Clinical trials
Progressive Aphasia clinical trials
Below are recruiting progressive aphasia clinical trials, each written for real people, not researchers. We’re tracking 31 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03313011Recruiting
Study brain patterns in progressive apraxia of speech
This study looks at brain changes in two types of progressive apraxia of speech, a condition that slowly worsens speech clarity. It may help researchers better understand the brain basis of your speech symptoms and how these types differ.
Rochester, MinnesotaAges 18 years+ - NCT05386394RecruitingPhase 2
Brain stimulation to help primary progressive aphasia speech
This trial tests a non-painful brain stimulation method to improve language and speech problems caused by primary progressive aphasia. It may help some people communicate more clearly by targeting specific brain regions.
Baltimore, MarylandAges 50–90 - NCT06511752RecruitingEarly Phase 1
Support group for Spanish/English speakers with progressive aphasia
This trial tests a support group program for people with progressive aphasia (a language disorder that gets worse over time) and their caregivers. The groups meet online to share experiences and learn together.
Austin, TexasAges 18 years+ - NCT07219680Recruiting
Communication quality of life in primary progressive aphasia
This trial tests a therapy to improve communication for people with primary progressive aphasia (PPA), a condition that slowly affects language. You and a care partner will attend video sessions to work on communication goals together.
Austin, TexasAges 40 years+ - NCT07260253Recruiting
Remote brain stimulation for language in primary progressive aphasia
This study tests if a non-invasive brain stimulation technique called tDCS, done at home with remote supervision, can help improve language skills in people with the logopenic variant of primary progressive aphasia (PPA).
San Francisco, CaliforniaAges 40 years+ - NCT06649084Enrolling by invitation
Language treatment study for primary progressive aphasia
This study tests a multi-component language treatment for people with primary progressive aphasia (a type of dementia that first affects language). It aims to help improve communication skills with support from a study partner.
Austin, TexasAges Any age - NCT03887481Recruiting
Brain stimulation study for a language-loss dementia subtype
This trial tests whether a painless form of brain stimulation can improve language and thinking skills in people with the logopenic variant of primary progressive aphasia (a dementia that affects language). You may receive brain stimulation along with repeated clinic visits to track changes over time.
Baltimore, MarylandAges 50–80 - NCT04920318Recruiting
Study to improve language in primary progressive aphasia
This trial looks at ways to improve language abilities in people with primary progressive aphasia (a long-term brain condition that affects speech and language). It may help if your communication problems come from this condition and you can safely take part in the study activities, which likely involve language practice and MRI scanning.
Tucson, ArizonaAges 45–80 - NCT05741853Recruiting
Speech therapy study for bilingual people with primary progressive aphasia
This study looks at how well speech-language therapy works in bilingual people with primary progressive aphasia, a condition that gradually affects language. It also tests whether different language skills (Spanish/Catalan or Spanish/English) affect response to treatment.
Austin, TexasAges 40 years+ - NCT06066710RecruitingEarly Phase 1
Propranolol for Primary Progressive Aphasia
This trial tests whether the drug propranolol, often used for high blood pressure, can help people with primary progressive aphasia (a condition that slowly affects language skills). You would take the drug and have MRI brain scans to see if it slows language decline.
Columbia, MissouriAges 50 years+ - NCT06473714Recruiting
Brain stimulation for language in progressive aphasia
This trial tests a gentle, non-invasive brain stimulation called tDCS to see if it can help improve language control in people with primary progressive aphasia. It is done in a hospital in Nice, France.
NiceAges 18 years+ - NCT00537004Recruiting
Study of language in primary progressive aphasia
This study looks at how language changes in people with primary progressive aphasia. It may help researchers better understand the condition and how it affects speech and communication over time.
Chicago, IllinoisAges Any age - NCT01818661RecruitingPhase 4
Imaging study for progressive apraxia of speech
This trial uses repeated brain scans to study how progressive apraxia of speech changes over time. It may help doctors better understand the condition and improve future tracking and care.
