Clinical trials
Salivary Gland Cancer clinical trials
Below are recruiting salivary gland cancer clinical trials, each written for real people, not researchers. We’re tracking 34 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05000892RecruitingPhase 2
Immunotherapy plus chemotherapy before surgery for salivary cancer
This trial studies giving an immunotherapy drug (sintilimab) plus two chemotherapy medicines before surgery to shrink salivary gland cancer. The goal is to improve how well the cancer responds and is controlled, while still aiming for a cure through surgery.
Guangzhou, GuangdongAges 18–80 - NCT07464366RecruitingPhase 2
MRG003 with or without putrelimab for salivary gland cancer
This trial tests a new drug combination (MRG003 with or without putrelimab) for people with advanced salivary gland cancer that has EGFR protein. It aims to see if the treatment is safe and helps shrink tumors.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07124000Recruiting
T-DXd for advanced HER2-positive solid tumors
This trial is for people with advanced HER2-positive solid tumors (cancers that cannot be removed by surgery or have spread). It tests the drug T-DXd (also called Enhertu) when your doctor has already decided it's the right treatment for you and you have no other good options.
Birmingham, AlabamaAges 18–130 - NCT03556228RecruitingPhase 1/Phase 2
Tested medicine for tumors with TrkA changes, alone or with pembrolizumab
This early-phase study tests VMD-928, a targeted cancer medicine, for cancers that have TrkA-related tumor changes. It may be given by itself or with pembrolizumab to see if it can shrink tumors when standard treatments have not worked.
Santa Rosa, CaliforniaAges 18–80 - NCT03740256RecruitingPhase 1
HER2-targeted oncolytic virus plus custom immune cells for solid cancers
This Phase 1 study tests a treatment plan that combines a virus designed to attack cancer with your own custom immune cells that target HER2. It aims to shrink advanced HER2-positive solid tumors (and make future options safer/more effective).
Houston, TexasAges 18 years+ - NCT04452162Recruiting
MRI study for salivary gland tumors
This trial uses special MRI scans to learn how salivary gland tumors work in the body. It may help improve diagnosis and how tumors are evaluated without needing treatment yet.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04620187RecruitingPhase 2
Study medicine T-DM1 after surgery for HER2-positive salivary cancer
This Phase 2 trial studies T-DM1 given after surgery for salivary gland cancer that is HER2-positive. The goal is to reduce the risk of the cancer coming back by targeting HER2-positive tumor cells.
Atlanta, GeorgiaAges 18 years+ - NCT05408845RecruitingPhase 2
Study drug vs standard care for HER2 salivary gland cancer
This Phase 2 trial tests how well ado-trastuzumab emtansine (and compares to two standard treatment options) works for salivary gland cancers that are HER2-positive or HER2-low. It aims to see whether the study drug can control cancer better and with acceptable side effects.
Birmingham, AlabamaAges 18 years+ - NCT05483374Recruiting
Head and neck cancer registry for adult patients
This study builds a European database (registry) of adults with certain head and neck cancers to better understand how these cancers are diagnosed and treated over time. It may help future care by collecting real-world information, rather than testing a new medicine.
Brno, BrnoAges 18 years+ - NCT05553782RecruitingEarly Phase 1
IMD device study for certain head and neck cancers
This early-phase study tests a new small device (placed through the skin) plus standard surgery to study head and neck cancers. It may help researchers understand how the device works and gather safety information for people who need definitive surgery for a measurable tumor.
Boston, MassachusettsAges 18 years+ - NCT05884320RecruitingPhase 2
Sacituzumab govitecan for advanced salivary gland cancers
This Phase 2 trial tests sacituzumab govitecan, an anti-cancer medicine, in people with recurrent or metastatic (coming back or spread) secretory gland cancers or related salivary gland cancers. It aims to see how well the treatment can shrink tumors and control disease when surgery or radiation is not a cure.
Houston, TexasAges 18 years+ - NCT06047236Recruiting
Immune markers in salivary gland cancer
This study looks at immune cells and substances in blood, saliva, and stool from people with salivary gland cancer. The goal is to find markers that could help predict how the disease behaves.
