Clinical trials
Stress Disorder clinical trials
Below are recruiting stress disorder clinical trials, each written for real people, not researchers. We’re tracking 396 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06332209Recruiting
Telehealth vs. in-person therapy for trauma in Puerto Rican youth
This trial compares two ways of giving a type of therapy called Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) to children and teens in Puerto Rico who have been through a traumatic event and have post-traumatic stress symptoms. One group receives therapy in person at a clinic, and the other group receives therapy through video calls (telehealth), to see which works better.
Charleston, South CarolinaAges 7–18 - NCT06298279Recruiting
Online CBT for public safety personnel in Canada
This study tests an online therapy program (cognitive behavioral therapy, or CBT) designed specifically for public safety personnel. It looks at how the timing of the course and learning from others affects your progress. You can join from anywhere in Canada.
Regina, SaskatchewanAges 18 years+ - NCT06296589Recruiting
Guilt Reduction vs. Prolonged Exposure for PTSD in Veterans
This study compares two types of talk therapy for Veterans with PTSD who also struggle with trauma-related guilt. One therapy focuses on reducing guilt, while the other is a standard trauma-focused treatment.
Little Rock, ArkansasAges 18 years+ - NCT06294106Recruiting
Brain stimulation for PTSD in veterans and first responders
This study tests a new type of brain stimulation (eTMS) to help reduce PTSD symptoms in veterans and first responders. It uses an MRI to guide the treatment, and aims to see if it can improve your quality of life.
Roanoke, VirginiaAges 18–65 - NCT06266364Recruiting
Vagus nerve stimulation for treatment-resistant PTSD
This study tests if stimulating the vagus nerve with an implanted device can help adults with chronic PTSD who haven't gotten better with standard treatments. You would have the device implanted and then follow the study plan for several months.
Austin, TexasAges 22–79 - NCT06234969Recruiting
Brain stimulation for PTSD: a learning study
This study tests whether a non-invasive brain stimulation technique called cTBS can help people with PTSD learn to overcome fear. You will have brain scans and receive stimulation to see if it improves how your brain processes fear-related memories.
Philadelphia, PennsylvaniaAges 18–60 - NCT06210711Recruiting
Prolonged exposure therapy for trauma injury patients
This study tests if prolonged exposure therapy can help people who were injured in a trauma and admitted to a Level I trauma center. It aims to reduce the psychological impact of the traumatic event, such as PTSD symptoms.
Dallas, TexasAges 18–75 - NCT06219408Recruiting
Stepped care for chronic pain and PTSD
This study tests a stepped-care program that combines complementary health approaches for people who have both chronic pain and PTSD. It aims to help patients manage both conditions together using treatments like acupuncture, massage, or mind-body therapy.
Seattle, WashingtonAges 18 years+ - NCT06218381Recruiting
Brief exposure for PTSD in combat veterans
This study tests a very brief exposure therapy to help U.S. combat veterans with PTSD. It is designed for veterans who have not had recent mental health treatment and experienced combat trauma within the last 10 years.
Los Angeles, CaliforniaAges 18–50 - NCT06215313Enrolling by invitation
Comparing two therapies for trauma memories
This study compares two types of therapy—EMDR and imagery rescripting—to help people who have upsetting memories or nightmares from past events. It's for people with depression or PTSD, and you'll need to come to therapy twice a week.
Eindhoven, North BrabantAges 18–70 - NCT06194851RecruitingPhase 2
Oxytocin nasal spray plus couples therapy for Veterans with PTSD
This study tests whether a nasal spray of oxytocin (a natural hormone) can boost the effects of a brief couples therapy for Veterans with PTSD. You and your partner would receive either the spray or a placebo (inactive spray) during therapy sessions to see if it helps reduce PTSD symptoms and improve relationship satisfaction.
