Clinical trials
Posttraumatic Stress Disorder clinical trials
Below are recruiting posttraumatic stress disorder clinical trials, each written for real people, not researchers. We’re tracking 106 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04529031Recruiting
Study of reminder-based positive thinking for teens with PTSD
This study looks at whether a “reminder-focused positive thinking” approach can help teens with PTSD. It may benefit you by testing how certain cues and supportive thoughts affect PTSD symptoms and related wellbeing.
Los Angeles, CaliforniaAges 11–15 - NCT04672551Recruiting
EMDR therapy for PTSD after a heart attack
This trial studies whether EMDR (a structured therapy that helps process distressing memories) can reduce PTSD symptoms in people who developed PTSD after a cardiac event. It may help you feel less overwhelmed by memories and stress related to the heart event.
ZurichAges 18–70 - NCT04877093RecruitingPhase 3
Low-dose clonidine for PTSD nightmares in veterans
This Phase 3 study tests whether low-dose clonidine can reduce PTSD symptoms and especially nightmares in U.S. veterans. You’d be screened for PTSD severity and current treatments, then asked to visit the clinic as scheduled to see if the treatment helps.
Wauwatosa, WisconsinAges 18 years+ - NCT04887116RecruitingEarly Phase 1
Virtual reality sessions to treat PTSD in healthcare workers
This early-phase study tests whether guided virtual reality experiences can reduce symptoms of PTSD (post-traumatic stress disorder) or near-PTSD in healthcare workers. It may help people who have stress reactions related to work during the COVID-19 era.
New York, New YorkAges 18 years+ - NCT04959695Recruiting
PE Coach app for veterans with PTSD therapy
This study tests whether a mobile app called “PE Coach” can support PTSD treatment (Prolonged Exposure therapy) for veterans. It may help you stay engaged with therapy sessions done in-person or by video/telehealth using a phone or tablet.
Seattle, WashingtonAges 18–65 - NCT05086757Recruiting
Trauma counseling for teens after injury
This study tests a trauma-center program to help teens cope after a serious injury. It may help with upsetting memories and distress after the incident.
Charleston, South CarolinaAges 12–17 - NCT05133804RecruitingPhase 2
Testing two medications for PTSD attention and emotions
This Phase 2 study tests whether reboxetine or methylphenidate can improve attention and emotional or sensory problems in adults with post-traumatic stress disorder (PTSD). You may be eligible if you have a confirmed PTSD diagnosis and are able to meet medication and safety requirements.
AfulaAges 20–60 - NCT05267665Recruiting
Family-involved PTSD therapy coaching for Veterans
This study tests a brief way to include a Veteran’s family member to improve PTSD treatment results and help people stay engaged in care. It’s for Veterans who are just starting evidence-based PTSD therapy and have a closely involved family member who can participate too.
Boston, MassachusettsAges 18 years+ - NCT05497115Recruiting
Care model to improve access to mental health after trauma
This trial tests a practical care plan to help people get mental health support after a traumatic injury, especially if screening suggests risk for PTSD or depression. It may help you connect faster to the right kind of treatment after your injury.
Washington, VirginiaAges 16 years+ - NCT05624931Recruiting
Helping pregnant women stay on PrEP after starting it
This study tries to reduce the psychological barriers that make it hard for pregnant or postpartum women to keep taking PrEP. It may help by offering support tailored to stress, trauma symptoms, or depression—especially soon after PrEP is started.
Boston, MassachusettsAges 15 years+ - NCT05700201Recruiting
Study of heart health in adults with trauma symptoms
This study looks at how trauma-related symptoms (like PTSD symptoms) may affect heart health. You may be asked to do light activity—so your study team can see how your body responds.
Fort Lauderdale, FloridaAges 18 years+ - NCT05737693RecruitingPhase 2
Ketamine plus weekly therapy for severe PTSD
This study tests whether adding ketamine to a structured, one-week psychological therapy program can reduce severe PTSD symptoms. It may help people who have had PTSD for a long time and still feel very affected.
