Clinical trials
Spasticity With Multiple Sclerosis clinical trials
Below are recruiting spasticity with multiple sclerosis clinical trials, each written for real people, not researchers. We’re tracking 34 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06782490RecruitingPhase 2
Testing a new drug for MS muscle stiffness
This study tests an investigational drug (BMS-986368) to see if it helps reduce muscle stiffness and spasms caused by multiple sclerosis. It may be an option if you have had spasticity for at least 6 months and are not currently using other treatments that cannot be paused.
Birmingham, AlabamaAges 18–70 - NCT05092191RecruitingPhase 2
Cannabis pill study for MS-related muscle stiffness
This Phase 2 trial tests whether cannabis can reduce muscle stiffness (spasticity) in people with multiple sclerosis. You may be able to participate if your stiffness is not improving with your current treatments.
Montreal, QuebecAges 21 years+ - NCT05735691Recruiting
Gait training for people with multiple sclerosis using treadmill exercises
This study tests a high-intensity treadmill walking program designed to improve walking stability for people with multiple sclerosis (MS). It may help you build safer, more confident walking, but you must meet several health and ability requirements to take part.
Indianapolis, IndianaAges 18–75 - NCT06394310Recruiting
Dry needling for leg tightness in MS
This study tests whether dry needling (a therapy using thin needles to release muscle tightness) can help reduce leg stiffness and improve walking in people with multiple sclerosis. If you have leg spasticity and can walk with some help, this trial may be a good fit.
Kansas City, KansasAges 18–64 - NCT06552611RecruitingPhase 1
Spinal cord stimulation for hand function in MS
This study tests whether a gentle electrical stimulation applied to the skin over the spinal cord can help improve hand and arm function in people with MS. If you have MS and difficulty using your hands, you may be able to join.
Seattle, WashingtonAges 21–70 - NCT06875908Recruiting
Turkish sleep survey test for multiple sclerosis
This study tests a Turkish-language sleep survey for people with multiple sclerosis. It aims to see if the survey is a reliable way to measure sleep problems in MS patients.
Bağcılar, IstanbulAges 18–65 - NCT07096700Recruiting
VR and wearable brace for multiple sclerosis rehabilitation
This trial tests whether combining virtual reality exercises with a leg brace can help people with multiple sclerosis improve their walking and balance. If you have mild to moderate disability and can use the Exoband brace, you may be eligible.
Bologna, BolognaAges 18–65 - NCT07193823Recruiting
Sexual function study for women with MS
This study looks at sexual health in women with relapsing-remitting multiple sclerosis. It aims to understand how MS might affect sexual function and to find ways to help.
Izmir, BornovaAges 25–50 - NCT07202195Recruiting
Using stimulation suits at home for MS symptoms
This trial tests whether wearing a special suit at home can help manage muscle stiffness (spasticity) or lack of coordination (ataxia) caused by multiple sclerosis. The suit delivers gentle stimulation to improve movement in your arms or legs.
SteenokkerzeelAges 18 years+ - NCT07252895Recruiting
Testing the EXOPULSE Suit for walking in multiple sclerosis
This trial tests whether the EXOPULSE Suit can help people with multiple sclerosis walk better. You will try the suit and we will measure how it affects your walking over time.
BerckAges 18 years+ - NCT07466823Recruiting
Spasticity Patterns and Quality of Life in MS
This study looks at patterns of muscle stiffness (spasticity) in people with multiple sclerosis and how these patterns affect daily life and well-being. It aims to better understand the link between spasticity and quality of life.
IstanbulAges 18 years+ - NCT07648277Recruiting
Spine Position, Movement, and Balance in Multiple Sclerosis
This study examines how multiple sclerosis affects your spine alignment, flexibility, and balance. Understanding these changes may help develop better physical therapies and support for people living with MS.
Ankara, ÇubukAges 18–65 - NCT05835622Recruiting
Home walking brace study to improve quality of life in MS
This study tests whether using a home “walking exoskeleton” brace can improve quality of life for people with relapsing-remitting multiple sclerosis who have moderate walking problems. You would use the device at home, and the study team will check your walking safety and comfort during and after training.
