Clinical trials
Schizophrenia clinical trials
Below are recruiting schizophrenia clinical trials, each written for real people, not researchers. We’re tracking 317 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05316883RecruitingPhase 4
Testing blood markers in people on clozapine for schizophrenia
This study looks at “biomarkers,” or blood measures, in people with schizophrenia who respond to clozapine. It may help researchers understand who benefits from clozapine and why, by linking test results to symptom changes.
Glostrup Municipality, DenmarkAges 18–64 - NCT05343598Recruiting
Using TMS to study hallucinations in schizophrenia
This study uses a non-invasive brain stimulation method (TMS) along with brain scans (MRI) to better understand why hallucinations happen in schizophrenia. It may help researchers learn more about brain processes involved, which could guide future treatments.
Belmont, MassachusettsAges 18–55 - NCT05389787Recruiting
Brain stimulation to improve thinking in schizophrenia
This pilot study tests whether stimulating the cerebellum (a part of the brain) using TMS can improve brain function and thinking in people with schizophrenia. If you qualify, you may receive TMS and undergo brain/cognitive assessments to see whether it helps.
New York, New YorkAges 18–60 - NCT05435300Recruiting
tDCS study using brain scans in schizophrenia
This trial tests whether a non-invasive brain stimulation approach (tDCS) changes brain connections in people with schizophrenia. It also uses specialized scans to look for changes in the brain that could help explain how treatment works.
Toronto, OntarioAges 18 years+ - NCT05580211Recruiting
Brain stimulation for schizophrenia with low insight
This trial tests a brain-stimulation approach for people with schizophrenia (or schizoaffective disorder) who don’t always recognize how their illness affects them. It may help improve symptoms and insight while you stay on stable medications during the study.
Toronto, OntarioAges 18 years+ - NCT05603104RecruitingPhase 3
Medication intensification after first treatment failure in mood and psychosis
This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.
Ramat GanAges 18–70 - NCT05661448Recruiting
Online cognitive health program for people with psychosis
This study tests an online, group-based program aimed at supporting thinking and memory (“cognitive health”) for people living with psychosis. It may help by teaching strategies and monitoring progress, while keeping participation safe through clinician judgment and emergency planning.
Vancouver, British ColumbiaAges 18 years+ - NCT05671185Recruiting
Brain stimulation for schizophrenia symptoms and depression
This study tests repeated brain stimulation (rTMS) to see if it can improve symptoms of schizophrenia and related depression, and measure body/brain changes. You may be considered if you have schizophrenia or schizoaffective disorder with enough depressive symptoms, and if recent treatments and medical safety factors fit the rules.
Douliu, YunlinAges 20 years+ - NCT05731414Recruiting
Testing behavior programs to improve outcomes in schizophrenia
This study looks at how a behavioral program (including remediation and behavior-based techniques) may improve outcomes for adults with schizophrenia-spectrum conditions. You may be eligible if you meet basic age/language needs and haven’t done certain therapies recently.
Scarborough Village, OntarioAges 18–65 - NCT05748990Recruiting
Brain insulin differences in schizophrenia and thinking
This study tests whether unusual insulin action in the brain is linked to thinking problems and body/metabolic issues in schizophrenia. It may help researchers understand the cause and identify targets for future treatments.
Toronto, OntarioAges 17–45 - NCT05778591RecruitingPhase 2
Low-dose buprenorphine to improve social drive in schizophrenia
This study tests whether low-dose buprenorphine can improve social motivation in people with schizophrenia. It compares social motivation changes while keeping participants stable on treatment and avoiding certain medicines and substances.
Los Angeles, CaliforniaAges 18–60 - NCT05823532RecruitingPhase 4
Anti-inflammatory treatment test in people with schizophrenia
This Phase 4 study tests how an anti-inflammatory approach affects people with schizophrenia or schizoaffective disorder who also have signs of body inflammation. It may help by targeting inflammation that could be linked to symptoms for some people.
