Clinical trials
Posttraumatic Stress Disorder (PTSD) clinical trials
Below are recruiting posttraumatic stress disorder (ptsd) clinical trials, each written for real people, not researchers. We’re tracking 95 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06989957RecruitingPhase 1
Psilocybin and MDMA therapy for PTSD in veterans
This study tests whether a combination of two investigational drugs, psilocybin and MDMA, can help veterans with post-traumatic stress disorder (PTSD). You would receive the drugs in a controlled setting and be monitored closely.
Baltimore, MarylandAges 21 years+ - NCT06968832Recruiting
Prolonged therapy for PTSD and substance use
This trial tests a therapy that helps people with both post-traumatic stress disorder (PTSD) and a substance use disorder (SUD). You'll receive extended therapy sessions to reduce PTSD symptoms and support your recovery from substance use, while continuing your current substance use treatment.
Jacksonville, FloridaAges 18 years+ - NCT06954025Enrolling by invitationPhase 2
MDMA therapy for PTSD inpatients
This trial tests whether high-dose MDMA, given during intensive inpatient therapy, can help people with PTSD that hasn't improved with other treatments. It takes place at a specialized trauma center and involves several therapy sessions with the drug.
OegstgeestAges 18 years+ - NCT06947538Recruiting
Stepped care for PTSD: a study at Boston Medical Center
This study tests a step-by-step approach to treat posttraumatic stress disorder (PTSD). It aims to help you feel better by offering different treatment options based on your needs.
Boston, MassachusettsAges 18 years+ - NCT06937892Recruiting
Metacognitive therapy vs. Cognitive therapy for anxiety
This study compares two different types of therapy for anxiety disorders: metacognitive therapy (which focuses on how you think about your thoughts) versus cognitive-behavioral therapy (which works on changing thoughts and behaviors). It may help you find which approach works best for you.
StockholmAges 18 years+ - NCT06923423Recruiting
Cognitive processing therapy for drug use and trauma in prison
This study tests if a type of therapy called cognitive processing therapy (CPT) can help people in prison who have both a drug use problem and trauma-related stress. If you qualify, you would receive CPT and be compared to those getting usual care.
Little Rock, ArkansasAges 18 years+ - NCT06820138RecruitingPhase 2
Focused ultrasound treatment for PTSD in veterans
This study tests a non-invasive treatment called focused ultrasound for veterans with PTSD. Focused ultrasound uses sound waves to target specific brain areas without surgery. It aims to reduce PTSD symptoms like distress and anxiety.
Providence, Rhode IslandAges 22–70 - NCT06804525Recruiting
Adapting a mental health survey in Hong Kong
This study adapts a mental health survey for Hong Kong adults. It is open to adults aged 25 and older who live in randomly selected households and can speak Chinese or English.
Hong KongAges 25 years+ - NCT03642028RecruitingPhase 4
Sleep medicine study for PTSD-related sleep problems
This trial tests suvorexant, a sleep medicine, to help improve sleep disturbance in people with PTSD. It’s designed for adults who have had PTSD symptoms for at least a few months and also have insomnia.
Long Beach, CaliforniaAges 18–75 - NCT05701111Recruiting
School-based treatment for teens with trauma symptoms
This study tests a school-based approach to help teens who have experienced trauma and now have post-trauma symptoms. It also collects emotional and physical (biologic) information to understand how treatment may help.
Palo Alto, CaliforniaAges 11–17 - NCT06788678Recruiting
Web-based moral elevation for veterans with PTSD
This trial tests a website designed to help veterans with PTSD feel inspired by stories of others' good deeds, which may reduce PTSD symptoms. You would complete sessions online and answer questions about your experiences.
Temple, TexasAges 18 years+ - NCT05837845RecruitingPhase 2
MDMA plus therapy versus therapy alone for severe PTSD
This Phase 2 study compares MDMA-assisted Cognitive Processing Therapy (a structured talk-therapy) to Cognitive Processing Therapy alone for Veterans with severe PTSD. It aims to see whether adding MDMA helps reduce PTSD symptoms and improve recovery.
