Clinical trials
Post Operative Pain clinical trials
Below are recruiting post operative pain clinical trials, each written for real people, not researchers. We’re tracking 186 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07227064RecruitingPhase 3
Methadone for pain relief after hip replacement surgery
This study tests whether a single dose of methadone given during hip replacement surgery can better control pain and reduce the need for other opioid painkillers afterward. It may help you recover with less pain and fewer side effects.
Charleston, South CarolinaAges 18–75 - NCT07185724RecruitingPhase 4
Ketorolac for fresh embryo transfer in IVF
This trial tests whether a medicine called ketorolac (a type of NSAID, similar to ibuprofen) can improve outcomes when you have a fresh embryo transfer during IVF. It may help reduce cramping or inflammation that could affect implantation.
Iowa City, IowaAges 18–37 - NCT07101250RecruitingPhase 4
Study of acetazolamide before laparoscopic hysterectomy
This trial tests a medication called acetazolamide given before surgery to see if it can help prevent shoulder pain after a laparoscopic hysterectomy. If you are a woman scheduled for this type of hysterectomy, you may be able to join.
Greenville, South CarolinaAges 21–65 - NCT06977009Recruiting
Does tooth grinding relief help with post-dental pain?
This study tests whether reducing a tooth's contact with its opposite tooth before root canal treatment can lower pain after the procedure. It's for people with a dead nerve in a back molar that needs a crown.
Amman, Amman GovernorateAges 18–70 - NCT06978179Recruiting
Nerve blocks for pain after lower belly surgery
This trial compares two types of nerve blocks (QL block vs TAP block) to see which one provides better pain relief after lower abdominal surgery. If you are having this surgery, you may be able to join and receive one of these blocks to help manage your pain.
SohagAges 18–65 - NCT06869967Recruiting
Pain Control After Ear Surgery (Mastoidectomy)
This study tests a pain-blocking injection to reduce pain after a specific type of ear surgery (mastoidectomy). It may help you feel less pain after your operation.
IstanbulAges 18 years+ - NCT05382962Recruiting
Using an app to help teens cope with post-surgery pain
This trial tests whether a phone app (iCanCope) can help teens better manage pain after surgery for scoliosis or certain chest conditions (pectus carinatum/excavatum). If you’re having one of these surgeries soon, the app may help with coping and day-to-day comfort after the operation.
Boston, MassachusettsAges 12–18 - NCT06206148Recruiting
Comparing ways to record pain after surgery
This study compares different methods of recording pain after surgery to see which is easiest and most accurate. If you have surgery and can use a smartphone or a button, you may be able to help.
San Francisco, CaliforniaAges 18 years+ - NCT06800209RecruitingPhase 2
Pain Reprocessing Therapy for ongoing knee pain after replacement
This study tests if Pain Reprocessing Therapy can help reduce knee pain that continues 3 months after a knee replacement. It uses a telehealth approach so you can participate from home.
Aurora, ColoradoAges 18 years+ - NCT06504277Recruiting
Lower gas pressure during surgery for shoulder pain reduction
This study compares two different gas pressures used during laparoscopic surgery to see if lower pressure reduces shoulder pain afterward. It may help if you're having surgery to remove an ovary, fallopian tube, or ovarian cyst.
Toronto, OntarioAges 18 years+ - NCT05973045Recruiting
Warm or cool fluid during hysteroscopy: comfort and safety
This study looks at whether the temperature of the fluid used during hysteroscopy affects image quality, risk of low blood sodium, and pain after the procedure. It may help find a safer, more comfortable way to do hysteroscopy for certain uterine growths.
IzmirAges 18–65 - NCT06469177Enrolling by invitation
Pain management app study for joint replacement recovery
This study tests a smartphone tool to help manage pain after hip, knee, or shoulder replacement. It aims to see if using the tool improves your recovery compared to standard care.
Dartmouth, Nova ScotiaAges 19 years+ - NCT06466941Recruiting
Understanding acute pain after surgery
This study surveys surgical patients about their pain and emotional experience to better understand acute pain. You may help by answering questions or sharing your story.
Boston, MassachusettsAges 18 years+ - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT06350981Enrolling by invitationPhase 2/Phase 3
Pain control after lower back fusion surgery
This study is comparing different ways to manage pain after a specific type of lower back fusion surgery called TLIF. The goal is to find the best pain control plan to make recovery more comfortable.
Tampa, FloridaAges 18 years+ - NCT06123715RecruitingPhase 2
Vitamin C to reduce pain after knee replacement
This study tests whether taking vitamin C before and after knee replacement surgery can reduce long-term pain. You may be eligible if you are having knee replacement for osteoarthritis and are generally healthy.
Toronto, OntarioAges 18 years+ - NCT05953766RecruitingPhase 2
Nerve block versus sham block after hysterectomy
This trial compares a targeted pain-relief injection near the lower back (a “nerve block”) to a sham (placebo-like) procedure during recovery from a total laparoscopic hysterectomy. It aims to see whether the real block reduces post-operative pain.
Toronto, OntarioAges 18 years+ - NCT05146778Recruiting
Opioid-free anesthesia to reduce long-term post-mastectomy pain
This study tests whether a pain-control approach without opioids (strong pain medicines) can lower persistent pain after mastectomy. It may help people avoid long-term pain and opioid side effects.
SeoulAges 19–80 - NCT05920382Recruiting
Radiofrequency treatment for long-term knee pain after knee surgery
This trial studies whether a radiofrequency procedure can reduce chronic knee pain after knee replacement surgery. It may help people who still have bothersome pain between 6 months and 5 years after their operation, as long as their pain pattern and medications are stable.
Barcelona, CataloniaAges 18 years+ - NCT05278494Recruiting
Dextromethorphan to reduce pain after knee replacement
This trial studies whether dextromethorphan (a medicine sometimes used for cough) can reduce pain after total knee replacement surgery. If you’re having this operation and meet safety criteria, it may help improve how you feel during recovery.
Los Angeles, CaliforniaAges 18 years+ - NCT05131178Recruiting
Study for pain control after C-section
This trial looks at how to reduce pain after a C-section (cesarean delivery). You may be able to join if you’re having a scheduled or urgent C-section and can use the planned pain-control method.
Aurora, ColoradoAges 18–50 - NCT04371445RecruitingPhase 4
Dextenza drops after eye surgery to reduce post-op pain
This trial studies whether Dextenza (a steroid pain-relief eye insert) can improve comfort after a specific type of retina surgery (pars plana vitrectomy). It looks at people getting surgery for conditions like macular hole, epiretinal membrane, or vitreomacular traction.
Cleveland, OhioAges 18 years+ - NCT02083835Recruiting
Study to improve pain after surgery using patient questionnaires
This trial studies how to better understand and improve pain after surgery by asking patients to complete short questionnaires. It may help hospitals find ways to reduce postoperative pain and better track recovery.
JenaAges 4 years+ - NCT07801586Recruiting
Pain education with pre-surgery physical therapy for spine surgery recovery
This study tests whether adding pain neuroscience education to standard physical therapy before spinal surgery helps reduce pain and disability after surgery. This could help you recover better by understanding how pain works and learning coping strategies before your operation.
IslamabadAges 35–60
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Common questions
- Are there clinical trials for post operative pain?
- Yes. Clin2 currently lists 186 recruiting post operative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a post operative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a post operative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.