Clinical trials
Smoking Cessation clinical trials
Below are recruiting smoking cessation clinical trials, each written for real people, not researchers. We’re tracking 159 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06470321Recruiting
Predictors of nicotine relapse in smokers
This study looks at factors that might predict whether someone will start smoking again after quitting. It is for adults who smoke daily, want to quit, and are not on any medications.
NicosiaAges 18–60 - NCT06471387Recruiting
Study of genes linked to nicotine addiction
This study looks at your genes to understand why some people get addicted to nicotine. Your participation could help develop new treatments for quitting smoking.
NicosiaAges 18–60 - NCT06837220Recruiting
Smoking cessation program for people in community behavioral health
This study tests a smoking cessation program designed for people who receive care at community behavioral health centers in Chicago. If you're a daily smoker interested in quitting, you may be able to join and get support to help you stop.
Chicago, IllinoisAges 18–26 - NCT06798324RecruitingPhase 4
Brain stimulation plus smoking cessation medication for quitting smoking
This trial tests whether combining brain stimulation (tDCS) with a smoking cessation medication (varenicline) helps people quit smoking. You would attend daily visits for two weeks.
Toronto, OntarioAges 18–85 - NCT06883097Recruiting
Quitting smoking with HIV: A smoking cessation trial
This study tests whether nicotine replacement therapy (like patches or gum) can help people living with HIV quit smoking. You'll be part of a program that supports your quit attempt while you receive care for HIV.
Winston-Salem, North CarolinaAges 18 years+ - NCT06931054Recruiting
Acupuncture, ear acupressure and nicotine patches for quitting smoking
This trial tests whether adding acupuncture and ear acupressure to nicotine replacement therapy helps people quit smoking. If you smoke at least 10 cigarettes a day, are 18 or older, and can read Chinese, you may be eligible.
Hong KongAges 18 years+ - NCT07013968Recruiting
Mindfulness smoking cessation for abuse survivors
This study tests whether a mindfulness-based program can help people who smoke and have experienced intimate partner violence quit smoking. It offers a supportive approach to address both stress and smoking.
Rapid City, South DakotaAges 18 years+ - NCT07080788Recruiting
Native American Pain Risk Study: Smoking Cessation
This study looks at how quitting smoking affects pain in Native American adults. Eligible participants are daily smokers who own a smartphone and do not have heart problems or chronic pain.
Tulsa, OklahomaAges 18 years+ - NCT07129590Recruiting
Trauma-informed care to help pregnant people quit smoking
This study tests whether a trauma-informed care approach can help pregnant people who have experienced trauma to quit smoking. The study involves clinicians and patients working together to improve smoking cessation support.
San Francisco, CaliforniaAges 18 years+ - NCT07487818RecruitingPhase 2/Phase 3
Vagus nerve stimulation with nicotine patch for quitting smoking
This study tests if a gentle electrical stimulation of a nerve in your neck can help you quit smoking when used with nicotine replacement therapy (patches or gum). It might offer a new way to reduce cravings and withdrawal.
Rochester, MinnesotaAges 18 years+ - NCT07576595Recruiting
Lung Cancer Screening and Quit-Smoking Support for African Americans
This study helps African American smokers get lung cancer screening and receive support to quit smoking. Researchers will provide guidance and resources tailored to help you stop smoking and catch lung disease early if needed.
New Orleans, LouisianaAges 50–80 - NCT06945120Recruiting
Lung Health Program for Chinese and Korean Smokers
This study is testing a program to help Chinese and Korean adults who smoke to improve their lung health. You may be able to join if you are a current smoker, speak Korean, Mandarin, or English, and live in the U.S.
Boston, MassachusettsAges 18–100 - NCT06213532Recruiting
Connect to lung care study for smokers
This study, called CONNECTing to LungCare, helps current smokers who get their primary care at UCSF clinics learn about lung cancer screening. The goal is to make it easier for people to get screened and to support smokers in their health journey.
San Francisco, CaliforniaAges 18 years+ - NCT07489443Recruiting
Helping pregnant women reduce tobacco and cannabis use
This study is testing a program to help pregnant women and new mothers cut back on or quit using tobacco and cannabis. It’s designed to see if the program is easy to use and helps improve health for both mom and baby.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05515354RecruitingPhase 4
Smoking quit plan matched to your menstrual cycle phase
This Phase 4 study tests a smoking-quit treatment plan timed to your menstrual cycle. It may help you quit smoking and learn how quitting support works for people who menstruate regularly.
Toronto, OntarioAges 18–40 - NCT07766655RecruitingPhase 3
Medication for quitting smoking
This study tests if an investigational medication helps adults stop smoking. Participation takes place of over several weeks, and may increase your chances of quitting successfully.
Little Rock, ArkansasAges 18–65 - NCT06451081Recruiting
Helping Hong Kong smokers quit with a text-based program
This study tests a new program that uses text messages to help people who smoke daily to quit. It is designed for Hong Kong residents who can read Chinese and own a smartphone.
Hong KongAges 18 years+ - NCT05589220Recruiting
Music and nicotine patches to reduce cravings in student smokers
This study tests whether combining music therapy with nicotine replacement (like a patch or gum) can reduce smoking cravings when students try to quit. It’s aimed at motivated students who smoke regularly and want help with quitting.
PoitiersAges 18–25 - NCT07331519Recruiting
Smoking cessation with lung cancer screening
This trial tests if combining smoking cessation support with a low-dose CT scan for lung cancer can help people quit. It is for long-term, heavy smokers who may be at higher risk for lung cancer.
HelsinkiAges 50–74 - NCT04783857RecruitingPhase 4
Hormone therapy to prevent smoking relapse after childbirth
This trial tests whether giving progesterone after childbirth can help new mothers stay quit from smoking, reducing secondhand smoke exposure to their babies. It's for women who smoked before pregnancy and want to remain smoke-free after delivery.
Minneapolis, MinnesotaAges 18–45 - NCT05233228RecruitingPhase 2
Phone-based coaching to help you quit smoking in Laos
This study tests a mobile phone program that gives personalized help to support quitting smoking. If you’re eligible, it may help you plan a quit date and stick with quitting using the app.
ChampasakAges 18–65 - NCT05415371Enrolling by invitation
Smoking help program for pregnant women in Medicaid
This study tests a smoking-cessation program for pregnant people who smoke while using Medicaid. It may help reduce smoking during pregnancy through structured support calls.
Oklahoma City, OklahomaAges 18–105 - NCT07210567Recruiting
Mindfulness App for Quitting Smoking in Cancer Survivors
This study tests a mindfulness app to help cancer survivors quit smoking. You will use the app for a short time each day and answer quick questions about your mood and cravings.
New Brunswick, New JerseyAges 18 years+ - NCT05276050Recruiting
Brain-circuit treatment to help people with schizophrenia quit smoking
This study tests a circuitry-guided approach to help people with schizophrenia quit smoking. It may help reduce cravings and improve quitting, while also watching for safety issues.
Houston, TexasAges 22–65
Hear when a new Smoking Cessation trial opens
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Common questions
- Are there clinical trials for smoking cessation?
- Yes. Clin2 currently lists 159 recruiting smoking cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a smoking cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a smoking cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.