Clinical trials
Substance Use (Drugs, Alcohol) clinical trials
Below are recruiting substance use (drugs, alcohol) clinical trials, each written for real people, not researchers. We’re tracking 101 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06676059Recruiting
Substance use monitoring study with a smartphone app
This study uses a smartphone app and daily surveys to track alcohol or drug use. It aims to create a database for future research on addiction patterns and recovery.
Baltimore, MarylandAges 18–120 - NCT05178069RecruitingPhase 2
Probiotic supplement study for alcohol use disorder and liver injury
This Phase 2 trial studies whether a probiotic (LGG) can improve health in people with alcohol use disorder and alcohol-related liver injury. It’s not an alcohol treatment study, so participants are mainly joining to see how the supplement affects the body and liver-related outcomes.
Louisville, KentuckyAges 21–65 - NCT05778734Recruiting
Study to help young adults improve alcohol steadiness
This study is looking at ways to increase “alcohol abstinence,” meaning drinking less or stopping. It focuses on young adults who currently drink and have symptoms of alcohol use disorder, and it may help them build skills to reduce or stop drinking.
Chicago, IllinoisAges 18–24 - NCT05929677RecruitingEarly Phase 1
Study tests effects on impulsivity and how alcohol feels
This early-phase study looks at how alcohol affects impulsivity (tendency to act quickly) and people’s subjective experiences. You may be able to join if you drink regularly and meet the study safety rules.
Boston, MassachusettsAges 21–25 - NCT06853873Enrolling by invitation
Alcohol counseling for safer pregnancies
This trial tests a counseling program to help pregnant women reduce risky alcohol use. The program is designed to support women in making healthier choices for themselves and their baby.
Cape TownAges 18 years+ - NCT06136195RecruitingPhase 1
Mavoglurant for alcohol craving in heavy drinkers
This trial tests whether a medication called mavoglurant can reduce alcohol cravings and drinking in people who are heavy drinkers with alcohol use disorder and are not looking for treatment.
New Haven, ConnecticutAges 21–50 - NCT04793685RecruitingPhase 2
Prazosin for alcohol withdrawal symptoms in alcohol use disorder
This study tests whether prazosin can reduce symptoms that happen when someone stops or cuts back on heavy drinking. It may help people with moderate-to-severe alcohol use disorder who also have alcohol withdrawal symptoms.
New Haven, ConnecticutAges 18–70 - NCT06580457Recruiting
Personalized smartphone program for Veterans with substance use
This study tests a personalized smartphone program to help Veterans reduce harmful substance use. It uses daily surveys and feedback to support healthier habits.
Minneapolis, MinnesotaAges 18 years+ - NCT07734623Recruiting
Ultrasound treatment for severe opioid or amphetamine use disorder
This trial tests a low-intensity focused ultrasound treatment for people with severe opioid or amphetamine use disorder. The ultrasound targets a part of the brain linked to addiction, and the goal is to see if it is safe and helpful.
TaipeiAges 20–50 - NCT06845124RecruitingPhase 2
Testing CBD and naltrexone for alcohol craving
This trial is testing if taking cannabidiol (CBD) plus naltrexone can reduce alcohol craving in people with alcohol dependence. Naltrexone is already used to help with alcohol cravings, and CBD may add extra benefit.
Wiesloch, Baden-WurttembergAges 18–70 - NCT05169385Recruiting
Parent support for teens in residential treatment for substance misuse
This trial tests a parent-focused program (via interviews and texting) for families when a teen is leaving residential treatment. It aims to help parents/guardians support their teen after discharge and reduce substance-related risk.
Rockford, IllinoisAges 12–18 - NCT05630781Recruiting
Orexin's role in the neurobiology of addiction
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Baltimore, MarylandAges 18–60 - NCT06115746Recruiting
A drug education program for middle and high school students
This study tests a program called iDECIDE, which helps students who have had a substance use issue at school. The program aims to provide education and support instead of punishment. Participants will attend up to 9 online study visits over about a year.
Boston, MassachusettsAges 9–22 - NCT06074354Recruiting
MY-RIDE app for HIV prevention and substance use in homeless youth
This study tests a smartphone app called MY-RIDE to help homeless youth prevent HIV and reduce substance use. The app sends helpful tips at the right time to support healthier choices.
Houston, TexasAges 18–25 - NCT06349083RecruitingPhase 2
Psilocybin-assisted treatment for alcohol use disorder
This study tests whether psilocybin, a psychedelic drug, combined with therapy can help people reduce or stop drinking. It aims to understand how psilocybin affects the brain and behavior in people with alcohol use disorder.
New York, New YorkAges 18–65 - NCT07740395Recruiting
Support app for people in recovery and their loved ones
This study tests a support app (KulaMind-Recovery) that helps people in recovery stay connected with a loved one. You and someone important to you would both use the app to see if it helps your recovery journey.
Providence, Rhode IslandAges 18 years+ - NCT04084860RecruitingPhase 2
Brief medicine trial to help reduce heavy alcohol drinking
This Phase 2 study tests a brief medication approach meant to reduce “problem drinking.” It may help people cut back or stop alcohol use by adjusting brain signaling related to drinking cravings and urges.
New York, New YorkAges 21–70 - NCT05943665RecruitingPhase 2
MDMA-assisted therapy for PTSD and alcohol use in veterans
This study tests whether MDMA, given in a controlled clinical setting, can reduce symptoms of PTSD and alcohol use disorder in veterans. It also combines the medication with structured therapy sessions to help you manage symptoms without relying on alcohol or other substances.
Providence, Rhode IslandAges 18 years+ - NCT06216600Recruiting
Women's strength and resilience program for HIV and substance use
This study tests a program for women living with HIV who also struggle with substance use or heavy drinking. It combines exercise and support to help build strength and resilience. You may qualify if you've missed some HIV medications, have a detectable viral load, and have experienced violence.
San Diego, CaliforniaAges 18 years+ - NCT06489782Recruiting
New approach to test alcohol use disorder medications
This study tests a new way to quickly screen medications for alcohol use disorder (AUD). You will have lab sessions where your drinking is monitored to see how different medicines affect your alcohol use.
New Haven, ConnecticutAges 21–65 - NCT06559774Recruiting
Strong Man program for American Indian men with substance use
This study tests a program called Strong Man, which is designed to help American Indian men who have used alcohol or drugs. The program aims to support their health and well-being. If you join, you will take part in sessions and assessments to see if the program helps.
Chinle, ArizonaAges 18 years+ - NCT07193914Recruiting
Program for people with addiction and trauma
This trial tests a program called ECCCLORE to help people who struggle with both addiction and trauma. It aims to see if the program can improve their well-being.
Nîmes, NîmesAges 18 years+ - NCT05957848RecruitingPhase 2
Guanfacine for teens with cannabis use problems
This Phase 2 study tests whether extended-release guanfacine can reduce cannabis use in adolescents and young adults. It may help by targeting brain pathways that can drive cravings or continued use.
Parkville, VictoriaAges 12–25 - NCT06232434RecruitingPhase 2/Phase 3
New gel treatment for advanced stomach cancer that has spread
This trial tests a new gel called Prospidelong given once into the abdomen during surgery for stomach cancer that has spread to the lining of the belly. The goal is to see if it is safe and works well.
Minsk, Minsk CityAges 18–75
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Common questions
- Are there clinical trials for substance use (drugs, alcohol)?
- Yes. Clin2 currently lists 101 recruiting substance use (drugs, alcohol) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use (drugs, alcohol) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use (drugs, alcohol) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.