Palo Alto, CaliforniaAges 18 years+ - NCT06740487Recruiting
AR therapy for PTSD in military members
This study tests a new therapy using augmented reality (a type of headset that adds digital images to what you see) to help treat posttraumatic stress disorder (PTSD) in current or former military members. The therapy aims to make exposure therapy more effective by letting you face trauma-related situations in a controlled, virtual way.
Charleston, South CarolinaAges 18 years+ - NCT06746818Enrolling by invitation
Building resilience in older adults with PTSD
This trial tests if a HeartMath-based program can help older adults improve resilience, reduce posttraumatic stress, and boost spiritual and psychosocial well-being. It may be an option if you are 60 or older and have experienced trauma.
Al MansurahAges 60 years+ - NCT06670079Recruiting
Prolonged exposure therapy for PTSD in pregnant patients
This trial tests if prolonged exposure therapy, a type of talk therapy for PTSD, is safe and helpful for pregnant people. If you have PTSD and are early in your pregnancy, this treatment may help you process trauma and feel better.
Burlington, VermontAges 18 years+ - NCT06641115Recruiting
Integrated treatment for opioid use disorder and PTSD
This study tests a combined therapy for people with both opioid use disorder and PTSD. It aims to help you manage both conditions together, rather than treating them separately.
Charleston, South CarolinaAges 18–70 - NCT06629064Recruiting
Memory training for PTSD symptoms
This study tests a computer-based memory training program for people with PTSD. It aims to see if this training can help reduce PTSD symptoms by improving how your brain processes memories. The study involves 8 remote sessions over 4 weeks and two MRI scans to look at brain changes.
San Diego, CaliforniaAges 18–65 - NCT06630884RecruitingPhase 1
Immune response to trauma and fear
This study looks at how the body's immune and stress systems work together in people who have experienced trauma, by giving a harmless vaccine to temporarily boost inflammation. It may help explain why some people develop PTSD and others don't, which could lead to better treatments.
San Francisco, CaliforniaAges 18–65 - NCT06608277RecruitingPhase 2
Ketamine and nerve block for headache or PTSD after brain injury
This study tests if ketamine infusions or a stellate ganglion block (a numbing injection near the neck) can help people with long-term headaches or PTSD after a traumatic brain injury. It compares these treatments alone and together.
Chicago, IllinoisAges 18 years+ - NCT06573970RecruitingPhase 4
Atomoxetine for PTSD and executive function in veterans
This trial tests if the medication atomoxetine can improve thinking and memory in veterans with PTSD and attention difficulties. It may help those who have not responded fully to other treatments.
Charleston, South CarolinaAges 18–75 - NCT05895006Recruiting
Study brain responses in PTSD using stimulation and brain scans
This study looks at how anxiety and stress show up in the brain in people with PTSD, using brain stimulation and brain scanning. If you’re eligible, it may help researchers understand your symptoms and how they relate to brain activity.
Houston, TexasAges 18–50 - NCT06434766Recruiting
Brain stimulation for PTSD treatment study
This study tests a noninvasive brain stimulation method called iTBS to see if it can help people with post-traumatic stress disorder (PTSD). You would receive the treatment and be monitored for changes in your symptoms.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06418178RecruitingPhase 2
Optimizing MDMA therapy dose for PTSD in veterans
This trial tests different doses of MDMA (a drug sometimes called 'ecstasy') combined with therapy to see which dose works best for treating PTSD in veterans. The goal is to find a safer, more effective dose to help reduce PTSD symptoms.
The Bronx, New YorkAges 18 years+ - NCT06412757RecruitingPhase 3
Silexan for PTSD: A new treatment option
This trial tests a natural treatment called Silexan (an extract from lavender) to see if it helps reduce PTSD symptoms. It might be an option if standard treatments haven't worked or you prefer a non-medication approach.
Carlton, VictoriaAges 18 years+
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Common questions
- Are there clinical trials for posttraumatic stress disorder (ptsd)?
- Yes. Clin2 currently lists 95 recruiting posttraumatic stress disorder (ptsd) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a posttraumatic stress disorder (ptsd) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a posttraumatic stress disorder (ptsd) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.