Clinical trials
Safety and Effectiveness clinical trials
Below are recruiting safety and effectiveness clinical trials, each written for real people, not researchers. We’re tracking 397 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06408259RecruitingPhase 3
Comparing ozanimod and fingolimod for children with MS
This study compares two oral medications, ozanimod and fingolimod, to see which one works better and is safer for children and teenagers with relapsing-remitting MS. Both drugs help reduce MS attacks and slow down the disease.
Loma Linda, CaliforniaAges 10–17 - NCT06425224RecruitingPhase 3
TENS therapy for premature ejaculation
This trial tests if a painless electrical nerve stimulation (TENS) treatment can help men with premature ejaculation last longer and feel more in control. It's for men who have had this condition for at least 6 months and are in a stable relationship.
Mexico CityAges 18–62 - NCT06441110RecruitingPhase 3
BCG instillation for medium- to high-risk bladder cancer
This trial tests whether a specific schedule of BCG (a weakened germ that boosts the immune system) placed directly into the bladder is safe and effective for medium- to high-risk bladder cancer that hasn't grown into the muscle. It aims to see if adjusting the standard BCG course can work better for people with a PD-L1-positive tumor.
Fuzhou, FujianAges 18–75 - NCT06455098Recruiting
Pulsed field ablation for paroxysmal atrial fibrillation
This study tests a new procedure called pulsed field ablation using a special catheter to treat paroxysmal atrial fibrillation (AF), a type of heart rhythm problem that comes and goes. It may be an option for people whose AF hasn't been controlled well with medication.
Phoenix, ArizonaAges 18–80 - NCT06485206Recruiting
Hybrid disc replacement and fusion for two-level neck disease
This study tests a combination of a disc replacement (Mobi-C) and a spinal fusion (ACDF) for people with degenerative disc disease at two levels in the neck. The goal is to see if this approach is safe and effective for relieving pain and nerve symptoms.
Sacramento, CaliforniaAges 22–69 - NCT06492798RecruitingPhase 1/Phase 2
Stem cells for Long COVID: a safety and effectiveness study
This study tests whether a single infusion of mesenchymal stem cells can help with Long COVID symptoms—without causing serious side effects. It’s for people who are still struggling with COVID-related health problems months after their initial infection.
ShanghaiAges 18–70 - NCT06499363Recruiting
Treprostinil for pulmonary hypertension in newborns
This study collects information on how well a medicine called treprostinil works and how safe it is for newborn babies with pulmonary hypertension (high blood pressure in the lungs). It is for babies who have already received this treatment as part of their regular care.
BronAges Up to 10 months - NCT06501872Recruiting
Custom stent-graft for large chest and belly aneurysms
This study tests a special stent-graft, custom-shaped by your doctor to fit your aneurysm while keeping blood flow to important organs like your kidneys and stomach. It's for people with large aneurysms in the chest and belly who cannot safely have open surgery.
Lebanon, New HampshireAges 50–95 - NCT06519149Recruiting
Device for sleep apnea without CPAP
This trial tests a device placed in your mouth during sleep to treat obstructive sleep apnea. It may be an option if you cannot or do not want to use a CPAP machine.
Austin, TexasAges 18 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Phoenix, ArizonaAges 18 years+ - NCT06541847RecruitingPhase 2
Testing HLX-1502 for NF1 with Plexiform Neurofibromas
This trial tests an experimental drug called HLX-1502 for people with NF1 who have a plexiform neurofibroma (a type of nerve tumor) that is growing or causing problems. It aims to see if the drug is safe and can shrink or stop the tumor from worsening.
Birmingham, AlabamaAges 12 years+ - NCT06543758RecruitingPhase 4
Gait rehab with a wearable robot at home
This trial tests whether using a wearable robotic device at home can improve walking ability in people who have had a stroke. If you have trouble walking due to a stroke, this study may help you regain strength and mobility.