San Diego, CaliforniaAges 18 years+ - NCT06162741Recruiting
Brief mindfulness training for Veterans in primary care
This study tests whether brief mindfulness training offered in VA primary care can help Veterans with symptoms of PTSD, depression, or anxiety. It aims to see if this approach works well in everyday clinic settings.
Phoenix, ArizonaAges 18 years+ - NCT06179485Enrolling by invitation
Ketamine vs. Etomidate for emergency breathing tube: long-term study
This study compares how two common medicines (ketamine and etomidate) used during emergency breathing tube placement affect long-term recovery. It is only for patients already enrolled in another related trial.
Birmingham, AlabamaAges 18 years+ - NCT06127342Recruiting
Exercise and emotional learning for PTSD
This study tests whether exercise can help people with PTSD learn to feel safer in their bodies. You will do some exercise sessions and emotional learning tasks, and have an MRI brain scan to see how your brain changes.
Lexington, KentuckyAges 18–64 - NCT06094933Recruiting
Mobile anger reduction for veterans with PTSD
This study tests a mobile app that helps veterans with PTSD manage anger. If you often feel angry or irritable, this app might help you learn ways to feel calmer and more in control.
Durham, North CarolinaAges Any age - NCT06088303Recruiting
Improving PTSD treatment through better communication
This study tests if improving how you talk with your doctor can make PTSD treatment work better. You can join if you have PTSD and have been on stable medications for at least 4 weeks.
Boston, MassachusettsAges 18 years+ - NCT05560113Recruiting
Study uses brain stimulation to disrupt fear memory in PTSD
This study tests a brain stimulation approach to affect how fear memories “stick” after they are formed. If you have PTSD, it may help reduce fear-related learning, but you must meet several safety and health criteria.
Atlanta, GeorgiaAges 18–65 - NCT03755401Recruiting
Therapy trial for PTSD after prior treatment didn’t fully help
This trial studies a specific talk-therapy approach (psychodynamic psychotherapy) for people with post-traumatic stress disorder (PTSD) who still have significant symptoms despite prior treatment. You may be able to join if your PTSD symptoms are in a moderate range and you can safely participate without urgent safety risks or certain other conditions.
New York, New YorkAges 18–70 - NCT04585685Recruiting
Healthy recovery program for PTSD after sexual trauma
This study looks at how to help people recover from PTSD symptoms after sexual trauma, including feeling mentally “contaminated.” You may be eligible if you currently meet criteria for PTSD and report these contamination feelings, and you can avoid starting other trauma treatments during the study.
Lexington, KentuckyAges 18 years+ - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT05788302Recruiting
Studying prolonged exposure for PTSD and how it helps
This trial studies how a therapy called “prolonged exposure” works for people with post-traumatic stress disorder (PTSD). You may be able to join if you have PTSD, are interested in starting prolonged exposure, and meet other safety and participation rules.
Boston, MassachusettsAges 18 years+ - NCT03578003Recruiting
Bright morning light to improve sleep in veterans
This study tests whether using bright morning light can improve sleep quality in veterans. You may be able to join if you’re not already using a light box and you don’t have certain eye or mood conditions.
Portand, OregonAges 18 years+ - NCT06044675RecruitingPhase 2
MDMA plus therapy for PTSD – a study with a partner
This study tests whether MDMA, combined with a type of talk therapy called CBCT (cognitive behavioral conjoint therapy), is more effective than CBCT alone for treating PTSD. You and a close partner will both participate in therapy sessions and take MDMA together.
Toronto, OntarioAges 18–80 - NCT06035809Recruiting
Smart treatment study for PTSD using brain activity feedback
This study tests a new therapy called SMART, which uses brain imaging to help regulate arousal linked to PTSD. It aims to see if combining brain feedback with therapy reduces PTSD symptoms.
London, OntarioAges 18–65
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Common questions
- Are there clinical trials for stress disorder?
- Yes. Clin2 currently lists 396 recruiting stress disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a stress disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a stress disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.