Erlangen, BavariaAges 18 years+ - NCT06695845RecruitingPhase 2
Study of zanidatamab for HER2-positive solid tumors
This trial tests a drug called zanidatamab in people with advanced solid tumors that have high levels of HER2 protein (called HER2-positive). It aims to see if zanidatamab can shrink or slow the growth of these tumors.
Prescott, ArizonaAges 18 years+ - NCT06805617RecruitingPhase 2
Ivonescimab for advanced salivary gland cancer
This trial tests a new drug called Ivonescimab for people with advanced salivary gland cancer that has spread or cannot be removed surgically. The goal is to see if the drug can shrink tumors or slow cancer growth.
Boston, MassachusettsAges 18 years+ - NCT06923826RecruitingPhase 2
Study of sacituzumab govitecan for advanced salivary gland and thyroid cancers
This trial tests a drug called sacituzumab govitecan in people with advanced salivary gland cancer or thyroid cancer that has spread or cannot be removed. The goal is to see if the drug can help shrink or slow down the cancer.
SingaporeAges 21 years+ - NCT01365169Recruiting
How activity level and daily function relate to cancer survival
This study looks at how physical activity (movement during the day) and a clinician-rated “day-to-day function” score relate to overall survival in people with certain cancers. It may help doctors understand who benefits most from activity-focused care and better monitoring.
Houston, TexasAges 18 years+ - NCT02012699Recruiting
Cancer registry for people with or at risk of cancer
This trial collects health information and samples (a “cancer repository”) to help researchers study cancer and cancer risk. You may be able to join if you’ve had cancer before or if you’re at higher risk or have concerning findings.
Greenwood Village, ColoradoAges 19–110 - NCT06686979Recruiting
Drug sensitivity test for advanced salivary gland cancer
This trial tests whether a laboratory-grown mini-tumor (organoid) from your biopsy can predict which drugs will work best for your recurrent or metastatic salivary gland cancer. You would need to provide a tumor sample and have adequate organ function.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05727410RecruitingPhase 2
Nivolumab and chemotherapy before surgery and radiation for salivary cancer
This Phase 2 study tests giving nivolumab plus docetaxel and cisplatin before surgery and radiation for certain resectable, high-grade salivary gland cancers. It aims to shrink or control the cancer early to improve outcomes after treatment.
SeoulAges 19 years+ - NCT07251543Enrolling by invitation
Salivary gland massage for dry mouth in older adults
This study tests whether a simple salivary gland massage program can help older adults with dry mouth improve chewing, swallowing, and overall oral health. It's designed for people aged 65 and older who can follow instructions and participate in activities.
Chiayi City, TaiwanAges 65 years+ - NCT02327884Recruiting
Study saliva and related diseases to learn health patterns
This study looks at diseases that involve the salivary (saliva) glands, and may also include people with active hepatitis, oral cancer, or healthy adults. Researchers collect blood, urine, saliva, and sometimes tissue to better understand what’s happening and how these conditions relate to saliva and oral health.
Bethesda, MarylandAges 4–100 - NCT06464198Recruiting
Radiation and chemo after surgery for salivary gland cancer
This study tests giving radiation and chemotherapy together after surgery for aggressive salivary gland cancers of the head and neck. It aims to see how well this standard treatment works in real-world settings.
ErlangenAges 18–99 - NCT07678515Enrolling by invitation
Massage and scents to help people with dementia eat better
This study tests whether a gentle massage of the salivary glands (under the jaw) and pleasant smells (like essential oils) can help people with dementia who have trouble eating. It may encourage them to eat by mouth and reduce feeding difficulties.
TainanAges Any age - NCT06348264RecruitingPhase 2
Rezvilutamide with hormone therapy for high-risk salivary duct cancer
This trial tests a new drug, Rezvilutamide, combined with standard hormone therapy for people with a rare and aggressive type of salivary gland cancer that has a high risk of coming back. The treatment aims to reduce the chance of cancer returning after surgery.
Beijing, Beijing MunicipalityAges 18 years+
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Salivary Gland Cancer trials by city
Studies with a site in or near these metro areas.
Salivary Gland Cancer trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for salivary gland cancer?
- Yes. Clin2 currently lists 34 recruiting salivary gland cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a salivary gland cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a salivary gland cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.