Clinical trials
Semaglutide clinical trials
Below are recruiting semaglutide clinical trials, each written for real people, not researchers. We’re tracking 142 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06894784RecruitingPhase 3
Combining two diabetes drugs with an automated insulin pump
This trial tests if adding semaglutide and empagliflozin to your automated insulin delivery system (like a smart pump) can improve blood sugar control for adults with type 1 diabetes. It may help with both glucose levels and weight management.
Montreal, QuebecAges 18 years+ - NCT07225816RecruitingPhase 1
How fasting affects stomach food with GLP-1 drugs
This study looks at how long fasting and temporarily stopping certain diabetes or weight-loss medications (like semaglutide or liraglutide) affects how much food stays in your stomach. It may help understand how these medications work in people who are overweight.
Cypress, CaliforniaAges 18 years+ - NCT07294950RecruitingPhase 3
What happens when you stop semaglutide after weight loss
This study looks at what happens to your body and weight when you stop taking semaglutide (Wegovy/Ozempic) after losing at least 10% of your starting weight. The goal is to understand how your metabolism and heart health change once the medication is paused.
Toronto, OntarioAges 18–75 - NCT07325500RecruitingPhase 2
Low dose GLP-1 for heart health in HIV
This study tests a very low dose of a medication called a GLP-1 receptor agonist to see if it can improve heart and metabolic health in people with HIV who have excess weight.
Houston, TexasAges 18 years+ - NCT07728383RecruitingPhase 4
Obesity treatment study using tongue-applied semaglutide
This trial tests a new way to deliver semaglutide through a strip placed on the tongue for weight loss in adults with obesity. It may help you lose weight without a needle.
Minneapolis, MinnesotaAges 18–65 - NCT05569772RecruitingPhase 3
Semaglutide for prediabetes after gestational diabetes
This trial studies whether semaglutide can help women with prediabetes after past gestational diabetes return to better blood sugar levels and lower progression to diabetes. It is designed for women who are no longer breastfeeding and can use effective birth control.
AalstAges 18 years+ - NCT07272343RecruitingPhase 4
Semaglutide vs. diet changes for new type 2 diabetes
This study compares a weekly injection called semaglutide with a calorie-restricted diet to see which helps control blood sugar better. If you have just been diagnosed with type 2 diabetes and have overweight, this trial might help you choose a treatment path.
Jiangxi, NanchangAges 18–75 - NCT07465965RecruitingPhase 1
Weight loss study of semaglutide nasal spray in overweight or obese adults
This study tests a nasal spray containing semaglutide (a GLP-1 receptor agonist) to see if it helps adults who are overweight or obese lose weight. It may be an option if you have a BMI between 27 and 35 and have not used other weight loss medications recently.
Secaucus, New JerseyAges 18–65 - NCT07527195RecruitingPhase 1
Study of CagriSema on Muscle Health in Adults with Obesity
This study tests a new medication called CagriSema to understand how it affects muscle health while helping people lose weight. You'll be in the trial for about a year, and researchers will monitor your muscle function and body composition.
Aarhus NAges 50–70 - NCT07668388RecruitingPhase 2
Testing different doses of UBT251 for type 2 diabetes
This trial tests a new medicine, UBT251, to see how well it lowers blood sugar in people with type 2 diabetes. It compares different doses to find the best one for you.
Birmingham, AlabamaAges 18–75 - NCT03884075RecruitingPhase 2
Semaglutide study for fatty liver and how sugar affects the liver
This Phase 2 study tests how semaglutide (a diabetes medication also used for weight) affects fatty liver and the liver’s response to sugar. It may help people with non-alcoholic fatty liver disease understand whether the drug improves liver fat and related changes.
Bethesda, MarylandAges 18–100 - NCT06691243RecruitingPhase 2
Testing semaglutide for cocaine use in adults
This study tests if the diabetes drug semaglutide (also used for weight loss) can help reduce cocaine use in adults, including those living with HIV. It's free and lasts about 8 weeks.
