Preterm clinical trials

Pacifier use and feeding in preterm babies

This trial looks at how using a pacifier helps premature babies learn to feed better. If your baby is stable, starting feedings for the first time, and can use a pacifier safely, they may be eligible.

Brain Injury & Vision Screening in Newborns

This study looks for early signs of vision problems in babies who had brain injuries around the time of birth. It aims to help doctors better identify and predict these issues.

Can supplements prevent early birth for short cervix?

This study tests if taking a combination of magnesium, a natural supplement (palmitoylethanolamide), hyaluronic acid, and vitamins B6 and D can help prevent preterm birth in women with a shorter-than-ideal cervix.

AI to help doctors predict preterm birth

This trial tests whether artificial intelligence (AI) helps doctors feel more confident when predicting preterm birth. You would use ultrasound images and get AI feedback to compare with standard care.

Nutrition plan for very early preterm infants

This study tests a special nutrition plan for babies born before 32 weeks of pregnancy. The goal is to find the best way to feed these tiny newborns to help them grow and develop.

Family care for preterm babies in the hospital

This trial tests whether a program that brings parents into the daily care of their preterm or low-birth-weight baby can help the baby recover faster and go home sooner. If you can spend up to 8 hours a day at the hospital, this study may be a good fit.

Study brain “habituation” in preterm and full-term babies

This study looks at how babies’ brains get used to repeated sights or sounds (habituation) in both preterm and full-term infants. It may help researchers understand early brain development differences and improve care for newborns.

Ultrasound checks of cervical length after prior preterm birth

This study uses a vaginal ultrasound to measure cervical length in people who previously had a spontaneous preterm birth. It aims to understand who may be at higher risk, so screening and next steps can be better planned in future pregnancies.

PPROM pregnancy registry for women under 37 weeks

This registry is collecting information from pregnant people diagnosed with preterm premature rupture of membranes (PPROM) before 37 weeks. It may help researchers better understand PPROM and improve care for future patients.

Testing a treatment from donor breast milk for early preterm babies

This trial studies a treatment made from special particles in donor breast milk, given to very early-born babies who are at risk of a serious gut infection called NEC. It aims to see if these particles can help protect their intestines.

Xylitol gum to prevent gum disease and early birth

This trial tests if chewing xylitol gum during pregnancy can reduce gum disease and preterm birth. You would chew gum after meals and attend dental visits and follow-ups.

Safe bathing methods for moderately premature babies

This study tests a gentle swaddled bathing technique for babies born at 32–37 weeks of pregnancy. Researchers will measure whether this method keeps babies physically stable and comfortable during their first bath.

How Caffeine Moves Through Pregnancy and to the Baby

This study looks at how caffeine is absorbed and transferred to a baby during pregnancy in women at risk of early delivery. Researchers hope to understand safe caffeine use in this situation and potentially help prevent complications.

AI prediction of early birth using cervical ultrasound images

This study uses artificial intelligence to analyze cervical ultrasound images taken during pregnancy to predict whether a baby might be born early. The goal is to help doctors identify pregnancies at higher risk so they can plan better care.

Support for first-time dads of preterm babies

This study tests a support program for first-time fathers whose preterm babies are in the hospital for more than a week. It aims to help fathers cope and be more involved during this stressful time.

Skin-to-skin Care Using the Skincubator: Feasibility and Safety Trial

Surfactant Delivery Methods for Premature Babies with Breathing Problems

This study looks at different ways doctors give a life-saving medication called surfactant to premature babies who are struggling to breathe. Researchers want to understand which delivery methods work best and help improve care.

Ventilator Pressure Levels During Surfactant Therapy in Preterm Infants

This study tests whether different pressure levels used during a minimally invasive surfactant procedure (MIST)—a way to deliver lung-coating medicine without a breathing tube—affect how well preterm infants' lungs inflate. Researchers hope to find the best pressure settings to help babies breathe more easily.

Testing music to improve breathing and brain oxygen in preemies

This study looks at whether planned music sessions can help preterm babies breathe more steadily and improve oxygen reaching the brain. It may help staff learn how to use music therapy safely for newborns in the NICU.

Prenatal education on environmental exposures

This study provides education about everyday environmental exposures during pregnancy. It aims to help women make safer choices for their health and their baby's health.

Comparing surfactant delivery methods for preterm infants

This trial compares two ways to give surfactant (a substance that helps preterm babies' lungs work better) to preterm infants who need breathing support. It studies whether a small tube placed through the throat or a thin catheter works better for delivering the medication.

Chloride imbalance in preterm babies

This study looks at chloride levels in preterm babies admitted to the neonatal intensive care unit (NICU) within their first day of life. It aims to understand chloride imbalance and how it might affect their health.

Testing a new surfactant for breathing problems in premature babies

This study tests a new medicine called APC-0101, a type of surfactant, for premature babies with breathing problems (respiratory distress syndrome). It may help their lungs work better and reduce the need for more breathing support.

How very premature babies learn to eat by mouth

This study looks at how very premature babies (born at 28 weeks or earlier) learn to eat by mouth and whether they develop any feeding or mouth problems later. Researchers will review medical records from past years to see what helped or hindered their progress.