Yongin-si, Gyeonggi-doAges 19–79 - NCT06559475Recruiting
Testing a new aspiration catheter for large vessel stroke
This trial tests a new catheter (Super-Bore 8/7F) to remove blood clots in people having a major stroke caused by a blocked large artery in the brain. The goal is to see if it is safe and effective at restoring blood flow when used within 24 hours of stroke symptoms starting.
Hefei, AnhuiAges 18 years+ - NCT06562270Recruiting
Adolescent Alopecia Areata Drug Safety Registry
This registry follows teenagers (ages 12–17) with severe alopecia areata who are starting a new prescription medicine. The goal is to track safety and how well the medicines work in the real world.
Waltham, MassachusettsAges 12–17 - NCT06567522RecruitingPhase 4
Nerve block vs. no block for hip surgery pain
This trial compares a lumbar erector spinae plane block (L-ESPB), a type of nerve numbing injection, to not using any block for managing pain after hip surgery. The goal is to see which approach works better and is safer.
Vigo, PontevedraAges 18 years+ - NCT06575426RecruitingPhase 1/Phase 2
Testing pig pancreas cells for type 1 diabetes
This trial tests a treatment made from pig pancreas cells (OPF-310) to see if it's safe and can help people with unstable type 1 diabetes. The cells are meant to replace the insulin-producing cells your body has lost, potentially reducing dangerous low blood sugar events.
Chicago, IllinoisAges 35–65 - NCT06593574Recruiting
Robot-Assisted Back Surgery Study
This study tests a robot that helps surgeons perform a type of back surgery called a laminectomy. It aims to see if the robot makes surgery safer and more effective for people with certain lower spine problems.
BeijingAges 18–80 - NCT06594289Recruiting
Liver surgery trial with special blood flow control
This trial tests a new way to control blood flow during laparoscopic liver surgery. It compares two methods to see which is safer and more effective for patients with certain liver conditions.
Guangzhou, China/GuangdongAges 18–70 - NCT05172960Recruiting
Study of a new heart valve for severe aortic stenosis
This trial tests a new version of a heart valve (SAPIEN X4) placed without open-heart surgery. It's for people with severe aortic stenosis who have symptoms like shortness of breath or chest pain.
La Jolla, CaliforniaAges Any age - NCT06603246RecruitingPhase 1
Study of inhaled GDC-6988 for mucus lung diseases
This study tests an inhaled medicine (GDC-6988) to see if it is safe and helps clear mucus from the lungs in people with mucus-related lung diseases like chronic bronchitis, COPD, or bronchiectasis. You may qualify if your lung function is fairly stable and you produce daily mucus.
Birmingham, AlabamaAges 18 years+ - NCT06605209Recruiting
A covered stent study for iliac artery blockage
This trial tests a balloon-expandable covered stent to treat blockages in the iliac artery (a major blood vessel in your pelvis). It may be an option for people with leg pain from poor blood flow.
Beijing, Beijing MunicipalityAges 18–80 - NCT06613438Recruiting
New wearable device for GERD symptoms
This study tests a new wearable device (eGERD) that aims to reduce symptoms of GERD (heartburn and regurgitation). The trial will check if the device is safe and works well without needing medication.
Chicago, IllinoisAges 22–75 - NCT06615960Recruiting
Testing a snake antivenom for snakebite victims
This trial tests a snake antivenom called PANAF-Premium to see if it is safe and works well for people bitten by snakes. It is for anyone with signs of venom poisoning, and you can join even if you have had other snakebite treatments or are pregnant.
Garoua, North RegionAges Any age - NCT06620757Recruiting
Short-term single blood thinner after LAmbre device implant
This study tests whether it is safe and effective to use just one blood thinner (aspirin or clopidogrel) for a short time after getting a LAmbre device implanted to close off a heart pouch that can cause strokes. It is for people with atrial fibrillation who cannot take standard blood thinners long-term.
A CoruñaAges 18–100
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Common questions
- Are there clinical trials for safety and effectiveness?
- Yes. Clin2 currently lists 397 recruiting safety and effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a safety and effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a safety and effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.