Washington D.C., District of ColumbiaAges 18–65 - NCT07302802Recruiting
Semaglutide for weight loss in teens with genetic obesity
This trial studies whether semaglutide (a once-weekly injection) helps adolescents with a specific genetic form of obesity lose weight. It is for teens who are already being prescribed semaglutide as part of their regular care.
ParisAges 12–21 - NCT06986993RecruitingPhase 4
Semaglutide for smoking and weight in people with obesity
This study tests whether the medication semaglutide (similar to Ozempic/Wegovy) can help people who smoke and have obesity cut down on cigarettes, even if they aren't ready to quit. Participants will receive the drug and be monitored for changes in smoking habits and health.
Oklahoma City, OklahomaAges 18–65 - NCT07293325Recruiting
Semaglutide and Tirzepatide for slowing aging in adults with obesity
This trial tests if two newer weight-loss medications, semaglutide and tirzepatide, can help slow the aging process in adults with obesity. It compares the drugs to each other and to a placebo to see which might offer anti-aging benefits beyond weight loss.
HangzhouAges 18–75 - NCT07254715RecruitingPhase 4
Itopride for stomach issues from semaglutide in diabetic women
This trial tests if itopride can help with stomach problems caused by semaglutide in diabetic women having a hysterectomy. It aims to see if this combination can improve symptoms like slow stomach emptying.
Cairo, Cairo GovernorateAges 40–60 - NCT07673900RecruitingPhase 1
Testing a new patch for semaglutide in healthy overweight adults
This trial tests a new skin patch (VX-201) that delivers semaglutide, a medicine used for weight management, compared to a standard injection. It is for healthy overweight or obese adults who are not taking other weight loss medications.
Tempe, ArizonaAges 18–60 - NCT07732426Recruiting
Semaglutide and brain response to food in obesity with food addiction
This trial tests if semaglutide can change how your brain responds to food cues, like seeing or smelling food, in people with obesity and a tendency toward food addiction. It may help understand why some people struggle with overeating and how this medication could help.
SeoulAges 19–50 - NCT07284979RecruitingPhase 3
Weekly injection for obesity without diabetes
This trial tests a new once-weekly injection called Ribupatide for weight loss in people with obesity who do not have diabetes. It compares the study drug to an existing medication (semaglutide) and a placebo to see how well it works and if it's safe.
Glendale, ArizonaAges 18 years+ - NCT07272837Recruiting
How semaglutide affects heart and muscle mass
This study looks at how semaglutide (Ozempic or Wegovy) changes heart muscle and body muscle. It may help people with type 2 diabetes or those taking the drug for weight loss understand if their heart is affected.
Edmonton, AlbertaAges 18–80 - NCT07253285RecruitingPhase 3
Study on cagrilintide and CagriSema for kids with excess weight
This trial tests two new medicines (cagrilintide and CagriSema) to see if they help children and teens lose weight. It's for young people who have tried lifestyle changes without enough success.
Escondido, CaliforniaAges 8–18 - NCT06575738RecruitingPhase 1
Semaglutide for teens after weight-loss surgery
This study looks at how teenagers and young adults respond to weight-loss surgery (sleeve gastrectomy) and whether adding a medication called semaglutide can help improve weight loss. It has two parts: first observing how surgery affects you, then testing if semaglutide helps those who didn't lose enough weight after surgery.
Aurora, ColoradoAges 12–24 - NCT07662213RecruitingPhase 3
Elecoglipron vs semaglutide for type 2 diabetes
This study tests an experimental diabetes pill (elecoglipron) to see if it works as well as a current medicine, semaglutide, for people with type 2 diabetes who also have heart risk factors. It aims to help better control blood sugar and weight.
Birmingham, AlabamaAges 18 years+ - NCT04174755Recruiting
Semaglutide for weight loss in adults with HIV
This trial studies whether semaglutide (a diabetes-type weight-loss injection) helps adults with HIV lose weight. It also checks that it’s safe for people whose HIV is well controlled on regular treatment.
Dublin, DublinAges 18 years+
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Common questions
- Are there clinical trials for semaglutide?
- Yes. Clin2 currently lists 142 recruiting semaglutide studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a semaglutide trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a semaglutide trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.