Atlanta, GeorgiaAges 18–55 - NCT05830903Recruiting
Virtual reality job training for people with schizophrenia
This trial tests a virtual reality (VR) training program to help people with schizophrenia prepare for work. It aims to see whether VR-based job skills training is safe and helpful for improving readiness and functioning.
TaipeiAges 20–40 - NCT05890183Recruiting
Telehealth exercise and brain training after a first psychosis episode
This trial tests whether a combination of at-home (telehealth) aerobic exercise and computer-based cognitive training can improve thinking and day-to-day function after a first episode of schizophrenia-spectrum illness. It may help by strengthening attention and learning skills after the initial psychotic episode.
Los Angeles, CaliforniaAges 18–45 - NCT05951660Recruiting
Study sexual side effects in schizophrenia with diabetes
This study looks at how sexual functioning is affected in people with schizophrenia, especially in those who also have diabetes or weight-related risk. It also examines how psychiatric medicines and diabetes/weight factors may be connected, which could help improve care for patients.
SlagelseAges 18 years+ - NCT05956327Recruiting
Study physical training to change brain signals in schizophrenia
This trial studies whether structured physical training can change brain “signal wiring” in people with schizophrenia. Researchers will also look at related molecular changes to understand why exercise might improve symptoms.
Munich, BavariaAges 18–65 - NCT05956951Recruiting
Auditory stimulation for early schizophrenia brain efficiency
This study tests whether special sound-based stimulation can help improve brain “communication timing” in people with early-course schizophrenia. It compares participants with early-course schizophrenia to healthy volunteers without a psychiatric history to see how brain function changes.
Pittsburgh, PennsylvaniaAges 18–40 - NCT05958875RecruitingPhase 4
Six-week medicine switch for schizophrenia after first treatment failure
This trial tests whether a more intensive medication approach for schizophrenia (or related conditions) helps people who didn’t improve on their first tried medicine. Participants will usually switch medicines and be compared against “treatment as usual.”
InnsbruckAges 18–70 - NCT06021197RecruitingPhase 2
NMDA-enhancing treatment for cognitive symptoms in schizophrenia
This study tests a new treatment that may help with thinking and memory problems in people with schizophrenia. It is for people whose schizophrenia symptoms are stable and who are already on a steady medication.
TaichungAges 18–65 - NCT06123897Recruiting
Schizophrenia database and biobank study
This study builds a database and collects samples (like blood) from people with schizophrenia to learn more about the condition. If you join, you help researchers understand schizophrenia better, which may lead to improved treatments.
Hefei, AnhuiAges Any age - NCT06155682Recruiting
TMS for Improving Self-Control in Schizophrenia
This trial tests whether a type of brain stimulation called TMS can help people with schizophrenia improve their ability to stop impulsive actions. By targeting the part of the brain that controls inhibition, researchers hope to reduce symptoms and improve daily functioning.
Catonsville, MarylandAges 18–45 - NCT06174116RecruitingPhase 4
Adding lumateperone to clozapine for schizophrenia
This trial tests whether adding lumateperone, an antipsychotic medication, to clozapine can improve metabolic health in people with schizophrenia. It aims to see if this combination helps with weight, blood sugar, and cholesterol levels.
Worcester, MassachusettsAges 18–65 - NCT06191965RecruitingPhase 2/Phase 3
MitoQ supplement for early psychosis
This study tests whether a supplement called MitoQ can help people with early-stage psychosis by improving how their cells produce energy. If you are younger and have been treated for psychosis for less than 5 years, this trial may be an option for you.
New Haven, ConnecticutAges 18–35 - NCT06231732Recruiting
Brain stimulation to improve thinking in schizophrenia
This trial tests a type of brain stimulation (high-definition transcranial alternating current stimulation, or hi-tACS) to see if it can help with memory, attention, and other thinking skills in people with schizophrenia. You may join if you are clinically stable and on a steady dose of antipsychotic medication.
Hanzhou, ZhejiangAges 18 years+
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Common questions
- Are there clinical trials for schizophrenia?
- Yes. Clin2 currently lists 317 recruiting schizophrenia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a schizophrenia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a schizophrenia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.