Clinical trials
Smoking Cessation; Tobacco Dependence clinical trials
Below are recruiting smoking cessation; tobacco dependence clinical trials, each written for real people, not researchers. We’re tracking 35 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06264154Recruiting
Can e-cigarette flavor help you quit smoking?
This study looks at whether the flavor of an e-cigarette can help people who keep smoking switch completely away from regular cigarettes. Participants will use e-cigarettes with different flavors for 6 weeks.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06688539RecruitingPhase 4
Quitting e-cigarettes in adults who also use cannabis
This trial tests if varenicline, a stop-smoking medication, can help people ages 18 to 40 quit e-cigarettes while also using cannabis. It's designed for regular e-cigarette users who want to quit and who use cannabis at least 10 days per month.
Charleston, South CarolinaAges 18–40 - NCT06543407Recruiting
Safer smoking options for people with mental illness
This study offers a way to reduce harm from smoking for people with mental health conditions who are not ready to quit. It tests if switching to a less harmful product can help improve health without requiring you to stop smoking completely.
Louisville, KentuckyAges 21 years+ - NCT03249428Enrolling by invitation
Cytisine vs nicotine patches for quitting smoking
This study compares cytisine (an aid to reduce cravings) with nicotine replacement therapy (like patches or gum) to help people quit tobacco/nicotine. It also looks at whether the two options work for people facing higher barriers like low income or housing insecurity.
Ottawa, OntarioAges 18 years+ - NCT05660798Recruiting
Switching from cigarettes to heat-not-burn to protect heart arteries
This study looks at whether switching from regular cigarettes to a tobacco heating product slows buildup of plaque in the heart arteries. You’d be guided through smoking change and monitored using heart scans, to see if artery plaque stays the same or improves.
WarsawAges 18–75 - NCT06534047RecruitingPhase 4
Brain stimulation or nicotine patch to help you quit smoking
This study tests whether a brain stimulation treatment called rTMS can help people with psychiatric conditions quit smoking. You will be randomly assigned to get either rTMS or a nicotine patch, and your progress will be tracked to see which treatment works better.
Toronto, OntarioAges 18–70 - NCT06372899Recruiting
Switching to E-cigarettes or Nicotine Pouches for Smokers
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
Philadelphia, PennsylvaniaAges 21 years+ - NCT07466875Recruiting
Ear stimulation for nicotine withdrawal in psychiatric patients
This trial tests whether gentle electrical stimulation on the ear can help relieve nicotine withdrawal symptoms for smokers who are in a psychiatric hospital and must stop smoking. It is added on top of standard nicotine replacement therapy.
Nantou CityAges 18–65 - NCT06239350Recruiting
Young adult tobacco and cannabis co-use study
This study tests a program to help young adults who use both nicotine and cannabis products reduce or quit nicotine use. If you are between 18 and 25, use nicotine products at least 20 days a month and cannabis at least 10 days a month, and want to quit nicotine, you may be eligible.
Charleston, South CarolinaAges 18–25 - NCT06765291Recruiting
Help for teens to quit or reduce vaping
This program is for teens aged 14 to 19 who vape at least once a week and want to quit or cut back. It tests a behavioral support approach to help them stop using nicotine vapes.
Boston, MassachusettsAges 14–19 - NCT07250230Recruiting
Nicotine patch for pain after lung surgery in male smokers
This study tests if a high-dose nicotine patch worn before and after lung surgery can reduce pain in men who smoke but are quitting for the procedure. It aims to help manage pain during recovery.
Zhengzhou, HenanAges 18–75
Hear when a new Smoking Cessation; Tobacco Dependence trial opens
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Common questions
- Are there clinical trials for smoking cessation; tobacco dependence?
- Yes. Clin2 currently lists 35 recruiting smoking cessation; tobacco dependence studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a smoking cessation; tobacco dependence trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a smoking cessation; tobacco dependence trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.