Rochester, MinnesotaAges 18 years+ - NCT06921265Enrolling by invitation
Magnetic brain stimulation for language in primary progressive aphasia
This study tests whether targeted magnetic stimulation to the brain can help improve language and speech in people with primary progressive aphasia. It compares the effects of real stimulation versus a placebo to see if it is a safe and useful treatment.
Milan, MilanoAges 40–85 - NCT05901233Enrolling by invitation
Remote brain stimulation and speech therapy for primary progressive aphasia
This study tests whether combining speech-language treatment with remotely supervised brain stimulation (a mild current to the scalp) can improve communication in people with primary progressive aphasia. You and a study partner would also join online training and regular video check-ins.
San Francisco, CaliforniaAges Any age - NCT04957537Recruiting
Speech and meaning therapy for primary progressive semantic aphasia
This study tests a “semantic rehabilitation” program—therapy focused on improving word meaning and understanding—for people with primary progressive semantic aphasia. If you qualify, it may help slow or improve language difficulties and daily communication.
ToulouseAges 18–100 - NCT04363684Recruiting
Study of frontotemporal dementia and related syndromes over time
This study follows people with frontotemporal dementia (FTLD) and related conditions, and collects health and (for some people) body fluid information, to understand how these illnesses change over time. It may help researchers track disease signs and find better ways to measure progression.
Birmingham, AlabamaAges 18 years+ - NCT05730023Recruiting
Testing a new approach for primary progressive aphasia diagnosis
This study focuses on people with primary progressive aphasia (PPA), a condition that affects language over time. It tests a “multimodal” set of assessments and treatment planning, which may help your care team diagnose and support you more accurately.
Brescia, BSAges 40 years+ - NCT05443633Recruiting
Brain and speech training for people with aphasia
This study looks at ways to improve language (speaking and understanding) for people with aphasia caused by stroke or dementia, using MRI to study brain function. It may help by testing language-focused approaches and how brain activity changes during treatment.
Tucson, ArizonaAges 21–80 - NCT03174938Recruiting
BioFINDER 2 study for healthy aging and memory problems
This study uses brain scans and a spinal fluid test to better understand memory and thinking changes in different groups, from people with healthy thinking to early or established dementia. If you qualify, it may help researchers learn what’s driving these conditions and how they progress.
ÄngelholmAges 20–100 - NCT07567664Enrolling by invitation
Brain Changes in Neurodegenerative Diseases: A Tracking Study
This research study tracks how brain damage progresses in rare neurodegenerative diseases like frontotemporal dementia, primary progressive aphasia, PSP, CBS, and ALS. Researchers use brain imaging and tests to understand how these diseases spread in the brain, which could help develop better treatments.
Milan, LombardyAges 20–85 - NCT06529744Recruiting
Using blood tests to better diagnose early dementia
This study is testing whether simple blood tests can help doctors better understand the type and progression of memory or thinking problems in people with early dementia. It aims to improve confidence in the diagnosis and future outlook.
North York, OntarioAges 30–95 - NCT04715399Recruiting
Research study collecting data for neurodegenerative diseases
This study collects health information from people with neurodegenerative diseases, some family members, and healthy controls to help researchers better understand these conditions. It may help future diagnosis and research, and participation may include noninvasive checks and other procedures depending on your situation.
Philadelphia, PennsylvaniaAges 18 years+ - NCT02740634Recruiting
Brain imaging study for Alzheimer's disease
This study uses brain scans to understand Alzheimer's disease and related conditions that affect memory, language, or vision. It looks at how changes in the brain happen over time in people with these diagnoses.
Rochester, MinnesotaAges 21–80
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Progressive Aphasia trials by city
Studies with a site in or near these metro areas.
Progressive Aphasia trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for progressive aphasia?
- Yes. Clin2 currently lists 31 recruiting progressive aphasia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a progressive aphasia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a progressive aphasia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.