 recruiting placebo - control studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a placebo - control trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a placebo - control trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.