Saint-Genis-Laval, Auvergne-Rhône-AlpesAges 18 years+ - NCT07376772Recruiting
Wearable vibration therapy for arm and hand function in multiple sclerosis
This study tests if a wearable device that gently vibrates the arm can improve hand and arm function in people with multiple sclerosis. You would use the device at home while doing daily activities.
Gainesville, FloridaAges 18–100 - NCT06782464Recruiting
Freezing nerves for shoulder pain after stroke or brain injury
This trial tests if freezing certain nerves in the upper arm (cryoneurolysis) works as well as standard care for reducing shoulder pain and muscle tightness after a stroke or brain injury. It aims to improve function and ease caregiving tasks.
LuxembourgAges 18 years+ - NCT05500963Recruiting
TENS to reduce fatigue in relapsing-remitting multiple sclerosis
This study tests whether TENS, a non-drug device that delivers mild electrical signals through the skin, can reduce fatigue in people with relapsing-remitting multiple sclerosis (MS). It also includes an exercise-training portion and checks safety and comfort during the program.
Boulder, ColoradoAges 18–65 - NCT07108920Recruiting
Balance and Botox for Stiff Knee Gait
This study tests whether botulinum toxin (Botox) injections into the rectus femoris thigh muscle can improve balance and walking in people with a stiff knee gait (a common problem after stroke, brain injury, or multiple sclerosis).
Héricourt, Nord Franche-ComtéAges 18 years+ - NCT07159789Recruiting
Brain stimulation to improve leg weakness in MS
This study tests whether a noninvasive brain stimulation technique (rTMS) can help people with multiple sclerosis who have leg stiffness and weakness. You will receive daily sessions over two weeks to see if it improves walking and quality of life.
Gatineau, QuebecAges 18–70 - NCT06920524Recruiting
Music therapy for stress during botox injections
This study tests whether listening to music can reduce stress and anxiety during botulinum toxin (botox) injections for muscle spasticity. It may help you feel more calm and comfortable during treatment.
Clermont-FerrandAges 18 years+ - NCT06937723Recruiting
App-based monitoring for spasticity in multiple sclerosis
This trial tests if a smartphone app can help monitor spasticity (muscle tightness or stiffness) in people with multiple sclerosis. If you have MS and spasticity that needs treatment, using your own smartphone might help track your health.
Düsseldorf, North Rhine-WestphaliaAges 18 years+ - NCT07132775Recruiting
Full-body electrical stimulation suit for spasticity and pain
This study tests a full-body suit that delivers gentle electrical pulses to help reduce muscle stiffness, spasms, and pain in people with conditions like multiple sclerosis, fibromyalgia, or other neurological problems. It may help with movement and comfort.
Chicago, IllinoisAges 18–75 - NCT06201026Recruiting
Reducing Fatigue in New MS With Individualized Training
This trial tests if a personalized home training program can help reduce severe fatigue in people with relapsing-remitting MS who were recently diagnosed. You'll use a phone app to do exercises designed for you, and researchers will check your energy levels over time.
Saint-EtienneAges 18–60 - NCT07451600Recruiting
TMS for spasticity and balance in multiple sclerosis
This study tests if transcranial magnetic stimulation (TMS) can help reduce muscle stiffness (spasticity) and improve balance in people with multiple sclerosis. TMS uses magnetic pulses to stimulate parts of the brain.
Ankara, YenimahalleAges 18–60 - NCT07303582RecruitingPhase 4
Freezing nerves to ease pain from muscle tightness
This study tests if freezing specific nerves (cryoneurolysis) can reduce pain caused by muscle tightness (spasticity) after a brain or spinal cord injury, or from multiple sclerosis. It is for people who already get Botox injections for this pain.
OxfordAges 18 years+
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Common questions
- Are there clinical trials for spasticity with multiple sclerosis?
- Yes. Clin2 currently lists 34 recruiting spasticity with multiple sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a spasticity with multiple sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a spasticity with multiple sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Multiple Sclerosis, Relapsing-Remitting
- Multiple Sclerosis (MS) - Relapsing-remitting
- Multiple Sclerosis, Secondary Progressive
- Relapsing Multiple Sclerosis
- Multiple Sclerosis, Primary Progressive
- Progressive Multiple Sclerosis
- Multiple Sclerosis (MS) Primary Progressive
- Multiple Sclerosis (MS) Secondary Progressive
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.