New Haven, ConnecticutAges 21–70 - NCT05776056RecruitingPhase 4
Methylphenidate for PTSD and thinking problems in Veterans
This study tests whether methylphenidate (a stimulant medicine) can improve PTSD symptoms and help with memory or thinking problems people report. It may help Veterans who have both PTSD and recent cognitive difficulties.
Birmingham, AlabamaAges 18–65 - NCT05837845RecruitingPhase 2
MDMA plus therapy versus therapy alone for severe PTSD
This Phase 2 study compares MDMA-assisted Cognitive Processing Therapy (a structured talk-therapy) to Cognitive Processing Therapy alone for Veterans with severe PTSD. It aims to see whether adding MDMA helps reduce PTSD symptoms and improve recovery.
Palo Alto, CaliforniaAges 18 years+ - NCT06047691Recruiting
Couples therapy for PTSD in military couples
This study tests whether intensive couples therapy helps military couples dealing with PTSD, compared to a relationship education class. If you are a service member or veteran with PTSD and your partner is willing to join, this trial might offer a way to improve your relationship and PTSD symptoms together.
San Antonio, TexasAges 18 years+ - NCT06094933Recruiting
Mobile anger reduction app for veterans with PTSD
This trial tests a mobile app designed to help veterans with PTSD reduce anger. If you have PTSD and struggle with anger, you may be able to join and use the app to see if it helps.
Durham, North CarolinaAges Any age - NCT06127342Recruiting
Exercise and emotional learning for PTSD
This study tests whether exercise can help people with PTSD learn to feel safer in their bodies. You will do some exercise sessions and emotional learning tasks, and have an MRI brain scan to see how your brain changes.
Lexington, KentuckyAges 18–64 - NCT06185244Recruiting
Online trauma therapy for teens with PTSD
This study tests an online therapy for teenagers with PTSD. It's a type of talk therapy that helps you deal with trauma, and you and your parent take part from home.
StockholmAges 13–17 - NCT06193161Recruiting
Prolonged Exposure Therapy for PTSD in Immigrants
This trial tests prolonged exposure therapy for immigrants in Sweden who have PTSD. You will receive this online therapy to see if it helps reduce trauma symptoms.
SolnaAges 18 years+ - NCT06210711Recruiting
Prolonged exposure therapy for trauma injury patients
This study tests if prolonged exposure therapy can help people who were injured in a trauma and admitted to a Level I trauma center. It aims to reduce the psychological impact of the traumatic event, such as PTSD symptoms.
Dallas, TexasAges 18–75 - NCT06219408Recruiting
Stepped care for chronic pain and PTSD
This study tests a stepped-care program that combines complementary health approaches for people who have both chronic pain and PTSD. It aims to help patients manage both conditions together using treatments like acupuncture, massage, or mind-body therapy.
Seattle, WashingtonAges 18 years+ - NCT06234969Recruiting
Brain stimulation for PTSD: a learning study
This study tests whether a non-invasive brain stimulation technique called cTBS can help people with PTSD learn to overcome fear. You will have brain scans and receive stimulation to see if it improves how your brain processes fear-related memories.
Philadelphia, PennsylvaniaAges 18–60 - NCT06348472Recruiting
Biomarkers and PTSD psychotherapy response
This study is looking at whether certain biomarkers in your blood (related to inflammation and the oxytocin system) can predict how well you respond to trauma-focused psychotherapy. It may help find better ways to personalize PTSD treatment.
Hod HaSharonAges 18–80 - NCT06363968Recruiting
Eye tests to predict PTSD treatment response in veterans
This study looks at whether certain eye tests can help predict how well PTSD treatments work. It's for veterans with PTSD who are not taking certain medications and have no serious eye or health conditions.
Seattle, WashingtonAges 21–75
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Common questions
- Are there clinical trials for posttraumatic stress disorder?
- Yes. Clin2 currently lists 106 recruiting posttraumatic stress disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a posttraumatic stress disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a posttraumatic stress disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.