Clinical trials
Smoking Cessation clinical trials
Below are recruiting smoking cessation clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06474299RecruitingPhase 4
Quitting cigarettes and vaping with medication support
This study tests whether using two quit-smoking medicines together helps people stop both cigarettes and vaping. It may offer extra support to help you quit.
Madison, WisconsinAges 21 years+ - NCT06236347Enrolling by invitation
Rural COPD study using e-visits for smokers
This study tests whether online e-visits can help rural smokers without COPD quit smoking. It uses smartphone tools and mailed devices to track progress remotely.
Charleston, South CarolinaAges 40 years+ - NCT06127589Recruiting
Quit for Kids: help parents quit smoking and protect children
This study offers a program to help parents who smoke quit for good, while protecting their young children from secondhand smoke. It uses text messaging and support to make quitting easier.
Hong KongAges 18 years+ - NCT05868421Recruiting
Veteran coaching with a trusted person to quit smoking
This study tests whether involving a supportive family member or friend can help a veteran use smoking-quit treatment more effectively. If you’ve smoked recently and can name a trusted contact who will join, you may be able to participate.
Minneapolis, MinnesotaAges 18 years+ - NCT05764759Recruiting
Help with quitting smoking using phone and primary care support
This study tests a new way to help people quit smoking in rural primary care settings using regular phone check-ins and air/smoke measurements. If you’re trying to stop, it may offer structured support and monitoring to help you quit.
Charleston, South CarolinaAges 18 years+ - NCT05660525Recruiting
Helping rural smokers quit with pharmacist support and nicotine replacement
This study tests a smoking-cessation program delivered through community pharmacies in rural Appalachia. It may help people quit smoking using nicotine replacement (patch or lozenges) plus support from pharmacists.
Charlottesville, VirginiaAges 18 years+ - NCT05627674Enrolling by invitation
Help improve lung cancer screening and quitting support uptake
This study tests a “precision” approach to help people who are newly eligible for lung cancer screening actually get screened and start smoking-cessation treatment. If it works, it could make screening and quitting help easier to access and more engaging.
St Louis, MissouriAges 18 years+ - NCT05493254Recruiting
Telehealth help to quit smoking in primary care visits
This study tests a phone/video-based program to help people quit smoking through primary care. It may help you get support and track your progress remotely.
Charleston, South CarolinaAges 18 years+ - NCT07489443Recruiting
Helping pregnant women reduce tobacco and cannabis use
This study is testing a program to help pregnant women and new mothers cut back on or quit using tobacco and cannabis. It’s designed to see if the program is easy to use and helps improve health for both mom and baby.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06945120Recruiting
Lung Health Program for Chinese and Korean Smokers
This study is testing a program to help Chinese and Korean adults who smoke to improve their lung health. You may be able to join if you are a current smoker, speak Korean, Mandarin, or English, and live in the U.S.
Boston, MassachusettsAges 18–100 - NCT06442514Recruiting
Pain and Smoking Study: Phone Support for Veterans
This study tests a phone-based program to help Veterans with chronic pain quit smoking. If you're a VA patient who uses tobacco and has ongoing pain, you may be able to join and get support from home.
West Haven, ConnecticutAges 18 years+ - NCT05515354RecruitingPhase 4
Smoking quit plan matched to your menstrual cycle phase
This Phase 4 study tests a smoking-quit treatment plan timed to your menstrual cycle. It may help you quit smoking and learn how quitting support works for people who menstruate regularly.
Toronto, OntarioAges 18–40 - NCT07766655RecruitingPhase 3
Medication for quitting smoking
This study tests if an investigational medication helps adults stop smoking. Participation takes place of over several weeks, and may increase your chances of quitting successfully.
Little Rock, ArkansasAges 18–65 - NCT05589220Recruiting
Music and nicotine patches to reduce cravings in student smokers
This study tests whether combining music therapy with nicotine replacement (like a patch or gum) can reduce smoking cravings when students try to quit. It’s aimed at motivated students who smoke regularly and want help with quitting.
PoitiersAges 18–25 - NCT07331519Recruiting
Smoking cessation with lung cancer screening
This trial tests if combining smoking cessation support with a low-dose CT scan for lung cancer can help people quit. It is for long-term, heavy smokers who may be at higher risk for lung cancer.
HelsinkiAges 50–74 - NCT04783857RecruitingPhase 4
Hormone therapy to prevent smoking relapse after childbirth
This trial tests whether giving progesterone after childbirth can help new mothers stay quit from smoking, reducing secondhand smoke exposure to their babies. It's for women who smoked before pregnancy and want to remain smoke-free after delivery.
Minneapolis, MinnesotaAges 18–45 - NCT05233228RecruitingPhase 2
Phone-based coaching to help you quit smoking in Laos
This study tests a mobile phone program that gives personalized help to support quitting smoking. If you’re eligible, it may help you plan a quit date and stick with quitting using the app.
ChampasakAges 18–65 - NCT07210567Recruiting
Mindfulness App for Quitting Smoking in Cancer Survivors
This study tests a mindfulness app to help cancer survivors quit smoking. You will use the app for a short time each day and answer quick questions about your mood and cravings.
New Brunswick, New JerseyAges 18 years+ - NCT05276050Recruiting
Brain-circuit treatment to help people with schizophrenia quit smoking
This study tests a circuitry-guided approach to help people with schizophrenia quit smoking. It may help reduce cravings and improve quitting, while also watching for safety issues.
Houston, TexasAges 22–65 - NCT06654414Recruiting
Smoking cessation support for transgender and gender-diverse adults
This study tests a skills-based program to help transgender and gender-diverse adults quit smoking or vaping. The program focuses on managing stress related to identity and health, and may be more supportive than standard quit programs.
Boston, MassachusettsAges 18 years+ - NCT06651684Recruiting
Quit smoking help for parents with social needs
This trial tests if health navigators can help parents who smoke and have unmet social needs to quit smoking. If you smoke and face challenges like trouble paying bills or finding childcare, this program may support you.
Montreal, QuebecAges 18 years+ - NCT06675526Recruiting
Detour: a smartphone game to help youth quit smoking
This trial tests a smartphone game called Detour designed to help young people quit smoking. If you smoke at least once a week and are motivated to stop, playing this game might support you in quitting.
Nijmegen, GelderlandAges 16–25 - NCT05738408Recruiting
Remote smoking help for hospitalized heart patients
This trial tests a phone-based (remote) smoking quit program for people hospitalized for a recent heart-related event. It may help you quit smoking by offering support when you’re in the hospital and afterward.
Burlington, VermontAges 18 years+ - NCT06762210Recruiting
Quit smoking with AI and dental health checks
This trial tests whether a smartphone app that uses artificial intelligence (AI) can help you quit smoking by looking at how it affects your dental health. If you smoke at least 5 cigarettes a day and want to quit, you may be able to join.
Fayoum, Alexandria GovernorateAges 21–65
Hear when a new Smoking Cessation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for smoking cessation?
- Yes. Clin2 currently lists 148 recruiting smoking cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a smoking cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a smoking cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.